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17
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10328 |
Anti-parasitic agent 3
|
Others | Others |
Anti-parasitic agent 3 是一种抗寄生虫剂,对耐药寄生虫具有活性。 | |||
T0395 |
Pyrantel tartrate
Banminth,酒石酸噻吩嘧啶 |
Antibiotic; Parasite | Microbiology/Virology |
Pyrantel tartrate (Banminth) 是一种四氢嘧啶类广谱牲畜驱虫剂,是烟碱乙酰胆碱受体激动剂。它能引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。 | |||
T1259 |
Pyrantel pamoate
双羟萘酸噻嘧啶,Pyrantel embonate |
Others; Antibiotic; Parasite | Microbiology/Virology; Others |
Pyrantel pamoate (Pyrantel embonate) 是一种四氢嘧啶光谱驱虫剂,是烟碱乙酰胆碱受体激动剂。它可引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。 | |||
T0850 |
Primaquine diphosphate
Primaquine phosphate,磷酸伯氨喹,Primaquine bisphosphate,磷酸伯安喹 |
Antibiotic; Parasite | Microbiology/Virology |
Primaquine diphosphate 是一种合成的 8-氨基喹啉衍生物,具有抗疟特性。它是一种能破坏间日疟原虫和卵形疟原虫肝脏晚期和潜在组织形态的化合物。 | |||
T1172 |
Diclazuril
地克珠利,R-64433 |
Antibiotic; Parasite | Microbiology/Virology |
Diclazuril (R-64433) 是一种具有口服活性的抗球虫剂,是苯乙腈衍生物。它可用于某些传染病和寄生虫病的相关研究。 | |||
T1546 |
Nitazoxanide
NSC 697855,硝唑尼特 |
Others; Influenza Virus; Parasite; Autophagy | Autophagy; Microbiology/Virology; Others |
Nitazoxanide (NSC-697855) 是一种广谱驱虫剂,对感染动物和人类的各种蠕虫、原生动物和肠道细菌都具有作用活性。 它在无菌培养中抑制Giardia lamblia 滋养体增殖,IC50为 2.4 μM。它可研究寄生虫性胃肠炎,具有抗病毒特性。 | |||
T8999 | Soporidine | Others | Others |
Soporidine 是由寄生植物 Striga hermonthica 萌发的拮抗剂。它能够特异性抑制 S. hermonthica 独脚金内酯受体,阻碍寄生虫的萌发。 | |||
T61538 | Antiparasitic agent-10 | ||
Antiparasitic agent-10 (Compound 94) is a potent anti-parasitic agent specifically designed to target and combat parasitic infections. It demonstrates notable anti-schistosomal activity, particularly against adults of Schistosoma mansoni. As a result, this compound holds significant potential for utilization in Schistosomiasis research as a viable treatment option [1]. | |||
T83024 | Antiparasitic agent-20 | Parasite | Microbiology/Virology |
Antiparasitic agent-20 (Compound 1p) 是一种抗寄生虫剂,对T. brucei和T. cruzi展现出显著效力,其EC50值分别为0.09 μM和14.1 μM,表现出其广泛的抗寄生虫活性。 | |||
T61160 | Antiparasitic agent-2 | ||
Antiparasitic agent-2 (compound 8a) 对 L. infantum 和 T. cruzi 展示出较高的抗寄生效力,其 IC50 值分别为 7.28 μM 和 2.30 μM。同时,Antiparasitic agent-2 对 HepG2 癌细胞亦表现出一定的细胞毒性,CC50 值为 26.79 μM。 | |||
T60519 |
Antiparasitic agent-4
|
||
Antiparasitic agent-4 (compound 4q) 具有高抗寄生虫活性,其对于婴儿利什曼原虫 (L. infantum)的 IC50值为 8.51 μM,对克氏锥虫 (T. cruzi)的IC50值为2.20 μM。Antiparasitic agent-4 对癌细胞 HepG2 也具有细胞毒性,CC50值为 18.97 μM。 | |||
T61245 |
Antiparasitic agent-7
|
||
Antiparasitic agent-7 (compound 5d) displays specific antiparasitic activity against Leishmania infantum (L. infantum), exhibiting an IC50 value of 2.85 μM. Additionally, Antiparasitic agent-7 demonstrates cytotoxicity against HepG2 cells with a CC50 value of 10.61 μM [1]. | |||
