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Search Results for " plasminogen "

43

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T78018	Plasminogen
	Plasminogen是一种可由尿激酶血浆蛋白原激活剂(uPA)或组织血浆蛋白原激活剂(tPA)裂解激活的分泌性蛋白，生成血浆蛋白，该酶可以广泛裂解纤维蛋白及其他ECM成分。作为促炎调节剂，Plasminogen能促进急性及糖尿病相关伤口愈合。该蛋白在伤口愈合、炎症和低纤溶酶原血症的研究中有重要应用。
T13408	ZK824190	Others; Serine Protease	Others; Proteases/Proteasome
	ZK824190 是具有口服活性尿激酶型纤溶酶原激活剂 (uPA) 选择性抑制剂，对 uPA，tPA 和 Plasmin 的IC50分别为 237，1600 和 1850 nM。ZK824190在多发性硬化症中有研究价值。
T28788	SK-216 SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor
	SK-216 is a specific PAI-1 inhibitor. SK-216 reduced the extent of angiogenesis in the tumors and inhibited VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. SK-216 reduced the degree of bleomycin-induced pulmon
T8962	TM5007	PAI-1	Metabolism
	TM5007 是纤溶酶原激活物抑制剂-1（PAI-1；IC50 为 29 uM）的强效抑制剂。
T4254	TM5441	PAI-1; Apoptosis	Apoptosis; Metabolism
	TM5441 是口服生物可利用的纤溶酶原激活物抑制剂-1 抑制剂，抑制多个癌症细胞系的 IC50值在 13.9 到 51.1 μM。它诱导几种人类癌症细胞的内在调亡，减弱 Nω-硝基-1-精氨酸甲酯诱导的心脏高血压和血管衰老。
T3442	UK-371804 UK371804	PAI-1; Serine Protease	Metabolism; Proteases/Proteasome
	UK-371804 是一种尿嘧啶型纤溶酶原激活物的抑制剂，Ki=10 nM。
T13257	Upamostat	PAI-1; Serine/threonin kinase; Serine Protease	Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome
	Upamostat 是一种丝氨酸蛋白酶抑制剂，也是一种具有口服活性的 WX-UK1 前药，是一种尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。
T4255	TM5275 sodium TM5275 sodium salt	PAI-1	Metabolism
	TM5275 sodium (TM5275 sodium salt) 是一种纤溶酶原激活物抑制剂，IC50=6.95 μM。
T2030	Tiplaxtinin PAI-039,Tiplasinin	PAI-1; Apoptosis	Apoptosis; Metabolism
	Tiplaxtinin (Tiplasinin) 是一种具有口服活性的选择性纤溶酶原激活物抑制剂-1 抑制剂，IC50为 2.7 μM。
T29856	Aleplasinin PAZ 417,PAZ417,PAZ-417	PAI-1	Metabolism
	Aleplasinin (PAZ 417) 是纤溶酶原激活物抑制剂 1 (PAI-1) 的选择性和口服活性抑制剂，是纤溶系统的关键负调节剂。 Aleplasinin 可用于阿尔茨海默病研究。
T8362	Benzamidine hydrochloride Benzamidine HCl,苄脒盐酸盐	Serine/threonin kinase; Serine Protease	Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome
	Benzamidine hydrochloride (Benzamidine HCl) 是可逆的胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 竞争性抑制剂，对 uPA、类胰蛋白酶、胰蛋白酶和 Xa 因子作用的Ki 分别为 97 µM、20 µM、21 µM 和 110 µM。
TP2338L	Cenupatide acetate Cenupatide acetate(1006388-38-0 Free base)	Others	Others
	Cenupatide acetate 是一种尿激酶纤溶酶原激活物受体 (uPAR) 抑制剂，用于治疗与细胞迁移改变相关的疾病，例如癌症。
T3359	Aprotinin 抑酶肽,抑肽酶,Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin	Others; Serine Protease; Influenza Virus; Proteasome	Microbiology/Virology; Others; Proteases/Proteasome; Ubiquitination
	Aprotinin (Traskolan) 是分离自牛肺的一种广谱丝氨酸蛋白酶抑制剂，可抑制多种不同酯酶和蛋白酶的活性。
T60248	4-Aminobenzamidine dihydrochloride p-Aminobenzamidine dihydrochloride	Serine Protease	Proteases/Proteasome
	4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) 是一种强胰蛋白酶 (trypsin)抑制剂，也是一种相对较弱的尿激酶型纤溶酶原激活剂 (uPA) 抑制剂 (Ki=82 μM)。4-Aminobenzamidine 可抑制 SCID 小鼠体内前列腺肿瘤的生长。
