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Search Results for " proteinase "

58

抑制剂 & 化合物

7

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8936	Proteinase K proteinase K for tritirachium album,Protease K,蛋白酶 K	Others	Others
	Proteinase K (proteinase K for tritirachium album) 是一种非特异性丝氨酸蛋白酶，可用于蛋白消化。它在有 SDS 或尿素存在的情况下，在很大 pH 值 (4-12)、盐浓度和温度单位内均有活性。
T6037	E-64 Proteinase inhibitor E 64,E 64,E64	Cysteine Protease; Antibacterial; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	E-64 (Proteinase inhibitor E 64)是一种不可逆的半胱氨酸蛋白酶抑制剂，抑制papain 的IC50为 9 nM。
T39101	HAV 3C proteinase-IN-1
	HAV 3C proteinase-IN-1 is a inhibitor of Hepatitis A virus 3C proteinase .
T76202	Recombinant Proteinase K
	Recombinant Proteinase K为一种serine protease，专门裂解脂肪族及芳香族氨基酸的羧基端肽键，适用于蛋白质消化与清除核酸制剂中的污染。
T6064	UK-383367 UK 383367	Procollagen C Proteinase	Metabolism
	UK-383367 是一种有效、选择性的 BMP-1 抑制剂，IC50=44 nM，对其选择性远高于 MMP 1，2，3，9 和 14。
T8676	FOY 251	Others; Serine/threonin kinase; SARS-CoV	Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Others
	FOY 251 是一种蛋白酶抑制剂，是具有抗蛋白水解活性的 Camostate 代谢物，能抑制 SARS-CoV-2 的感染。
T14968	Cinanserin hydrochloride SQ 10643	Influenza Virus; 5-HT Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Cinanserin hydrochloride (SQ 10643) 是一种高亲和力拮抗剂，对 5-HT2 受体的Ki 值为 41 nM。它也是严重急性呼吸综合征冠状病毒的 3C 样蛋白酶抑制剂。
T19763	Cetraxate hydrochloride DV-1006,DV 1006,Cetraxate HCl,盐酸西曲酸酯,DV1006	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	Cetraxate hydrochloride (DV10062) 是一种有效的顶体蛋白酶 (acrosomal proteinase acrosin) 抑制剂，Ki 和 IC50分别为 0.94 μM 和 3.3 μM。它是一种口服有活性的抗溃疡试剂 (anti-ulcer)，具有粘膜保护作用，可用于研究胃溃疡。
T78365	Endoproteinase Lys-C
	Endoproteinase Lys-C是一种特异性蛋白酶，它专门在赖氨酸残基的C端切割蛋白，常应用于蛋白质序列分析。
T7740	Protease-Activated Receptor-4 diTFA Protease-Activated Receptor-4 diTFA(245443-52-1(free base))	Protease-activated Receptor	GPCR/G Protein
	Protease-Activated Receptor-4 diTFA 是蛋白酶激活受体 4 (PAR4) 激动剂。
T7674	Thrombin Receptor Activator for Peptide	Protease-activated Receptor	GPCR/G Protein
	Thrombin Receptor Activator for Peptide 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5)，用于研究冠心病 (CHD)。
T40363	Poly-D-lysine hydrobromide (MW 30000-70000) Poly-D-lysine HBr (MW 30000-70000)	CaSR	GPCR/G Protein
	Poly-D-lysine hydrobromide (MW 30000-70000)(Poly-D-lysine HBr) 是一种可口服的肽类 CaSR 激动剂，可从朊病毒感染的 SN56 神经母细胞瘤细胞中去除蛋白酶 K 抗性的 PrP。
T0372	Gabexate mesylate 甲磺酸加贝酯,FOY	Factor Xa; Serine Protease; Proteasome	Metabolism; Proteases/Proteasome; Ubiquitination
	Gabexate mesylate (FOY) 是一种非抗原的类胰蛋白酶丝氨酸蛋白酶抑制剂。
TP1065	PAR-4 Agonist Peptide, amide TFA PAR-4-AP (TFA),AY-NH2 (TFA)	Protease-activated Receptor	GPCR/G Protein
	PAR-4 Agonist Peptide, amide TFA (PAR-4-AP (TFA)) 是一种蛋白酶激活受体 4 (PAR-4) 激动剂，对 PAR-1 或 PAR-2 均无影响，其作用可被 PAR-4 拮抗剂阻断。
T38836L	Protease-Activated Receptor-1, PAR-1 Agonist acetate	Protease-activated Receptor	GPCR/G Protein
	Protease-Activated Receptor-1, PAR-1 Agonist acetate 是一种选择性蛋白酶激活受体 1 (PAR-1) 激动剂肽。它对应于 PAR1 栓系配体，可以选择性地模拟凝血酶通过该受体的作用。
