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Search Results for " pancreatic β "

56

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8982	RH01687	Others	Others
	RH01687 是可以保护胰腺 β 细胞免受内质网应激诱导的细胞死亡的化合物。它对糖尿病具有潜在的研究价值。
T2055	WS3	EGFR; IκB/IKK	Angiogenesis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors
	WS3 是一种可促进鼠和人原代胰岛的胰腺 β 细胞增殖的增殖分子。它可用于研究 I 型糖尿病。
TP1137L	Pancreatic Polypeptide (human) acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Pancreatic Polypeptide (human) acetate 是一种 C 末端酰胺化的 36 个氨基酸肽，可作为神经肽 Y (NPY) Y4/Y5 受体激动剂。
TP1044L	Pancreatic Polypeptide, rat acetate	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	Pancreatic Polypeptide, rat acetate 是 NPY 受体的激动剂，对 NPYR4 具有高亲和力。
T15159	Dorzagliatin HMS5552	Glucokinase	Metabolism
	Dorzagliatin (HMS5552) 是双重作用的葡萄糖激酶 (glucokinase;GK) 激活剂，可改善 2 型糖尿病的血糖控制，提高胰腺 β 细胞功能。
T1603	Glipizide CP 28720,K 4024,格列吡嗪	Potassium Channel; PPAR; ABC	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Glipizide (CP 28720) 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent)，在 2 型糖尿病的研究中具有价值，但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性。
T76538	Pancreatic polypeptide
	Pancreatic polypeptide 是由胰腺内分泌的 PP 细胞所分泌的多肽，具有调节胰腺分泌功能、影响肝糖原储存及胃肠分泌的作用。
T63015	Pancreatic lipase/Carboxylesterase 1-IN-1
	Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) 是一种有效的、双重的胰脂酶 (PL) 和人羧酸酯酶 1A (hCES1A) 抑制剂，作用于 PL (IC50: 2.13 μM) 和 hCES1A (IC50: 0.055 μM)。
TP1382L	HAEGTFTSDVS acetate HAEGTFTSDVS acetate(864915-61-7 free base)	Glucagon Receptor	GPCR/G Protein
	HAEGTFTSDVS acetate 是 GLP-1 的一个 N 末端 1-11 残基，GLP-1 可刺激胰腺 β 细胞分泌胰岛素。
TP1125	Insulin(cattle) 牛胰岛素,Insulin from bovine pancreas,胰岛素	IGF-1R	Tyrosine Kinase/Adaptors
	Insulin cattle (Insulin from bovine pancreas) 是一种在胰腺 β 细胞中产生的两链多肽激素，在很多哺乳动物细胞培养体系中用作生长因子。
T1755	LY2090314	GSK-3	PI3K/Akt/mTOR signaling; Stem Cells
	LY2090314 是GSK-3抑制剂，抑制 GSK-3α (IC50:1.5 nM) 和 GSK-3β (IC50:0.9 nM)。
T6961	PX-478 PX-478 2HCl	HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism
	PX-478 是一种 HIF-1α 抑制剂，具有选择性、口服活性和血脑屏障渗透性。PX-478 具有抗肿瘤活性，还可以保护糖尿病中的胰腺 β 细胞功能，用于 2 型糖尿病的研究。
T4400	DIM-C-pPhOH CDIM8	Apoptosis; Others	Apoptosis; Others
	DIM-C-pPhOH (CDIM8) 是一种核受体 4A1(NR4A1) 拮抗剂，可降低细胞增殖，对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。它抑制癌细胞的生长和 mTOR 信号传导，诱导细胞凋亡和细胞应激。
T3162	IDE1	Others	Others
	IDE1 是定形内胚层诱导物，有用于器官移植等方面的潜力。
T27736	KM10103 KM-10103,KM 10103
	KM10103 exhibits β-cell-protective activities against ER stress, which plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes.
TP1202	Calcitonin Gene Related Peptide (CGRP) II, rat CGRP II, rat
	Calcitonin Gene Related Peptide II is a potent, long-lasting vasodilator; activation of CGRP receptors on pancreatic β-cells increases plasma levels of pancreatic enzymes.
