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Cat. No.	Product Name	Target	Signaling Pathways
T6668	SGC-CBP30	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	SGC-CBP30 是高选择性CBP/p300溴结构域的有效抑制剂，对CBP 和p300的Kd 值分别为 21 和 32 nM。它强烈减少 Th17 细胞中 IL-17A 的分泌，具有抗炎作用。
T77560	Histone acetyltransferase p300 Inhibitor 4c	Carbonic Anhydrase; AChE	Metabolism; Neuroscience
	Histone acetyltransferase p300 Inhibitor 4c 是2-氨基噻唑衍生物，Histone acetyltransferase p300 Inhibitor 4c 对 hCA I 、hCA II、AChE 和 BChE 具有抑制作用，Ki 值为 0.008 ± 0.001 、 0.124 ± 0.017、0.129 ± 0.030 和 0.083 ± 0.041 μM。
T1962	ASP3026 ASP 3026	Apoptosis; ALK	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	ASP3026 是一种选择性的，具有口服活性的间变性淋巴瘤激酶抑制剂，可诱导肿瘤细胞凋亡，可研究非小细胞肺癌。
T7264	CBP/EP300-IN-1	Epigenetic Reader Domain	Chromatin/Epigenetic
	CBP/EP300-IN-1是一种 CBP/EP300 溴结构域抑制剂。
T12345	CBP/p300-IN-3 P300/CBP-IN-3	Histone Acetyltransferase	Chromatin/Epigenetic
	CBP/p300-IN-3 (P300/CBP-IN-3) 是一种组蛋白乙酰转移酶抑制剂。
TNU0864	HUP30	Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	HUP30是一种强效的血管舒张剂。HUP30可以刺激可溶性鸟苷酸环化酶，激活 K+离子通道，阻断细胞外 Ca2+的内流。
T36682	USP30 inhibitor 18	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP30 inhibitor 18 是有效的USP30选择性抑制剂，IC50为 0.02 μM。它增加蛋白质泛素化并加速线粒体自噬。
T13267	USP30 inhibitor 11 USP30-IN-11	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP30 inhibitor 11 (USP30-IN-11) 是一个选择性的 USP30 抑制剂(IC50 ： 0.01 µΜ)，抑制 SVA，可用于研究癌症、线粒体功能障碍和帕金森。
T41181	iP300v
	iP300v is a negative control for iP300w
T10702	CBP/p300-IN-2 CBP/EP300-IN-2	Epigenetic Reader Domain; c-Myc	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	CBP/EP300-IN-2 is an inhibitor of CBP/EP300 (IC50s: 1.07 nM and 5.96 nM for CBP/HTRF and Myc).
T13191	TP3011 CH0793011	Others	Others
	TP3011 is a potent topoisomerase I inhibitor equipotent as SN38 and is an active metabolite of CH-0793076.
T40144	CBP/p300 ligand 2
	CBP/p300 ligand 2 is a selective ligand that binds to the target protein for PROTAC of dCBP-1, a potent and selective heterobifunctional degrader of p300/CBP.
T40143	PROTAC CBP/P300 Degrader-1 PROTAC CBP/P300 Degrader-1	PROTACs	PROTAC
	PROTAC CBP/P300 Degrader-1 is an effective compound that degrades CBP/P300 in a potent manner. It significantly reduces cell viability in various cancer cell lines.
T63767	P300 bromodomain-IN-1
	P300 bromodomain-IN-1 是 p300 (EP300) bromodomain 的有效抑制剂 (IC50: 49 nM)。P300 bromodomain-IN-1 能够阻碍 c-Myc 的表达，并诱导 OPM-2 细胞的细胞周期阻滞在 G1/G0 期及诱导其凋亡 (apoptosis)。
T62415	CBP/p300-IN-17
	CBP/p300-IN-17 (compound 7) 是一种 EP300/CBP HAT 的有效抑制剂，能够作用于 HAT EP300 (IC50: 0.18 μM) 和 LK2 H3K27 (IC50: 0.69 μM)。
T63565	CBP/p300-IN-19 hydrochloride
