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94

抑制剂 & 化合物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T9103	BVDV-IN-1	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BVDV-IN-1 是一种牛病毒性腹泻病毒 (BVDV) 的非核苷抑制剂 (NNI)，EC50 为 1.8 μM。它直接与 BVDV RdRp 的疏水口袋结合，对耐 NNI 氨基硫脲 (TSC) 的 BVDV 具有抗病毒活性。
T6729	Lomibuvir VX-222,VCH-222	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Lomibuvir (VCH-222) (VX-222) 是丙型肝炎病毒 NS5B 聚合酶的一种非核苷变构抑制剂，Kd 值为 17 nM，已证明具有临床疗效。Lomibuvir 抑制 1b/Con1 型 HCV 亚基因组复制子，EC50为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。
T2330	Rilpivirine TMC278,R278474,利匹韦林,DB08864	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Rilpivirine (R278474) 是一种二芳基嘧啶衍生物和非核苷逆转录酶抑制剂，具有抗 HIV-1 的抗病毒活性，用于治疗 HIV 感染。
T7700	Lersivirine 3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈,Lersivirine(UK 453061),UK-453061	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Lersivirine (UK-453061) 是非核苷逆转录的抑制剂 (NNRTI)，有效抑制 NNRTI 耐药病毒。它对野生型人类免疫缺陷病毒和临床相关 NNRTI 耐药菌株显示出强大的抗逆转录病毒活性。
T2393	Efavirenz EFV,依非韦伦,DMP 266,依法韦仑,Sustiva,Stocrin,L-743726	HIV Protease; Reverse Transcriptase; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Efavirenz (DMP 266) 是一种人类免疫缺陷病毒 1 非核苷类似物逆转录酶抑制剂。它也是一种野生型HIV-1 RT 抑制剂，Ki 为 2.93 nM，有效抑制 HIV-1 复制，IC95为 1.5 nM。
T3172	Trovirdine 曲韦定,LY300046	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Trovirdine (LY300046) 是一种硫脲类非核苷类逆转录酶抑制剂。
T1815	Dapivirine R147681,达匹维林,TMC120	Apoptosis; HIV Protease; Reverse Transcriptase; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome
	Dapivirine (R147681) 是一种二芳基嘧啶非核苷类逆转录酶抑制剂。
T31860	Fosdevirine GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fosdevirine (GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂，具有抗 HIV 活性，可用于研究迟发性癫痫等神经系统相关疾病。
T68103L	Mk-6186 HCl Mk-6186 HCl（1034474-19-5 Free base)	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	MK-6186 HCl，一种新型非核苷类逆转录酶抑制剂，具有抗病毒活性，可用于研究HIV。
T67788	BAY-43-9695	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	BAY-43-9695是具有抗人巨细胞病毒(HCMV)活性的非核苷类化合物，是BAY-38-4766的主要代谢产物。
T68103	MK-6186	Reverse Transcriptase	Microbiology/Virology
	MK-6186 是一种新型非核苷类逆转录酶抑制剂，具有抗病毒活性，可用于研究病毒感染。
T3632	Doravirine 多拉维林,多拉韦林,MK-1439	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Doravirine (MK-1439) 是一种高度特异性的HIV-1非核苷逆转录酶抑制剂，对野生型以及K103N 和Y181C 逆转录酶突变体的IC50值分别为 4.5 nM，5.5 nM 和 6.1 nM。
T67804	KM-023	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	KM-023是一种新的第二代非核苷类逆转录酶抑制剂，可用于研究人类免疫缺陷病毒（HIV）1型感染。
T3489	Dasabuvir ABT-333,达塞布韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Dasabuvir (ABT-333) 是丙型肝炎病毒非结构蛋白 5B 的非核苷抑制剂，是一种 RNA 依赖性 RNA 聚合酶，具有抗 HCV 的潜在活性。