T35627	Amylin (human) (trifluoroacetate salt)
	Amylin is a 37-residue peptide hormone secreted from pancreatic β-cells that reduces food intake, decreases glucagon secretion, slows gastric emptying, and increases satiety. It binds to amylin receptors with IC50 values of 2 and 0.2 nM for porcine and guinea pig nucleus accumbens membrane preparations, respectively. Amylin is present in amyloid aggregates derived from the pancreatic islets of humans with type 2 diabetes. Amylin forms fibrils that react to thioflavin T and are organized in a cro...
T22860	Imeglimin	Others	Others
	Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents. It has been shown to act on the liver, muscle, and pancreatic β-cells to uniquely target the key defects of type 2 diabetes.
T26895	BRD0476 BRD-0476,ML 187,ML187,ML-187,BRD 0476
	BRD0476 is a suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. BRD0476 inhibits JAK-STAT
T29154	WB403 WB-403,WB 403
	WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores the normal distribution pattern of α-
T28157	Nephrin
	Nephrin is a cell surface signaling receptor protein that regulates podocyte function and plays a role in β-cell survival signaling; it is a protein necessary for the proper functioning of the renal filtration barrier. Nephrin belongs to a family of highl
TP1630	A-71915 TFA (132956-87-7 free base) A-71915 TFA
	A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriuretic peptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells.
TP2017	GIP (1-39)
	Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.
T60743	Vin-C01
	Vin-C01 可用于研究Ⅱ型糖尿病，是胰腺 β 细胞的有效保护剂 (EC 50 = 0.22 μM)。Vin-C01 保护 β 细胞免受 STZ 诱导的细胞凋亡，并有效促进 β 细胞存活。
T76037	A-71915 TFA
	A-71915 (TFA) 为一种选择性心房利钠肽受体 (ANP receptor) 抑制剂，其作用能够诱导 RINm5F 胰腺 β 细胞凋亡，并减少胰岛素释放。
TP1954	PHM-27 (human)
	Endogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insu
TP2020	[Pro3]-GIP (Mouse)
	GIP receptor antagonist (IC50 = 2.6μM). Inhibits GIP-stimulated insulin release from pancreatic β cells in vitro. In ob/ob mice, blocks the effects of GIP on insulin release and plasma glucose levels. Also improves intraperitoneal glucose tolerance, insul
T61040	Vin-F03
	Vin-F03 可用于研究2型糖尿病，它是胰腺 β 细胞的有效保护剂 (EC50 = 0.27 μM)。Vin-F03 有效促进 β 细胞存活并且保护 β 细胞免受 STZ 诱导的细胞凋亡。
T38764	Amylin (8-37), human
	Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the absence of insulin and is a key pathological feature of type II diabetes mellitus.
T35918	N-Arachidonoyl Taurine
