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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12421 |
PF-04885614
|
Sodium Channel | Membrane transporter/Ion channel |
PF-04885614是一种有效的NaV1.8抑制剂。PF-04885614有用于神经系统疾病和神经发育疾病研究的潜力。 | |||
T77565 |
Fluparoxan hydrochloride
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Fluparoxan hydrochloride 是一种高度选择性和有效的α2-肾上腺素受体拮抗剂,可用于预防、改善或治疗神经发育障碍和神经退行性疾病。 | |||
T77566 |
(3aR,9aR)-Fluparoxan
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
(3aR,9aR)-Fluparoxan 是一种高度选择性和有效的肾上腺素能受体α2B 拮抗剂,可用于预防、改善或治疗神经发育障碍和神经退行性疾病。 | |||
T39252 |
TAK-418
|
Histone Demethylase | Chromatin/Epigenetic |
TAK-418 是一种选择性、口服活性 LSD1/KDM1A 酶抑制剂,IC50 为 2.9 nM。TAK-418 能解锁异常表观遗传机制,改善神经发育障碍模型中的自闭症症状。 | |||
T39940 |
Plazinemdor
|
||
Plazinemdor is an NMDA receptor positive allosteric modulator with potential applications in psychiatric, neurological, neurodevelopmental disorders, and diseases of the nervous system. | |||
T74649 |
Rugonersen
|
||
Rugonersen (RG6091; RO7248824) 是一种通过锁定核酸 (LNA) 技术修饰的反义寡核苷酸 (ASOs),目的在于降低泛素蛋白连接酶 E3A (UBE3A) 的沉默。它被用于研究由于神经元 E3 连接酶 UBE3A 缺失所导致的严重神经发育障碍——Angelman 综合征 (AS)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2775 |
2-Methoxystypandrone
|
MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells |
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant |