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Search Results for " thrombotic "

16

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8719	SC99	Apoptosis; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	SC99 是一种口服有效选择性STAT3抑制剂，靶向 JAK2-STAT3 途径，抑制血小板活化和聚集，有抗骨髓瘤和抗血栓活性。它结合在 JAK2 的 ATP 结合袋中，抑制 JAK2 和 STAT3 的磷酸化。
T25364L	Efegatran sulfate LY294468 sulfate,GYKI-14766 sulfate,LY 294468 sulfate,LY-294468 sulfate	Thrombin	Proteases/Proteasome
	Efegatran sulfate (LY294468 sulfate) 是一种有效的凝血酶抑制剂，可用于治疗血栓类疾病。
T68092	Letaxaban TAK-442	Factor Xa	Metabolism
	Letaxaban (TAK-442) 是一种口服活性的四氢嘧啶-2(1H)- 1衍生物和具有抗凝血活性的凝血因子Xa(激活因子X)抑制剂。Letaxaban 不影响出血时间。Letaxaban 已被用于研究静脉血栓栓塞和急性冠状动脉综合征的治疗和预防的试验。
T40802	Poloxamer 188
	Poloxamer 188, a nonionic linear copolymer possessing surfactant properties, demonstrates anti-thrombotic, anti-inflammatory, and cytoprotective activities across different tissue injury models.
T11659	Inogatran 伊诺加群,H-314-27	Others	Others
	Inogatran is a synthetic thrombin inhibitor, developed for the possible treatment and prophylaxis of venous and arterial thrombotic diseases.
T78666	Egaptivon pegol ARC 1779	Integrin	Cytoskeletal Signaling
	Egaptivon pegol (ARC1779)为一种核酸适配体，能够阻断von Willebrand Factor (VWF)与血小板GPIb受体的结合，从而展现其抗血栓功能。
T62949	(1R,3S)-THCCA-Asn
	(1R,3S)-THCCA-Asn (4j) 是一种凝血酶 (thrombin) 的选择性抑制剂 (IC50: 0.07-0.14 μM)，具有抗血栓形成作用。
T70106	F-050
	F-050 is a biochemical that has been shown to inhibit platelet aggregation induced by CaCl2, arachidonic acid, collagen, adenosine diphosphate (ADP) and thrombin in guinea pigs, rabbits and rats in vitro. F-050 may be useful in the treatment of thrombotic diseases.
T71429	O-Demethyl apixaban sulfate
	O-Demethyl apixaban sulfate is a metabolite of Apixaban, a potent and highly selective factor Xa inhibitor. Apixaban is currently under development for treatment of arterial and venous thrombotic diseases.
T64257	FXIa-IN-8
	FXIa-IN-8 是一种有效的、选择性的 FXIa 抑制剂 (IC50: 14.2 nM)。FXIa-IN-8 表现出抗血栓形成效果，而且不会提高出血风险及明显的毒性 sup>[1]。
T75689	Mumefural
	Mumefural，Prunus mumeSieb 加工果实中的一种生物活性成分，具有抑制血小板聚集、显示抗血栓作用及改善认知障碍的功能。
T62507	Protease-Activated Receptor-1 antagonist 1
	Protease-Activated Receptor-1 antagonist 1 (Compound 13) 是一种蛋白酶激活受体 1 (PAR-1) 拮抗剂，通过 FLIPR 技术得到的 IC50 为 3 nM。Protease-Activated Receptor-1 antagonist 1 能够用于研究血栓性心血管、心肌梗塞和外周动脉疾病。
T71532	Fondaparinux free base
	Fondaparinux Free Base is a synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery. Fondaparinux is a clinically approved anticoagulant pentasaccharide for the treatment of thrombotic diseases, displays better efficacy and biosafety than other heparin-based anticoagulant drugs.
T78283	Caplacizumab ALX-0081,ALX-0681
	Caplacizumab (ALX-0681)为人源化抗血管性血友病因子(vWF)纳米抗体，具有抑制vWF介导的血小板粘附作用，可阻止微血栓进一步形成。该化合物在血栓性血小板减少性紫癜（TTP）研究中应用。
T75408	Batroxobin
	Batroxobin (DF-521)，一种从Bothrops atrox moojeni获得的蛇毒，能促进血栓溶解，防止血栓复发并具有神经保护作用，显示出在脑静脉血栓性疾病研究中的潜力。
T20765	Atorvastatin 阿托伐他汀,阿伐他汀	HMG-CoA Reductase; Autophagy	Autophagy; Metabolism
	Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，通过激活肝细胞色素p450加快代谢，具有有效降低血脂的能力。Atorvastatin 以 IC50 值分别为 0.39 μM 和 2.39 μM 来抑制人 SV-SMC 细胞的增殖和侵袭。Atorvastatin 与氯吡格雷同时服用两种可能会导致患者血栓事件增加。

