16
1
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13523 |
Bronchospasmolytic agent 1
|
Others | Others |
Bronchospasmolytic agent 1 is a flutropium bromide compound and acts as a bronchospasmolytic agent. | |||
T25995 |
Prospasmine
Tropiston |
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Prospasmine is an anticholinergic. | |||
T1308 |
Orphenadrine hydrochloride
Mebedrol,Mephenamin,盐酸邻甲苯海拉明 |
Sodium Channel; NMDAR; Norepinephrine; iGluR; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience |
Orphenadrine hydrochloride (Mephenamin) 是一种非竞争性的NMDA 受体拮抗剂, Ki=6.0 ± 0.7 μM。 | |||
T4981 |
Anisotropine Methylbromide
|
Prostaglandin Receptor; AChR | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Anisotropine Methylbromide 是一种抗胆碱能药物,已用于缓解胃肠道痉挛和抑制胃酸分泌。 | |||
T0277 |
Metaproterenol hemisulfate
Orciprenaline sulfate,Metaproterenol Sulfate,硫酸奥西那林 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Metaproterenol hemisulfate (Orciprenaline sulfate) 是一种 β2-肾上腺素能受体 (β2AR) 激动剂(IC50=68 nM),是一种直接作用的拟交感神经药,具有抗炎活性。 | |||
T0715 |
Chlormezanone
Trancopal,氯美扎酮,芬那露 |
Others; GABA Receptor | Membrane transporter/Ion channel; Neuroscience; Others |
Chlormezanone (Trancopal) 是一种非苯二氮卓类药物,用于治疗焦虑症和肌肉痉挛。 | |||
T1409 |
Methocarbamol
Lumirelax,美索巴莫,Metocarbamol,AHR 85,Robaxin |
Sodium Channel; Carbonic Anhydrase | Membrane transporter/Ion channel; Metabolism |
Methocarbamol (AHR 85) 是口服有效的中枢肌肉松弛剂,可阻断肌肉Nav1.4通道,阻断作用具有可逆性。Methocarbamol 具有用于肌肉痉挛和疼痛综合症研究的潜力。 | |||
T14345 |
Atropine methyl bromide
甲溴阿托品,Methylatropine bromide |
AChR | Neuroscience |
Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist. It functions as a mydriatic to dilate the pupil during ophthalmic examination. Compared to atropine, it demonstrates reduced penetration into the central nervous system[1][2]. Its high polarity makes it particularly effective in relieving pyloric spasm in infants. | |||
T3126 |
Bethanechol chloride
(±)-Bethanechol,Urecholine,Myocholine,氯贝胆碱,Carbamyl-β-methylcholine chloride |
AChR | Neuroscience |
Bethanechol chloride (Carbamyl-β-methylcholine chloride) 是一种拟副交感神经剂,是毒蕈碱型受体 (mAChR) 激动剂,通过直接刺激副交感神经系统的 mAChR 发挥作用。 | |||
T1215 |
Nicardipine hydrochloride
盐酸尼卡地平,RS-69216,Nicardipine HCl,YC-93 Hydrochloride |
Calcium Channel; Adrenergic Receptor; AChR; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Nicardipine hydrochloride (YC-93 Hydrochloride) 是一种钙通道阻滞剂,IC50为 1 μM。它可阻断某些细胞壁中的钙离子并抑制冠状动脉和外周动脉的收缩,从而降低对氧气的需求心肌和减少动脉收缩和痉挛。它在临床上用作脑和冠状血管扩张剂。 | |||
T21077 |
Tolperisone free base
Mydeton,Atmosgen free base,Mideton,Menopatol,Besnoline free base,Mydocalm |
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Tolperisone free base, a centrally acting muscle relaxant, has been used for the symptomatic treatment of spasticity and muscle spasm. | |||
T36159 |
8-iso Prostaglandin E1
8-iso Prostaglandin E1 |
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8-iso Prostaglandin E1 能引起犬肺静脉中的痉挛,还能够起到血管舒张作用。 | |||
T61438 |
Propiverine
|
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Propiverine is a potent antimuscarinic agent that effectively inhibits cellular calcium influx, leading to the reduction of muscle spasm. It exhibits neurotropic and musculotropic effects specifically on the smooth muscles of the urinary bladder. Propiverine proves valuable in research concerning overactive bladder (OAB) [1] [2]. | |||
T61228 |
Pirenzepine
|
||
Pirenzepine (LS 519 free base) is a selective antagonist of the M1 muscarinic acetylcholine receptor (mAChR). It effectively inhibits gastric acid secretion and reduces muscle spasm, making it a valuable compound for investigating peptic ulcers. Additionally, Pirenzepine exhibits anti-proliferative activity against cancer cells [1] [2]. | |||
T68598 |
Ataprost
ONO 41483 |
||
Ataprost (ONO 41483) 是一种口服有效的 Carboprostacyclin 同系物。Ataprost 抑制 ADP 诱导的血小板聚集,效力比 Carboprostacyclin 高 2.6 倍。Ataprost 具有缓解冠状动脉痉挛的能力。 | |||
T60751 | Dicyclomine | ||
Dicyclomine (Dicycloverine) 是口服有效的毒蕈碱胆碱能受体拮抗剂,它是一种解痉剂,可缓解体内胃肠道平滑肌痉挛。Dicyclomine 对 M1 受体亚型和 M2 受体亚型具有高亲和力,在刷状缘膜和基底质膜中的Ki 值分别为5.1 nM 和54.6 nM 。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1084 |
1,3,5,8-Tetrahydroxyxanthone
Desmethylbellidifolin,去甲基雏叶龙胆酮 |
Anti-infection | Microbiology/Virology |
1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) 是一种天然黄酮,从 Gentianella acuta 中提取得到。它具有镇痉作用和抗炎作用。 |