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Search Results for " neurotoxin "

44

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13664	DSP-4 hydrochloride Neurotoxin DSP 4 (hydrochloride)	Others	Others
	DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) 是一种高选择性的神经毒素，主要是来自蓝斑 (LC) 的神经元，容易通过血脑屏障。它对成年和发育中大鼠去甲肾上腺素能神经元具有神经毒性作用，可用于中枢和外周去甲肾上腺素能神经元的暂时选择性降解。
T12214	Neurotoxin Inhibitor	Others	Others
	Neurotoxin Inhibitor is an inhibitor of neurotoxin.
T4081	MPTP hydrochloride MPTP-hydrochloride	Apoptosis; Dopamine Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	MPTP hydrochloride 是 MPP+ 的前体，是一种多巴胺神经毒素，具有血脑屏障渗透性。MPTP hydrochloride 对多巴胺能神经元有毒，可以导致帕金森症，被广泛应用于帕金森动物模型的构建。
T27794	λ-Cyhalothrin lambda-Cyhalothrin,Karate,λ-氯氟氰菊酯,Icon	Sodium Channel; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	λ-Cyhalothrin (Icon) 是广谱的 II 型合成除虫菊酯杀虫剂，含有 α-氰基，用于防治多种害虫。它是一种钠通道神经毒素，靶向中枢神经系统中神经元膜。
T9354	2,4-Difluorobenzaldehyde 2,4-Difluoro-benzaldehyde,2,4-二氟苯甲醛	Others	Others
	2,4-Difluorobenzaldehyde 靶点-A 型肉毒杆菌神经毒素（肉毒杆菌）。
T28655	Sabeluzole R 58735,R58735,R-58735	Microtubule Associated	Cytoskeletal Signaling
	Sabeluzole (R-58735) 具有抗癫痫和增强认知的作用，抑制神经毒素诱导的tau表达和细胞死亡。Sabeluzole 对氯氮卓诱导的习惯障碍有保护作用，可用于研究阿尔茨海默症。
TP1223L	Apamin acetate Apamine acetate,Apamin acetate(24345-16-2 Free base)	Potassium Channel	Membrane transporter/Ion channel
	Apamin acetate (Apamine acetate) 是一种具有选择性的 Ca2+ 激活的 K+ (SK) 通道的阻断剂，是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素。Apamin acetate 可增强皮质神经元撕裂损伤后的神经突生长和再生。Apamin acetate 具有抗炎和抗纤维化的作用。
T9169	MPP+ iodide	Mitochondrial Metabolism; Autophagy	Autophagy; Metabolism
	MPP+ iodide 是一种 5-羟色胺转运体的高亲和力底物，也是一种神经毒素 MPTP 的有毒代谢物，通过选择性破坏黑质多巴胺能神经元，在动物模型中引起帕金森病症状。它被多巴胺转运体吸收进入多巴胺能神经元，通过影响呼吸链复合体 I 对线粒体发挥神经毒性作用。
T26937	C562-1101
	C562-1101 is a novel potent botulinum neurotoxin serotype E (BoNT/E) inhibitor.
T13819	Pi-Methylimidazoleacetic acid hydrochloride	Others	Others
	Pi-Methylimidazoleacetic acid hydrochloride is a potential neurotoxin.
T14763	BoNT-IN-1	Others	Others
	BoNT-IN-1 is a potent Botulinum neurotoxin A light chain (BoNTA LC) inhibitor(IC50 : 0.9 uM).
T33346	Methylaminoalanine-nickel(II) L-Bmma-nickel(II),L-Medap-nickel(II)
	Methylaminoalanine-nickel(II) can be regarded as a naturally occurring neurotoxin.
T32850	Lolitrem A
	Lolitrem A is a neurotoxin from staggers-producing ryegrass pastures.
T34794	Tecoram
	Tecoram is a dithiocarbamate and a possible neurotoxin.
T25890	NSC-84096 CID 256758,CID-256758,CID256758
	NSC-84096 is an endopeptidase activity inhibitor of botulinum neurotoxin type A light chain (rBoNT/A-LC).
T33644	Nephilatoxin 7 NPTX 7,NPTX7,NPTX-7
	Nephilatoxin 7 is a neurotoxin of the Joro spider (Nephila clavata).
