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30

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7533	Taurolidine	Apoptosis; Others; Antibacterial; Antibiotic	Apoptosis; Microbiology/Virology; Others
	Taurolidine 是一种广谱抗菌剂，用于预防中心静脉导管相关感染。它具有抗真菌和抗肿瘤作用。
T31668	Eribaxaban PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292	Factor Xa	Metabolism
	Eribaxaban (PD348292) 是一种可口服的 Xa 因子抑制剂，可用于预防和治疗静脉血栓栓塞。
T0259	Chromocarb Chromone-2-carboxylic acid,色烯卡,Chromocarbe	Others	Others
	Chromocarb (Chromone-2-carboxylic acid) 是合成的血管保护剂。
T31806	Flovagatran TGN 255	Thrombin	Proteases/Proteasome
	Flovagatran (TGN 255) 是一种具有口服活性和有效性的凝血酶和肠外直接因子 II 抑制剂。Flovagatran 可用于研究静脉血栓栓塞。
T27920	LY 517717 LY-517717,LY517717	Factor Xa	Metabolism
	LY 517717 是一种具有口服活性的凝血因子 Xa 抑制剂，具有抗血栓活性，可用于研究静脉血栓栓塞（VTE）。
T9845	Thrombin inhibitor 5
	Thrombin inhibitor 5 (compound 385) 是一种凝血酶抑制剂，IC50范围为 0.1 μM~1 μM，可用于静脉血栓栓塞的研究。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T24170	Iodoantipyrine 碘安替比林,Jodantipyrine,EINECS 204-966-6,Arthripur,Iodophenazone	Others	Others
	Iodoantipyrine (Arthripur) 是一种常用的指示剂，用于在正常和高CBF 条件下通过测量全身注射指示剂后的循环静脉流出量来评价大鼠。
T29215	Zifaxaban TY 602,TY602,TY-602	Factor Xa	Metabolism
	Zifaxaban (TY-602) 是一种具有口服活性、竞争性和选择性的 Xa 因子 (FXa) 抑制剂，对人 FXa 的 IC50 为 11.1 nM。Zifaxaban 的亲和力很高，比其他丝氨酸蛋白酶高 10000 倍以上。Zifaxaban 可用于研究动脉和静脉血栓形成。
T4341	Betrixaban 贝曲西班,PRT054021	Factor Xa	Metabolism
	Betrixaban (PRT054021) 是一种口服具有活力的选择性factor Xa(fXa) 抑制剂，IC50=1.5 nM。
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
T0871	Noradrenaline bitartrate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Noradrenaline bitartrate 直接作用于 α 和 β 肾上腺素能受体。它是去甲肾上腺素的酒石酸氢盐，去甲肾上腺素是一种合成苯乙胺，可模拟内源性去甲肾上腺素的拟交感神经作用。临床上，去甲肾上腺素用作外周血管收缩剂，通过其α-肾上腺素能作用导致动脉和静脉床收缩。它还被用作通过其 β-1 肾上腺素能作用介导的强效正性肌力和变时性心脏刺激剂。
T68002	Naroparcil	Thrombin	Proteases/Proteasome
	Naroparcil 是一种可口服的硫代苷类化合物，是一种 4-甲基伞形 β-D-木糖苷类似物，在静脉血栓形成（颈静脉）的Wessler淤滞模型中显示出抗血栓形成作用。Naroparcil 增强了凝血酶/肝素辅因子II复合物的形成，诱导了处理兔血浆中硫酸皮肤素样物质的出现，但减少了与（125I）-人α-凝血酶孵育的血浆中的凝血酶/抗凝血酶III复合物的形成。
T1577	Midodrine hydrochloride Pro-Amatine,盐酸米多君	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Midodrine hydrochloride (Pro-Amatine) 通过去甘氨酸反应转化为其活性代谢物 desglymidodrine。Desglymidodrine 选择性地结合并激活小动脉和静脉血管系统的 α-1-肾上腺素能受体。这会导致平滑肌收缩并导致血压升高。 Desglymidodrine 在血脑屏障中的扩散很差，因此与对中枢神经系统的影响无关。Midodrine hydrochloride 是 midodrine 的盐酸盐形式，是一种直接作用的前药和拟交感神经药，具有抗低血压特性。
T4980	Betrixaban maleate	Factor Xa	Metabolism
	Betrixaban maleate 是一种非维生素 K 口服抗凝剂，其作用是由 Xa 因子的竞争性和可逆抑制作用驱动的。
T70510	CVS-1123
	CVS-1123 is a direct thrombin inhibitor, preventing occlusive arterial and venous thrombosis in a canine model of vascular injury.
T70681	G-4120
	G-4120 is a biochemical that has been shown to have a dose-dependent complete inhibition of arterial and venous thrombosis.
T11659	Inogatran 伊诺加群,H-314-27	Others	Others
	Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases.
T71362	GCC-4401C free base
	GCC-4401C free base is a factor Xa inhibitor similar to rivaroxaban that is currently under development for venous thromboembolic disease (VTE).
T70184	YM-60828 dihydrochloride
	YM-60828 dihydrochloride is a Factor Xa (FXa) inhibitor and anticoagulant used in the treatment of venous thromboembolic disease.
T71429	O-Demethyl apixaban sulfate
	O-Demethyl apixaban sulfate is a metabolite of Apixaban, a potent and highly selective factor Xa inhibitor. Apixaban is currently under development for treatment of arterial and venous thrombotic diseases.
T71096	GCC-4401C methanesulfonate
	GCC-4401C methanesulfonate is a factor Xa inhibitor similar to rivaroxaban that is currently under development for venous thromboembolic disease (VTE).
T70108	Fasudil hydrochloride hydrate
	Fasudil hydrochloride hydrate is an HCl salt of Fasudil -- a Rho-kinase (ROCK) inhibitor that has been shown to be effective in hindering the development of mature Cerebral Cavernous Malformation (CCM) lesions as well as reducing portal venous pressure in cirrhotic rats.
T71532	Fondaparinux free base
	Fondaparinux Free Base is a synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. Fondaparinux is a clinically approved anticoagulant pentasaccharide for the treatment of thrombotic diseases, displays better efficacy and biosafety than other heparin-based anticoagulant drugs.
T75408	Batroxobin
	Batroxobin (DF-521)，一种从Bothrops atrox moojeni获得的蛇毒，能促进血栓溶解，防止血栓复发并具有神经保护作用，显示出在脑静脉血栓性疾病研究中的潜力。
T64250	Desirudin
	Desirudin (CGP 39393) 是一种凝血酶 (thrombin) 抑制剂，能够抑制血栓形成和静脉淤血性血栓形成。Desirudin 能够用于研究血小板减少症或血小板功能障碍相关。
T68847	Aspirin calcium
	Aspirin calcium is the prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
T70097	Acefylline piperazine
	Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimula...
T72034	LI-2242	Others	Others
	LI-2242是一种强效肌醇六磷酸激酶（IP6K）抑制剂，对 IP6K1、IP6K2、IP6K3和 IPMK 的 IC50s 分别为31 nM、42 nM、8.7 nM 和1944 nM。LI-2242通过减少增强脂质吸收、脂质稳定和脂肪生成的基因的表达，改善了肝脏脂肪变性，增强体外脂肪细胞和肝细胞的线粒体耗氧率（OCR）和胰岛素信号传导。 LI-2242可改善饮食诱导的小鼠肥胖症、高血糖症和肝脂肪变性。LI-2242可用于研究 II 型糖尿病、肥胖症、代谢并发症、静脉血栓和精神疾病。
T36427	PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	Pituitary adenylate cyclase-activating peptide (PACAP) (6-27) is a PACAP receptor antagonist with IC50 values of 1,500, 600, and 300 nM, respectively, for rat PAC1, rat VPAC1, and human VPAC2 recombinant receptors expressed in CHO cells. It binds to PACAP receptors on SH-SY5Y and SK-N-MC human neuroblastoma and T47D human breast cancer cells (IC50s = 24.5, 106, and 105 nM, respectively) and inhibits cAMP accumulation induced by PACAP (1-38) (Kis = 457, 102, and 283 nM, respectively, in SH-SY5Y, ...

化合物

Cat.No: T7533

Target: Apoptosis, Others, Antibacterial, Antibiotic

Cat.No: T31668

Synonym: PD 348292,PD0348292,PD-0348292,PD-348292,PD 0348292,PD348292

Target: Factor Xa

Cat.No: T0259

Synonym: Chromone-2-carboxylic acid,色烯卡,Chromocarbe

Target: Others

Cat.No: T31806

Synonym: TGN 255

Target: Thrombin

Cat.No: T27920

Synonym: LY-517717,LY517717

Target: Factor Xa

Thrombin inhibitor 5

Cat.No: T9845

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Cat.No: T24170

Synonym: 碘安替比林,Jodantipyrine,EINECS 204-966-6,Arthripur,Iodophenazone

Target: Others

Cat.No: T29215

Synonym: TY 602,TY602,TY-602

Target: Factor Xa

Cat.No: T4341

Synonym: 贝曲西班,PRT054021

Target: Factor Xa

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

Noradrenaline bitartrate

Cat.No: T0871

Target: Adrenergic Receptor

Cat.No: T68002

Target: Thrombin

Midodrine hydrochloride

Cat.No: T1577

Synonym: Pro-Amatine,盐酸米多君

Target: Adrenergic Receptor

Betrixaban maleate

Cat.No: T4980

Target: Factor Xa

Cat.No: T70510

Cat.No: T70681

Cat.No: T11659

Synonym: 伊诺加群,H-314-27

Target: Others

GCC-4401C free base

Cat.No: T71362

YM-60828 dihydrochloride

Cat.No: T70184

O-Demethyl apixaban sulfate

Cat.No: T71429

GCC-4401C methanesulfonate

Cat.No: T71096

Fasudil hydrochloride hydrate

Cat.No: T70108

Fondaparinux free base

Cat.No: T71532

Cat.No: T75408

Cat.No: T64250

Aspirin calcium

Cat.No: T68847

Acefylline piperazine

Cat.No: T70097

Cat.No: T72034

Target: Others

PACAP (6-27) (human, chicken, mouse, ovine, porcine, rat) (trifluoroacetate salt)

Cat.No: T36427

Target: PACAP

Cat. No.	Product Name	Target	Signaling Pathways
T0070	Pentoxifylline Oxpentifylline,PTX,己酮可可碱,BL-191	HIV Protease; PDE; Adenosine Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Pentoxifylline (PTX) 是一种具有口服活性的磷酸二酯酶非选择性抑制剂，具有免疫调节、抗炎、抗纤溶、抗增殖和血液流变学改善作用。它可研究周围血管疾病、脑血管疾病和其他一些涉及局部微循环缺陷的疾病。
T6654	Saponins Sapogenins Glycosides,皂素,Saponin	Others	Others
	Saponins (Sapogenins Glycosides) 是一种苷类的化合物，多发现于多种植物中，可保护植物免受微生物和真菌的破坏。

天然产物

Cat.No: T0070

Synonym: Oxpentifylline,PTX,己酮可可碱,BL-191

Target: HIV Protease, PDE, Adenosine Receptor, Autophagy

Cat.No: T6654

Synonym: Sapogenins Glycosides,皂素,Saponin

Target: Others

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