T37071	Pyrimethanil	Antifungal	Microbiology/Virology
	Pyrimethanil 是苯胺嘧啶类广谱接触杀菌剂，用于控制多种作物上的Botrytis spp.。它抑制灰霉病菌中氨基酸的生物合成，可用于霉菌感染的水果、蔬菜和观赏植物真菌病害防治的相关研究。
T26219	SQ 32970 SQ32,970,SQ32970,SQ-32970,SQ 32,970,SQ-32,970
	SQ 32970 is a potent Endothia aspartic proteinase inhibitor.
T24311	L 658758 L 658,758,L-658758,L-658,758,L658,758,L658758
	L 658758 is an inhibitor of serine proteinase.
T33852	P 34081 P34081,P-34081
	P 34081 rapidly blocks parasite cysteine proteinase activity in vivo.
T24028	ENMD-1068 HBr ENMD 1068 HBr
	ENMD-1068 HBr is a novel Proteinase-Activated Receptor 2 antagonist.
T70828	HBY-793
	HBY-793 is an HIV-1 proteinase inhibitor.
T36955	Trigalacturonic Acid
	Trigalacturonic acid is an oligosaccharide that inhibits proteinase activity in tomato plants (ED50 = 2.6 μg/plant).
T69882	Pefabloc
	Pefabloc is an irreversible serine proteinase inhibitor. Pefabloc efficiently inhibits both human and rat platelet activating factor (PAF)-degrading acetylhydrolase (acetylhydrolase).
T7380	Protease-Activated Receptor-4 蛋白酶活化的受体-4	Protease-activated Receptor	GPCR/G Protein
	Protease-Activated Receptor-4 是蛋白酶激活受体 4 激动剂，具有抗血小板治疗。
T38130	Z-LVG-CHN2 Z-Leu-Val-Gly-diazomethylketone
	The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication. Irreversible inhibitor of streptopain.
T71079	I 432
	I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (Ki =0.9 nM).
T26302	Tyrostatin N-Isovaleryl-tyrosyl-leucyl-tyrosinal
	Tyrostatin is a new pepstatin-insensitive carboxyl proteinases peptide proteinase inhibitor isolated from Kitasatosporia.
T24989	85548e 85548 e,85548-e,U 85548e,U85548e,U-85548e
	85548e is used as an inhibitor that exhibiting subnanomolar affinity towards HIV type-1 aspartic proteinase (HIV-1 PR).
T71635	Murayaquinone
	Murayaquinone is a hepatitis C virus proteinase inhibitor and small molecule antagonist of the oncogenic Tcf/β-catenin protein complex.
T11316	FOY 251 free base	Others	Others
	FOY 251 free base acts as a proteinase inhibitor. FOY 251 free base is an anti-proteolytic active metabolite camostate.
T26435	A 70450 A-70450,A70450
	A 70450, an inhibitor of aspartyl proteinase, can be used as an antifungal agent and may have a role in HIV protease inhibition therapy.
T38363	MeOSuc-AAPV-pNA
	Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by b...
T27708	K-14585
	K-14585 is a proteinase-activated receptor 2 antagonist. K-14585 inhibited PAR(2)-mediated p65 NFkappaB phosphorylation and NFkappaB-DNA binding. K-14585 inhibited SLIGKV-stimulated IL-8 production, but given alone increased IL-8.
T36289	Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA
	Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA is a peptide that acts as an agonist for the proteinase-activated receptor (PAR-3)[1].
T81822	MeOSuc-AAPF-CMK MeOSuc-Ala-Ala-Pro-Phe-CH₂Cl
	MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH2Cl) 是蛋白酶 K 抑制剂，具有较高效能。
T69936	NK314