T69377	BoNT-IN-33
	BoNT-IN-33 is a potent inhibitor of Botulinum neurotoxin/A light chain (BoNT/A LC).
T21464	Methiocarb Mercaptodimethur,Mesurol
	Methiocarb, a carbamate pesticide, is used as an insecticide, acaricide, bird repellent, and molluscicide. Methiocarb stimulates cholinergic by inhibiting reversibly acetylcholinesterase activity, making methiocarb a potent neurotoxin.
TP2064	ω-Conotoxin MVIIC
	Peptide neurotoxin; wide spectrum blocker of N, P and Q type calcium channels.
T26961	CBIP
	CBIP is a small-molecule inhibitors of botulinum neurotoxin serotype A light chain (BoNT/A LC). CBIP possesses low micromolar activity against BoNT/A.
T31582	DSP 4 DSP4,UNII-PQ1P7JP5C1,DSP-4,az-Dsp 4
	DSP 4 is a selective neurotoxin selective for noradrenergic neurons in the locus coeruleus noradrenergic system and capable of crossing the blood–brain barrier and cyclizes to a reactive aziridinium derivative that is accumulated into the noradrenergic ne
TP2062	ω-Conotoxin GVIA
	Peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG -induced long term depression in vivo.
TP1223	Apamin Apamine
	Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity. Apamin is a bee venom compone
T80064	Dendrotoxin-I DTX-I	Potassium Channel	Membrane transporter/Ion channel
	Dendrotoxin-I是一种高效的K+通道阻滞剂，特异性针对KV1.1和KV1.2电压门控钾通道亚基。该化合物为从Dendroaspis蛇毒中提取的神经毒素。
T83223	AaHI
	AaHI，源自北非蝎子Androctonus australis hector的毒液，这种化合物是一种神经毒素，常用作开发能够中和毒素的活性物质的工具。
T80160	ω-Hexatoxin-Hv1a ω-ACTX-Hv1,ω-Atracotoxin-HV1	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ω-Hexatoxin-Hv1a，一种从毒液蜘蛛 (Hadronyche versuta) 分离得到的神经毒素，能够阻断电压门控钙通道 (calcium channels)。
TP2077	α-Bungarotoxin
	Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM
T80078	Calciseptin	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Calciseptine 是从黑曼巴Dendroaspis p. polylepis分离得到的天然神经毒素。含有60个氨基酸和四个二硫键，特异性阻断L型钙通道（calcium channel）[1]。
TP1576	SNAP-25 187-203
	This amino acids187 to 203 fragment is derived from the C-terminal helix of synaptosomal-associated protein of 25 kDa (SNAP-25). This peptide is able to rescue exocytosis from botulinum neurotoxin E (BoNT/E)-treated cells, albeit at higher concentrations
T20396	Levadopa Related Compound A 6-Hydroxydopa, L-,L-Hydroxydopa
	Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Exogenously administered 6-Hydroxy-L-DOPA is biotransformed by an amino acid decarboxylase to the highly potent and catecholamine-selective neurot
T80454	BmK-M1	Sodium Channel	Membrane transporter/Ion channel
	BmK-M1，一种含64个氨基酸通过四个二硫桥交联形成的蝎子毒素，作用于抑制Na+通道，属于心脏毒素和神经毒素类。
TP2016	Huwentoxin-IV Huwentoxin IV
	Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin recepto
T80704	α-Pompilidotoxin α-PMTX