化合物

Cat.No: T8719

Target: Apoptosis, JAK, STAT

Efegatran sulfate

Cat.No: T25364L

Synonym: LY294468 sulfate,GYKI-14766 sulfate,LY 294468 sulfate,LY-294468 sulfate

Target: Thrombin

Cat.No: T68092

Synonym: TAK-442

Target: Factor Xa

Cat.No: T40802

Cat.No: T11659

Synonym: 伊诺加群,H-314-27

Target: Others

Egaptivon pegol

Cat.No: T78666

Synonym: ARC 1779

Target: Integrin

(1R,3S)-THCCA-Asn

Cat.No: T62949

Cat.No: T70106

O-Demethyl apixaban sulfate

Cat.No: T71429

Cat.No: T64257

Cat.No: T75689

Protease-Activated Receptor-1 antagonist 1

Cat.No: T62507

Fondaparinux free base

Cat.No: T71532

Cat.No: T78283

Synonym: ALX-0081,ALX-0681

Cat.No: T75408

Cat.No: T20765

Synonym: 阿托伐他汀,阿伐他汀

Target: HMG-CoA Reductase, Autophagy

Cat. No.	Product Name	Target	Signaling Pathways
T3P2904	α-Linolenic acid Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	α-Linolenic acid (Alpha-Linolenic Acid) 是一种必需脂肪酸，人体无法合成，从种子油中分离得到。它可调节 PI3K/Akt 信号传导，影响血栓形成过程。它具有抗心律失常的特性，并且与心血管疾病和癌症等有关。
T2S1749	Protogracillin 原纤细薯蓣皂甙	Others	Others
	Protogracillin 是一种甾体皂苷，分离自Dioscorea zingiberensisWright (DZW) 中。从 DZW 根状茎中获得的甾体皂苷具有抗血栓作用，同时由降低心血管疾病风险的潜力。
T3809	Liriope muscari baily saponins C	Others	Others
	Liriope muscari baily saponins C 是一种L. muscari (Decne.) Baily 的主要活性成分。它已被作为肿瘤转移候选药物进行研究。它具有很强的抗炎、免疫药理和心脏保护作用。
TN1312	6-Hydroxykaempferol 3-O-β-D-glucoside 6-Hydroxykaempferol 3-O-beta-D-glucoside,6-羟基山柰酚-3-O-Β-D-葡萄糖苷	Others	Others
	6-Hydroxykaempferol 3-O-beta-D-glucoside has anti-thrombotic,and antioxidative activities.
T3839	Cycloolivil Isoolivil,环橄榄树脂素	Free radical scavengers; Others; Platelet aggregation	Others; oxidation-reduction
	Cycloolivil (Isoolivil) 是一种天然多酚化合物，在橄榄树中具有显着的自由基清除活性。 Cycloolivil 具有抗氧化活性，它可以预防与血小板过度聚集相关的血栓并发症，是开发抗聚集治疗策略的基础。
TN1550	Danshenxinkun A 丹参新醌甲,丹参新醌A	Others	Others
	Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental ada
TN2106	Protodeltonin 原三角叶皂苷	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhibit the proliferation of a panel of established human and murine cancer cell lines in vitro.

天然产物

α-Linolenic acid

Cat.No: T3P2904

Synonym: Alpha-Linolenic Acid,Linolenic acid,α-亚麻酸

Target: Akt, PI3K

Cat.No: T2S1749

Synonym: 原纤细薯蓣皂甙

Target: Others

Liriope muscari baily saponins C

Cat.No: T3809

Target: Others

6-Hydroxykaempferol 3-O-β-D-glucoside

Cat.No: TN1312

Synonym: 6-Hydroxykaempferol 3-O-beta-D-glucoside,6-羟基山柰酚-3-O-Β-D-葡萄糖苷

Target: Others

Cat.No: T3839

Synonym: Isoolivil,环橄榄树脂素

Target: Free radical scavengers, Others, Platelet aggregation

Danshenxinkun A

Cat.No: TN1550

Synonym: 丹参新醌甲,丹参新醌A

Target: Others

Cat.No: TN2106

Synonym: 原三角叶皂苷

Target: BCL, PARP, Caspase

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