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99

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T6446	Clevudine L-FMAU,克拉夫定,Levovir	HBV; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Clevudine (Levovir) 是一种非自然 L-构型的核苷类似物，是一种与聚合酶结合的非竞争性抑制剂，具有较强的抗 HBV 活性，半衰期长，毒性低的特点。
T21474	Navuridine AZddU,CS 87,CS-87,AzUrd,3'-Azido-2',3'-dideoxyuridine,AZdU,3'-叠氮-2',3'-双脱氧尿苷	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Navuridine (AZdU) 是一种口服活性的 HIV 逆转录酶抑制剂，半衰期相对较短。
T67905	GS-829845	JAK; Drug Metabolite	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Metabolism; Stem Cells
	GS-829845 是一种 JAK1 抑制剂，是 Filgotinib 活性代谢物的主要成分，其效力比母体低约 10 倍且半衰期更长。
T33941	PF-03635659 PF03635659,PF 03635659	AChR	Neuroscience
	PF-03635659是一种强效且解离半衰期长的毒蕈碱M3拮抗剂（Ki：0.2 nM），显示出治疗慢性阻塞性肺病（COPD）的潜力。
T10392	Aspoxicillin	Anti-infection; Antibacterial	Microbiology/Virology
	Aspoxicillin 是一种广谱抗菌剂，对分离的胸膜肺炎放线杆菌 68 菌株抑制作用的MIC90值 ≤ 0.05 μg/ml。
T3967	Exendin-4 艾塞那肽,Exenatide,Exenatide Acetate	Glucagon Receptor	GPCR/G Protein
	Exendin-4 (Exenatide) 是一种长效的 glucagon-likepeptide-1 受体激动剂(IC50: 3.22 nM)，是一种由 39 个氨基酸组成的多肽。
T1223	Ceftriaxone sodium hydrate Ceftriaxone Sodium Trihydrate,头孢曲松钠,Ceftriaxone disodium hemiheptahydrate,头孢曲松钠水合物,Ceftriaxone sodium	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Ceftriaxone sodium hydrate 是一种头孢菌素类抗生素，对革兰氏阳性和革兰氏阴性菌均有活性。它具有抗炎和抗氧化作用。
T1410	Torsemide AC-4464,JDL-464,托拉塞米,Torasemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂，也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T71708	Minamestane	Aromatase	Endocrinology/Hormones
	Minamestane 是一种新型不可逆芳香化酶抑制剂。Minamestane 引起人胎盘芳香化酶的时间依赖性抑制，半衰期为4分钟，K 为59nM。Minamestane 具有抗肿瘤活性。
T0195	Secnidazole RP-14539,PM-185184,塞克硝唑	Antibiotic; Parasite	Microbiology/Virology
	Secnidazole (PM-185184) 是一种具有口服活性唑类抗生素，半衰期比甲硝唑更长。它有潜力研究细菌性阴道病。
T15300	Fluorofenidone AKF-PD	Others	Others
	Fluorofenidone (AKF-PD) 是 AMR69 的类似物，抗纤维化活性与 AMR69相同，但 Fluorofenidone 的毒性更低，半衰期长。它部分通过 PI3K/Akt 信号通路抑制 NADPH 氧化酶和细胞外基质 (ECM) 的沉积，能够减少肾间质纤维化的发生。
T60919	SARS-CoV-2-IN-13	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-13 (compound 6) 是氯硝柳胺的类似物。在人血浆和肝S9酶测定中，SARS-CoV-2-IN-13 比氯硝柳胺更稳定。SARS-CoV-2-IN-13 口服给药时可以提高生物利用度和半衰期。SARS-CoV-2-IN-13 是SARS-CoV-2的有效抑制剂，IC50值为 0.057 μM。
T15117	Didesmethyl cariprazine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Didesmethyl cariprazine 是 Cariprazine 的代谢物，是主要的循环活性部分。 Didesmethyl cariprazine 有较长的半衰期，为 1-3 周。Cariprazine 是一种有效的多巴胺D3偏好D3/D2受体部分激动剂，用于治疗精神分裂症、双相躁狂和抑郁症，对d3和d2受体具有高亲和力，对5-HT 1A 受体具有中等亲和力。
T60538	SARS-CoV-2-IN-14 3',5-Dichlorosalicylanilide	SARS-CoV	Microbiology/Virology
	SARS-CoV-2-IN-14 是一种有效的、可口服的 SARS-CoV-2 抑制剂（IC50 ：0.39 μM），是一种氯硝柳胺类似物。SARS-CoV-2-IN-14在人血浆和肝 S9 酶测定中比氯硝柳胺稳定性更强。SARS-CoV-2-IN-14以口服的方式给药可以提高其生物利用度和半衰期。
T3716	Rolapitant 罗拉吡坦,SCH619734,罗拉匹坦	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂，Ki 值为0.66 nM。
T2671	Regadenoson CVT-3146,瑞加德松,Lexiscan	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Regadenoson (CVT-3146) 是一种腺苷衍生物和选择性 A2A 腺苷受体激动剂，具有冠状动脉舒张活性，对大鼠和猪腺苷 A2A 受体的Ki 分别为 290 和 1120 nM。它是血管扩张剂，可增加啮齿动物血脑屏障的通透性。
T8947	dasiglucagon acetate dasiglucagon acetate(1544300-84-6 free base)	Others	Others
	dasiglucagon acetate 是一种用于糖尿病低血糖治疗的新型胰高血糖素类似物。它已证明在水性制剂中的溶解度和稳定性。药代动力学研究表明，与传统的重组胰高血糖素相比，它的胰高血糖素具有更高的吸收率和更长的血浆消除半衰期。
