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Search Results for " fungicidal "

35

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0202	Sulbentine Dibenzthione,舒苯汀	Antifungal	Microbiology/Virology
	Sulbentine (Dibenzthione) 是一种具有抑菌和杀真菌活性的唑类抗真菌试剂，可作为局部抗菌试剂。
T0776	Phenothiazine ENT 38,吩噻嗪	Dopamine Receptor; Antibacterial; Antibiotic; Antifungal	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Phenothiazine (ENT 38) 是一种抗生素，具有杀虫，抗菌，驱虫和杀真菌活性。它也可研究神经系统疾病。
T64346	DDAC Quaternium 12	Antibacterial	Microbiology/Virology
	DDAC (Quaternium 12), also known as Didecyldimethylammonium chloride, is a dialkyl-quaternary ammonium compound widely utilized in various products due to its bactericidal, virucidal, and fungicidal characteristics.
T7533	Taurolidine	Apoptosis; Others; Antibacterial; Antibiotic	Apoptosis; Microbiology/Virology; Others
	Taurolidine 是一种广谱抗菌剂，用于预防中心静脉导管相关感染。它具有抗真菌和抗肿瘤作用。
T0328	Hexetidine NSC-17764,海克替啶	Antibacterial; Antifungal	Microbiology/Virology
	Hexetidine (NSC-17764) 是一种口服活性的抗菌抗真菌试剂，可用于口腔感染的相关研究。
T1543	Naftifine hydrochloride Naftifungin,盐酸萘替芬,Naftifine HCl,Naftin,Exoderil	Hedgehog/Smoothened; Antibiotic; Antifungal	GPCR/G Protein; Microbiology/Virology; Stem Cells
	Naftifine hydrochloride (Naftifine HCl) 是一种抗生素。它具有抗真菌活性，对皮肤真菌、曲霉、Sporothrix schenckii、假丝酵母属的酵母有抑制作用。
T26087	Rilopirox
	Rilopirox is a synthetic fungicidal antimycotic with hydrophobic characteristics.
T83071	Antifungal agent 62
	Antifungalagent 62 (Compound 3a) 是针对Fusarium oxysporum f.sp. cucumerinum展现出卓越抑制效果的杀菌剂，适用于抗病毒及杀菌机制研究。
T78891	SDH-IN-8
	SDH-IN-8（compound G40）是一种针对猪琥珀酸脱氢酶（SDH）IC50为27 nM的有效抑制剂，且展现出杀菌性能。
T70383	Fenamidone
	Fenamidone is a foliar fungicide used on grapes, ornamentals, potatoes, tobacco, and vegetables. It exerts its fungicidal effects by acting as a Qo inhibitor.
T39143	Y12196
	Y12196, a newly developed succinate dehydrogenase inhibitor (SDHI), demonstrates potent fungicidal effects specifically targeting F. graminearum.
T37349	Cymoxanil
	Cymoxanil is a fungicidal against plant diseases caused by fungi belonging to the Perenosporales[1]. [1]. Frederique Tellier , et al. Characterization of Metabolites of Fungicidal Cymoxanil in a Sensitive Strain of Botrytis Cinerea. J Agric Food Chem. 2008 Sep 10;56(17):8050-7.
T78900	Antibacterial agent 157
	Antibacterialagent 157 (compound B12)，作为一种杀真菌剂，能够干扰Botrytis cinerea的蛋白质合成，主要应用于灰霉病防治的研究领域。
T83070	Antifungal agent 63
	Antifungalagent 63 (Compound 3i) 是针对 Fusarium oxysporum f.sp. cucumerinum 展现出优异杀菌活性的抗真菌剂，适用于抗病毒与杀菌领域的研究。
T79522	Antifungal agent 65
	Antifungalagent 65 (Compound 5d) 是一种针对Fusarium oxysporum f.sp. cucumerinum表现出优异杀菌活性的抗真菌化合物，可应用于抗病毒与杀菌研究。
T79521	Antifungal agent 64
	Antifungalagent 64 (Compound 5c) 对Fusarium oxysporum f.sp. cucumerinum 表现出优异的抗菌活性，主要应用于抗病毒和杀菌领域的研究。
T79595	Antimicrobial agent-24
	Antimicrobial agent-24 (compound E8)是一种酰肼化合物，展现出卓越的广谱抗菌特性。该化合物主要通过破坏质膜的正常功能，从而导致菌丝体形态和亚细胞结构的改变。
T74772	Antifungal agent 47
	Antifungal agent 47 (compound 3b) 表现出极高的广谱杀真菌活性、强呼吸抑制活性和腺苷5'-三磷酸合成抑制活性。 Antifungal agent 47 具有作为杀菌剂的潜力。
T76065	Omiganan-FITC
	Omiganan-FITC 是由 Omiganan 和 FITC 组成的肽-FITC 复合物。Omiganan 是一种抗细菌和真菌的阳离子肽，可作为一种局部凝胶用于预防导管相关感染。FITC 是荧光素的衍生物，用于标记伯胺。
T70029	Ibrexafungerp citrate
	Ibrexafungerp citrate is a triterpenoid antifungal. Similarly to echinocandins, it inhibits the synthesis of 1,3-β-d-glucan. However, it binds to a different site on the enzyme than echinocandins, resulting in limited cross-resistance. Ibrexafungerp exerts concentration-dependent fungicidal activity against Candida species and retains in vitro activity against most fluconazole-resistant strains.