T71851	5-trans-Prostaglandin E2
	5-trans-Prostaglandin E2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator. It also inhibits platelet aggregation in human PRP.
T13251	UKI-1 UKI-1C	Others	Others
	UKI-1 is a urokinase-type plasminogen activator system synthetic inhibitor.
T70734	U46,195
	U46,195 stimulates the production of tissue-type plasminogen activator, and is a PAF antagonist.
T70417	XR 1853
	XR 1853 is a low molecular weight modulator of human plasminogen activator inhibitor-1 activity.
T69751	UK-356202
	UK-356,202 is a potent and selective urokinase-type plasminogen activator (Ki = 37 nM). Urokinase plasminogen activator (uPA, urokinase) is a trypsinlike serine protease and a therapeutical target for many cancer types, including breast, ovarian, and pancreatic cancer. uPA is a valuable oncology target.
T68572	IMD-1622
	IMD-1622 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor.
T69890	PS-519
	PS-519 is a human tissue plasminogen activator and proteasome inhibitor.
T68659	Valyl-glycyl-arginine-4-nitroanilide
	Valyl-glycyl-arginine-4-nitroanilide is a tissue plasminogen activator.
T69319	U 34599
	U 34599 stimulates the production of tissue-type plasminogen activator.
T25915	Diaplasinin PAI-749,PAI749,PAI 749
	PAI-749 is a selective and effective antagonist agent of plasminogen activator inhibitor 1 (PAI-1).
T13409L	ZK824859 hydrochloride (2271122-53-1 free base) ZK824859 hydrochloride	Others	Others
	ZK824859 hydrochloride is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
T70927	UCD74A HCl
	UCD74A HCl is a cell impermeant homolog of UCD38B, inhibitor of uPA (urokinase plasminogen activator).
T13409	ZK824859	Others	Others
	ZK824859 is an oral available and selective inhibitor of urokinase plasminogen activator (uPA)(IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively).
T41085	UK122 UK122
	UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). Functioning as a 4-oxazolidinone analogue, UK122 is an anticancer agent that effectively inhibits cancer cell migration and invasion.
T70810	THR-18
	THR-18 is an 18-mer peptide derived from the sequence of human plasminogen activator inhibitor 1 (PAI-1), having the ability to bind to a site of tissue plasminogen activator (tPA) distal to its catalytic site and uncouple the beneficial clot-dissolving properties of tPA from its deleterious non-fibrinolytic effects.
T41029	Streptokinase
	Streptokinase is a bacterial protein that acts as a plasminogen activator, commonly employed in the investigation of blood-clotting disorders. Its application extends to enhancing reperfusion blood flow after coronary artery occlusion.
T68682	Piriprost
	Piriprost is a leukotriene inhibitor attenuates the smoke-induced increase in alveolar-capillary barrier permeability and decrease in plasminogen activator activity and causes a swelling of type I alveolar epithelium.
