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Search Results for " triazole "

70

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1371	1H-1,2,4-Triazole-3-carboxylic acid	Others	Others
	1H-1,2,4-Triazole-3-carboxylic acid，具有 isoprenyl transferases 抑制蛋白质的特性。
T77765	FSEN1 3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole	Ferroptosis	Apoptosis
	FSEN1 是一种新型高效的非竞争性 FSP1 抑制剂，IC50 值为 313 nM。 FSEN1 通过抑制 FSP1 诱导癌细胞中的铁死亡。FSEN1 可用于预防和治疗癌症。
T41244	Triticonazole	Antifungal	Microbiology/Virology
	Triticonazole 是一种三唑类农药。它具有杀菌和干扰内分泌作用。
T7867	Flutriafol	NMDAR; Antifungal	Microbiology/Virology; Neuroscience
	Flutriafol 是一种三唑类广谱杀菌试剂。
T67498	3-Amino-1,2,4-triazole Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	3-Amino-1,2,4-triazole (Trapidil impurity B) 是一种过氧化氢酶抑制剂，能够诱导过氧化氢解毒的补偿机制。该机制涉及增加谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性。
T17676	Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA	Others	Others
	Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double claevable 3-unit and 4-unit PEG linker for antibody-drug-conjugation (ADC).
T67137	1-Methyl-1,2,4-triazole
	1-Methyl-1,2,4-triazole 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67137，CAS号为 6086-21-1。
T12103	MR-L2	PDE	Metabolism
	MR-L2 是可逆的、非竞争性的长型异构体磷酸二酯酶 -4激活剂，可以激活代表性的 PDE4 长型异构体 (PDE4A4、PDE4B1、PDE4C3、PDE4D5)。它可抑制 PGE2- 诱导的 MDCK 细胞囊肿形成，其EC50=1.2 µM。
T78235	4-Phenyl-1H-1,2,3-triazole	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	4-Phenyl-1H-1,2,3-triazole，一种IDO1抑制剂（IC50：60 μM），可应用于癌症研究。
T9998	MIND4-19	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	MIND4-19 是一种具有抗肿瘤活性的 SIRT2 抑制剂。
T67127	1H-1,2,4-Triazole-1-carboximidamide hydrochloride
	1H-1,2,4-Triazole-1-carboximidamide hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67127，CAS号为 19503-26-5。
T0120	Voriconazole UK-109496,伏立康唑	Antifection; Antifungal	Microbiology/Virology
	Voriconazole (UK-109496) 是一种三唑类抗真菌剂，可抑制真菌麦角甾醇的生物合成。它特异性抑制由真菌细胞色素 P450 酶介导的 14-α-羊毛甾醇去甲基化作用
T66475	Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate
	Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66475，CAS号为 217448-86-7。
T2305	Isavuconazole 艾沙康唑,BAL-4815,RO-0094815	P450; Antibiotic; Antifungal	Metabolism; Microbiology/Virology
	Isavuconazole (RO-0094815) 是一种三唑类前药，对酵母、霉菌和二型真菌具有抗真菌活性。它抑制麦角固醇生物合成，导致真菌膜结构和功能的破坏。它是 CYP3A4抑制剂。
T67440	Ethyl 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate
	Ethyl 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67440，CAS号为 361990-21-8。
T67318	1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate
	1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67318，CAS号为 86386-77-8。
TNU0339	Ribavirin carboxylic acid
	Nucleoside Derivatives - Other modified nucleosides; Drugs and Inhibitors; Ribavirin related compound A; metabolite of Ribavirin
T14871	Carboxyamidotriazole Orotate L-651582 Orotate,CAI Orotate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Carboxyamidotriazole Orotate (L-651582 Orotate) 是一种可口服的信号转导抑制剂，是Carboxyamidotriazole (CAI) 的乳清酸盐形式。它是一种非电压性钙通道和钙通道介导的信号通路的细胞抑制剂，具有抗癌、抗炎活性和抗血管生成作用。
