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Search Results for " neurogenic "

26

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2711	Chembridge-5861528 TCS 5861528	TRP/TRPV Channel	Membrane transporter/Ion channel
	Chembridge-5861528 (TCS 5861528) 是有效的 TRPA1离子通道阻断剂。
T1092	Zolmitriptan 佐米曲普坦,311C90,BW-311C90	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
T2547	Droxidopa 屈昔多巴,屈西多巴,SM5688,DOPS,L-DOPS	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Droxidopa (L-DOPS) 是 Droxidopa (w/w80%) 和 Pharmaceutical starch (w/w20%) 的混合物，能透过血脑屏障，可作为神经递质去甲肾上腺素和肾上腺素的原药。
T9263	cim0216 N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide	TRP/TRPV Channel	Membrane transporter/Ion channel
	CIM0216 是选择性的TRPM3激动剂，对 TRPM3 的选择性高于 TRPM1、TRPM2 和 TRPM4-8。它以TRPM3依赖性的方式引起疼痛并唤起感觉神经末梢的神经肽释放，可用于神经源性炎症的相关研究。
T20423	Dibenzylamine 二苄胺,Dibenzyl-amine,N-Benzylbenzylamine,Bibenzylamine,N-benzyl-1-phenylmethanamine,Benzenemethanamine, N-(phenylmethyl)-,AI315327,AI3-15327,AI3 15327	Others	Others
	Dibenzylamine (N-Benzylbenzylamine) 是强效神经生成剂的一种成分。
T1833	NSI189 NSI-189,NSI 189	Others	Others
	NSI189 (NSI-189) 是一种促智和神经源性研究化学品，源自烟酰胺和吡嗪。
T21244	NSI-189 Phosphate NSI189 Phosphate,NSI 189 Phosphate,NSI-189磷酸盐	Others	Others
	NSI-189 Phosphate 是一种新型神经源性分子，具有多效性，包括临床前研究中证明的抗抑郁、促认知、突触和神经营养活性。其抗抑郁活性不依赖于单胺。
T25615	Lanepitant LY303870,LY-303870,LY 303870	Others	Others
	Lanepitant (LY303870) 是一种非肽类神经激肽-1（NK-1）拮抗剂,具有镇痛活性，可抑制神经源性硬脑膜炎症,可用于预防偏头痛。
T10012	P7C3-OMe	Others	Others
	P7C3-OMe 是促神经原性化合物，其 R-对映体活性远高于 S-对映体。可以用于研究神经精神疾病和神经退行性疾病。
T25616	Lanepitant 2HCl LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Lanepitant 2HCl 是一种非肽类神经激肽-1 受体拮抗剂，具有镇痛和抗炎活性。Lanepitant 2HCl 抑制 P 物质与神经激肽-1 受体的结合，抑制神经源性炎症和疼痛传递，可用于研究偏头痛等疼痛性神经病变类疾病。
T1993	J-147 J147	Epigenetic Reader Domain; Dopamine Receptor; Monoamine Oxidase	Chromatin/Epigenetic; GPCR/G Protein; Neuroscience
	J-147 是一种高效的、具有口服活性的、可透过血脑屏障神经保护剂，可增强认知能力。它抑制单胺氧化酶 B 和多巴胺转运体，EC50分别为 1.88 μM 和 0.649 μM。它有研究阿尔茨海默氏症的潜力。
T39733	Hu7691 free base	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Hu7691 free base 是一种具有口服活性、高效性和选择性的 Akt 抑制剂，对多种神经母细胞瘤细胞系的抗增殖和神经发生作用。Hu7691 free base 抑制 Akt1、Akt2 和 Akt3 ，诱导神经母细胞瘤细胞分化。
T27059	CP-122288
	CP-122288 is a potent and selective agonist for the 5-HT1B, 5-HT1D and 5-HT1F serotonin receptor subtypes. CP-122288 is potent as an inhibitor of plasma protein extravasation and neurogenic inflammation.
T3290L	Pikamilone Sodium GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na
	Pikamilone Sodium is a prodrug of GABA used for therapy of neurogenic bladder in spinal and benign prostatic hyperplasia.
T7825	Distigmine Bromide BC 51,Ubretid,BC51,Hexamarium,BC-51
	Distigmine Bromide is an acetylcholinesterase inhibitor. It is used for the treatment of underactive neurogenic bladder and myasthenia gravis.
T33652	Neurodazole
	Neurodazole is a neurogenic inducer for converting pluripotent P19 cells into electrophysiologically active neurons.
T27915	LY 302148 LY-302148,LY302148
	LY 302148 , a 5-HT1F receptor agonist, inhibits neurogenic dural inflammation in guinea pigs. It has potential for migraine therapeutics.
T78606	P2X3-IN-1	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	P2X3-IN-1（示例7）为P2X3受体抑制剂，适用于神经源性疾病的研究。
T25617	Lanepitant HCl trihydrate Lanepitant dihydrochloride trihydrate
	Lanepitant HCl trihydrate is an effective non-peptide neurokinin-1 receptor antagonist, suppresses neurogenic dural inflammation, and may have a role in migraine therapy.
T70248	4991W93
	4991W93 is a 5HT(1B/1D) receptor partial agonist, inhibiting electrically induced plasma extravasation, blocking neurogenic plasma protein extravasation, inhibiting release of calcitonin gene-related peptide.
T28516	ReN-1869 NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869
	ReN-1869 is a histamine H1 receptor antagonist. ReN 1869 is active against inflammation and neurogenic pain. ReN-1869 produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and neuropathy.
T26781	BF-1 BF1
	BF-1 is a 5-Hydroxytryptamine receptor 2B antagonist. BF-1 was tested as potential migraine prophylactic drug by blocking BW723C86 (5-((thiophen-2-yl)methoxy)-α-methyltryptamine) or meta-chlorophenylpiperazine (mCPP) induced neurogenic dural plasma protei
T61309	(R)-Oxybutynin
	(R)-Oxybutynin (Aroxybutynin) is an orally active muscarinic receptor antagonist, which exhibits antimuscarinic, antispasmodic, and anticholinergic activity. This compound, being the (R)-isomer of Oxybutynin, competitively antagonizes Carbachol-induced contractions. It is particularly useful in researching neurogenic bladder dysfunction-related incontinence [1] [2] [3].
T76429	Neurokinin Receptor (393-407), rat
	Neurokinin Receptor(393-407), rat (SPR393–407) 是一段属于大鼠神经激肽1受体(NK1R)的特定肽。它与P物质(SP)结合后，通过内吞作用迅速被NK1R内化，并循环至质膜。此化合物主要应用于神经源性炎症研究领域。
T80172	Stromatoxin 1	Potassium Channel	Membrane transporter/Ion channel
	Stromatoxin 1是从狼蛛中分离出的肽类钾通道抑制剂，特异性地抑制K(V)2.1、K(V)2.2、K(V)4.2和K(V)2.1/9.3通道。其中，K(V)2.1和K(V)2.2通道亚基对大鼠肌源性和神经源性膀胱平滑肌(UBSM)的收缩起关键调控作用，然而K(V)4.2则不参与此作用。
T60369	Droxidopa hydrochloride
	Droxidopa (L-DOPS) hydrochloride 是一种有效的、具有口服活性的去甲肾上腺素前体。Droxidopa hydrochloride 可增加站立血压，改善直立性低血压症状并提高站立能力。Droxidopa hydrochloride 具有研究神经源性直立性低血压（nOH）和替代性多动症 (注意缺陷多动障碍) 的潜力[3]。