T35868	BCAT-IN-2
	BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema[1]. BCAT-IN-2 (compound 61) inhibits BCATm in differentiated primary human adipocyte, with pIC50 of 6.5[1]. BCAT-IN-2 (compound 61) (10-100 mg/kg; p.o.) increases the level of leucine from 473 μM to 1.2 mM at the dose of 100 mg/kg i...
TP1895L1	KYL acetate(676657-00-4 free base)	Ephrin Receptor	Tyrosine Kinase/Adaptors
	KYL acetate(676657-00-4 free base) 是EphA4受体酪氨酸激酶抑制剂（Kd = 0.8 μM）；抑制 EphA4-EphrinA5 相互作用 (IC50 = 6.34 μM)。防止 AβO 诱导的突触损伤、树突棘丢失并防止海马 CA3-CA1 传输中 LTP 的阻断。在细胞培养基中表现出较长的半衰期（在 PC3 和 C2C12 培养基中分别为 8 和 12 小时）。它有神经保护作用。
T29075	UR-7247 UR7247
	UR-7247 is an angiotensin type 1 receptor antagonist with a very long plasma elimination half-life.
T24390	LB-205
	LB-205 is a Zn 2+ dependent pan-inhibitor of class I and class II HDACs. It also has a long half-life in vivo.
T36510	V-PYRRO/NO
	V-PYRRO/NO is a NO donor in vivo. Following hepatic metabolism, it spontaneously decomposes with a half-life of 3 seconds to liberate NO.
T34590	SD-254 Venlafaxine deuterium-substituted,D9-venlafaxine
	SD-254 is a deuterium analog of Effexor, with fewer side effects and a longer half-life.
T40239	Tenofovir-C3-O-C15-CF3 ammonium Tenofovir-C3-O-C15-CF3 ammonium
	Tenofovir-C3-O-C15-CF3 (ammonium) demonstrates prolonged half-life values compared to tenofovir in human liver microsomes. It exhibits potent anti-HIV activity in vitro and enhances pharmacokinetic properties in vivo.
T27374	FR-181877 FR181877,FR 181877
	FR-181877, a nonprostanoid PGI2 agonist, inhibits ADP-induced aggregation of human platelets with an IC50 value of 0.081 microM and has high oral bioavailability (56%) with a long half-life (4.3 h) in rats.
T40238	Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
	Tenofovir-C3-O-C12-trimethylsilylacetylene (ammonium) displays a prolonged half-life (t1/2) compared to tenofovir in human liver microsomes. Moreover, it demonstrates potent in vitro anti-HIV activity and improves in vivo pharmacokinetic properties.
T36210	15-keto Treprostinil (sodium salt)
	15-keto Treprostinil is an impurity found in treprostinil , which is a stable analog of prostaglandin I2 with a longer plasma half-life. Formulations containing treprostinil are used for the treatment of primary pulmonary hypertension.
T34589	SD-1077 d3-L-DOPA,deuldopa,deuterated levodopa,SD1077
	SD-1077, also known as d3-L-DOPA, is a deuterium containing levodopa. SD-1077 has been shown in preclinical models to improve the half-life of dopamine in the brain resulting in a prolonged treatment effect.
T27141	Delimotecan MEN4901,MEN 4901,T-0128,MEN-4901,T 0128
	Delimotecan is a DNA topoisomerase I inhibitor. Delimotecan had a long terminal half-life of 109 h, and relatively high exposures to T-2513 and SN-38 were obtained. The percentage decrease in WBC and absolute neutrophil count significantly correlated with
T35960	PROLI NONOate
	PROLI NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 1.8 seconds at 37°C (pH 7.4) to liberate 2 moles of NO per mole of parent compound.
T68563	Piroxicam olamine
	Piroxicam olamine is a cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
T81826	Meayamycin D
	Meayamycin D, 作为FR901464的类似物，能够诱导MCL-1的选择性剪接，并在小鼠血浆中展现出较长的半衰期。
T68345	GTS511
	GTS511 is a EAAT2 Activator. Pharmacokinetic profiles (PK) of GTS511 show a >6 h half-life and higher bioavailability in plasma and the brain under all three routes of administration in rats. GTS511 can be further developed to treat neurological disorders caused by excitotoxicity
T27799	LAS191859 LAS-191859,LAS 191859
	LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasti
T62919	CDK9-IN-13
	CDK9-IN-13 是一种有效的、选择性的 CDK 抑制剂 (IC50<3 nM)。CDK9-IN-13 在啮齿动物中的半衰期很短。
T76930	Bifarcept
	Bifarcept为一种针对干扰素受体I型(IFN-RI)的重组抗体，能与IFN-β结合，从而延长其在血清中的半衰期。
T74714	TP0597850
	TP0597850为MMP2选择性抑制剂，展现出卓越的亲和力（IC50=0.22 nM）和较长的MMP2解离半衰期（t1/2=265 min）。
T36615	DPTA NONOate Dipropylenetriamine NONOate
	DPTA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of three hours and five hours at 37°C and 22-25°C, pH 7.4, respectively, to liberate 2 moles of NO per mole of parent compound. [1][2]
T36546	Prostaglandin I3 (sodium salt) Prostaglandin I3 (sodium salt)
	PGI3 is synthesized from EPA by COX and PGI synthase. PGI3 has a short in vivo half-life and is hydrolyzed to δ17-6-keto PGF1α. The platelet and vascular activity of PGI3 is equivalent to that of PGI2.
T62855	OX2R-IN-1
	OX2R-IN-1 是一种 OX2R 拮抗剂 (一种潜在的 OX2R 结合剂)，表现出低细胞毒性 (IC50: 484 μM)。OX2R-IN-1 具有血脑屏障通透性，药物半衰期短。
T61639	S1P1 agonist 4
	S1P1 agonist 4 在效价（EC50< 0.05 mg/kg）和预测人类半衰期方面都有更好的表现（t1/2 ～ 5 天）。
T36177	Angeli’s Salt Angeli’s Salt,Sodium α-oxyhyponitrite
	Angeli’s salt is regarded as a classical nitroxyl (NO-) donor, but under certain conditions evolution of NO is also observed.1 It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 2.3 minutes at 37°C (pH 7.4) to liberate 0.54 moles of NO per mole of parent compound.[1],[2]
T68765	Spirorenone
	Spirorenone is an androstadienone derivative as a highly effective aldosterone antagonist. Spirorenone is 8.6 times as potent as spironolactone, but showed a lower affinity for the mineralocorticoid receptors. In phase I clinical trials Spirorenone was absorbed with a half-life of 20-30 min, achieving maximum concentrations of about 100 ng/ml (10 mg) and 260 ng/ml (40 mg) after 1-2 h. Disposition of the parent drug was biphasic with half-lives of 50-60 min (distribution) and 5-6 h (elimination)....
T78533	JG-23
	JG-23是一种4-氯修饰类似物，能促进t-tau降解，并在小鼠肝微粒体检测中显示出良好的代谢稳定性，具备较长的半衰期(T1/2值为36分钟)。
T10589L	BPN-15606	Others	Others
	BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 has acceptable PK/PD properties, including bioavai
T81525	Pegylated synthetic human c-peptide
	Pegylated synthetic human c-peptide 保留与天然（即非聚乙二醇化）C 肽相当的生物活性，且延长了在血浆中的循环停留时间，适用于糖尿病性周围神经病变的研究。
T36239	6β-Prostaglandin I1 6β-Prostaglandin I1
	6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 μM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.
T69608	TG11-77 HCl
	TG11-77 is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.
T35969	NOC-5
	NOC-5 is a stable nitric oxide (NO)-amine complex that acts as a NO donor. It can release two equivalents of NO in solution under physiological conditions without a cofactor. [1] The half-life of NOC-5 in PBS (pH 7.4) is 93 minutes at 22°C, and it remains relatively stable in alkaline solution (pH >=10.0). [1]
T69609	TG11-77 free base
	TG11-77 is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties.