T79309	Antibacterial agent 149
	Antibacterialagent 149 (Compd 3j) 是漆酶抑制剂，表现出显著的杀菌活性，适用于水稻纹枯病的研究。
T36437	Sphinganine (d17:0) Sphinganine (d17:0)
	Sphinganine is a synthetic bioactive sphingolipid that inhibits the growth of C. glabrata and C. albicans with a minimum fungicidal concentration (MFC) value of 0.5 μg/ml for both. More commonly, sphinganine is used as an internal standard in the analysis of sphingoid compounds by chromatographic or spectrometric methods.
T76065L	Omiganan-FITC TFA
	Omiganan-FITC TFA 是由 Omiganan 和 FITC 组成的肽-FITC 复合体。Omiganan 是一种抗细菌和真菌的阳离子肽，可作为一种局部凝胶用于预防导管相关感染。
TP1741	Histatin 5
	Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Histatin 5 is a human basic salivary peptide with strong fungicidal properties in vitro.
T79765	SDH-IN-9
	SDH-IN-9 (compound Ip)作为Succinate Dehydrogenase的有效抑制剂，对Fusarium graminearum Schw展现出了0.93 μg/mL的EC50值。
T78890	SDH-IN-7
	SDH-IN-7（compound G28），作为一种琥珀酸脱氢酶（SDH）抑制剂，对猪SDH表现出高效抑制活性，其中IC50值为26 nM，同时具备杀菌特性。
T37750	Benanomicin B (formate)
	Benanomicin B is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans, andP. oryzae(MICs = 1.56-50 μg/ml).1Benanomicin B inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B from an act...
T37749	Benanomicin A
	Benanomicin A is a microbial metabolite that has been found inActinomycetesand has antifungal, fungicidal, and antiviral activities.1,2It is active against a variety of mammalian and plant pathogenic fungi, includingC. albicans,T. mentagrophytes,C. neoformans,P. oryzae, andA. niger(MICs = 3.13-50 μg/ml).1Benanomicin A inhibits HIV-1 viral infection in MT-4 cells in a concentration-dependent manner.2 1.Takeuchi, T., Hara, T., Naganawa, H., et al.New antifungal antibiotics, benanomicins A and B fr...
T79759	Antifungal agent 74
	Antifungalagent 74 (compound 3c) 是一种高效抗真菌化合物，展现出对C. arachidicola和R. solani的显著杀菌效果。其机制主要通过破坏真核生物的类固醇生物合成及核糖体生物发生来实现。
T79270	TMV-IN-6
	TMV-IN-6（Compound 4g）是抗病毒和杀真菌剂，其作用机制为结合烟草花叶病毒（TMV）CP，从而抑制病毒组装，并干扰TMVCP与RNA的组装过程。
T68562	FTR-1335
	FTR1335 is a CaNMT inhibitor (IC50 = 0.49 nM) with good fungal selectivity. CaNMT inhibitors are fungicidal and show antifungal activity against Candida (especially fluconazole-resistant strains). They function by inhibiting N-myristoyltransferase (NMT), which catalyzes the transfer of a C14 fatty acif from myristoyl-CoA to the N-terminal of glycine in many fungal proteins. Without this process, fungi can die. This process also occurs in humans, and as such selectivity is an important characteri...
T64263	HSP90-IN-9
	HSP90-IN-9 是一种选择性的、有效的 HSP90 抑制剂。HSP90-IN-9 以剂量依赖性地表现出杀真菌效果。HSP90-IN-9 联合 FLC 用药，可以抑制真菌生物膜形成和真菌形态变化。HSP90-IN-9 能够下调 ERG11、CDR1 和 CDR2 基因表达，恢复 FLC 的耐药性。
T35453	β-Defensin-4 (human) (trifluoroacetate salt)
	β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts. It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils. β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes. It also stimulates calcium mobilization, migration, and pro...
T37674	Aspyrone
	Aspyrone is a polyketide fungal metabolite that has been found inAspergillusand has diverse biological activities.1,2It is active against a panel of 13 fungi when used at a concentration of 20 μg/ml and a panel of 21 bacteria in a disc assay when used at a concentration of 100 μg per disc.1Aspyrone (10-1,000 mg/L) is nematocidal againstP. penetrans.2 1.Torres, M., Balcells, M., Sala, N., et al.Bactericidal and fungicidal activity of Aspergillus ochraceus metabolites and some derivativesPestic. S...
T35904	O-11
	O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface gl...

