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Search Results for " mitf "

Targets Recommended: TRP/TRPV Channel

5

抑制剂 & 化合物

10

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4028	ML329	TRP/TRPV Channel	Membrane transporter/Ion channel
	ML329 是小眼畸形相关转录因子抑制剂，它抑制 TRPM-1 启动子活性(IC50:1.2 μM)。
T77743	TT-012	Others	Others
	TT-012 具有抗肿瘤活性，选择性结合动态 MITF，并破坏后者的二聚体形成和 DNA 结合。TT-012 对 B16F10 黑色素瘤细胞中 MITF 的转录有抑制作用。TT-012 在动物模型中对 MITF黑色素瘤细胞的生长和肿瘤生长转移有抑制作用。TT-012 对肝脏和免疫细胞具有较少的细胞毒性。
TP2487	Oligopeptide-68 Acetate Oligopeptide-68 Acetate(1206525-47-4 Free base),醋酸寡肽-68	Others	Others
	Oligopeptide-68 Acetate 是一种多肽。它是一种新型美白原料，它模拟 TGF-β和细胞表面的受体结合，通过抑制 MITF 分子内通道达到降低诱发型和遗传性色素沉积，以实现美白亮肤的功效。
T76597	Prolylserine
	Prolylserine 是一种二肽，是 Mel-Ab 细胞中黑色素生成的抑制剂。Prolylserine 降低小眼相关转录因子 (MITF) 和酪氨酸酶的表达，诱导ERK 的磷酸化，但不诱导 cAMP 反应元件结合蛋白 (CREB)。
T75535	5-epi-Arvestonate A
	5-epi-Arvestonate A是一种从(Seriphidium transiliense)绢毛菊中提取的倍半萜化合物，能够通过激活(MITF)小眼相关转录因子和酪氨酸酶家族基因来促进黑色素的产生。此外，5-epi-Arvestonate A还能通过JAK/STAT信号通路，抑制永生化人角化细胞(HaCaT)中IFN-γ趋化因子的表达。

化合物

Cat.No: T4028

Target: TRP/TRPV Channel

Cat.No: T77743

Target: Others

Oligopeptide-68 Acetate

Cat.No: TP2487

Synonym: Oligopeptide-68 Acetate(1206525-47-4 Free base),醋酸寡肽-68

Target: Others

Cat.No: T76597

5-epi-Arvestonate A

Cat.No: T75535

Cat. No.	Product Name	Target	Signaling Pathways
T2P2810	Methyl Linoleate Linoleic acid methyl ester,亚油酸甲酯,Telfairic Acid methyl ester	Antioxidant	oxidation-reduction
	Methyl Linoleate (Telfairic Acid methyl ester) 是一种 Sageretia thea 果实的主要活性成分，能够下调小眼畸形相关转录因子和酪氨酸酶相关蛋白，是一种主要的抗黑色素生成化合物。
T3676	Sesamol 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分，具有抗氧化和抗肿瘤活性。它是一种自由基清除剂，在 DPPH 实验中，IC50为 5.95±0.56 μg/mL。
TN2246	Swertiajaponin	Tyrosinase	Proteases/Proteasome
	Swertiajaponin 是酪氨酸酶抑制剂，与酪氨酸酶结合囊形成多个氢键和疏水相互作用，IC50=43.47 μM。它能抑制黑色素积累，具有较强的抗氧化活性。它还能通过抑制氧化应激介导的 MAPK/MITF 信号导致酪氨酸酶蛋白水平下降。
T79996	N,N′-Diferuloylputrescine	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	N,N′-Diferuloylputrescine 作为pigmentation的抑制剂，有效减少了57%的色素沉着，并显著降低了MITF蛋白水平。同时，该化合物对活性氧表现出强大的抗氧化活性。
TMA0003	Trans-caffeic acid	cAMP; Tyrosinase	GPCR/G Protein; Proteases/Proteasome
	Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyrosinase activity, DOPA oxidase activity and melanin synthesis.
T75506	6-Acetylnimbandiol
	6-Acetylnimbandiol (6-O-Acetylnimbandiol) 是一种无细胞毒性的 tyrosinase 抑制剂 (IC50=69.85 μM)，能有效抑制黑色素的生成和MITF 的表达。6-Acetylnimbandiol 可用于黑色素瘤的研究。
T13762	Luteolin 7-sulfate	Others	Others
	Luteolin 7-sulfate, derived from the marine plant Phyllospadix iwatensis Makino, suppresses TYR gene expression by intervening in a signaling pathway involving the cAMP-responsive element binding protein (CREB) and microphthalmia-associated transcription factor (MITF). This inhibition ultimately leads to a decrease in melanin synthesis.
TN4468	(-)-Lyoniresinol 9'-O-glucoside	Others	Others
	(-)-Lyoniresinol 9'-O-glucoside is a natural product from Phyllostachys heterocycla MITF.
TN4179	Haginin A	ERK; Tyrosinase; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activation, MITF, and also by the subsequent downregulation of tyrosinase and TRP-1 production. Hag
TN4489	Manassantin A	ERK; cAMP; TNF; NF-κB; MAPK; COX; HIF; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells
	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-ÎºB act

天然产物

Methyl Linoleate

Cat.No: T2P2810

Synonym: Linoleic acid methyl ester,亚油酸甲酯,Telfairic Acid methyl ester

Target: Antioxidant

Cat.No: T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚

Target: Apoptosis, AMPK

Cat.No: TN2246

Target: Tyrosinase

N,N′-Diferuloylputrescine

Cat.No: T79996

Target: Melanocortin Receptor

Trans-caffeic acid

Cat.No: TMA0003

Target: cAMP, Tyrosinase

6-Acetylnimbandiol

Cat.No: T75506

Luteolin 7-sulfate

Cat.No: T13762

Target: Others

(-)-Lyoniresinol 9'-O-glucoside

Cat.No: TN4468

Target: Others

Cat.No: TN4179

Target: ERK, Tyrosinase, Akt

Cat.No: TN4489

Target: ERK, cAMP, TNF, NF-κB, MAPK, COX, HIF, Prostaglandin Receptor, JNK, STAT

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01173	TFF3 Protein, Mouse, Recombinant (His) Itf,Trefoil factor 3,Intestinal trefoil factor,mITF...	Mouse	HEK293 Cells
	Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process called restitution. TFF comprises the gastric peptides (TFF1), spasmolytic peptide (TFF2), and the intestinal trefoil factor (TFF3). They have an important and necessary role in epithelial restitution within the gastrointestinal tract. Members of the trefoil family are characterized b...
TMPJ-00281	CADM1 Protein, Mouse, Recombinant (hFc) IgSF4,NECL-2,Nectin-like protein 2,Immunoglobulin superfamil...	Mouse	HEK293 Cells
	Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in...

重组蛋白

TFF3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01173

Species: Mouse

Expression System: HEK293 Cells

CADM1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00281

Species: Mouse

Expression System: HEK293 Cells

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