T5953	1-Aminobenzotriazole 3-Aminobenzotriazole,1-氨基苯并三唑,ABT	P450	Metabolism
	1-Aminobenzotriazole (ABT) 是一种不可逆的细胞色素 P450 非特异性抑制剂。
T25403	Farnesylthiotriazole
	Farnesylthiotriazole is a persistent PKC activator agent.
T14872	Carboxyamidotriazole CAI,L-651582	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Carboxyamidotriazole is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling pathways. It shows anti-inflammatory, anti-tumor, and antiangiogenic effects.
T20058	Prothioconazole HSDB7893,HSDB-7893,Proline 480 SC Fungicide,JAU 6476,丙硫菌唑,HSDB 7893	Antifungal	Microbiology/Virology
	Prothioconazole (Proline 480 SC Fungicide) 是一种手性三唑类杀菌剂，用于植物病原控制。
T7152	Ravuconazole 立福康唑,雷夫康唑,BMS-207147,ER-30346	Antifungal	Microbiology/Virology
	Ravuconazole (ER-30346) 是一种口服的三唑广谱抗真菌剂。
T2523	Rufinamide CGP 33101,E 2080,卢非酰胺,RUF 331	Sodium Channel	Membrane transporter/Ion channel
	Rufinamide (E 2080) 是一种新型镇痫化合物，可用于研究 Lennox-Gastaut 综合症。
T26829	Bitertanol KWG-0599,联苯三唑醇,KWG0599,Baycor,Biloxazol,KWG 0599,Sibutol	Antifungal	Microbiology/Virology
	Bitertanol (KWG 0599) 是一种三唑类杀菌剂。 Bitertanol 抑制去甲基化，破坏膜功能，并阻止甾醇合成。
T67766	HHS-0701	Others	Others
	HHS-0701，一种硫-三唑交换 (SuTEx) 配体，是酪氨酸反应性前列腺素还原酶 2 (PTGR2) 的有效抑制剂。HHS-0701 可以抑制脂质底物 15-Keto-PGE2 的 PTGR2 代谢。
T11070	DO34 analog	Others	Others
	DO34 analog 是二酰基甘油脂肪酶 α (DAGLα) 的抑制剂，DO34 analog 也是 DO34 的一个类似物。
T7086	Tris(benzyltriazolylmethyl)amine 三[(1-苄基-1H-1,2,3-三唑-4-基)甲基]胺,TBTA	Others	Others
	Tris(benzyltriazolylmethyl)amine (TBTA) 是一种能作为生化工具的配体，可用于标记蛋白质和酶。
T15033	Cyproconazole	Antibacterial	Microbiology/Virology
	Cyproconazole 是一种三唑类杀菌剂，在农业上用于保护作物免受多种真菌病原体的侵害。
T2199	Myclobutanil Systhane,腈菌唑	Antifungal	Microbiology/Virology
	Myclobutanil (Systhane) 是康唑类抗真菌剂，可用作农药。
T67988	Embeconazole R 120758,CS 758	Antifungal	Microbiology/Virology
	Embeconazole (R 120758) 是一种三唑类抗真菌剂。Embeconazole 对念珠菌、曲霉菌、新型隐球菌等临床重要真菌具有较强的体外活性。
T27617	Inz-1	P450	Metabolism
	Inz-1 是一种有效的真菌特异性线粒体细胞色素 bc1 抑制剂，对酵母和人类的 IC50 分别为 8.092 和 45.320 μM。 Inz-1 可逆转氟康唑或其他三唑类抗真菌药对致病性真菌白色念珠菌的耐药性。
T5966	Hexaconazole 己唑醇,(-)-Hexaconazol	Reactive Oxygen Species; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Hexaconazole ((-)-Hexaconazol) 是一种广谱三唑类杀菌剂，通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成，从而导致真菌细胞膜的破坏和细胞死亡。
T60929	Brassinazole (2S,3R)-Brassinazole	Others	Others
	Brassinazole 是一种选择性的三唑型类固醇 (BR)生物合成抑制剂。Brassinazole 可用于调节油芸素类固醇 (BR) 信号转导通路，用于调节植物木质部的生长和发育。
T2213	Terconazole Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,特康唑,曲康唑,R42470	Antifection; Antifungal	Microbiology/Virology
	Terconazole (Terazol 7) 是一种广谱抗真菌药物，用于研究阴道酵母菌感染。
T7866	Difenoconazole	Others; Antifungal	Microbiology/Virology; Others
	Difenoconazole 是一种广谱三唑类杀菌剂，通过抑制羊毛甾醇的细胞色素 P450 依赖性 14α-去甲基化来抑制麦角甾醇的生物合成，从而导致真菌细胞膜的破坏和细胞死亡。