	CBP/p300-IN-19 hydrochloride 是选择性的、有效的 p300/CBP HAT 抑制剂，能够作用于 p300-HAT (IC50: 1.4 μM)、CBP-HAT (IC50: 2.2 μM)、PCAF (IC50>100 μM)、Myst3 (IC50>100 μM)。CBP/p300-IN-19 hydrochloride 具有抗肿瘤作用。
T12346	CBP/p300-IN-5 P300/CBP-IN-5	Epigenetic Reader Domain	Chromatin/Epigenetic
	P300/CBP-IN-5 is a potent inhibitor of p300/CBP histone acetyltransferase (IC50 of 18.8 nM).
T73921	Ep300/CREBBP-IN-2
	Ep300/CREBBP-IN-2 (Example 73) 是一种有效的和具有口服活性的Ep300和CREBBP 抑制剂，IC50分别为 0.052 μM 和 0.148 μM。Ep300/CREBBP-IN-2 可用于癌症研究。
T73922	Ep300/CREBBP-IN-3
	Ep300/CREBBP-IN-3 (Example 61) 是一种有效的Ep300和CREBBP 抑制剂，IC50分别为 0.056 μM 和 0.095 μM。Ep300/CREBBP-IN-3 可用于癌症研究。
T63110	CBP/p300-IN-15
	CBP/p300-IN-15 (compound 13a) 是一种有效的 p300 (IC50: 2.5 nM) 和 CBP (IC50: 28.0 nM) 抑制剂。CBP/p300-IN-15 能够较好的抑制 OVCAR-3 细胞 (EC50: 0.865 μM) 和 A2780 细胞 (EC50: 2.71 μM)。 CBP/p300-IN-15 能够用于研究卵巢癌。
T73920	Ep300/CREBBP-IN-8
	Ep300/CREBBP-IN-8 (Example 37) 是一种有效的和具有口服活性的 Ep300和CREBBP 抑制剂，IC50分别为 0.014 μM 和 0.018 μM。Ep300/CREBBP-IN-8 可用于癌症研究。
T72815	CBP/p300-IN-10
	CBP/p300-IN-10 是一种高效的组蛋白乙酰转移酶 EP300和CREBBP 的抑制剂，IC50分别为 26 nM 和 39 nM。
T63122	CBP/p300-IN-19
	CBP/p300-IN-19 是一种 p300/CBP HAT 的有效抑制剂，能够作用于 p300-HAT (IC50: 1.4 μM)、CBP-HAT (IC50: 2.2 μM)、PCAF (IC50>100 μM)、Myst3 (IC50>100 μM)。CBP/p300-IN-19 具有抗肿瘤活性。
T62720	CBP/p300-IN-18
	CBP/p300-IN-18 (compound 8) 是一种 EP300/CBP HAT 的有效抑制剂，能够作用于 HAT EP300 (IC50: 0.056 μM) 和 LK2 H3K27 (IC50: 0.46 μM)。
T40344	CBP/p300-IN-14 CBP/p300-IN-14
	CBP/p300-IN-14, efficiently inhibits CBP/EP300 (lysine acetyltransferase) with an IC50 value of 3.3 nM.
T39826	CBP/p300-IN-8 CBP/p300-IN-8
	CBP/p300-IN-8 is a potent inhibitor of the CBP/P300 family of bromodomains . CBP/p300-IN-8 inhibits CBP ( IC 50 =0.01-0.1 μΜ) and BRD4 ( IC 50 =1-1000 μΜ) activity.
T40142	Thalidomide-NH-CBP/p300 ligand 2 Thalidomide-NH-CBP/p300 ligand 2	PROTACs	PROTAC
	Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).
T73923	Ep300/CREBBP-IN-4
	Ep300/CREBBP-IN-4 (Example 56) 是一种有效的Ep300和CREBBP 抑制剂，IC50分别为 0.024 μM 和 0.064 μM。Ep300/CREBBP-IN-4 可用于癌症研究。
T79395	CBP/p300-IN-21	Epigenetic Reader Domain	Chromatin/Epigenetic
	CBP/p300-IN-21 (Compound 5d) 作为一种选择性CBP/p300抑制剂，展现出对p300和CBP具有差异性的IC50值，分别为0.07 μM和1.755 μM。该化合物能有效降低H3K18Ac的水平，并抑制小鼠4T1肿瘤的生长。
T28439	PP30 PP 30,PP-30
	PP30 is an inhibitor of mTORC1 and mTORC2. It is selective within the PI3K family, inhibiting other PI3Ks only at high concentrations.
T62700	CBP/p300-IN-16
	CBP/p300-IN-16 (compound 1) 是一种 EP300/CBP HAT 的有效抑制剂，作用于 HAT EP300 (IC50: 0.61 μM) 和 LK2 H3K27 (IC50: 2.24 μM)。
T23489	UBP301 UBP 301	Others	Others
	UBP301 is a kainate receptor antagonist.