化合物

Cat.No: T0202

Synonym: Dibenzthione,舒苯汀

Target: Antifungal

Cat.No: T0776

Synonym: ENT 38,吩噻嗪

Target: Dopamine Receptor, Antibacterial, Antibiotic, Antifungal

Cat.No: T64346

Synonym: Quaternium 12

Target: Antibacterial

Cat.No: T7533

Target: Apoptosis, Others, Antibacterial, Antibiotic

Cat.No: T0328

Synonym: NSC-17764,海克替啶

Target: Antibacterial, Antifungal

Naftifine hydrochloride

Cat.No: T1543

Synonym: Naftifungin,盐酸萘替芬,Naftifine HCl,Naftin,Exoderil

Target: Hedgehog/Smoothened, Antibiotic, Antifungal

Cat.No: T26087

Antifungal agent 62

Cat.No: T83071

Cat.No: T78891

Cat.No: T70383

Cat.No: T39143

Cat.No: T37349

Antibacterial agent 157

Cat.No: T78900

Antifungal agent 63

Cat.No: T83070

Antifungal agent 65

Cat.No: T79522

Antifungal agent 64

Cat.No: T79521

Antimicrobial agent-24

Cat.No: T79595

Antifungal agent 47

Cat.No: T74772

Cat.No: T76065

Ibrexafungerp citrate

Cat.No: T70029

Antibacterial agent 149

Cat.No: T79309

Sphinganine (d17:0)

Cat.No: T36437

Synonym: Sphinganine (d17:0)

Omiganan-FITC TFA

Cat.No: T76065L

Cat.No: TP1741

Cat.No: T79765

Cat.No: T78890

Benanomicin B (formate)

Cat.No: T37750

Cat.No: T37749

Antifungal agent 74

Cat.No: T79759

Cat.No: T79270

Cat.No: T68562

Cat.No: T64263

β-Defensin-4 (human) (trifluoroacetate salt)