	N-Arachidonoyl taurine is an arachidonoyl amino acid. It is oxygenated by 12(S)- and 15(S)-lipoxygenase and is converted to 12-HETE-taurine (12-HETE-T) in murine resident peritoneal macrophages. N-Arachidonoyl taurine is an activator of the transient receptor potential vanilloid (TRPV) channels TRPV1 and TRPV4 (EC50s = 28 and 21 μM, respectively). It increases calcium flux in HIT-T15 pancreatic β-cells and INS-1 rat islet cells when used at a concentration of 10 μM and increases insulin secretio...
T76028	Amylin (IAPP), feline TFA
	Amylin (IAPP), feline TFA，一种来自猫科动物、含37个氨基酸的多肽，为胰岛β细胞的主要分泌物之一。作为调节肽，它能够抑制胰岛素和胰高血糖素的分泌。
TP2018	GIP, human GIP (human),抑胃肽
	Potent insulinotropic hormone synthesized by duodenal K-cells. High affinity GIP receptor agonist (EC50 = 0.81 nM) that inhibits gastric acid secretion and stimulates pancreatic insulin release in response to glucose. Also affects lipid metabolism and dis
T35625	Aminoacetone (hydrochloride)
	Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases. It has been identified as one of several endogenous sources of methylglyoxal found in the plasma of diabetes patients. As a pro-oxidant, 0.10-5 mM aminoacetone can induce cell death in RINm5f pancreatic β-cells. Aminoacetone is used as a growth substrate for Pseudomonas.
T68976	Piragliatin
	Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus. Piragliatin has an acute glucose-lowering action in patients with mild type 2 diabetes, mainly mediated through a generalized enhancement of β-cell function and through fasting restricted changes in ...
T3984	GLP-1(7-36), amide MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide	Glucagon Receptor	GPCR/G Protein
	GLP-1(7-36), amide (MKC 253) 是一种生理性肠降血糖素，能够刺激胰岛素分泌。
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin...
T69380	Cinnamic acid, hydrazide
	Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various mechanism of actions including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of hepatic gluconeogenesis, enhanced glucose uptake, increased insulin signaling pathway, delay of carbohydrate digestion and glucose absorption, and inhibiti...
T80060	Pyruvate carboxylase	Endogenous Metabolite	Metabolism
	Pyruvate carboxylase是一种催化反应中丙酮酸与HCO3−和MgATP进行依赖性羧化生成草酰乙酸的含生物素酶。它在调控肝脏糖异生、脂肪细胞脂肪酸合成及胰腺β细胞胰岛素分泌方面，对全身能量平衡发挥关键作用。
T36408	Rhein-13C4 Rhein-13C4
	Rhein-13C4 is intended for use as an internal standard for the quantification of rhein by GC- or LC-MS. Rhein is an anti-inflammatory anthraquinone found in rhubarb and is the bioactive derivative of its prodrug diacerein . At 10 μM, rhein inhibits IL-1β signaling, suppressing signaling through NF-κB, and reduces the expression of the matrix metalloproteases MMP-1 and MMP-13.1 It inhibits IKKβ (IC50 = 11.8 μM), decreasing iNOS and IL-6 expression in LPS-stimulated macrophages but paradoxically i...