T74773 | Antiparasitic agent-14 | ||
Antiparasitic agent-14 是一种抗寄生虫剂,具备细胞毒性和抗寄生虫活性,能够抑制锥体鞭毛体和无鞭毛体的生长。 | |||
T61001 |
Antiparasitic agent-6
|
||
Antiparasitic agent-6 (compound 5b) 对婴儿利什曼原虫表现出选择性抗寄生活性 (IC50 = 3.89 μM)。Antiparasitic agent-6 还对 HepG2 细胞表现出一定的细胞毒性,CC50值为 13.64 μM。 | |||
T61221 |
Antiparasitic agent-8
|
||
Antiparasitic agent-8 (Compound 9) exhibits potent antiparasitic activity against Hymenolepis nana, while demonstrating low levels of cytotoxicity [1]. | |||
T61641 |
Antiparasitic agent-5
|
||
Antiparasitic agent-5 (compound 8h) exhibits potent selectivity as an antiparasitic agent against Leishmania infantum (L. infantum), with an IC50 value of 2.50 μM. Additionally, this compound displays cytotoxic effects on HepG2 cells with a CC50 value of 6.78 μM [1]. | |||
T61683 |
Antiparasitic agent-9
|
||
Antiparasitic agent-9 (compound 47) is a highly active and orally administered antiparasitic agent, exhibiting potent antiparasitic efficacy against the human parasite [1]. | |||
T83025 | Antiparasitic agent-19 | ||
Antiparasitic agent-19 (compound 40) 是一种化合物,具备广泛的抗寄生虫活性,且对布氏锥虫、婴儿利什曼原虫和克氏锥虫具有较低的毒性。 | |||
T79415 | Antiparasitic agent-18 | Parasite | Microbiology/Virology |
Antiparasitic agent-18 (compound 3a) 对T. brucei (EC50=0.4 μM)、T. cruzi (EC50=0.21 μM) 和 L. donovani (EC50=0.26 μM) 表现出高度的活性和选择性,证明其为一种有效的抗原虫化合物。 | |||
T78966 |
Antiparasitic agent-17
|
Parasite | Microbiology/Virology |
Antiparasitic agent-17(化合物 5u)为口服有效的抗寄生虫药物,针对氯喹敏感菌株 (Pf3D7) 与氯喹耐药菌株 (PfK1) 表现出抑制作用,其IC50分别为0.96 μM及1.67 μM。 | |||
T0356 |
Nitromide
硝米特,3, 5-Dinitrobenzamide,3,5-Dinitrobenzamide |
Parasite | Microbiology/Virology |
Nitromide (3,5-Dinitrobenzamide) 是一种抗寄生虫药。 | |||
T11013L1 |
Dextrorotation nimorazole phosphate ester TFA
|
Others | Others |
Dextrorotation nimorazole phosphate ester TFA 是一种抗厌氧菌和抗原虫感染的试剂。 | |||
T11013L2 |
Levorotation nimorazole phosphate ester TFA
|
Others | Others |
Levorotation nimorazole phosphate ester TFA 是一种抗厌氧菌和抗原虫感染的试剂。 | |||
T16705 |
Quinfamide
喹法米特,WIN-40014 |
Others; Parasite | Microbiology/Virology; Others |
Quinfamide 是一种具有治疗热带寄生虫感染(如阿米巴病和蠕虫病)的潜力的化合物。 | |||
T0838 |
Triclabendazole
三氯苯咪唑,三氯苯达唑,CGA89317 |
Microtubule Associated; Parasite | Cytoskeletal Signaling; Microbiology/Virology |
Triclabendazole (CGA89317) 是一种苯并咪唑,与微管蛋白结合,损害细胞内运输机制,且干扰蛋白质的合成。 | |||
T12022 |
Metronidazole Benzoate
Benzoyl metronidazole |
Antibacterial | Microbiology/Virology |
Metronidazole Benzoate (Benzoyl metronidazole) 是甲硝唑和苯甲酸衍生物,具有抗菌,抗寄生虫,抗滴虫等作用,常用于治疗由厌氧菌引起的感染。 | |||
T37514 |