	α-Pompilidotoxin (α-PMTX) 是从 Anoplius samariensis 的毒液中分离的一种神经毒素。它能剂量依赖性地增强兴奋性突触后电流（EPSCs），并且这种增强作用是可逆的。α-Pompilidotoxin 在神经科学研究中被作为实验工具广泛应用。
T75746	Apamin TFA
	Apamin TFA (Apamine TFA) 是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素，是一种 Ca2+激活的 K+(SK) 通道的特异性和选择性的阻断剂，具有抗炎和抗纤维化的作用。
T80427	Jingzhaotoxin-II	Sodium Channel	Membrane transporter/Ion channel
	Jingzhaotoxin-II是由32个氨基酸组成的神经毒素，包括两个酸性残基和两个碱性残基。该毒素能够抑制电压门控钠通道(VGSC)，并在心肌细胞上明显减缓TTX抗性(TTX-R) VGSC的快速失活，其IC50值为0.26μM。
T80530	Spinoxin SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13	Potassium Channel	Membrane transporter/Ion channel
	Spinoxin是一种从Heterometrus spinifer蝎子毒液中提取的神经毒素，由34个氨基酸残基组成，通过4个二硫桥交联。它能有效抑制Kv1.3钾通道（IC50= 63 nM），是研发诊断及治疗自身免疫性疾病和癌症策略时的潜在分子靶点。
T69578	D-Ibotenic Acid
	D-Ibotenic Acid is a chemical compound and psychoactive drug which occurs naturally in Amanita muscaria and related species of mushrooms typically found in the temperate and boreal regions of the northern hemisphere. It is a conformationally-restricted analogue of the neurotransmitter glutamate, and due to its structural similarity to this neurotransmitter, acts as a non-selective glutamate receptor agonist. Because of this, ibotenic acid can be a powerful neurotoxin, and is employed as a brain-...
T83136	alpha-Cobratoxin
	alpha-Cobratoxin 是从泰国眼镜蛇的毒液中提取的神经毒素，具有调节神经系统、抗病毒和镇痛的活性。此外，alpha-Cobratoxin 对急性及慢性多发性硬化症表现出免疫抑制作用，目前正在被进一步研究其在肾上腺脊髓神经病方面的潜在应用。
T80426	Jingzhaotoxin-IX	Sodium Channel	Membrane transporter/Ion channel
	Jingzhaotoxin-IX是由35个氨基酸残基组成的C端酰胺化神经毒素。该化合物既抑制电压门控钠通道（包括河豚毒素抗性和河豚毒素敏感亚型）又抑制Kv2.1通道，但对延迟整流钾通道Kv1.1、1.2和1.3无效。
T81519	Pentapeptide-3
	Pentapeptide-3为源自韦氏腹蛇毒素waglerin-1的五肽神经毒素，作为尼古丁乙酰胆碱受体(nAChRs)的竞争性拮抗剂，能够在突触后膜发挥阻滞神经的效果。该化合物具有抗衰老功能，可与其他化妆品肽配合使用。
T75856	Huwentoxin-IV TFA
	Huwentoxin-IV TFA是一种具有高效性和选择性的钠通道阻滞剂，能够抑制Nav1.7、Nav1.2、Nav1.3和Nav1.4神经元，其IC50分别为26、150、338和400nM。通过优先结合于神经毒素受体位点4，Huwentoxin-IV TFA特异性地阻断周围神经的Nav1.7亚型。该化合物适用于炎症性及神经性疼痛动物模型的研究。
T80166	α-Conotoxin BuIA
	α-Conotoxin BuIA 是一种麻痹性肽类神经毒素，同时也是竞争性nAChR拮抗剂。它对nAChR亚型表现出不同的IC50值：0.258 nM（α6/α3β2）、1.54 nM（α6/α3β4）、5.72 nM（α3β2）。该化合物可用于鉴别包含β2与β4亚单位的nAChR亚型。此外，α-Conotoxin BuIA 对αxβ2nAChR的区分能力按照α6>α3>α2>α4的顺序减弱。
T80165	α-Conotoxin GID
	α-Conotoxin GID为一种麻痹性肽类神经毒素，能选择性地拮抗nAChR，具有不同亚型的IC50值：5 nM（α7）、3 nM（α3β2）和150 nM（α4β2）。该化合物是含有丰富二硫键的小分子肽，拥有缓解慢性疼痛的潜在效用。α-Conotoxin GID含C端羧酸酯结构，替换为羧酰胺会使其对α4β2nAChR的作用降低。该化合物可从锥螺科海洋生物中提取。
T83894	4A7C-301-Nurr1 Agonist 4A7C-301-Nuclear Receptor-Related 1
	4A7C-301-Nurr1激动剂是一种核受体相关1（Nurr1）的激动剂。它通过与Nurr1配体结合域（LBD；IC50 = 48.22 nM）结合，增加了在使用SK-N-BE(2)C人神经母细胞瘤细胞进行的报告基因测定中Nurr1-LBD和全长Nurr1的转录活性（EC50s = 6.53 和 50-70 µM，分别）。每天5 mg/kg的4A7C-301-Nurr1激动剂能减少在经MPTP神经毒素或α-突触核蛋白过表达诱导的帕金森病鼠模型中纹状体和黑质compacta部分多巴胺能细胞的死亡，并减少运动和嗅觉缺陷，而不诱发类似运动障碍的行为。