Cat.No: T35453

Cat.No: T37674

Cat.No: T35904

Cat. No.	Product Name	Target	Signaling Pathways
TN1114	Carabrone	Antibacterial; Antifection	Microbiology/Virology
	Carabrone 是分离自Carpesium abrotanoides 果实的一种倍半萜，表现出显著抗肿瘤活性和抗菌活性，如灰霉病菌Botrytis cinerea，炭疽病菌Colletotrichum lagenarium 和禾白粉菌Erysiphe graminis。
TN2080	Pinoresinol 松脂酚，松脂素,(+)-Pinoresinol	Apoptosis; NF-κB; CDK; p53	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Pinoresinol ((+)-Pinoresinol) 是一种植物来源的木质素，具有抗炎、保肝和杀真菌活性。它导致 CDK 抑制剂 p21(WAF1/Cip1) 在 mRNA 和蛋白质水平上调，抑制 NF-kappaB 和激活蛋白 1 。
TN1853	Lariciresinol (+)-落叶松树脂醇	VEGFR; Antifection	Angiogenesis; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Lariciresinol 是一种肠木脂素前体，它通过破坏真菌质膜具有杀真菌活性，并具有作为治疗人类真菌感染性疾病的新型抗真菌剂的治疗潜力。膳食 lariciresinol 可以减缓乳腺肿瘤的生长并降低人 MCF-7 乳腺癌异种移植物和致癌物诱导的大鼠乳腺肿瘤的血管密度。
TN1163	2'-Hydroxychalcone	Others	Others
	2'-Hydroxychalcone 是一种药物合成中间体，可用于合成黄酮类化合物。负载在纳米乳液中的2'-Hydroxychalcone 在Danio rerio 模型对副球孢子菌显示出杀真菌活性。2'-Hydroxychalcone 通过负载脂质的Hepg2细胞中的氧化应激诱导细胞毒性。2'-Hydroxychalcone 抑制通过逆转录聚合酶链反应确定的肿瘤坏死因子-α诱导ICAM-1，VCAM-1和E-选择素的稳态转录水平，因此可能会干扰其基因的转录。
T25926	Pecilocin NSC-291839,NSC291839,Supral,Pecilocinum,NSC 291839
	Pecilocin is a fungicidal antibiotic generated by Paecilomyces varioti Bainier var. antibioticus.
T40200	5-epi-Jinkoheremol
	5-epi-Jinkoheremol exhibits more potent fungicidal activity than validamycin.
T73401	Debneyol
	Debneyol 具有比 validamycin 更强的杀真菌活性。
TN5264	Xanthoxyletin	TNF; NOS; ROS; COX; Antifection	Apoptosis; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory effect on iNOS protein expression at 10 microM, it also can inhibit the synthesis of nitric oxide and the protein expression of tumor necrosis factor-alpha and cyclooxygenase-2. Xanthoxyletin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells, the effects are associated with the DNA damage, apoptosis thro...
T72916	Justicidin B 爵床脂素B
	Justicidin B是一种高效的抗癌木脂素及促凋亡剂，同时具备显著的骨吸收抑制作用，并展现出强大的抗病毒、杀真菌和抗原虫能力。此外，Justicidin B能显着抑制血小板聚集。
TN3708	Coronarin D	BCL; c-Myc; TNF; NF-κB; Caspase; COX; Antifection	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i
T35741	Gliovirin
	Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease...

天然产物

Cat.No: TN1114

Target: Antibacterial, Antifection

Cat.No: TN2080

Synonym: 松脂酚，松脂素,(+)-Pinoresinol

Target: Apoptosis, NF-κB, CDK, p53

Cat.No: TN1853

Synonym: (+)-落叶松树脂醇

Target: VEGFR, Antifection

2'-Hydroxychalcone

Cat.No: TN1163

Target: Others

Cat.No: T25926

Synonym: NSC-291839,NSC291839,Supral,Pecilocinum,NSC 291839

5-epi-Jinkoheremol

Cat.No: T40200

Cat.No: T73401

Cat.No: TN5264

Target: TNF, NOS, ROS, COX, Antifection

Cat.No: T72916

Synonym: 爵床脂素B

Cat.No: TN3708

Target: BCL, c-Myc, TNF, NF-κB, Caspase, COX, Antifection

Cat.No: T35741

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