	NK314 is a novel synthetic benzo[c]phenanthridine alkaloid that shows strong antitumor activity. It inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. The DNA breaks occurred within 1h after treatment with NK314 even without digestion of topoisomerase II by proteinase K, whereas etoposide required digestion of the enzyme protein in cleavable complex to detect DNA breaks. Pretreatment with topoisomerase II catalytic inhibitors, ICRF-193 and suramin, reduc...
TP1478	2-Furoyl-LIGRLO-amide 2-Furoyl-LIGRLO-amide TFA(729589-58-6,FREE)
	2-Furoyl-LIGRLO-amide TFA is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.
T7623L	PAR-4 Agonist Peptide, amide acetate PAR-4 Agonist Peptide, amide acetate(352017-71-1 free base)	Protease-activated Receptor	GPCR/G Protein
	PAR-4 Agonist Peptide, amide acetate 是蛋白酶激活受体 4 (PAR-4) 的激动剂。
T36288	Protease-Activated Receptor-1, PAR-1 Agonist TFA
	Protease-Activated Receptor-1 (PAR-1) Agonist TFA is a selective peptide that acts as an agonist for the proteinase-activated receptor-1 (PAR-1). Corresponding to the tethered ligand of PAR-1, this compound mimics the actions of thrombin through the PAR-1 receptor[1][2].
T73982	Digalacturonic acid
	Digalacturonic acid，果胶或果胶酸的代谢产物，可用于蛋白酶 K 等酶的共结晶。
T75905	2-Furoyl-LIGRLO-amide TFA
	2-Furoyl-LIGRLO-amide TFA 为高效选择性PAR2 (蛋白酶激活受体2) 激动剂，pD2值达7.0。
T36340	Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt)
	Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1). Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm; em = 420 nm).
T7623	PAR-4 Agonist Peptide, amide AY-NH2,PAR-4 Agonist Peptide, amide(2TFA),PAR-4-AP	Protease-activated Receptor	GPCR/G Protein
	PAR-4 Agonist Peptide, amide (AY-NH2) 是蛋白酶激活受体 4 (PAR-4) 的激动剂，对 PAR-1 或 PAR-2 均无影响，其作用可被 PAR-4 拮抗剂阻断。
T38116	Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2
	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].
T7496	Thrombin Receptor Activator for Peptide 5 (TRAP-5) Thrombin Receptor Activator for Peptide	Protease-activated Receptor	GPCR/G Protein
	Thrombin Receptor Activator for Peptide 5 (TRAP-5) 也称为凝血因子 II 受体 (1-5) 或蛋白酶激活受体 1 (1-5)，用于研究冠心病 (CHD)。
T78119	Z-L(D-Val)G-CHN2	HSV	Microbiology/Virology
	Z-L(D-Val)G-CHN2（即Z-LVG-CHN2）是半胱氨酸蛋白酶抑制剂的异构体，作为一种三肽衍生物，模仿了人体半胱氨酸蛋白酶结合中心的部分结构。它可以抑制HSV，并且能有效阻断SARS-COV-2的3CL pro蛋白酶，从而抑制病毒活性（EC50=190 nM），但对脊髓灰质炎病毒复制无显著作用。
T75369	DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS
	DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS 为一种用于人类疟原虫天冬氨酰蛋白酶的荧光底物，属于荧光染料类。储存条件：需避光。
T80254	Elafin(human)
	Elafin，亦称为ESI（elafin-specific inhibitor）或SKALP（skin anti-leucoprotease），为一种低分子量抑制剂，专一性地抑制肺部中性粒细胞中的HNE（人中性粒细胞弹性蛋白酶）和proteinase 3。同时，Elafin对Pseudomonas aeruginosa和Staphylococcus aureus亦具有抗生素效果。
T74192	Z-Leu-Arg-AMC
	Z-Leu-Arg-AMC为带有羧基苯甲酰(Z)的4-甲基香豆素基-7-酰胺(AMC)亮氨酸衍生物，是锥虫半胱氨酸蛋白酶Tb活性位点。
T78633	MeOSuc-AAPV-CMK Elastase Inhibitor III
	MeOSuc-AAPV-CMK (Elastase Inhibitor III) 为一种特定抗体，不仅抑制白细胞弹性蛋白酶，也能够抑制组织蛋白酶 G 及蛋白酶 3。此外，MeOSuc-AAPV-CMK 可有效阻断白细胞弹性蛋白酶对脂联素进行裂解的作用。

