Cat. No. | Product Name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T19489 | O-Desmethyl gefitinib D8
化合物 T19489
|
T19489 | 98% |
|
O-Desmethyl gefitinib D8 is a deuterium labeled O-Desmethyl gefitinib that is an active metabolite of Gefitinib in human plasma. | ||||
T73128 | EGFR-IN-61
化合物 EGFR-IN-61
|
2890261-81-9 | 98% |
|
EGFR-IN-61(化合物22a)为一种高效EGFR激酶抑制剂,其对L858R/T790M、L858R/T790M/C797S和WT的IC50值分别为42 nM、137 nM和743 nM。此外,EGFR-IN-61对A549和H1975细胞株展现抗增殖效应,其IC50值依次为2.14 μM和1.82 μM。 | ||||
T73165 | EGFR-IN-73
化合物 EGFR-IN-73
|
2857033-34-0 | 98% |
|
EGFR-IN-73 (Compound 3f) 对EGFR突变EGFRDel19显示出高效抑制,其IC50值为119 nM。 | ||||
T73995 | EGFR/CSC-IN-1
化合物 EGFR/CSC-IN-1
|
2820447-02-5 | 98% |
|
EGFR/CSC-IN-1为针对三阴性乳腺癌研究的潜在EGFR(IC50为10.52 nM)及肿瘤干细胞(CSC)双重抑制剂。 | ||||
T10556 | BKI-1369
化合物 T10556
|
1951431-22-3 | 98% |
|
BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM). | ||||
T10433 | Osimertinib dimesylate
奥希替尼二甲磺酸盐
|
2070014-82-1 | 98% |
|
Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor (IC50s: 12 and 1 nM against EGFR L858R and EGFR L858R/T790M). | ||||
T11213L | Epertinib
化合物 T11213L
|
908305-13-5 | 98% |
|
Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ... | ||||
TN3711 | Corylifol C
化合物 TN3711
|
775351-91-2 | 98% |
|
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor... | ||||
T16362 | Nuvenzepine
化合物 T16362
|
96487-37-5 | 98% |
|
Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment. | ||||
TN5100 | Taspine
化合物 TN5100
|
602-07-3 | 98% |
|
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H... | ||||
TN4213 | Hirsutenone
化合物 TN4213
|
41137-87-5 | 98% |
|
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero... | ||||
T12131 | Mutated EGFR-IN-3
化合物 T12131
|
2375107-27-8 | 98% |
|
Mutated EGFR-IN-3 is a ATP-competitive and highly selective allosteric dibenzodiazepinone EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) inhibitor(IC50 of 12 nM a... | ||||
T13743 | JH-XI-10-02
化合物 T13743
|
2209085-22-1 | 98% |
|
JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrade... | ||||
TN1912 | Marinobufogenin
南美蟾毒精
|
470-42-8 | 98% |
|
Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure. | ||||
T9922 | Matuzumab
马妥珠单抗
|
339186-68-4 | 98% |
Matuzumab
|
Matuzumab 是一种用于癌症治疗的人源化单克隆抗体。它对 EGFR 具有高亲和力,通常与恶性肿瘤中血管的生长有关,从而促进肿瘤的生长和存活。 | ||||
TN2504 | 1,5-Dihydroxyxanthone
化合物 TN2504
|
14686-65-8 | 98% |
|
1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have ant... | ||||
T12130 | Mutated EGFR-IN-2
化合物 T12130
|
2050906-97-1 | 98% |
|
Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR. | ||||
T11159 | EGFR-IN-2
化合物 T11159
|
1643497-70-4 | 98% |
|
EGFR-IN-2 is a non-covalent, mutation-selective and irreversible second-generation EGFR inhibitor. | ||||
T8525 | EGFR-IN-16
化合物AG473
|
133550-22-8 | 98% |
|
EGFR-IN-16 (AG473) 是一种EGFR 抑制剂,对 EGFR 和 HER-2 的pIC50分别为4.85和4.74。 | ||||
TN4638 | Neolinine
化合物 TN4638
|
112515-37-4 | 98% |
|
Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity. |