化合物

Cat.No: T6446

Synonym: L-FMAU,克拉夫定,Levovir

Target: HBV, DNA/RNA Synthesis

Cat.No: T21474

Synonym: AZddU,CS 87,CS-87,AzUrd,3'-Azido-2',3'-dideoxyuridine,AZdU,3'-叠氮-2',3'-双脱氧尿苷

Target: HIV Protease

Cat.No: T67905

Target: JAK, Drug Metabolite

Cat.No: T33941

Synonym: PF03635659,PF 03635659

Target: AChR

Cat.No: T10392

Target: Anti-infection, Antibacterial

Cat.No: T3967

Synonym: 艾塞那肽,Exenatide,Exenatide Acetate

Target: Glucagon Receptor

Ceftriaxone sodium hydrate

Cat.No: T1223

Synonym: Ceftriaxone Sodium Trihydrate,头孢曲松钠,Ceftriaxone disodium hemiheptahydrate,头孢曲松钠水合物,Ceftriaxone sodium

Target: Others, Antibacterial, Antibiotic

Cat.No: T1410

Synonym: AC-4464,JDL-464,托拉塞米,Torasemide

Target: Na-K-Cl cotransporter

Cat.No: T71708

Target: Aromatase

Cat.No: T0195

Synonym: RP-14539,PM-185184,塞克硝唑

Target: Antibiotic, Parasite

Cat.No: T15300

Synonym: AKF-PD

Target: Others

SARS-CoV-2-IN-13

Cat.No: T60919

Target: SARS-CoV

Didesmethyl cariprazine

Cat.No: T15117

Target: Dopamine Receptor, 5-HT Receptor

SARS-CoV-2-IN-14

Cat.No: T60538

Synonym: 3',5-Dichlorosalicylanilide

Target: SARS-CoV

Cat.No: T3716

Synonym: 罗拉吡坦,SCH619734,罗拉匹坦

Target: Neurokinin receptor

Cat.No: T2671

Synonym: CVT-3146,瑞加德松,Lexiscan

Target: Adenosine Receptor

dasiglucagon acetate

Cat.No: T8947

Synonym: dasiglucagon acetate(1544300-84-6 free base)