T72113	6-Aminocaproic acid hydrochloride EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride
	6-Aminocaproic acid hydrochloride，一种单氨基羧酸，作为有效及口服活性的纤溶酶和纤溶酶原抑制剂，具备显著的抗纤溶能力。通过竞争性结合纤溶酶原上的赖氨酸残基，6-Aminocaproic acid hydrochloride 阻止血块溶解，抑制纤溶酶生成，减少纤维蛋白溶解，用于出血性疾病研究。
T35931	GGACK (hydrochloride)
	GGACK is an inhibitor of urokinase-type plasminogen activator (uPA) and factor Xa (Kis = 1.8 and 8.7 μM, respectively).1,2 1.Kettner, C., and Shaw, E.The susceptibility of urokinase to affinity labeling by peptides of arginine chloromethyl ketoneBiochim. Biophys. Acta569(1)31-40(1979) 2.Kettner, C., and Shaw, E.The selective affinity labeling of factor Xa by peptides of arginine chloromethyl ketoneThromb. Res.22(5-6)645-652(1981)
T73701	Urokinase (peptidolytic)
	Urokinase peptidolytic (Urokinase-type plasminogen activator) 是一种丝氨酸蛋白酶，是丝氨酸蛋白酶纤溶酶的一种非活性形式(酶原)。纤溶酶的激活可触发蛋白水解级联反应，进而参与血栓溶解或细胞外基质降解，涉及血管疾病和癌症相关研究。
TP2338	Cenupatide UPARANT,Cenupatide trifluoroacetic acid salt,Ac-Arg-Aib-Arg-α(Me)Phe-NH2)
	Cenupatide is a urokinase plasminogen activator receptor (uPAR) inhibitor. Cenupatide inhibits uPAR binding to the formyl peptide receptors (FPRs) can improve kidney lesions in a rat model of STZ-induced diabetes. Cenupatide reverted STZ-induced up-regula
T40614	LCKLSL
	LCKLSL, an N-terminal hexapeptide, acts as a competitive inhibitor of annexin A2 (AnxA2), effectively preventing the binding of tissue plasminogen activator (tPA) to AnxA2 while also inhibiting the generation of plasmin. In addition, LCKLSL exhibits anti-angiogenic properties.
T11152	Edaravone-d5 MCI-186 D5	Others	Others
	Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the original compound's attributes while offering isotopic labeling benefits.
T80859	Vitronectin
	Vitronectin为一类多功能糖蛋白，广泛分布于血液及细胞外基质。该蛋白质与糖胺聚糖、胶原蛋白、纤溶酶原及尿激酶受体发生结合，并对纤溶酶原激活抑制剂1的抑制构象起稳定作用。Vitronectin常用于促进伤口愈合和肿瘤进展研究领域。
T80736	Z-Gly-Gly-Arg-AFC
	Z-Gly-Gly-Arg-AFC为具有生物活性的肽类化合物，属于(纤溶酶原激活剂顶体碱底物，荧光Z-Gly-Gly-Arg-AFC)。
T68513	BSc2118
	BSc2118 is a potent proteasome inhibitor. BSc2118 shows significant antimyeloma activity and may be considered as a promising agent in cancer drug development. BSc2118 is also a promising new candidate for stroke therapy, which may in addition alleviate recombinant tissue-plasminogen activator-induced brain toxicity.
TP2482	LCKLSL acetate LCKLSL acetate(533902-29-3 free base)	Annexin A	GPCR/G Protein
	LCKLSL acetate 是一种竞争性膜联蛋白 A2 (AnxA2) 抑制剂。 LCKLSL acetate 有效抑制组织纤溶酶原激活剂 (tPA) 与 AnxA2 的结合和纤溶酶的产生。 LCKLSL acetate 具有抗血管生成作用。
T64287	Reteplase
	Reteplase (BM 06.022) 是一种重组纤溶酶原 (plasminogen) 激活剂，由人组织型纤溶酶原激活剂的 kringle 2 和蛋白酶结构域构成。Reteplase 能够将纤溶酶原转化为纤溶酶，促使血栓溶解。Reteplase 通过 DNA 技术在大肠杆菌中产生的 t-PA 突变体，未糖基化。
T78015	LCKLSL hydrochloride
	LCKLSL hydrochloride为N端六肽，作为膜联蛋白A2（AnxA2）的竞争性抑制剂，有效阻止组织纤溶酶原激活物（tPA）与AnxA2结合。此化合物还能够抑制纤溶酶生成，并表现出抗血管生成活性。