化合物

DSP-4 hydrochloride

Cat.No: T13664

Synonym: Neurotoxin DSP 4 (hydrochloride)

Target: Others

Neurotoxin Inhibitor

Cat.No: T12214

Target: Others

MPTP hydrochloride

Cat.No: T4081

Synonym: MPTP-hydrochloride

Target: Apoptosis, Dopamine Receptor

Cat.No: T27794

Synonym: lambda-Cyhalothrin,Karate,λ-氯氟氰菊酯,Icon

Target: Sodium Channel, Parasite

2,4-Difluorobenzaldehyde

Cat.No: T9354

Synonym: 2,4-Difluoro-benzaldehyde,2,4-二氟苯甲醛

Target: Others

Cat.No: T28655

Synonym: R 58735,R58735,R-58735

Target: Microtubule Associated

Cat.No: TP1223L

Synonym: Apamine acetate,Apamin acetate(24345-16-2 Free base)

Target: Potassium Channel

Cat.No: T9169

Target: Mitochondrial Metabolism, Autophagy

Cat.No: T26937

Pi-Methylimidazoleacetic acid hydrochloride

Cat.No: T13819

Target: Others

Cat.No: T14763

Target: Others

Methylaminoalanine-nickel(II)

Cat.No: T33346

Synonym: L-Bmma-nickel(II),L-Medap-nickel(II)