T22014	8-CPT-2Me-cAMP, sodium salt
	8-CPT-2Me-cAMP sodium is a sodium salt compound that selectively activates exchange proteins activated by cAMP (Epac). These Epac proteins are cAMP-sensitive guanine nucleotide exchange factors (GEFs) responsible for activating small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium specifically activates Epac1 with an EC50 value of 2.2 μM, while showing no activation of PKA with an EC50 value greater than 10 μM [1]. Additionally, 8-CPT-2Me-cAMP sodium stimulates the Epac-mediated release of calcium ...
T63019	GKA50 quarterhydrate
	GKA50 quarterhydrate 是一种有效的葡萄糖激酶激活剂，其 EC50 值为 33 nM。GKA50 quarterhydrate 是一种啮齿动物和人类胰岛中 β 细胞代谢的葡萄糖样激活剂，也是一种 Ca2+依赖性胰岛素分泌调节剂。GKA50 quarterhydrate 能够刺激小鼠胰岛分泌胰岛素，可以显著降低高脂喂养的雌性大鼠血糖。
T76333	(Ser8)-GLP-1 (7-36) amide, human
	(Ser8)-GLP-1 (7-36) amide, human 为源自胰高血糖素原的胰高血糖素样肽-1酰胺，属于 GLP-1(1-36) 酰胺肽裂解产物。作为肠促胰岛素激素，该化合物促进胰腺 β 细胞在葡萄糖依赖性条件下分泌胰岛素，并对消化道的运动与分泌功能产生影响。
TP1233	Amylin (8-37), rat Amylin (8-37) (mouse, rat)
	Amylin (8-37), rat is a truncated analog of native Amylin that selectively inhibits insulin-related glucose uptake and glycogen deposition in muscle tissue. Amylin is also known as islet amyloid precursor peptide (IAPP) and is co-secreted with insulin fro
T83928	DA ZP1
	DA ZP1（diacetylated Zinpyr1）是一种荧光性的Zn(II)传感器（KdZn2+= 0.6 nM），可用于体外成像和分离胰腺β细胞及类似β细胞，并用于纯化源自干细胞的活体类似β细胞。该传感器亦可用于体内成像移植的岛细胞移植物和内源性小鼠岛细胞。在没有Zn(II)离子存在时，DA ZP1不发光，但其与Zn(II)的结合促进乙酰基的水解裂解，产生强烈的荧光信号。其激发和发射最大波长（λ）分别为490 nm和522 nm。
T82317	GIP, rat
	GIP, rat 是一种由十二指肠和空肠 K 细胞在食物摄入后分泌的具有生物活性的肽，由 42 个氨基酸组成。作为肠促胰岛素激素肽家族的一员，GIP 与另一激素 GLP 共同负责刺激胰岛 β 细胞分泌胰岛素，并促进 β 细胞的增殖与存活。近期研究显示GIP 在调控脂质平衡及肥胖发病机制中发挥重要作用。
T76480	Amylin (1-37) (human)
	Amylin (1-37) (human) (hIAPP (1-37)) 为胰岛β细胞分泌颗粒中的肽类激素，其C端经酰胺化处理，第2和第7个半胱氨酸残基间形成二硫键。
T82329	GDI2-IN-1
	GDI2-IN-1（compound (+)-37）是β版GDP解离抑制剂GDI2的抑制剂，具有2.87 μM的IC50和36 μM的KD。在过表达GDI2的胰腺异种移植模型中，该化合物展示了显著的体内抗肿瘤效果。
T25739	Linogliride McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida
	Linogliride 是一种基于胍的胰岛素分泌抑制剂，也是 pirogliride 的结构类似物，具有降血糖活性。它可以阻断胰腺β细胞膜上对 ATP 敏感的钾通道，从而刺激胰岛素分泌并改善葡萄糖耐受性。
T35639	Sulfatides (bovine) (sodium salt)
	Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system. They are produced from the combination of ceramide and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. The ceramide portion contains variable fatty acid chain lengths, which are tissue- and pathology-dependent. Sulfatides are primarily found in the myelin sheath of oligodendrocytes and Schwann cells, wit...
T25739L	Linogliride fumarate McN 3935,McN-3935,McN3935
	Linogliride fumarate 是Linogliride 的富马酸盐。Linogliride 是一种基于胍的胰岛素分泌抑制剂，也是pirogliride 的结构类似物，具有降血糖活性。它可以阻断胰腺β细胞膜上对ATP 敏感的钾通道，从而刺激胰岛素分泌并改善葡萄糖耐受性。