Hydroxy Dimetridazole
|
Drug Metabolite | Metabolism |
Hydroxy Dimetridazole 是Dimetridazol 的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物,可用于对抗原生动物感染。 | |||
T39425 |
Umifoxolaner
|
||
Umifoxolaner is an anti-parasitic agent (veterinary). | |||
T2214 |
Flumethrin
|
Others | Others |
Flumethrin 是一种拟除虫菊酯类杀虫剂。外用在兽药中,用于防治牛、绵羊、山羊、马和狗身上的寄生虫和蜱,以及治疗蜜蜂群中的寄生虫。 | |||
T71419 | Diclazuril K | ||
Diclazuril K is a coccidiostat and GAPDH inhibitor used to prevent parasitic contamination of livestock and poultry feed. | |||
T11013 |
Dextrorotation nimorazole phosphate ester
|
Others | Others |
Dextrorotation nimorazole phosphate ester is an anti-anaerobic and anti-parasitic agent. D-morpholine ornidazole organic phosphate is a newly developed, highly efficient, well-tolerated fourth-generation nitroimidazole derivative. Objective: Antibacterial | |||
T33637 |
Neostibosan
Stibanilic acid,693B,Astaril,Ethylstibamine,p-Aminobenzenestibonic acid,Bayer 693 |
||
Neostibosan is an arsenic-containing parasitic agent. Due to the activity of arsenic on visceral L/Ashmaniasis, one of the pentvalent antimony, which is less toxic, is synthesized and has potential activity on tumor cells. | |||
T71418 | Diclazuril Na | ||
Diclazuril Na is a coccidiostat and GAPDH inhibitor used to prevent parasitic contamination of livestock and poultry feed. | |||
T70938 |
SN00799639
|
||
SN00799639, also known as SN639, is a potent inhibitor of the motility and development of parasitic larvae of Haemonchus contortus, a blood-feeding parasitic nematode of major economic importance in ruminants. SN639 displayed lower potency, with IC50 values of 8.4 μM (xL3 motility) and 0.29 μM (L4 development). | |||
T80625 | Fosthiazate | ||
Fosthiazate是一种作用机制为通过抑制包括根结线虫(Meloidogyne spp.)、球孢线虫(Globodera spp.)以及短体线虫(Pratylenchus spp.)在内的多种植物寄生线虫乙酰胆碱酯酶合成的广谱杀线虫剂。 | |||
T69469 |
Panepoxydone
|
||
Panepoxydone 是一种 NF-κB 活化抑制剂。Panepoxydone 通过抑制 IκB 的磷酸化来干扰 NF-κB 介导的信号转导。Panepoxydone 具有抗肿瘤、抗炎、抗疟疾和抗寄生虫活性。 | |||
T75536 | Koshidacin B | ||
Koshidacin B为针对疟原虫的环四肽类化合物,其针对抗疟原虫(P. falciparum) FCR3和K1系的IC50值分别为0.89 μM与0.83 μM。此化合物在体内能有效抑制疟原虫,适用于疟疾感染的科学研究。 | |||
T71917 |
FFK29
|
||
FFK29 is a synthetic class II HDACi (Histone deacetylase inhibitors) which have have recently emerged as novel therapeutic options for treating various protozoan and parasitic diseases. While these HDACi demonstrated a negligible effect on the viability of mature cysts, Acanthamoeba encystation was significantly inhibited by these HDACi. In conclusion, these synthetic HDACi demonstrated potent amoebicidal effects and inhibited the growth and encystation of Acanthamoeba, thus highlighting their e... | |||
