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Cat. No.	Product Name	Target	Signaling Pathways
T23310	SB-203186 hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	SB 203186 hydrochloride 是一种选择性的、竞争性的5-HT4拮抗剂。它拮抗5-HT4受体介导的多巴酚收缩大鼠离体食管弛缓，其在大鼠食管、豚鼠回肠和人类结肠的 pKB 值分别是 10.9、9.5 和 9.0。
T68087	Inaperisone	Others	Others
	Inaperisone 是一种新型的中枢作用的肌肉松弛剂，对排尿反射有抑制作用。Inaperisone 可能通过间接作用于脑干的GABAB 受体来抑制排尿反射。
T71356	Lanperisone HCl
	Lanperisone, also known as NK433, is a muscle relaxant. NK433 inhibited the facilitation of the flexor reflex mediated by group II afferent fibers that was induced by intrathecal administration of noradrenaline-HCl. NK433 had effects more than three times stronger and tending to be longer-lasting than those of eperisone-HCl. These results suggest that NK433 exerts a non-selective inhibition on spinal reflexes and that inhibition of the descending noradrenergic tonic facilitation within the spina...
T72038	YM-58790 YM-58790 free base	AChR	Neuroscience
	YM-58790 free base 是一种高效的 mAChR 拮抗剂。YM-58790 free base 对 M1 mAChR、M2 mAChR 和 M3 mAChR具有抑制作用， Ki 值分别为 28 nM ，260 nM ，和 15 nM 。YM-58790 free base 通过抑制膀胱加压来抑制大鼠的反射性节律性膀胱收缩。
T19723	AMTB hydrochloride AMTB	TRP/TRPV Channel	Membrane transporter/Ion channel
	AMTB hydrochloride (AMTB HCl) 是TRPM8通道的选择性阻滞剂。它抑制 icilin 诱导的 TRPM8 通道激活，pIC50为 6.23。它在膀胱过度活动和膀胱疼痛综合征中有研究的价值。它是电压门控钠通道的非选择性抑制剂 (NaV)。
T1439	Lacidipine SN-305,拉西地平,GX-1048,GR-43659X	Apoptosis; Calcium Channel; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Lacidipine (SN-305) 是一种L 型钙离子通道阻断剂。
T0217L	(+)-Dropropizine (+)-Dropropizine,左羟丙哌嗪	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	(+)-Dropropizine 可以抑制组胺受体，抗过敏，并通过调节参与咳嗽反射的神经肽和干扰感觉神经末梢的刺激激活来减少咳嗽。
T10893	CS-722 Free base	Others	Others
	CS-722 Free base是一种合成的中枢作用肌肉松弛剂，它展现出肌肉松弛效果并抑制脊髓反射。可能通过限制钠和钙流动，从而在海马培养物中减少自发的抑制性和兴奋性突触后电流。
T1158	Phenoxybenzamine hydrochloride 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl	CaMK; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。
TP2500	Cholecystokinin (26-33) free acid CCK (26-33) free acid	cholecystokinin	GPCR/G Protein
	Cholecystokinin (26-33) free acid 是胆囊收缩素 (CCK) 的一部分，是脊椎动物中枢神经系统中存在的 CCKB 型受体的高选择性配体，可诱导大鼠轻度味觉厌恶条件反射。
T1229	Erdosteine 厄多司坦,RV 144,KW-9144	NF-κB; Antibacterial; Adenosine deaminase	Metabolism; Microbiology/Virology; NF-κB
	Erdosteine (RV 144) 抑制脂多糖诱导的NF-κB 激活，具有粘液调节、抗菌、抗炎、抗氧化和自由基清除作用。
T28129	Naltalimide TRK-130,TRK 130,TRK130
	Naltalimide is a unique µ-opioid receptor partial agonist. Naltalimide also enhances the bladder storage function by modulating the afferent limb of the micturition reflex through µ-opioid receptors in the spinal cord.
T24450	Mephenoxalone Lenetran Lenetran,TAB Lenetranat
	Mephenoxalone is a muscle relaxant and mild anxiolytic. It inhibits neuron transmission and relaxing skeletal muscles by inhibiting the reflex arc.
T69143	S 332
	S 332 is an adrenergic beta3-agonist that is more potent in increasing the urinary storage volume than clenbuterol and less potent in inhibiting the contractile force of urinary bladder at micturition reflex than clenbuterol.
T37208	NAP-1
	NAP-1 is a compound with anesthetic activity.1 It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in tadpoles (EC50 = 0.53 μM).References NAP-1 is a compound with anesthetic activity.1 It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in tadpoles (EC50 = 0.53 μ...
T40744	Eperisone
	Eperisone is a centrally acting muscle relaxant and antispastic agent utilized in the treatment of conditions distinguished by muscle stiffness and pain. Its mechanism of action involves the relaxation of skeletal muscles and vascular smooth muscles, resulting in a range of beneficial effects including reduction of myotonia, enhancement of circulation, and suppression of the pain reflex. Additionally, Eperisone exhibits inhibitory properties on the pain reflex pathway and exerts a vasodilator ef...
T29742	AH-9700 free base
	AH-9700 free base 用于治疗急迫性尿失禁和尿毒症。在一项放射性配体结合研究中，AH-9700 free base 对 sigma 受体表现出较高的亲和力，对膀胱功能正常的实验动物的排尿反射(即膀胱容量增加作用)有明显的抑制作用。
T60493	Guaiacol Carbonate
	Guaiacol Carbonate 是一种祛痰剂，其作用是通过胃的反射作用，通过胃神经到达延髓中枢，然后再通过外周进入呼吸道，从而起到祛痰作用。
T73572	NS-8
	NS-8，一种吡咯衍生物，能够激活Ca2+-敏感的K+通道。通过降低盆腔传入神经活动，NS-8有助于抑制排尿反射，适用于尿频与尿失禁的研究。

化合物

SB-203186 hydrochloride

Cat.No: T23310

Target: 5-HT Receptor

Cat.No: T68087

Target: Others

Lanperisone HCl

Cat.No: T71356

Cat.No: T72038

Synonym: YM-58790 free base

Target: AChR

AMTB hydrochloride

Cat.No: T19723

Synonym: AMTB

Target: TRP/TRPV Channel

Cat.No: T1439

Synonym: SN-305,拉西地平,GX-1048,GR-43659X

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species

(+)-Dropropizine

Cat.No: T0217L

Synonym: (+)-Dropropizine,左羟丙哌嗪

Target: Histamine Receptor

CS-722 Free base

Cat.No: T10893

Target: Others

Phenoxybenzamine hydrochloride

Cat.No: T1158

Synonym: 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Cholecystokinin (26-33) free acid

Cat.No: TP2500

Synonym: CCK (26-33) free acid

Target: cholecystokinin

Cat.No: T1229

Synonym: 厄多司坦,RV 144,KW-9144

Target: NF-κB, Antibacterial, Adenosine deaminase

Cat.No: T28129

Synonym: TRK-130,TRK 130,TRK130

Cat.No: T24450

Synonym: Lenetran Lenetran,TAB Lenetranat

Cat.No: T69143

Cat.No: T37208

Cat.No: T40744

AH-9700 free base

Cat.No: T29742

Guaiacol Carbonate

Cat.No: T60493

Cat.No: T73572

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