T7212	Delavirdine mesylate U 90152 (mesylate),BHAP-U 90152 (mesylate),Delavirdine (mesylate)	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Delavirdine mesylate (BHAP-U 90152(mesylate)) 是一种口服活性非核苷逆转录酶抑制剂。它抑制 HIV-1 病毒复制，可以用于艾滋病的相关研究。它选择性地抑制 HIV-1 逆转录酶，其选择性超过 DNA 聚合酶 α 和 DNA 聚合酶 δ 。
T1595	Nevirapine NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Nevirapine (NVP) 是一种 HIV-1逆转录酶非核苷抑制剂，Ki 值为 270 μM，可用于研究 HIV/AIDS。
T31860L	(Iso)-Fosdevirine (Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	(Iso)-Fosdevirine ( (Iso)-GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂，具有抗 HIV 活性，可用于研究迟发性癫痫等神经系统相关疾病。
T2551	Etravirine TMC125,依曲韦林,R165335	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Etravirine (R165335) 是一种非核苷逆转录酶抑制剂，具有抗 HIV 的作用。
T29037	UC-781 NSC 675186,UC781,UC 781	Antiviral; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	UC-781 (NSC-675186) 是一种高效且具有选择性的人类免疫缺陷病毒 HIV-1 非核苷类逆转录酶(NNRTI)I抑制剂，C50 值为 5 nM。UC-781 具有抗病毒活性和耐药性。UC-781状态稳定，较低的 PH 或不同温度对其影响较小。
T8655	SR-717	STING	Immunology/Inflammation
	SR-717 是一种 cGAMP 的类似物，一种非核苷类 STING 激动剂，可以诱导 STING 形成“封闭”的激活构象。SR-717 具有抗肿瘤活性，可以促进免疫细胞的激活以及抗原的交叉提呈。
T28762	Setrobuvir RO-5466731,ANA-598,RG7790,ANA598,RG-7790	HCV Protease; SARS-CoV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Setrobuvir (ANA-598) 是一种口服活性非核苷类HCV NS5B 聚合酶抑制剂，对新的RNA 合成和引物延伸具有抑制作用，IC50s 在4到5nM 之间。Setrobuvir 对SARS-CoV-2 RdRp 显示出很好的结合亲和力，能诱导RdRp 受到抑制。
T38237	2′-O-Methylcytidine	Nucleoside Antimetabolite/Analog; HCV Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	2'-O-Methylcytidine 是 2'-代核苷，可抑制 HCV 复制。它在体外抑制 NS5B 催化的 RNA 合成，其抑制方式是与底物核苷三磷酸竞争。
T27625	IQP-0528 SJ-3991,SJ3991,IQP0528	Antiviral; HIV Protease; Reverse Transcriptase	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	IQP-0528是一种高效的非核苷类逆转录酶抑制剂（NNRTI），通过阻断病毒进入，有可能用于治疗HIV 感染，并且作为杀微生物凝胶显示出抗病毒活性。IQP-0528对HIV-1和HIV-2都显示出抑制作用，对HIV-1的EC50为0.2 nM，对HIV-2的EC50为100 nM。
T21537L	TMC647055 Choline Hydroxide Salt TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	TMC647055 Choline Hydroxide Salt 是一种新型有效的 HCV NS5B 聚合酶非核苷抑制剂，可用于治疗 HCV 感染。它具有纳摩尔级细胞效力（EC(50) 为 82 nM），相关细胞毒性较小（CC(50)>20 μM），在大鼠和狗中具有良好的药代动力学特征。 TMC647055 显示出有体外生化、动力学和病毒学特征的前景。
T28204	NSC-176377 NSC 176377
	NSC-176377 is a non-nucleoside reverse transcriptase inhibitor.
T2330L	Rilpivirine HCl Rilpivirine hydrochloride,TMC278,Rilpivirine,TMC-278,TMC 278. trade name Edurant
	Rilpivirine is a potent non-nucleoside reverse transcriptase inhibitor.
T23968	DC_501 DC 501,DC501
	DC_501 is a selective non-nucleoside DNA methyltransferase 1 inhibitor.
T24354	L 738372 L-738,372,L 738,372,L738372,L738,372,L-738372
	L 738372 is a non-nucleoside inhibitor of HIV-1 reverse transcriptase.
T25493	HEPT
	HEPT is a non-nucleoside inhibitor of HIV-1 reverse transcription.