化合物

Cat.No: T8936

Synonym: proteinase K for tritirachium album,Protease K,蛋白酶 K

Target: Others

Cat.No: T6037

Synonym: Proteinase inhibitor E 64,E 64,E64

Target: Cysteine Protease, Antibacterial, Autophagy

HAV 3C proteinase-IN-1

Cat.No: T39101

Recombinant Proteinase K

Cat.No: T76202

Cat.No: T6064

Synonym: UK 383367

Target: Procollagen C Proteinase

Cat.No: T8676

Target: Others, Serine/threonin kinase, SARS-CoV

Cinanserin hydrochloride

Cat.No: T14968

Synonym: SQ 10643

Target: Influenza Virus, 5-HT Receptor

Cetraxate hydrochloride

Cat.No: T19763

Synonym: DV-1006,DV 1006,Cetraxate HCl,盐酸西曲酸酯,DV1006

Target: Serine/threonin kinase

Endoproteinase Lys-C

Cat.No: T78365

Protease-Activated Receptor-4 diTFA

Cat.No: T7740

Synonym: Protease-Activated Receptor-4 diTFA(245443-52-1(free base))

Target: Protease-activated Receptor

Thrombin Receptor Activator for Peptide

Cat.No: T7674

Target: Protease-activated Receptor

Poly-D-lysine hydrobromide (MW 30000-70000)

Cat.No: T40363

Synonym: Poly-D-lysine HBr (MW 30000-70000)

Target: CaSR

Gabexate mesylate

Cat.No: T0372

Synonym: 甲磺酸加贝酯,FOY

Target: Factor Xa, Serine Protease, Proteasome

PAR-4 Agonist Peptide, amide TFA

Cat.No: TP1065

Synonym: PAR-4-AP (TFA),AY-NH2 (TFA)

Target: Protease-activated Receptor

Protease-Activated Receptor-1, PAR-1 Agonist acetate

Cat.No: T38836L

Target: Protease-activated Receptor

Cat.No: T37071

Target: Antifungal

Cat.No: T26219

Synonym: SQ32,970,SQ32970,SQ-32970,SQ 32,970,SQ-32,970

Cat.No: T24311

Synonym: L 658,758,L-658758,L-658,758,L658,758,L658758

Cat.No: T33852

Synonym: P34081,P-34081

Cat.No: T24028

Synonym: ENMD 1068 HBr

Cat.No: T70828

Trigalacturonic Acid

Cat.No: T36955

Cat.No: T69882

Protease-Activated Receptor-4

Cat.No: T7380

Synonym: 蛋白酶活化的受体-4

Target: Protease-activated Receptor

Cat.No: T38130

Synonym: Z-Leu-Val-Gly-diazomethylketone

Cat.No: T71079

Cat.No: T26302

Synonym: N-Isovaleryl-tyrosyl-leucyl-tyrosinal

Cat.No: T24989

Synonym: 85548 e,85548-e,U 85548e,U85548e,U-85548e

Cat.No: T71635

FOY 251 free base

Cat.No: T11316

Target: Others

Cat.No: T26435

Synonym: A-70450,A70450

MeOSuc-AAPV-pNA

Cat.No: T38363

Cat.No: T27708

Protease-Activated Receptor-3 (PAR-3) (1-6), human TFA

Cat.No: T36289

MeOSuc-AAPF-CMK

Cat.No: T81822

Synonym: MeOSuc-Ala-Ala-Pro-Phe-CH₂Cl

Cat.No: T69936

2-Furoyl-LIGRLO-amide

Cat.No: TP1478

Synonym: 2-Furoyl-LIGRLO-amide TFA(729589-58-6,FREE)

