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19

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7061	Duloxetine	Serotonin Transporter	Neuroscience
	Duloxetine 是一种 5 羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂，Ki=4.6 nM，可作用于广泛性焦虑症的研究。
T1471	Duloxetine hydrochloride Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI)，Ki=4.6 nM，可用于广泛性焦虑症的研究。
T28270	Osemozotan HCl Osemozotan hydrochloride,MN-305,MCI-242,MKC-242,MKC242,MCI242
	Osemozotan is a 5-HT1A receptor agonist potentially for the treatment of generalized anxiety disorder.
T2132	Buspirone hydrochloride Buspirone HCl,盐酸丁螺环酮,Narol,Buspar	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Buspirone hydrochloride (Buspar) 是一种 5HT(1A) 受体激动剂，可用于研究广泛性焦虑症。
T13569	Benin Butocine,Butocin	Others	Others
	Benin (Butocine) 是细胞生长抑制剂，可用于研究广义的乳腺癌。
T7136	AZD-6280	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	AZD-6280 是一种新型的亚型选择性 GABAAα2/3 受体阳性调节剂，用于治疗广泛性焦虑症。
T12156	N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea	Others	Others
	N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea 是一种抗惊厥剂，对广泛强直和部分性发作挛性具有潜在的研究价值。
T68058	Dulozafone F1933	Others	Others
	Dulozafone (F1933) 具有抗在脑杏仁核点燃模型中显示出抗惊厥活性，可保护完全点燃的大鼠免受全身性癫痫发作。
T1249	Beclamide N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon,贝克拉胺(INN)	Others	Others
	Beclamide (Chlorakon) 是一种抗惊厥药，具有抗惊厥作用。
T0675	Topiramate RWJ 17021,McN 4853,托吡酯	Potassium Channel; Calcium Channel; GABA Receptor; Sodium Channel; GluR; Carbonic Anhydrase; iGluR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Topiramate (RWJ 17021) 是一种GluR5受体拮抗剂，可通过增强GABAergic 活性，抑制kainate/AMPA 受体，抑制钠和钙通道的电压敏感，增加钾电导并抑制碳酸酐酶来产生抗癫痫作用，用于治疗部分性和全身性癫痫发作。
T76778	Risankizumab Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066	IL Receptor	Immunology/Inflammation
	Risankizumab (BI 655066) 是一种人源化靶向 IL-23 p19 亚基的 IgG 单克隆抗体(Kd <10 pM)。 Risankizumab 能抑制人 IL-23 在小鼠脾细胞中诱导的 IL-17 产生，IC50 值为 2 pM。Risankizumab 可用于预防和治疗如寻常型银屑病、银屑病关节炎、广泛性脓疱型银屑病和红皮病型银屑病类的免疫性和炎症性疾病。
T1885L	Siramesine Fumarate LU-28179,LU-28-179,LU 28 179
	Siramesine Fumarate, a sigma receptor agonist, is used potentially for the treatment of generalized anxiety disorder.
T14120	ACT-709478	Others	Others
	ACT-709478 is a potent, selective T-type calcium channel blocker that is orally active and capable of penetrating the brain. It is currently utilized in research focusing on generalized epilepsies[1].
T61376	Opipramol
	Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].
T27968	M-5011 T-3788,S-MTPPA,M 5011,M-5011C
	M-5011 is a non-steroidal anti-inflammatory drug and immunomodulator potentially for the treatment of inflammation and pain. M-5011 had an effective antinociceptive activity (ED50 value) of 0.63 mg/kg. M-5011 partially inhibits the generalized bone loss a
T11113	Duloxetine D3 hydrochloride (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride	Others	Others
	Duloxetine D3 hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) i
T77032	Imsidolimab
	Imsidolimab (ANB 019) 是一种高亲和力、人源化的抗IL-36R 单克隆抗体。Imsidolimab 拮抗IL-36细胞因子信号传导。Imsidolimab 在泛发性脓疱型银屑病 (GPP) 和其他炎症性皮肤病中有潜在应用。
T68976	Piragliatin
	Piragliatin, also known as RO4389620, is a glucokinase activator. Piragliatin greatly enhances glucose-induced pancreatic islet respiration and insulin release. Piragliatin lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus. Piragliatin has an acute glucose-lowering action in patients with mild type 2 diabetes, mainly mediated through a generalized enhancement of β-cell function and through fasting restricted changes in ...
T70063	GYKI 52466 HCl
	GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of general...

化合物

Cat.No: T7061

Target: Serotonin Transporter

Duloxetine hydrochloride

Cat.No: T1471

Synonym: Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T28270

Synonym: Osemozotan hydrochloride,MN-305,MCI-242,MKC-242,MKC242,MCI242

Buspirone hydrochloride

Cat.No: T2132

Synonym: Buspirone HCl,盐酸丁螺环酮,Narol,Buspar

Target: Dopamine Receptor, 5-HT Receptor

Cat.No: T13569

Synonym: Butocine,Butocin

Target: Others

Cat.No: T7136

Target: GABA Receptor

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

Cat.No: T12156

Target: Others

Cat.No: T68058

Synonym: F1933

Target: Others

Cat.No: T1249

Synonym: N-Benzyl-3-chloropropionamide,Chloracon,Chlorakon,贝克拉胺(INN)

Target: Others

Cat.No: T0675

Synonym: RWJ 17021,McN 4853,托吡酯

Target: Potassium Channel, Calcium Channel, GABA Receptor, Sodium Channel, GluR, Carbonic Anhydrase, iGluR

Cat.No: T76778

Synonym: Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066

Target: IL Receptor

Siramesine Fumarate

Cat.No: T1885L

Synonym: LU-28179,LU-28-179,LU 28 179

Cat.No: T14120

Target: Others

Cat.No: T61376

Cat.No: T27968

Synonym: T-3788,S-MTPPA,M 5011,M-5011C

Duloxetine D3 hydrochloride

Cat.No: T11113

Synonym: (S)-Duloxetine D3 hydrochloride,LY248686 D3 hydrochloride

Target: Others

Cat.No: T77032

Cat.No: T68976

Cat.No: T70063

Cat. No.	Product Name	Target	Signaling Pathways
T4762	L-Pipecolic acid L-哌啶酸,L-Homoproline,H-HoPro-OH	Endogenous Metabolite	Metabolism
	L-Pipecolic acid (L-Homoproline) 是赖氨酸的分解产物，它能在患有常染色体遗传性疾病的婴儿体液中积累，比如新生儿肾上腺机能障碍， Zellweger 综合征等。
T8769	Harmaline hydrochloride Harmidine hydrochloride	Others	Others
	Harmaline hydrochloride (Harmidine hydrochloride) 是一种荧光吲哚生物碱，来自 harmala 生物碱和 β-咔啉。它是 harmine 的部分氢化形式。 Harmaline 通过诱导下橄榄神经元的节律性放电在正常大鼠中产生全身性震颤。
T40910	Cognac oil
	Cognac oil, predominantly derived from wine lees, exhibits distinctive fatty acid compositions, characterized by high proportions of Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), and Oleic acid (8.3%) among other fatty acids. Notably, the application of Cognac oil enhances the permeability of Rhodamine 6G (R6G) across various membranes, resulting in a generalized increase in permeation.

天然产物

L-Pipecolic acid

Cat.No: T4762

Synonym: L-哌啶酸,L-Homoproline,H-HoPro-OH

Target: Endogenous Metabolite

Harmaline hydrochloride

Cat.No: T8769

Synonym: Harmidine hydrochloride

Target: Others

Cat.No: T40910

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