T38273	Paclobutrazol (2R,3R)-Paclobutrazol,多效唑,(R,R)-paclobutrazol,2R,3R-Paclobutrazol	Antifungal	Microbiology/Virology
	Paclobutrazol ((R,R)-paclobutrazol) 是一种含有三唑的植物生长延缓剂，能抑制赤霉素的生物合成。Paclobutrazol 还具有抗真菌 (antifungal) 活性。Paclobutrazol 能抑制脱落酸的合成，诱导植物的耐冷性植物。Paclobutrazol 通常用于赤霉素在植物生物学中作用的研究。
T3934	Isavuconazonium sulfate	Antifungal	Microbiology/Virology
	Isavuconazonium sulfate 是一种口服活性抗真菌药，是活性三唑类抗真菌药物 Isavuconazole 的前药，可用于侵袭性曲霉菌病和毛霉菌病。
T17731L	CL2A-SN-38 DCA 1279680-68-0(free base)	Others	Others
	CL2A-SN-38 DCA 1279680-68-0(free base) 是一种药物-接头偶联物，由有效的 DNA 拓扑异构酶 I 抑制剂 SN-38 和接头 CL2A 组成，用于制造抗体药物偶联物 (ADC)。CL2A-SN-38 由有效的 DNA 拓扑异构酶组成I 抑制剂 SN-38 和接头 CL2A 以制造抗体药物偶联物 (ADC)。 CL2A-SN-38 对一系列人类实体瘤类型提供显着和特异性的抗肿瘤作用。 CL2A 是一种不可切割的复杂 PEG8 和含有三唑的 PABC-肽-mc 接头。 CL2A 可通过 pH 敏感性裂解，产生旁观者效应，并通过二硫键在半胱氨酸残基处结合抗体。
T21276	Amisulbrom
	Amisulbrom is classified under the triazole group of fungicides.
T28717	Sch 39304 Sch-39304,Sch39304
	Sch 39304 is an oral triazole antifungal.
T12523	Posaconazole-D5 SCH 56592-D5	Others	Others
	Posaconazole-D5, a deuterium-labeled variant of Posaconazole, is a second-generation, broad-spectrum triazole compound with antifungal activity.
T16714	Saperconazole 沙康唑,R66905	Others	Others
	Saperconazole is a broad-spectrum antifungal triazole (MIC90: 0.19 mg/L).
T37796	Voriconazole N-oxide
	Voriconazole N-oxide is a major metabolite of the triazole antifungal voriconazole . It is formed via oxidation of voriconazole by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2C19.
T11585	Hydroxy Itraconazole D8 R-63373 D8	Others	Others
	Hydroxy Itraconazole D8 is the deuterium-labeled Hydroxy Itraconazole. Hydroxy Itraconazole is an active metabolite of Itraconazole, which is a triazole antifungal agent.
T12522	Posaconazole-D4 SCH 56592-D4	Others	Others
	Posaconazole-D4, a deuterium-labeled variant of Posaconazole, is a broad-spectrum, second-generation triazole with antifungal activity.
T11679	Isavuconazole-d4 BAL-4815 D4,RO-0094815 D4,Isavuconazole D4	Others	Others
	Isavuconazole D4 is a deuterium labeled Isavuconazole. Isavuconazole is a triazole prodrug with antifungal activity against yeasts, molds, and dimorphic fungi.
T17732	CL2A	Others	Others
	CL2A is a pH-sensitive, cleavable PEG8- and triazole-containing PABC-peptide-mc linker, characterized by its ability to induce a bystander effect. It forms a disulfide bond with an antibody at a cysteine residue. Labetuzumab govitecan utilizes this linker for its drug conjugation[1].
T23174	Posaconazole hydrate	Others	Others
	Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole is a sterol C14ɑ demethylase inhibitor (IC50: 0.25 nM). Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome P450-dependent enzyme.
T19974	Propargyl-PEG3-azide Propargyl-PEG3-amine
	Propargyl-PEG3-amine is a PEG derivative containing a propargyl group and an amino group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper-catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

