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Cat. No.	Product Name	Target	Signaling Pathways
T9370	dCBP-1	Epigenetic Reader Domain; Ligand for E3 Ligase	Chromatin/Epigenetic; PROTAC
	dCBP-1 是基于Cereblon 配体的p300/CBP 的选择性双功能降解剂。dCBP-1可以有效的杀死多发性骨髓瘤细胞，并降低驱动 MYC 表达的致癌增强子活性。
T8667	MC-Gly-Gly-Phe-Gly DSN28369	Others	Others
	MC-Gly-Gly-Phe-Gly (DSN28369) 是一种可降解的 ADC linker，是一种异双功能接头，可用于制备抗体药物偶联物。
T9116	SMCC N-Succinimidyl 4-(N-maleimidomethyl)cycl,4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯	Others	Others
	SMCC (N-Succinimidyl 4-(N-maleimidomethyl)cycl) 是一种异双功能蛋白质交联剂。它接合抗原耦合脾脏细胞来诱导抗原特异性免疫反应。
T14061	EMCS 6-Maleimidohexanoic acid N-hydroxysuccinimide ester	Others	Others
	EMCS (6-Maleimidohexanoic acid N-hydroxysuccinimide ester) 是一种异双官能团交联剂，是一种制备半抗原结合物和酶免疫偶联物的化合物，是抗体药物偶联物中一种有效的保护基团。
T5440	Dbet57	Epigenetic Reader Domain	Chromatin/Epigenetic
	dBET57 是基于 PROTAC 技术的 BRD4 异双功能降解剂，对 BRD4BD1 有显著降解作用，DC50/5h 为 500 nM。
T17389	AMAS	Others	Others
	AMAS 是一种不可裂解的异双功能交联剂，具有 NHS 酯和马来酰亚胺基团，可实现含胺和巯基分子的共价结合。
T5434	ARV-825	Epigenetic Reader Domain	Chromatin/Epigenetic
	ARV-825 是一种双功能 PROTAC，蛋白水解靶向嵌合体，将 BRD4 募集到 E3 泛素连接酶大脑中，导致 BRD4 在所有测试的 BL 细胞系中快速、有效和延长降解。对 BRD4 的 BD1 和 BD2 结构域具有高亲和力，Kd 值分别为 90 和 28 nM。
T18725	Sulfo-LC-SPDP	Others	Others
	Sulfo-LC-SPDP is a heterobifunctional crosslinker characterized by its thiol-cleavable and membrane impermeable properties.
T21269	Sulfo-EMCS
	Sulfo-EMCS is a heterobifunctional sulfhydryl- and amine-reactive crosslinker.
T24841	Sulfo-MBS Crosslinker Sulfo-MBS Cross linker,Sulfo-MBS Cross-linker
	Sulfo-MBS Crosslinker is a non-cleavable, water-soluble, heterobifunctional protein crosslinking reagent. It is commonly used to crosslink haptens to carrier proteins and enzymes to antibodies.
T19568	Sulfo-SMPB sodium	Others	Others
	Sulfo-SMPB sodium is a non-cleavable heterobifunctional chemical cross-linking reagent that combines N-hydroxysuccinimide ester and maleimide groups. This compound enables the covalent conjugation of molecules possessing amine and sulfhydryl functionalities.
T19941	MBS Crosslinker MBS protein crosslinker
	MBS crosslinker is a non-cleavable, water-insoluble, heterobifunctional protein crosslinking reagent. The MBS protein crosslinker extended spacer arm analog is SMPB crosslinker SATA Protein Modifier can be used to add sulfhydryl groups to proteins or pept
T11292	FKBP12 PROTAC dTAG-7 dTAG-7	Epigenetic Reader Domain	Chromatin/Epigenetic
	FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by connecting BET bromodomains to the E3 ubiquitin ligase CRBN. Additionally, it serves as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
T15395	GMBS	Others	Others
	GMBS is a heterobifunctional cross-linker.
T24842	Sulfo-SIA Crosslinker Sulfo-SIA Cross-linker,Sulfo-SIA Cross linker
	Sulfo-SIA Crosslinker is a non-cleavable, heterobifunctional protein crosslinker. Sulfo-SIA Crosslinker is useful in making antibody-drug conjugates.
T19942	SBA Crosslinker SBA Cross-linker,SBA Cross linker
	SBA crosslinker is a sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. SBA protein crosslinker is non-cleavable and is among the shortest amine and sulfhydryl reactive crosslinking reagents known with a spacer arm length of on
T18734	Sulfo-SPP	Others	Others
	Sulfo-SPP is a heterobifunctional, thiol-cleavable and membrane impermeable crosslinker.
T74412	dTAGV-1-NEG TFA
	dTAGV-1-NEG TFA 是一种非对映异构体，是 dTAGV-1 的异双功能阴性对照。dTAGV-1-NEG TFA 是一种 FKBP12F36V 选择性降解剂。
T15883	m-PEG4-phosphonic acid ethyl ester	Others	Others
	m-PEG4-phosphonic acid ethyl ester is a PEGylation-based linker for the design and synthesis of PROTACs, which are heterobifunctional molecules facilitating targeted protein degradation[1].
T39352	Piperidine-GNE-049-N-Boc
	Piperidine-GNE-049-N-Boc is a ligand that specifically binds to the target protein dCBP, enabling it to be degraded by a selective and potent heterobifunctional degrader, p300/CBP.
T40144	CBP/p300 ligand 2
	CBP/p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300/CBP.
T40036	Thalidomide-NH-PEG4-COOH Thalidomide-NH-PEG4-COOH
	Thalidomide-NH-PEG4-COOH is a conjugate comprising an E3 ligase ligand-linker, utilized in the synthesis of dCBP-1. dCBP-1 itself functions as a powerful and selective heterobifunctional degrader targeting p300/CBP.
T14809	Bromo-PEG5-phosphonic acid diethyl ester	Others	Others
	Bromo-PEG5-phosphonic acid diethyl ester is a polyethylene glycol (PEG)-based linker for PROTAC synthesis[1]. It is utilized in the construction of PROteolysis TArgeting Chimeras (PROTACs), which are heterobifunctional molecules designed to induce protein degradation.
T19943	SMPB Crosslinker SMPB Cross linker,SMPB Cross-linker
	SMPB crosslinker is a heterobifunctional protein crosslinking reagent that is reactive toward sulfhydryl and amino groups. The SMPB protein crosslinker is an extended chain length analog of MBS crosslinker. SMPB crosslinker's spacer arm is non-cleavable.
T18189	m-PEG3-Sulfone-PEG4-propargyl	Others	Others
	m-PEG3-Sulfone-PEG4-propargyl is a polyethylene glycol (PEG)-based prodrug-induced degradation (PROTAC) linker. It is utilized in the efficient synthesis of PROTACs, a class of heterobifunctional molecules designed to selectively target and degrade specific protein targets[1].
T74556	dTAG-47
	dTAG-47，异双功能 dTAG 分子，靶向突变型 FKBP12 (FKBP12F36V)。FKBP12F36V 可用作降解标签 (dTAG) 并与靶蛋白融合。dTAG-47可用于基底样乳腺癌（BBC）的研究。
T11291	FKBP12 PROTAC dTAG-13 dTAG-13	Epigenetic Reader Domain	Chromatin/Epigenetic
	FKBP12 PROTAC dTAG-13 (dTAG-13) is a degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 (dTAG-13) also is a selective degrader of BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to an E3 ubiquitin ligase CRBN. FKBP12 PROTAC dTAG-13 (dTAG-13) is a PROTAC-based heterobifunctional degrader.
T69506	dBRD4-BD1
	dBRD4-BD1 is a selective BRD4 bromodomain inhibitor. dBRD4-BD1 can selectively degrade BRD4 (DC50 = 280 nM). Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BRD4 selectivity up front enables analysis of BRD4 biology without wider BET-inhibition and simplifies designing BRD4-selective heterobifunctional molecules, such as degraders with new E3 recruiting ligands or for additional probes beyond degraders.
T82192	HLDA-221
	HLDA-221是一种异双功能小分子，其为调节诱导邻近靶向嵌合体(RIPTAC)。该分子通过在癌组织中选择性表达的靶蛋白与泛表达蛋白间形成稳定的三元复合物，特异性诱导表达该靶蛋白细胞的cell death。
T77915	CCT367766 formic	PROTACs	PROTAC
	CCT367766 formic 是一款有效的口服第三代异功能蛋白降解探针(PROTAC)，基于Cereblon配体，能在低浓度降低pirin蛋白表达。该化合物对CRBN-DDB1复合物具中等亲和力，IC50值为490 nM；同时，对重组pirin和CRBN的亲和力良好，Kd值分别为55 nM和120 nM。CCT367766 formic作为化学工具，对研究某些未开发蛋白质具有重要价值。