化合物

Chembridge-5861528

Cat.No: T2711

Synonym: TCS 5861528

Target: TRP/TRPV Channel

Cat.No: T1092

Synonym: 佐米曲普坦,311C90,BW-311C90

Target: 5-HT Receptor

Cat.No: T2547

Synonym: 屈昔多巴,屈西多巴,SM5688,DOPS,L-DOPS

Target: Adrenergic Receptor

Cat.No: T9263

Synonym: N-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-2-(1,2,3,4-tetrahydroquinolin-1-yl)acetamide

Target: TRP/TRPV Channel

Cat.No: T20423

Synonym: 二苄胺,Dibenzyl-amine,N-Benzylbenzylamine,Bibenzylamine,N-benzyl-1-phenylmethanamine,Benzenemethanamine, N-(phenylmethyl)-,AI315327,AI3-15327,AI3 15327

Target: Others

Cat.No: T1833

Synonym: NSI-189,NSI 189

Target: Others

NSI-189 Phosphate

Cat.No: T21244

Synonym: NSI189 Phosphate,NSI 189 Phosphate,NSI-189磷酸盐

Target: Others

Cat.No: T25615

Synonym: LY303870,LY-303870,LY 303870

Target: Others

Cat.No: T10012

Target: Others

Lanepitant 2HCl

Cat.No: T25616

Synonym: LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride

Target: Neurokinin receptor

Cat.No: T1993

Synonym: J147

Target: Epigenetic Reader Domain, Dopamine Receptor, Monoamine Oxidase

Hu7691 free base

Cat.No: T39733

Target: Akt

Cat.No: T27059

Pikamilone Sodium

Cat.No: T3290L

Synonym: GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na

Distigmine Bromide

Cat.No: T7825

Synonym: BC 51,Ubretid,BC51,Hexamarium,BC-51

Cat.No: T33652

Cat.No: T27915

Synonym: LY-302148,LY302148

Cat.No: T78606

Target: P2X Receptor

Lanepitant HCl trihydrate

Cat.No: T25617

Synonym: Lanepitant dihydrochloride trihydrate

Cat.No: T70248

Cat.No: T28516

Synonym: NNC-05-1869,NNC 05-1869,NNC-051869,ReN 1869

Cat.No: T26781

Synonym: BF1

Cat.No: T61309

Neurokinin Receptor (393-407), rat

Cat.No: T76429

Cat.No: T80172

Target: Potassium Channel

Droxidopa hydrochloride

Cat.No: T60369

Cat. No.	Product Name	Target	Signaling Pathways
TN5757	p-Hydroxybenzaldehyde glucoside 4-formylphenyl b-d-glucopyranoside,Gastrodin Impurity
	p-Hydroxybenzaldehyde glucoside (4-formylphenyl b-d-glucopyranoside) 是抑制天麻素衍生物，具有镇痛活性，可以用于研究神经源性疼痛。
TN6872	Trypsin	Protease-activated Receptor	GPCR/G Protein
	Trypsin 是一种可从鱼类分离出的丝氨酸蛋白酶，可水解赖氨酸或精氨酸羧基侧蛋白质。Trypsin 具有抗炎活性，可通过 PDCoV 的 S 糖蛋白与 pAPN 的相互作用诱导 PDCoV 感染的细胞膜融合，可激活 PAR2 和 PAR4，促进细胞增殖和分化。Trypsin 可用于促进伤口愈合和研究神经源性炎症。

天然产物

p-Hydroxybenzaldehyde glucoside

Cat.No: TN5757

Synonym: 4-formylphenyl b-d-glucopyranoside,Gastrodin Impurity

Cat.No: TN6872

Target: Protease-activated Receptor

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