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Search Results for " sesquiterpene lactone "

10

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T71553	Ainsliadimer A
	Ainsliadimer A 是一种来自 Ainsliaea macrocephala 的倍半萜内酯二聚体，具有抗肿瘤活性，可诱导各种癌细胞的细胞死亡。
T32256	Janerin
	Janerin is a sesquiterpene lactone.
T32661	Leucanthanolide
	Leucanthanolide is a sesquiterpene lactone from Montanoa leucantha.
T32576	Laserolide
	Laserolide is a sesquiterpene lactone.
T26546	Acantholide NSC 277282,NSC-277282,NSC277282
	Acantholide is a Sesquiterpene lactone isolated from Acanthospermum glabratum.
T32646	Leptocarpin
	Leptocarpin is a sesquiterpene lactone extracted from Leptocarpha rivularis.
T32766	Linifolin A NSC 153859,NSC-153859,NSC153859,PF 57,PF-57
	Linifolin A is a sesquiterpene lactone extracted from Helenium aromaticum.
T34288	Repin
	Repin, a plant responsible for Parkinson-like disease in horses, is the principal sesquiterpene lactone extracted from Russian knapweed.
T69173	Ambrosin
	Ambrosin is a sesquiterpene lactone and a potent NF-κβ inhibitor. It is currently being studied as a potential lead drug for Alzheimer disease therapeutics.
T71925	Isonanangenine B
	Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.