PAR-4 Agonist Peptide, amide acetate

Cat.No: T7623L

Synonym: PAR-4 Agonist Peptide, amide acetate(352017-71-1 free base)

Target: Protease-activated Receptor

Protease-Activated Receptor-1, PAR-1 Agonist TFA

Cat.No: T36288

Digalacturonic acid

Cat.No: T73982

2-Furoyl-LIGRLO-amide TFA

Cat.No: T75905

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt)

Cat.No: T36340

PAR-4 Agonist Peptide, amide

Cat.No: T7623

Synonym: AY-NH2,PAR-4 Agonist Peptide, amide(2TFA),PAR-4-AP

Target: Protease-activated Receptor

Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T38116

Synonym: Fmoc-Ala-Glu-Asn-Lys-NH2

Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Cat.No: T7496

Synonym: Thrombin Receptor Activator for Peptide

Target: Protease-activated Receptor

Z-L(D-Val)G-CHN2

Cat.No: T78119

Target: HSV

DABCYL-Glu-Arg-Nle-Phe-Leu-Ser-Phe-Pro-EDANS

Cat.No: T75369

Cat.No: T80254

Cat.No: T74192

MeOSuc-AAPV-CMK

Cat.No: T78633

Synonym: Elastase Inhibitor III

Cat. No.	Product Name	Target	Signaling Pathways
T19529	Proteinase	Others	Others
	Proteinase 是一种催化蛋白质分解的酶。它们通过水解作用来裂解蛋白质内的肽键，将蛋白质分解成更小的多肽或单个氨基酸。Proteinase 参与许多生物功能，包括消化进食的蛋白质、旧蛋白质的分解，以及细胞信号传递。它们同时促进新的蛋白质产物的形成
T4900	(±)-Methyl Jasmonate (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate	Others; Endogenous Metabolite	Metabolism; Others
	Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester) 是内源性代谢产物的一种。
T75648	Rivulariapeptolides 1155
	Rivulariapeptolides 1155 是一种有效的丝氨酸蛋白酶 (serine protease) 抑制剂，对糜蛋白酶、弹性蛋白酶、蛋白蛋白酶 K 的 IC50分别为 41.84、4.94、56.54 nM。
T75649	Rivulariapeptolides 1185
	Rivulariapeptolides 1185 是一种高效的选择性丝氨酸蛋白酶抑制剂，其对胰凝蛋白酶、弹性蛋白酶和蛋白酶 K 的 IC50分别为 13.17 nM、23.59 nM 和 55.26 nM。
T75652	Molassamide B
	Molassamide B，丝氨酸蛋白酶抑制剂，对胰凝乳蛋白酶、弹性蛋白酶及蛋白酶 K 具有显著抑制活性，其IC50值分别为24.65、11.69和5.42 nM。
T75651	Rivulariapeptolides 988
	Rivulariapeptolides 988作为一种高效选择性丝氨酸蛋白酶抑制剂，对胰凝蛋白酶、弹性蛋白酶和蛋白酶K的IC50分别为95.46 nM、15.29 nM和85.50 nM。
T75650	Rivulariapeptolides 1121
	Rivulariapeptolides 1121，作为一种高效的选择性丝氨酸蛋白酶抑制剂，对胰凝蛋白酶、弹性蛋白酶和蛋白酶K展示出了显著的抑制活性，其IC50值分别为35.52 nM、13.24 nM和48.05 nM。

天然产物

Cat.No: T19529

Target: Others

(±)-Methyl Jasmonate

Cat.No: T4900

Synonym: (±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate

Target: Others, Endogenous Metabolite

Rivulariapeptolides 1155

Cat.No: T75648

Rivulariapeptolides 1185

Cat.No: T75649

Cat.No: T75652

Rivulariapeptolides 988

Cat.No: T75651

Rivulariapeptolides 1121

Cat.No: T75650

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