T35745 |
Marcfortine A
|
||
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subuni... | |||
T72519 |
Niclosamide sodium
BAY2353 sodium |
||
Niclosamide (BAY2353) sodium 为用于研究寄生虫感染的口服抗蠕虫化合物,同时是STAT3抑制剂,在HeLa细胞中IC50为0.25μM。此化合物显示抗癌生物活性,并可抑制Vero E6细胞DNA复制。 | |||
T37757 |
Tyvelose
|
||
Tyvelose is an unusual 3,6-dideoxyhexose terminal sugar and the immunodominant component of glycoprotein antigens in the parasitic helminth T. spiralis, which is responsible for trichinosis in humans. It is produced in high amounts by the infective larva and is immunodominant during the muscle stage of infection. Mice immunized with tyvelose-BSA produce IgG1 antibodies to tyvelose but are not resistant to infection by T. spiralis. Tyvelose-specific antibodies (2.5 mg/20 g) administered to rat pu... | |||
T35419 |
τ-Fluvalinate
|
||
τ-Fluvalinate is a pyrethroid acaricide.1It induces tail currents in Western honeybee (A. mellifera) voltage-gated sodium channels (AmNav1) expressed inXenopusoocytes (EC50= 60 nM). It also induces tail currents in honeybee parasitic Varroa mite (V. destructor) Nav1 channels (VdNav1) expressed inXenopusoocytes (EC50= 160 nM) with a faster tail current decay than that of AmNav1 channels. Topical application of τ-fluvalinate (2 μl) in combination with coumaphos , atrazine , 2,4-DMPF, chlorpyrifos ... | |||
T83887 |
SLU-10482
|
||
SLU-10482是一种抗寄生虫化合物,能减少HCT-8细胞中C. parvum寄生虫的数量(EC50 = 0.07 µM)。相较于另一种抗寄生虫化合物SLU-2633,SLU-10482与人类ether-a-go-go (hERG; Kd = 43 µM)的结合能力较弱。在体内,SLU-10482以5和15 mg/kg的剂量,每天两次给药,能减少C. parvum感染小鼠模型中粪便中卵囊的数量。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5807 |
Stylopine hydrochloride
|
NOS; COX | Immunology/Inflammation; Neuroscience |
Stylopine hydrochloride 是一种生物碱类化合物,从紫堇属之植物块茎中分离得到,具有抗炎症和抗寄生虫作用。 | |||
T10388 |
Asparagusic acid
1,2-二噻戊环-4-羧酸,芦笋酸 |
Parasite | Microbiology/Virology |
Asparagusic acid 是芦笋植物中的一种含硫气味成分,是植物生长抑制剂,具有抗寄生虫作用。 | |||
T2198 |
Arecoline hydrobromide
Arecoline HBr,氢溴酸槟榔碱,Arecoline bromide |
AChR | Neuroscience |
Arecoline hydrobromide (Arecoline HBr) 是从槟榔中得到的一种生物碱,具有刺激、警觉、抗焦虑和抗寄生虫作用。它是烟碱和毒蕈碱乙酰胆碱受体的部分激动剂,可诱导氧化应激。 | |||
T2S0961 |
Chalcone
benzylideneacetophenone,phenyl styryl ketone,Cinnamophenone,benzalacetophenone,β-phenylacrylophenone,查耳酮 |
EGFR; Antibacterial | Angiogenesis; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Chalcone (Cinnamophenone) 是从甘草中分离得到的一种芳香酮,可合成查耳酮衍生物。它具有多种生物和药理的活性,如抗炎、抗菌、抗癌、抗氧化、抗寄生虫等活性。 | |||
T1104 |
Paromomycin Sulfate
Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐 |
Antibacterial; Antibiotic; Parasite | Microbiology/Virology |
