Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Protease-Activated Receptor-1, PAR-1 Agonist acetate 是一种选择性蛋白酶激活受体 1 (PAR-1) 激动剂肽。 它对应于 PAR1 栓系配体,可以选择性地模拟凝血酶通过该受体的作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,290 | 现货 | ||
5 mg | ¥ 2,650 | 现货 | ||
10 mg | ¥ 3,790 | 现货 | ||
25 mg | ¥ 5,970 | 现货 | ||
50 mg | ¥ 8,390 | 现货 | ||
100 mg | ¥ 11,300 | 现货 |
产品描述 | Protease-Activated Receptor-1, PAR-1 Agonist acetate is a selective proteinase-activated receptor1 (PAR-1) agonist peptide. Protease-Activated Receptor-1, PAR-1 Agonist acetate corresponds to PAR1 tethered ligand and which can selectively mimic theactions of thrombin via this receptor[1][2]. |
体外活性 | Protease-Activated Receptor-1, PAR-1 Agonist acetate induces activation of protein kinase C isoenzymes alpha and epsilon in human HT-29 colon carcinoma cells expressing PAR1 endogeneously. On the cellular level, Protease-Activated Receptor-1, PAR-1 Agonist acetate and thrombin prompted HT-29 cell migration and matrix adhesion by a PKCepsilon-dependent mechanism as concluded because of the inhibition of PAR1-mediated effects by the PKC inhibitor bisindolylmaleimide I and the PKCepsilon translocation inhibitory peptide EAVSLKPT but not by the PKC inhibitor G? 6976[2]. |
分子量 | 822.95 |
分子式 | C37H62N10O11 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 20 mg/mL (24.3 mM), Sonification is recommended
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 1.2151 mL | 6.0757 mL | 12.1514 mL | 30.3785 mL |
5 mM | 0.243 mL | 1.2151 mL | 2.4303 mL | 6.0757 mL | |
10 mM | 0.1215 mL | 0.6076 mL | 1.2151 mL | 3.0379 mL | |
20 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5189 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Protease-Activated Receptor-1, PAR-1 Agonist acetate GPCR/G Protein Protease-activated Receptor ProteaseActivated Receptor1, PAR1 Agonist acetate Protease Activated Receptor 1, PAR 1 Agonist acetate Inhibitor inhibitor inhibit