Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EGFR-IN-16 (AG473) 是一种EGFR 抑制剂,对 EGFR 和 HER-2 的pIC50分别为4.85和4.74。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 1,187 | 6-8周 | ||
10 mg | ¥ 1,888 | 6-8周 | ||
25 mg | ¥ 3,587 | 6-8周 |
产品描述 | EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells. |
体内活性 | Expressed the Ag473 lipoprotein from Neisseria meningitides, flagellin FlaB from Vibrio vulnificus and heat shock protein 70 from Mycobacterium tuberculosis (mHsp70) in Escherichia coli as single proteins and fusion proteins with VP2 protein of infectious bursal disease virus (IBDV).?Both cellular and humoral adjuvanticities of the three TLR ligands were compared by immunization of mice in two different ways.?Among the three co-administered TLR ligands, recombinant Ag473 lipoprotein exhibited the highest cellular and humoral adjuvanticities, including promotion of IL-4, IL-12, IFN-γ and IBDV VP2-specific antibody production.?Among the three genetically fused TLR ligands, fusion with Ag473 D1 domain exhibited the highest cellular and humoral adjuvanticities. |
别名 | AG473 |
分子量 | 265.26 |
分子式 | C16H11NO3 |
CAS No. | 133550-22-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
EGFR-IN-16 133550-22-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR FGFR Epidermal growth factor receptor inhibit Inhibitor AG-473 ErbB-1 AG 473 HER1 EGFRIN16 AG473 EGFR IN 16 inhibitor