化合物

Cat.No: T71553

Cat.No: T32256

Leucanthanolide

Cat.No: T32661

Cat.No: T32576

Cat.No: T26546

Synonym: NSC 277282,NSC-277282,NSC277282

Cat.No: T32646

Cat.No: T32766

Synonym: NSC 153859,NSC-153859,NSC153859,PF 57,PF-57

Cat.No: T34288

Cat.No: T69173

Isonanangenine B

Cat.No: T71925

Cat. No.	Product Name	Target	Signaling Pathways
T9144	Telekin	Others	Others
	Telekin 是一种从中草药 Carpesium divaricatum 中分离出来的 eudesmane 型倍半萜内酯化合物，据报道可强烈抑制癌细胞的增殖。
T8898	Granilin 大叶土木香内酯,Graniline	Others; Antibacterial; Antifungal	Microbiology/Virology; Others
	Granilin (Graniline) 是存在于Carpesium triste 的花蕾中的一种倍半萜内酯，可作杀菌和杀真菌剂。
TQ0234	Epoxymicheliolide 1β,10β-Epoxymicheliolide,环氧木香内酯	Others	Others
	Epoxymicheliolide (1β,10β-Epoxymicheliolide) 是木香内酯衍生物的一种。
TQ0096	Scabertopin	Others	Others
	Scabertopin 是一种从地胆草中分离得到倍半萜内酯，具有抗癌和抑菌活性。
T5688	Micheliolide	NOS; NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Micheliolide 是一种倍半萜内酯，能够抑制各种炎症反应。它能减弱高糖刺激的NF-κB 活化，IκBα的降解，和MCP-1，TGF-β1，FN 在鼠系膜细胞的表达。
T5793	Britannin	Apoptosis; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Britannin 是分离于旋覆花的一种倍半萜内酯，可通过激活由 ROS 调节的 AMPK 来诱导肝癌细胞凋亡和自噬，具有抗增殖和抗炎活性。
T2904	Sclareolide 香紫苏内酯,Norambreinolide	Others; Antibacterial	Microbiology/Virology; Others
	Sclareolide (Norambreinolide) 是一种从Salvia sclarea 的花中分离得到的天然产物，具有抗菌和细胞毒性作用。
T2896	Alantolactone 土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor	Apoptosis; STAT; TGF-beta/Smad	Apoptosis; JAK/STAT signaling; Stem Cells
	Alantolactone (Inula camphor) 是一种STAT3的选择性抑制剂，可诱导癌症相关的凋亡，具有抗肿瘤活性。
T13686	Ergolide	NF-κB	NF-κB
	Ergolide, 源自Inula Britannica干燥花朵提取的倍半萜内酯，有效抑制RAW 264.7巨噬细胞中可诱导型一氧化氮合酶(iNOS)和环氧化酶-2(COX-2)的表达，其机制为失活NF-κB。
TN6735	Bigelovin	Apoptosis; Reactive Oxygen Species; Retinoid Receptor; Autophagy; RAR/RXR	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Bigelovin 是从海百合中分离得到的一种倍半萜内酯，是选择性视黄素 X 受体 α 激动剂。它通过抑制ROS 的生成来调节 mTOR 信号通路。它诱导凋亡和自噬，有抗肿瘤活性。
TN1405	Arnicolide D 山金车内酯 D,山金车内酯D	Akt; Caspase; PI3K; STAT; mTOR	Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。
T4672	Brevilin A	Apoptosis; Anti-infection; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Brevilin A 是从Centipeda minima 中分离的倍半萜内酯，具有抗癌活性。它通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。它是一种选择性JAK-STAT 信号通路抑制剂，通过减弱 JAK 信号和阻塞 STAT3 信号起作用。
TN3780	Deacetyleupaserrin	Others	Others
	Deacetyleupaserrin is an antileukemic sesquiterpene lactone.
T81167	Shizukanolide
	Shizukanolide，一种倍半萜内酯，源自金兰属 (Chloranthus japonicus) 植物，其脱氢衍生物展现出中等抗真菌活性。
T15467	Helenalin	Others	Others
	Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.
T83442	17(13→14)-Abeo-ent-3S,13S,16-trihydroxystrob-8(15)-ene
	17(13→14)-Abeo-ent-3S,13S,16-trihydroxystrob-8(15)-ene是一款具有抗炎特性的天然倍半萜内酯。
T83554	(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one
	'(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one' 是倍半萜类内酯化合物。
T80956	Transilin
	Transilin为一种倍半萜内酯，从侧柏属植物根部可分离提取。该化合物因其抗炎、抗肿瘤及免疫调节的潜在药用效果而受到关注。Transilin还是多种工业过程的关键组分，尤其在制药与草药生产领域中占有重要位置。
T75678	Tomentosin	Apoptosis	Apoptosis
	Tomentosin 是一种从里海旋覆花中提取出来倍半萜内酯，具有潜在的抗炎和抗癌活性，可促进胰腺癌细胞的凋亡并抑制增殖、迁移和侵袭。

天然产物

Cat.No: T9144

Target: Others

Cat.No: T8898

Synonym: 大叶土木香内酯,Graniline

Target: Others, Antibacterial, Antifungal

Epoxymicheliolide

Cat.No: TQ0234

Synonym: 1β,10β-Epoxymicheliolide,环氧木香内酯

Target: Others

Cat.No: TQ0096

Target: Others

Cat.No: T5688

Target: NOS, NF-κB, COX

Cat.No: T5793

Target: Apoptosis, AMPK, Autophagy

Cat.No: T2904

Synonym: 香紫苏内酯,Norambreinolide

Target: Others, Antibacterial

Cat.No: T2896

Synonym: 土木香内酯,helenin,Eupatal,Helenine,(+)-Alantolactone,Alant camphor,土木香脑,Inula camphor

Target: Apoptosis, STAT, TGF-beta/Smad

Cat.No: T13686

Target: NF-κB

Cat.No: TN6735

Target: Apoptosis, Reactive Oxygen Species, Retinoid Receptor, Autophagy, RAR/RXR

Cat.No: TN1405

Synonym: 山金车内酯 D,山金车内酯D

Target: Akt, Caspase, PI3K, STAT, mTOR

Cat.No: T4672

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Deacetyleupaserrin

Cat.No: TN3780

Target: Others

Cat.No: T81167

Cat.No: T15467

Target: Others

17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene

Cat.No: T83442

(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one

Cat.No: T83554

Cat.No: T80956

Cat.No: T75678

Target: Apoptosis

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