Cat.No: T32850

Cat.No: T34794

Cat.No: T25890

Synonym: CID 256758,CID-256758,CID256758

Cat.No: T33644

Synonym: NPTX 7,NPTX7,NPTX-7

Cat.No: T69377

Cat.No: T21464

Synonym: Mercaptodimethur,Mesurol

ω-Conotoxin MVIIC

Cat.No: TP2064

Cat.No: T26961

Cat.No: T31582

Synonym: DSP4,UNII-PQ1P7JP5C1,DSP-4,az-Dsp 4

ω-Conotoxin GVIA

Cat.No: TP2062

Cat.No: TP1223

Synonym: Apamine

Cat.No: T80064

Synonym: DTX-I

Target: Potassium Channel

Cat.No: T83223

ω-Hexatoxin-Hv1a

Cat.No: T80160

Synonym: ω-ACTX-Hv1,ω-Atracotoxin-HV1

Target: Calcium Channel

α-Bungarotoxin

Cat.No: TP2077

Cat.No: T80078

Target: Calcium Channel

SNAP-25 187-203

Cat.No: TP1576

Levadopa Related Compound A

Cat.No: T20396

Synonym: 6-Hydroxydopa, L-,L-Hydroxydopa

Cat.No: T80454

Target: Sodium Channel

Cat.No: TP2016

Synonym: Huwentoxin IV

α-Pompilidotoxin

Cat.No: T80704

Synonym: α-PMTX

Cat.No: T75746

Jingzhaotoxin-II

Cat.No: T80427

Target: Sodium Channel

Cat.No: T80530

Synonym: SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13

Target: Potassium Channel

D-Ibotenic Acid

Cat.No: T69578

alpha-Cobratoxin

Cat.No: T83136

Jingzhaotoxin-IX

Cat.No: T80426

Target: Sodium Channel

Cat.No: T81519

Huwentoxin-IV TFA

Cat.No: T75856

α-Conotoxin BuIA

Cat.No: T80166

α-Conotoxin GID

Cat.No: T80165

4A7C-301-Nurr1 Agonist

Cat.No: T83894

Synonym: 4A7C-301-Nuclear Receptor-Related 1

Cat. No.	Product Name	Target	Signaling Pathways
T22911	β-N-methylamino-L-alanine hydrochloride L-BMAA hydrochloride	Others	Others
	β-N-methylamino-L-alanine hydrochloride (L-BMAA hydrochloride) 是由蓝细菌产生的一种神经毒素，既有导致肌萎缩性侧索硬化症 (ALS) 以及其他可能的神经退行性疾病可能性。
T8264	3-Methyl-2-oxovaleric acid	Endogenous Metabolite	Metabolism
	3-Methyl-2-oxovaleric acid 是神经毒素，代谢毒素和酸性原，它是支链氨基酸不完整分解产生的异常代谢物。
T5232	3-Methyl-2-oxobutanoic acid 3-甲基-2-氧丁酸,2-Oxoisovaleric acid,alpha-Ketoisovaleric acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Methyl-2-oxobutanoic acid (2-Oxoisovaleric acid) 是大肠杆菌中泛酸的前体。它是由支链氨基酸的不完全分解产生的一种异常代谢物。
T5071	4-Methyl-2-oxopentanoic acid 4-甲基-2-氧代戊酸,4-Methyl-2-oxovaleric acid	Others; Endogenous Metabolite	Metabolism; Others
	4-Methyl-2-oxopentanoic acid (4-Methyl-2-oxovaleric acid) 是一种非正常代谢物，是一种神经毒素和代谢毒素。
T19130	Porphobilinogen	Others	Others
	Porphobilinogen act as a phytotoxin, a metabotoxin, and a neurotoxin.
T34885	Tinyatoxin TNX,TTN,TTX
	Tinyatoxin is a neurotoxin that works through vanillin receptors on sensory nerves.
T13820	Pi-Methylimidazoleacetic acid	Others	Others
	Pi-Methylimidazoleacetic acid is a potential neurotoxin.
T75539	Nereistoxin
	Nereistoxin (Nereistoxine) 是一种神经毒素，从海洋环节动物 Lumbriconereis heteropoda 中分离出来，可以通过阻断烟碱乙酰胆碱受体发挥作用。
T36068	Brevetoxin B
	Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50 = 15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

天然产物

β-N-methylamino-L-alanine hydrochloride

Cat.No: T22911

Synonym: L-BMAA hydrochloride

Target: Others

3-Methyl-2-oxovaleric acid

Cat.No: T8264

Target: Endogenous Metabolite

3-Methyl-2-oxobutanoic acid

Cat.No: T5232

Synonym: 3-甲基-2-氧丁酸,2-Oxoisovaleric acid,alpha-Ketoisovaleric acid

Target: Others, Endogenous Metabolite

4-Methyl-2-oxopentanoic acid

Cat.No: T5071

Synonym: 4-甲基-2-氧代戊酸,4-Methyl-2-oxovaleric acid

Target: Others, Endogenous Metabolite

Porphobilinogen

Cat.No: T19130

Target: Others

Cat.No: T34885

Synonym: TNX,TTN,TTX

Pi-Methylimidazoleacetic acid

Cat.No: T13820

Target: Others

Cat.No: T75539

Cat.No: T36068

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