Powder: -20°C for 3 years | In solvent: -80°C for 1 year
dCBP-1 是基于Cereblon 配体的p300/CBP 的选择性双功能降解剂。dCBP-1可以有效的杀死多发性骨髓瘤细胞,并降低驱动 MYC 表达的致癌增强子活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 748 | 现货 | ||
5 mg | ¥ 1,980 | 现货 | ||
10 mg | ¥ 3,390 | 现货 | ||
25 mg | ¥ 5,530 | 现货 | ||
50 mg | ¥ 7,750 | 现货 | ||
100 mg | ¥ 9,870 | 现货 |
产品描述 | dCBP-1 is a chemical degrader of p300/CBP. dCBP-1 hijacks the E3 ubiquitin ligase CRBN for selective degradation of p300/CBP. Degradation of p300/CBP by dCBP-1 leads to effective multiple myeloma cell killing. |
体外活性 | Treatment of the human haploid cell line HAP1 for 6 h with dCBP-1 revealed almost complete loss of both CBP and p300 between 10 and 1,000 nM doses. A time course analysis with 250 nM dCBP-1 revealed almost complete degradation of p300/CBP within an hour of treatment[1]. dCBP-1 was also able to induce near-complete p300/CBP degradation across other multiple myeloma cell lines tested, including MM1R, KMS-12-BM, and KMS34[1]. |
分子量 | 1028.11 |
分子式 | C51H63F2N11O10 |
CAS No. | 2484739-25-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (48.63 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.9727 mL | 4.8633 mL | 9.7266 mL | 24.3165 mL |
5 mM | 0.1945 mL | 0.9727 mL | 1.9453 mL | 4.8633 mL | |
10 mM | 0.0973 mL | 0.4863 mL | 0.9727 mL | 2.4316 mL | |
20 mM | 0.0486 mL | 0.2432 mL | 0.4863 mL | 1.2158 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
dCBP-1 2484739-25-3 Chromatin/Epigenetic PROTAC Epigenetic Reader Domain Ligand for E3 Ligase Inhibitor p300 multiple CRBN myeloma cell degrader PROTACs MYC CBP inhibit dCBP 1 dCBP1 heterobifunctional inhibitor