化合物

1H-1,2,4-Triazole-3-carboxylic acid

Cat.No: T1371

Target: Others

Cat.No: T77765

Synonym: 3-(4-bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole

Target: Ferroptosis

Cat.No: T41244

Target: Antifungal

Cat.No: T7867

Target: NMDAR, Antifungal

3-Amino-1,2,4-triazole

Cat.No: T67498

Synonym: Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B

Target: Reactive Oxygen Species

Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA

Cat.No: T17676

Target: Others

1-Methyl-1,2,4-triazole

Cat.No: T67137

Cat.No: T12103

Target: PDE

4-Phenyl-1H-1,2,3-triazole

Cat.No: T78235

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T9998

Target: Sirtuin

1H-1,2,4-Triazole-1-carboximidamide hydrochloride

Cat.No: T67127

Cat.No: T0120

Synonym: UK-109496,伏立康唑

Target: Antifection, Antifungal

Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate

Cat.No: T66475

Cat.No: T2305

Synonym: 艾沙康唑,BAL-4815,RO-0094815

Target: P450, Antibiotic, Antifungal

Ethyl 1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylate

Cat.No: T67440

1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate

Cat.No: T67318

Ribavirin carboxylic acid

Cat.No: TNU0339

Carboxyamidotriazole Orotate

Cat.No: T14871

Synonym: L-651582 Orotate,CAI Orotate

Target: Calcium Channel

1-Aminobenzotriazole

Cat.No: T5953

Synonym: 3-Aminobenzotriazole,1-氨基苯并三唑,ABT

Target: P450

Farnesylthiotriazole

Cat.No: T25403

Carboxyamidotriazole

Cat.No: T14872

Synonym: CAI,L-651582

Target: Calcium Channel

Prothioconazole

Cat.No: T20058

Synonym: HSDB7893,HSDB-7893,Proline 480 SC Fungicide,JAU 6476,丙硫菌唑,HSDB 7893

Target: Antifungal

Cat.No: T7152

Synonym: 立福康唑,雷夫康唑,BMS-207147,ER-30346

Target: Antifungal

Cat.No: T2523

Synonym: CGP 33101,E 2080,卢非酰胺,RUF 331

Target: Sodium Channel

Cat.No: T26829

Synonym: KWG-0599,联苯三唑醇,KWG0599,Baycor,Biloxazol,KWG 0599,Sibutol

Target: Antifungal

Cat.No: T67766

Target: Others

Cat.No: T11070

Target: Others

Tris(benzyltriazolylmethyl)amine

Cat.No: T7086

Synonym: 三[(1-苄基-1H-1,2,3-三唑-4-基)甲基]胺,TBTA

Target: Others

Cat.No: T15033

Target: Antibacterial

Cat.No: T2199

Synonym: Systhane,腈菌唑

Target: Antifungal

Cat.No: T67988

Synonym: R 120758,CS 758

Target: Antifungal

Cat.No: T27617

Target: P450

Cat.No: T5966

Synonym: 己唑醇,(-)-Hexaconazol

Target: Reactive Oxygen Species, Antifungal

Cat.No: T60929

Synonym: (2S,3R)-Brassinazole

Target: Others

Cat.No: T2213

Synonym: Gyno-Terazol,Terazol 3,Terazol 7,Triaconazole,特康唑,曲康唑,R42470

Target: Antifection, Antifungal

Cat.No: T7866

Target: Others, Antifungal

Cat.No: T38273

Synonym: (2R,3R)-Paclobutrazol,多效唑,(R,R)-paclobutrazol,2R,3R-Paclobutrazol

Target: Antifungal

Isavuconazonium sulfate

Cat.No: T3934

Target: Antifungal

CL2A-SN-38 DCA 1279680-68-0(free base)

Cat.No: T17731L

Target: Others

Cat.No: T21276

Cat.No: T28717

Synonym: Sch-39304,Sch39304

Posaconazole-D5

Cat.No: T12523

Synonym: SCH 56592-D5

Target: Others

Cat.No: T16714

Synonym: 沙康唑,R66905

Target: Others

Voriconazole N-oxide

Cat.No: T37796

Hydroxy Itraconazole D8

Cat.No: T11585

Synonym: R-63373 D8

Target: Others

Posaconazole-D4

Cat.No: T12522

Synonym: SCH 56592-D4

Target: Others

Isavuconazole-d4

Cat.No: T11679

Synonym: BAL-4815 D4,RO-0094815 D4,Isavuconazole D4

Target: Others

Cat.No: T17732

Target: Others

Posaconazole hydrate

Cat.No: T23174

Target: Others

Propargyl-PEG3-azide

Cat.No: T19974

Synonym: Propargyl-PEG3-amine

Cat. No.	Product Name	Target	Signaling Pathways
T1388	Fluconazole 氟康唑,UK-49858	Antibiotic; Antifection; Antifungal	Microbiology/Virology
	Fluconazole (UK-49858) 是一种对多种真菌具有活性的三唑类抗真菌剂，抑制 C. albicans 和 Candida kefyr 的 IC99为 0.20 μg/mL 至 0.39 μg/mL。
T1011	Itraconazole 伊曲康唑,R51211	P450; Hedgehog/Smoothened; Antibiotic; Autophagy; Antifungal	Autophagy; GPCR/G Protein; Metabolism; Microbiology/Virology; Stem Cells
	Itraconazole (R51211) 是三唑类抗真菌药，也是口服活性的Hedgehog 信号通路拮抗剂，IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶，从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。
T7132	(Rac)-Brassinazole BRASSINAZOLE,3-(4-氯苯基)-1-甲基-1-苯基-2-(1,2,4-三唑-1-基)-1-丙醇,(Rac)-芸苔素唑	P450	Metabolism
	(Rac)-Brassinazole 是三唑型化合物，是油菜素甾醇 (BR) 生物合成抑制剂。它能够增强 CYP90B 在 BR 生物合成中的抑制作用。

天然产物

Cat.No: T1388

Synonym: 氟康唑,UK-49858

Target: Antibiotic, Antifection, Antifungal

Cat.No: T1011

Synonym: 伊曲康唑,R51211

Target: P450, Hedgehog/Smoothened, Antibiotic, Autophagy, Antifungal

(Rac)-Brassinazole

Cat.No: T7132

Synonym: BRASSINAZOLE,3-(4-氯苯基)-1-甲基-1-苯基-2-(1,2,4-三唑-1-基)-1-丙醇,(Rac)-芸苔素唑

Target: P450

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上海市静安区江场三路238号8楼