Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9073 |
SRS16-86
|
Ferroptosis | Apoptosis |
SRS16-86 是一种铁死亡抑制剂,可研究肾缺血再灌注损伤和脊髓损伤。它在体内比 Ferrostatin-1 对代谢和血浆更稳定。 | |||
T4612 |
NS309
|
EGFR; Potassium Channel; HER | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂,在 BK 通道上没有激活作用。 | |||
T14960 |
Chroman 1
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Chroman 1 是高效的的ROCK 选择性抑制剂,对 ROCK2 (IC50=1 pM) 的抑制作用强于 ROCK1 (IC50=52 pM) 。它对MRCK 也有抑制作用,IC50为 150 nM。 | |||
T36851L |
Peptide5 acetate
|
Others | Others |
Peptide5 acetate 可减少脊髓损伤后的动物肿胀、星形胶质细胞增生和神经元细胞死亡。 Peptide5 acetate 显着降低啮齿动物离体模型中的脊髓损伤 (SCI) 程度。 | |||
T27397 |
Gacyclidine
GK 11,OTO311,OTO-311,OTO 311,GK-11 |
NMDAR | Neuroscience |
Gacyclidine (OTO311) 是一种小分子 N-甲基-D-天冬氨酸(NMDA)受体拮抗剂。在耳蜗局部注射加西环定可抑制水杨酸盐引起的耳鸣,可用于治疗脑损伤、脊髓损伤和耳鸣。 | |||
T78575 |
KCL-286
|
Retinoid Receptor | Metabolism |
KCL-286是一种可口服且具有有效性的视黄酸受体β激动剂,可用于改善脊髓损伤(SCI)。 | |||
T28978 |
Tirilazad mesylate
U-74006 mesylate,U74006 mesylate,U 74006 mesylate,U 74006F mesylate,U-74006F mesylate,U74006F mesylate |
Antiviral | Immunology/Inflammation |
Tirilazad mesylate (U 74006F) 是一种非糖皮质激素,是一种脂质过氧化抑制剂,具有抗病毒活性和神经保护活性。Tirilazad mesylate 能使细胞膜内病灶局限化,可减轻创伤、中风、缺血再灌注损伤引起的脊髓损伤,抑制狗体内毒素的作用,降低了内毒素诱导的肠系膜和肾脏 DO2 比容升高。Tirilazad mesylate 可用于研究神经系统疾病。 | |||
T28778 |
Silperisone HCl
RGH5002,SILA336,RGH-5002,Silperisone hydrochloride,SILA-336 |
||
Silperisone HCl (RGH-5002) 阻断细胞中的钠和钙通道,使肌肉细胞的兴奋度和收缩度降低,降低外周张力,充当肌肉松弛剂和外周血管扩张剂。 Silperisone HCl 可用于治疗脊髓损伤引起的复发性疼痛性肌阵挛、脑血管病引起的异常高肌张力、肌张力症状、锥体紧张综合征、多发性硬化症肌痉挛和脊髓炎。Silperisone 是钠通道蛋白2型α通道阻滞剂。Silperisone 是一种类似于tolperisone 的有机硅化合物,具有中枢作用的肌肉松弛剂特性。 | |||
T32658 |
Leteprinim potassium
SPI-205,AIT-082,SPI 205,AIT082,AIT 082,SPI205 |
||
Leplinine (AIT-082, SPI-205) is a neurotrophic agent that may be used to treat Alzheimer's disease and spinal cord injury. | |||
T14187 |
ALLM
Calpain inhibitor II |
Others | Others |
ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2]. | |||
T36851 |
Peptide5
|
||
Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain. O'Carroll et al (2008) Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. 15 27 PMID:18649176 |Mao et al (2017) Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats.... | |||
T82947 |
Atinumab
ATI355,6A3-IgG4 |
||
Atinumab (6A3-IgG4) 为一种针对特定抗原的抗体,而 Teropavimab 则常用于脊髓损伤(SCI)的相关研究中。 | |||
T81492 |
Phenylbenzothiazole-PEG4-OH
|
||
Phenylbenzothiazole-PEG4-OH (化合物1) 具有治疗脊髓损伤和促进脊柱形成的作用。 | |||
T40602 |
Z-LEHD-FMK TFA
|
||
Z-LEHD-FMK TFA is a specific and irreversible inhibitor of caspase-9, offering protection against detrimental reperfusion injury and moderating apoptosis. Additionally, Z-LEHD-FMK TFA demonstrates its neuroprotective potential in a rat model of spinal cord trauma. | |||
T75550 | Hyp9 | ||
Hyp9为特异性激动剂,针对瞬时受体电位阳离子通道6(TRPC6),应用于脊髓损伤(SCI)的研究。 | |||
T80900 |
Unasnemab
MT-3921,rH116A3 |
||
Unasnemab (MT-3921),一种人源化IgG1单克隆抗体,与排斥引导分子A (RGMa) 结合,用以改善运动功能及促进神经再生,适用于脊髓损伤研究。 | |||
T37476 |
Cyclo(L-Phe-L-Val)
|
||
Cyclo(L-Phe-L-Val) is a metabolite of the sponge bacterium Pseudoalteromonas sp. NJ6-3-1 that can autoinduce production of antibacterial substances active against S. aureus when co-cultured at a low cell density. It induces neurite outgrowth and branching of chick cortical neurons in vitro when used at concentrations of 16 and 32 μM. It increases phosphorylation of the PI3K substrate Akt, and neurite outgrowth induced by cyclo(L-Phe-L-Val) can be blocked by the PI3K inhibitor LY294002 . Cyclo(L-... | |||
T14187L |
ALLM acetate(110115-07-6 Free base)
|
||
ALLM acetate(110115-07-6 Free base) 是一种有效的钙蛋白酶和组织蛋白酶抑制剂,不仅可以防止神经元细胞死亡,还可以增强脊髓损伤(SCI)后的慢性神经功能。 | |||
T78061 |
Peptide5 TFA
|
Gap Junction Protein | Cytoskeletal Signaling |
Peptide5 TFA,一种connexin 43模拟肽,能够降低动物脊髓损伤后的肿胀、抑制星形胶质细胞增生和神经元死亡。该化合物还可抑制NLRP3炎症小体,具有抗炎作用。 | |||
T82798 |
C3bot(154-182) TFA
|
||
C3bot(154-182) TFA 是C3 肽类化合物,能够通过促进脊髓损伤后下行纤维束的再生,增强其修复效能。此外,C3bot(154-182) TFA 或许能够促进中枢神经系统损伤后的轴突保护与修复,并有助于功能性恢复。 | |||
T80544 |
PTPσ Inhibitor, ISP
|
Phosphatase | Metabolism |
PTPσ Inhibitor, ISP 结合并抑制重组人PTPσ的信号传导,具有穿透细胞膜的能力,有助于缓解CSPG介导的脊髓损伤模型中轴突的生长抑制。该抑制剂能增强LPC引起的脊髓脱髓鞘损伤的髓鞘再生,并在MS动物模型中促进OPC的迁移、分化、髓鞘形成及功能恢复。 | |||
T73989 | Tirilazad | ||
Tirilazad是一种21-氨基类固醇非糖皮质激素,具有抑制脂质过氧化的能力。它对于脑或脊髓中因创伤、中风、缺血再灌注损伤所致的损害有减轻作用。此外,Tirilazad还展现出针对新型肺炎病毒的抗病毒活性,并在缺血性中风中提供神经保护,适用于蛛网膜下腔出血研究场景。 | |||
T35457 |
(±)12(13)-DiHOME
(±)12(13)-DiHOME,Isoleukotoxin diol |
||
(±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME , a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin. [1] It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. [2] 12(13)-DiHOME is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike isoleukotoxin, which is only toxic to cells containing sEH.[1] [2] Levels of 12(13)-DiHOME are increased in rat spinal cord following burn injury, and it enhances cold tolerance... | |||
T37728 | Methoctramine (hydrate) | ||
Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 μM.[2] In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholinein guinea pigs wit... | |||
T36722 |
Deltorphin II (trifluoroacetate salt)
|
||
Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [35S]GTPγS binding in mouse brain membrane preparations (EC50= 0.034 μM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the δ2-opioid... |