化合物

Cat.No: T6668

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Histone acetyltransferase p300 Inhibitor 4c

Cat.No: T77560

Target: Carbonic Anhydrase, AChE

Cat.No: T1962

Synonym: ASP 3026

Target: Apoptosis, ALK

Cat.No: T7264

Target: Epigenetic Reader Domain

CBP/p300-IN-3

Cat.No: T12345

Synonym: P300/CBP-IN-3

Target: Histone Acetyltransferase

Cat.No: TNU0864

Target: Potassium Channel, Calcium Channel

USP30 inhibitor 18

Cat.No: T36682

Target: DUB

USP30 inhibitor 11

Cat.No: T13267

Synonym: USP30-IN-11

Target: DUB

Cat.No: T41181

CBP/p300-IN-2

Cat.No: T10702

Synonym: CBP/EP300-IN-2

Target: Epigenetic Reader Domain, c-Myc

Cat.No: T13191

Synonym: CH0793011

Target: Others

CBP/p300 ligand 2

Cat.No: T40144

PROTAC CBP/P300 Degrader-1

Cat.No: T40143

Synonym: PROTAC CBP/P300 Degrader-1

Target: PROTACs

P300 bromodomain-IN-1

Cat.No: T63767

CBP/p300-IN-17

Cat.No: T62415

CBP/p300-IN-19 hydrochloride

Cat.No: T63565

CBP/p300-IN-5

Cat.No: T12346

Synonym: P300/CBP-IN-5

Target: Epigenetic Reader Domain

Ep300/CREBBP-IN-2

Cat.No: T73921

Ep300/CREBBP-IN-3

Cat.No: T73922

CBP/p300-IN-15

Cat.No: T63110

Ep300/CREBBP-IN-8

Cat.No: T73920

CBP/p300-IN-10

Cat.No: T72815

CBP/p300-IN-19

Cat.No: T63122

CBP/p300-IN-18

Cat.No: T62720

CBP/p300-IN-14

Cat.No: T40344

Synonym: CBP/p300-IN-14

CBP/p300-IN-8

Cat.No: T39826

Synonym: CBP/p300-IN-8

Thalidomide-NH-CBP/p300 ligand 2

Cat.No: T40142

Synonym: Thalidomide-NH-CBP/p300 ligand 2

Target: PROTACs

Ep300/CREBBP-IN-4

Cat.No: T73923

CBP/p300-IN-21

Cat.No: T79395

Target: Epigenetic Reader Domain

Cat.No: T28439

Synonym: PP 30,PP-30

CBP/p300-IN-16

Cat.No: T62700

Cat.No: T23489

Synonym: UBP 301

Target: Others

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