Paromomycin Sulfate (Aminosidine sulfate) 是一种广谱氨基糖苷类抗生素 ,是具有杀螨杀菌作用的新霉素衍生物。它通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合,使 mRNA 的翻译提前终止,并抑制蛋白质合成。它可研究细菌和寄生虫感染。 | |||
T25114 |
Ascaridole
NSC-406266,NSC 406266,NSC406266 |
Parasite | Microbiology/Virology |
Ascaridole (NSC-406266) 可作为驱虫化合物,能驱除人体和植物中的寄生蠕虫(蠕虫),具有较弱的抗疟活性。 | |||
T15717 |
Lasalocid
Lasalocid-A,Antibiotic X-537A,Ionophore X-537A |
Antibacterial | Microbiology/Virology |
Lasalocid (Lasalocid-A) 是一种由链霉菌产生的离子载体抗生素,具有抗菌和寄生虫作用,常添加进饲料中。 | |||
T1082 |
Benzyl isothiocyanate
Benzoylthiocarbimide,苄基异硫氰酸酯,异硫氰酸苯甲酯,Isothiocyanic Acid Benzoyl Ester |
Apoptosis; Antibacterial; Antibiotic | Apoptosis; Microbiology/Virology |
Benzyl isothiocyanate (Benzoylthiocarbimide) 是一种具有杀菌活性的天然异硫氰酸酯,最初存在于十字花科蔬菜中。 它显示出免疫调节、抗寄生虫、抗生素、抗氧化、抗动脉粥样硬化、抗血管生成、抗转移、抗癌化疗和化学预防活性。 | |||
T3897 |
Isoschaftoside
|
Anti-infection; Antifungal | Microbiology/Virology |
Isoschaftosid 是从 Desmodium uncinatum 根部分泌物中提取的 c- 糖基黄酮类天然产物,有抗肿瘤、抗氧化和抗菌活性,它还对 M. incognita 具有很强的杀线虫活性。 | |||
T68953 |
Arecoline
|
Reactive Oxygen Species; AChR | Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
Arecoline 是一种来自棕榈科植物槟榔的天然生物碱,是有效的烟碱和毒蕈碱乙酰胆碱受体的部分激动剂。Arecoline 具有抗焦虑和抗寄生虫活性,可诱导氧化应激,可用于研究阿尔茨海默病和老年性痴呆。 | |||
T0461 |
Berberine chloride
Berberine hydrochloride,盐酸小檗碱,Benzodioxide,Natural Yellow 18,盐酸黄连素 |
Reactive Oxygen Species; Topoisomerase; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine chloride (Natural Yellow 18) 是一种来自小檗科 Hydrastis canadensis L. 的生物碱,也存在于许多其他植物中,常用作抗生素。它对肠胃外的毒性相对较大,但已用于口服用于各种真菌和寄生虫感染以及止泻。 | |||
T1157 |
Moxidectin
milbemycin B,CL301423,莫昔克丁,莫西菌素 |
GluCls; Antibiotic; Parasite | Microbiology/Virology |
Moxidectin (CL301423) 是可用于预防和控制心丝虫和蛔虫的一种驱虫剂。 | |||
T3794 |
Pentagalloylglucose
Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖 |
Influenza Virus | Microbiology/Virology |
1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中,具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。 | |||
T14114 |
Acivicin
阿西维辛,AT-125,U-42126 |
Others | Others |
Acivicin (AT-125) is a γ-glutamyl transpeptidase (GGT) inhibitor derived from the Streptomyces sviceus natural product. It possesses anti-cancer and anti-parasitic properties and can effectively cross the blood-brain barrier[1][2]. | |||
TN4718 |
Orobanchyl acetate
|
Others | Others |
Orobanchyl acetate is a germination stimulant for root parasitic plants. | |||
T77207 | Acivicin hydrochloride | ||
Acivicin hydrochloride (AT-125 hydrochloride),一种猪链霉菌的天然产物,兼具透过血脑屏障的能力,是γ-谷氨酰转肽酶 (GGT) 的抑制剂,具有抗癌和抗寄生虫的特性。 | |||
T79985 |
Cryptosporioptide A
|
Phosphatase | Metabolism |
Cryptosporioptide A (Compound 3)是一种从昆虫寄生真菌Cordyceps gracilioides中分离出的色素蛋白酪氨酸磷酸酶抑制剂,针对PTP1B、SHP2、CDC25B、LAR和SHP1等酶展示了抑制作用,其IC50值分别为7.3、5.7、7.6、>50、4.9 μg/mL。 |