化合物

Cat.No: T78018

Cat.No: T13408

Target: Others, Serine Protease

Cat.No: T28788

Synonym: SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Cat.No: T8962

Target: PAI-1

Cat.No: T4254

Target: PAI-1, Apoptosis

Cat.No: T3442

Synonym: UK371804

Target: PAI-1, Serine Protease

Cat.No: T13257

Target: PAI-1, Serine/threonin kinase, Serine Protease

Cat.No: T4255

Synonym: TM5275 sodium salt

Target: PAI-1

Cat.No: T2030

Synonym: PAI-039,Tiplasinin

Target: PAI-1, Apoptosis

Cat.No: T29856

Synonym: PAZ 417,PAZ417,PAZ-417

Target: PAI-1

Benzamidine hydrochloride

Cat.No: T8362

Synonym: Benzamidine HCl,苄脒盐酸盐

Target: Serine/threonin kinase, Serine Protease

Cenupatide acetate

Cat.No: TP2338L

Synonym: Cenupatide acetate(1006388-38-0 Free base)

Target: Others

Cat.No: T3359

Synonym: 抑酶肽,抑肽酶,Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin

Target: Others, Serine Protease, Influenza Virus, Proteasome

4-Aminobenzamidine dihydrochloride

Cat.No: T60248

Synonym: p-Aminobenzamidine dihydrochloride

Target: Serine Protease

5-trans-Prostaglandin E2

Cat.No: T71851

Cat.No: T13251

Synonym: UKI-1C

Target: Others

Cat.No: T70734

Cat.No: T70417

Cat.No: T69751

Cat.No: T68572

Cat.No: T69890

Valyl-glycyl-arginine-4-nitroanilide

Cat.No: T68659

Cat.No: T69319

Cat.No: T25915

Synonym: PAI-749,PAI749,PAI 749

ZK824859 hydrochloride (2271122-53-1 free base)

Cat.No: T13409L

Synonym: ZK824859 hydrochloride

Target: Others

Cat.No: T70927

Cat.No: T13409

Target: Others

Cat.No: T41085

Synonym: UK122

Cat.No: T70810

Cat.No: T41029

Cat.No: T68682

6-Aminocaproic acid hydrochloride

Cat.No: T72113

Synonym: EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride

GGACK (hydrochloride)

Cat.No: T35931

Urokinase (peptidolytic)

Cat.No: T73701

Cat.No: TP2338

Synonym: UPARANT,Cenupatide trifluoroacetic acid salt,Ac-Arg-Aib-Arg-α(Me)Phe-NH2)

Cat.No: T40614

Cat.No: T11152

Synonym: MCI-186 D5

Target: Others

Cat.No: T80859

Z-Gly-Gly-Arg-AFC

Cat.No: T80736

Cat.No: T68513

Cat.No: TP2482

Synonym: LCKLSL acetate(533902-29-3 free base)

Target: Annexin A

Cat.No: T64287

LCKLSL hydrochloride

Cat.No: T78015

Cat. No.	Product Name	Target	Signaling Pathways
T3876	Loureirin B 龙血素B,龙血素 B	PAI-1; ERK; Potassium Channel; JNK	MAPK; Membrane transporter/Ion channel; Metabolism
	Loureirin B 是从剑叶龙血树中分离到的一种黄酮，是 PAI-1抑制剂，IC50值为 26.10 μM。它抑制 KATP，以及 ERK 和 JNK 的磷酸化，具有抗糖尿病的功效。
T4S0592	Toddalolactone (+)-Toddalolactone,飞龙掌血内酯,毛两面针素	PAI-1	Metabolism
	Toddalolactone ((+)-Toddalolactone) 是一种Toddalia asiatica 的主要成分，能够抑制重组人纤溶酶原激活物抑制物-1(PAI-1)的活性， IC50=37.31 μM。
T0881	6-Aminocaproic acid 氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid	Others	Others
	6-Aminocaproic acid (EACA) 是一种单氨基羧酸，是一种有效的、具有口服活性的纤溶酶和纤溶酶原的抑制剂。它是一种有效的抗纤维蛋白溶解剂，能够竞争性结合纤溶酶原上的赖氨酸残基，防止血块溶解，并抑制纤溶酶的形成，减少纤维蛋白溶解。它可用于出血性疾病的研究。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。

天然产物

Cat.No: T3876

Synonym: 龙血素B,龙血素 B

Target: PAI-1, ERK, Potassium Channel, JNK

Cat.No: T4S0592

Synonym: (+)-Toddalolactone,飞龙掌血内酯,毛两面针素

Target: PAI-1

6-Aminocaproic acid

Cat.No: T0881

Synonym: 氨基己酸,EACA,6-氨基己酸,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid

Target: Others

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

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