T27542	HI-207 HI207,HI 207
	HI-207 is an inhibitor of non-nucleoside reverse transcriptase.
T24087	GCA-186 I-EBU-dM,IEBUdM,I EBU dM,GCA 186
	GCA-186 is an effective non-nucleoside HIV-1 reverse transcriptase inhibitor.
T27384	FR-234938 FR 234938
	FR-234938 is a non-nucleoside adenosine deaminase inhibitor with anti-inflammatory activity.
T25501	HI-236 HI 236,D-PBT,D PBT,DPBT
	HI-236 is used as a non-nucleoside HIV-1 reverse-transcriptase inhibitor.
T33435	MK-4965
	MK-4965 is a new type of non-nucleoside reverse transcriptase inhibitor with antiviral activity.
T70851	U 88204
	U 88204 is a non-nucleoside HIV-1 reverse transcriptase inhibitor.
T28507	RDEA-427 RDEA 427
	RDEA-427, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
T26940	Calanolide A NSC 675451,NSC675451,NSC-675451
	Calanolide A, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
T70794	Nevirapine dimer
	Nevirapine dimer is a non-nucleoside reverse transcriptase inhibitor (NNRTI).
T68450	IDX-989
	IDX-989 is an HIV-1 non-nucleoside reverse transcriptase inhibitor.
T69435	GW-4511
	GW-4511 is a benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitor.
T26946	Capravirine S-1153,AG1549,S1153,AG-1549,AG 549
	Capravirine, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
T71566	MK-7445
	MK-7445 is a conformationally constrained inhibitor of non-nucleoside reverse transcriptase.
T27512	GW-695634 GW5634,GW695634,GW-5634G,GW-5634
	GW-695634, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection.
T70156	K-5a2
	K-5a2 is a novel human immunodeficiency virus type 1 (HIV-1) non-nucleoside reverse transcriptase inhibitor (NNRTI).
T31369	Deleobuvir BI207127,BI-207127,BI 207127,BI-207127NA
	Deleobuvir(BI207127) is an inhibitor of non-nucleoside hepatitis C virus NS5B polymerase for the treatment of hepatitis C.
T70545	HI-253
	HI-253 is a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus (HIV).
T71517	Nevirapine quinone methide
	Nevirapine quinone methide is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS.
T27383	FR-221647
	FR-221647 is a non-nucleoside adenosine deaminase inhibitor, it has moderate activity and good pharmacokinetics compared with the known inhibitors EHNA and pentostatin.
T70627	U 89674
	U 89674 is a non-nucleoside reverse transcriptase inhibitor used for the prevention of the spread of HIV-1 infection.
T24839	Stampidine HI-113,HI 113,HI113
	Stampidine can prevent the sexual transmission of HIV-1. It exhibited remarkable subnanomolar to low nanomolar in vitro antiretroviral potency against nucleoside reverse transcriptase inhibitor-resistant primary clinical HIV isolates, non-nucleoside RT-re

化合物

Cat.No: T9103

Target: DNA/RNA Synthesis

Cat.No: T6729

Synonym: VX-222,VCH-222

Target: HCV Protease

Cat.No: T2330

Synonym: TMC278,R278474,利匹韦林,DB08864

Target: HIV Protease, Reverse Transcriptase

Cat.No: T7700

Synonym: 3-氰基-5-[[3,5-二乙基-1-(2-羟基乙基)-1H-吡唑-4-基]氧基]苯腈,Lersivirine(UK 453061),UK-453061

Target: HIV Protease, Reverse Transcriptase

Cat.No: T2393

Synonym: EFV,依非韦伦,DMP 266,依法韦仑,Sustiva,Stocrin,L-743726

Target: HIV Protease, Reverse Transcriptase, Autophagy

Cat.No: T3172

Synonym: 曲韦定,LY300046

Target: HIV Protease

Cat.No: T1815

Synonym: R147681,达匹维林,TMC120

Target: Apoptosis, HIV Protease, Reverse Transcriptase, Autophagy

Cat.No: T31860

Synonym: GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A

Target: HIV Protease

Cat.No: T68103L

Synonym: Mk-6186 HCl（1034474-19-5 Free base)

Target: HIV Protease, Reverse Transcriptase

Cat.No: T67788

Target: HCV Protease

Cat.No: T68103

Target: Reverse Transcriptase

Cat.No: T3632

Synonym: 多拉维林,多拉韦林,MK-1439

Target: HIV Protease, Reverse Transcriptase

Cat.No: T67804

Target: HIV Protease

Cat.No: T3489

Synonym: ABT-333,达塞布韦

Target: HCV Protease

Delavirdine mesylate

Cat.No: T7212

Synonym: U 90152 (mesylate),BHAP-U 90152 (mesylate),Delavirdine (mesylate)

Target: HIV Protease, Reverse Transcriptase

Cat.No: T1595

Synonym: NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP

Target: HIV Protease, Reverse Transcriptase

(Iso)-Fosdevirine

Cat.No: T31860L

Synonym: (Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761

Target: HIV Protease

Cat.No: T2551

Synonym: TMC125,依曲韦林,R165335

Target: HIV Protease, Reverse Transcriptase

Cat.No: T29037

Synonym: NSC 675186,UC781,UC 781

Target: Antiviral, HIV Protease

Cat.No: T8655

Target: STING

Cat.No: T28762

Synonym: RO-5466731,ANA-598,RG7790,ANA598,RG-7790

Target: HCV Protease, SARS-CoV, DNA/RNA Synthesis

2′-O-Methylcytidine

Cat.No: T38237

Target: Nucleoside Antimetabolite/Analog, HCV Protease

Cat.No: T27625

Synonym: SJ-3991,SJ3991,IQP0528

Target: Antiviral, HIV Protease, Reverse Transcriptase

TMC647055 Choline Hydroxide Salt

Cat.No: T21537L

Synonym: TMC647055 Choline Hydroxide Salt (1204416-97-6 free base)

Target: HCV Protease

Cat.No: T28204

Synonym: NSC 176377

Rilpivirine HCl

Cat.No: T2330L

Synonym: Rilpivirine hydrochloride,TMC278,Rilpivirine,TMC-278,TMC 278. trade name Edurant

Cat.No: T23968

Synonym: DC 501,DC501

Cat.No: T24354

Synonym: L-738,372,L 738,372,L738372,L738,372,L-738372

Cat.No: T25493

Cat.No: T27542

Synonym: HI207,HI 207

Cat.No: T24087

Synonym: I-EBU-dM,IEBUdM,I EBU dM,GCA 186

Cat.No: T27384

Synonym: FR 234938

Cat.No: T25501

Synonym: HI 236,D-PBT,D PBT,DPBT

Cat.No: T33435

Cat.No: T70851

Cat.No: T28507

Synonym: RDEA 427

Cat.No: T26940

Synonym: NSC 675451,NSC675451,NSC-675451

Nevirapine dimer

Cat.No: T70794

Cat.No: T68450

Cat.No: T69435

Cat.No: T26946

Synonym: S-1153,AG1549,S1153,AG-1549,AG 549

Cat.No: T71566

Cat.No: T27512

Synonym: GW5634,GW695634,GW-5634G,GW-5634

Cat.No: T70156

Cat.No: T31369

Synonym: BI207127,BI-207127,BI 207127,BI-207127NA

Cat.No: T70545

Nevirapine quinone methide

Cat.No: T71517

Cat.No: T27383

Cat.No: T70627

Cat.No: T24839

Synonym: HI-113,HI 113,HI113

Cat. No.	Product Name	Target	Signaling Pathways
T16674	Pseudouridine	Endogenous Metabolite	Metabolism
	Pseudouridine 是非编码 RNA 中丰富的修饰核苷，通过稳定 RNA 结构增强核糖体 RNA 和的转移 RNA 功能。

天然产物

Cat.No: T16674

Target: Endogenous Metabolite

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