化合物

Cat.No: T9370

Target: Epigenetic Reader Domain, Ligand for E3 Ligase

MC-Gly-Gly-Phe-Gly

Cat.No: T8667

Synonym: DSN28369

Target: Others

Cat.No: T9116

Synonym: N-Succinimidyl 4-(N-maleimidomethyl)cycl,4-(N-马来酰亚胺基甲基)环己烷-1-羧酸琥珀酰亚胺酯

Target: Others

Cat.No: T14061

Synonym: 6-Maleimidohexanoic acid N-hydroxysuccinimide ester

Target: Others

Cat.No: T5440

Target: Epigenetic Reader Domain

Cat.No: T17389

Target: Others

Cat.No: T5434

Target: Epigenetic Reader Domain

Cat.No: T18725

Target: Others

Cat.No: T21269

Sulfo-MBS Crosslinker

Cat.No: T24841

Synonym: Sulfo-MBS Cross linker,Sulfo-MBS Cross-linker

Sulfo-SMPB sodium

Cat.No: T19568

Target: Others

MBS Crosslinker

Cat.No: T19941

Synonym: MBS protein crosslinker

FKBP12 PROTAC dTAG-7

Cat.No: T11292

Synonym: dTAG-7

Target: Epigenetic Reader Domain

Cat.No: T15395

Target: Others

Sulfo-SIA Crosslinker

Cat.No: T24842

Synonym: Sulfo-SIA Cross-linker,Sulfo-SIA Cross linker

SBA Crosslinker

Cat.No: T19942

Synonym: SBA Cross-linker,SBA Cross linker

Cat.No: T18734

Target: Others

dTAGV-1-NEG TFA

Cat.No: T74412

m-PEG4-phosphonic acid ethyl ester

Cat.No: T15883

Target: Others

Piperidine-GNE-049-N-Boc

Cat.No: T39352

CBP/p300 ligand 2

Cat.No: T40144

Thalidomide-NH-PEG4-COOH

Cat.No: T40036

Synonym: Thalidomide-NH-PEG4-COOH

Bromo-PEG5-phosphonic acid diethyl ester

Cat.No: T14809

Target: Others

SMPB Crosslinker

Cat.No: T19943

Synonym: SMPB Cross linker,SMPB Cross-linker

m-PEG3-Sulfone-PEG4-propargyl

Cat.No: T18189

Target: Others

Cat.No: T74556

FKBP12 PROTAC dTAG-13

Cat.No: T11291

Synonym: dTAG-13

Target: Epigenetic Reader Domain

Cat.No: T69506

Cat.No: T82192

CCT367766 formic

Cat.No: T77915

Target: PROTACs

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