化合物

Cat.No: T8982

Target: Others

Cat.No: T2055

Target: EGFR, IκB/IKK

Pancreatic Polypeptide (human) acetate

Cat.No: TP1137L

Target: Neuropeptide Y Receptor

Pancreatic Polypeptide, rat acetate

Cat.No: TP1044L

Target: Neuropeptide Y Receptor

Cat.No: T15159

Synonym: HMS5552

Target: Glucokinase

Cat.No: T1603

Synonym: CP 28720,K 4024,格列吡嗪

Target: Potassium Channel, PPAR, ABC

Pancreatic polypeptide

Cat.No: T76538

Pancreatic lipase/Carboxylesterase 1-IN-1

Cat.No: T63015

HAEGTFTSDVS acetate

Cat.No: TP1382L

Synonym: HAEGTFTSDVS acetate(864915-61-7 free base)

Target: Glucagon Receptor

Insulin(cattle)

Cat.No: TP1125

Synonym: 牛胰岛素,Insulin from bovine pancreas,胰岛素

Target: IGF-1R

Cat.No: T1755

Target: GSK-3

Cat.No: T6961

Synonym: PX-478 2HCl

Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy

Cat.No: T4400

Synonym: CDIM8

Target: Apoptosis, Others

Cat.No: T3162

Target: Others

Cat.No: T27736

Synonym: KM-10103,KM 10103

Calcitonin Gene Related Peptide (CGRP) II, rat

Cat.No: TP1202

Synonym: CGRP II, rat

Amylin (human) (trifluoroacetate salt)

Cat.No: T35627

Cat.No: T22860

Target: Others

Cat.No: T26895

Synonym: BRD-0476,ML 187,ML187,ML-187,BRD 0476

Cat.No: T29154

Synonym: WB-403,WB 403

Cat.No: T28157

A-71915 TFA (132956-87-7 free base)

Cat.No: TP1630

Synonym: A-71915 TFA

Cat.No: TP2017

Cat.No: T60743

Cat.No: T76037

Cat.No: TP1954

[Pro3]-GIP (Mouse)

Cat.No: TP2020

Cat.No: T61040

Amylin (8-37), human

Cat.No: T38764

N-Arachidonoyl Taurine

Cat.No: T35918

Amylin (IAPP), feline TFA

Cat.No: T76028

Cat.No: TP2018

Synonym: GIP (human),抑胃肽

Aminoacetone (hydrochloride)

Cat.No: T35625

Cat.No: T68976

GLP-1(7-36), amide

Cat.No: T3984

Synonym: MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide

Target: Glucagon Receptor

Cat.No: T71981

Cinnamic acid, hydrazide

Cat.No: T69380

Pyruvate carboxylase

Cat.No: T80060

Target: Endogenous Metabolite

Cat.No: T36408

Synonym: Rhein-13C4

8-CPT-2Me-cAMP, sodium salt

Cat.No: T22014

GKA50 quarterhydrate

Cat.No: T63019

(Ser8)-GLP-1 (7-36) amide, human

Cat.No: T76333

Amylin (8-37), rat

Cat.No: TP1233

Synonym: Amylin (8-37) (mouse, rat)

Cat.No: T83928

Cat.No: T82317

Amylin (1-37) (human)

Cat.No: T76480

Cat.No: T82329

Cat.No: T25739

Synonym: McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida

Sulfatides (bovine) (sodium salt)

Cat.No: T35639

Linogliride fumarate

Cat.No: T25739L

Synonym: McN 3935,McN-3935,McN3935

Cat. No.	Product Name	Target	Signaling Pathways
TN4383	Kazinol U	IL Receptor; IκB/IKK; NOS; NF-κB	Immunology/Inflammation; NF-κB
	Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-ÎºB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms.
T40584	Corymbiferin
	Corymbiferin, a chemical compound, exhibits significant anti-diabetic properties by enhancing antioxidant capacity and carbohydrate metabolism in diabetic rodents. In addition, Corymbiferin promotes the improvement of histopathology in both the liver and pancreatic β cells.
T15949	Mahanimbine	AChE	Neuroscience
	Mahanimbine 存在于Murraya koenigii 的根、叶和茎中，是从Murraya koenigii 中的提取的一种具有口服活性的生物碱。Mahanimbine 具有乙酰胆碱酯酶抑制活性，可抑制了高脂肪饮食（HFD）引起的小鼠代谢并发症的发展，对科尼氏分枝杆菌叶对链脲佐菌素诱导的糖尿病大鼠胰腺β细胞组织病理学变化有作用。

天然产物

Cat.No: TN4383

Target: IL Receptor, IκB/IKK, NOS, NF-κB

Cat.No: T40584

Cat.No: T15949

Target: AChE

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