Target: Others

Cat.No: T35868

KYL acetate(676657-00-4 free base)

Cat.No: TP1895L1

Target: Ephrin Receptor

Cat.No: T29075

Synonym: UR7247

Cat.No: T24390

Cat.No: T36510

Cat.No: T34590

Synonym: Venlafaxine deuterium-substituted,D9-venlafaxine

Tenofovir-C3-O-C15-CF3 ammonium

Cat.No: T40239

Synonym: Tenofovir-C3-O-C15-CF3 ammonium

Cat.No: T27374

Synonym: FR181877,FR 181877

Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium

Cat.No: T40238

Synonym: Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium

15-keto Treprostinil (sodium salt)

Cat.No: T36210

Cat.No: T34589

Synonym: d3-L-DOPA,deuldopa,deuterated levodopa,SD1077

Cat.No: T27141

Synonym: MEN4901,MEN 4901,T-0128,MEN-4901,T 0128

Cat.No: T35960

Piroxicam olamine

Cat.No: T68563

Cat.No: T81826

Cat.No: T68345

Cat.No: T27799

Synonym: LAS-191859,LAS 191859

Cat.No: T62919

Cat.No: T76930

Cat.No: T74714

Cat.No: T36615

Synonym: Dipropylenetriamine NONOate

Prostaglandin I3 (sodium salt)

Cat.No: T36546

Synonym: Prostaglandin I3 (sodium salt)

Cat.No: T62855

Cat.No: T61639

Angeli’s Salt

Cat.No: T36177

Synonym: Angeli’s Salt,Sodium α-oxyhyponitrite

Cat.No: T68765

Cat.No: T78533

Cat.No: T10589L

Target: Others

Pegylated synthetic human c-peptide

Cat.No: T81525

6β-Prostaglandin I1

Cat.No: T36239

Synonym: 6β-Prostaglandin I1

Cat.No: T69608

Cat.No: T35969

TG11-77 free base

Cat.No: T69609

Cat. No.	Product Name	Target	Signaling Pathways
T4814	(R)-5-Oxopyrrolidine-2-carboxylic acid D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid,D-焦谷氨酸	Others; Endogenous Metabolite	Metabolism; Others
	(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) 是内源性代谢产物的一种。
T4940	3-Methylhistamine dihydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	3-Methylhistamine dihydrochloride 是一种组胺的降解产物，与免疫反应有关，并在接种过疫苗的小鼠中表现出上调作用。
T75661	Thymopentin acetate
	Thymopentin acetate为胸腺皮质及髓质上皮细胞主要分泌的生物活性肽，是一有效免疫调节剂，具有极短的血浆半衰期(30秒)，能促进自人类胚胎干细胞生成T细胞群。
TN2255	Taccalonolide AJ	Others	Others
	Taccalonolide AJ is a microtubule stabilizer; it has excellent and highly persistent antitumor efficacy when administered directly to the tumor, suggesting that the lack of antitumor efficacy seen with systemic administration of AJ is likely due to its sh
T37997	Murideoxycholic Acid
	Murideoxycholic acid (MDCA) is a secondary bile acid produced from α-muricholic acid and β-muricholic acid.[1] It is also a metabolite of lithocholic acid in liver S9 fractions from humans and other species.[2] MDCA prevents gallstone formation in hamsters fed a lithogenic diet but does not resolve gallstones in prairie dogs fed a high cholesterol diet.[3],[4] Gallstones formed during MDCA administration after a high cholesterol diet are comprised of an insoluble calcium salt of murideoxycholyl ...

天然产物

(R)-5-Oxopyrrolidine-2-carboxylic acid

Cat.No: T4814

Synonym: D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid,D-焦谷氨酸

Target: Others, Endogenous Metabolite

3-Methylhistamine dihydrochloride

Cat.No: T4940

Target: Others, Endogenous Metabolite

Thymopentin acetate

Cat.No: T75661

Taccalonolide AJ

Cat.No: TN2255

Target: Others

Murideoxycholic Acid

Cat.No: T37997

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