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Search Results for " catecholamine "

33

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20700	Racemetirosine	Others	Others
	Racemetirosine 是一种酪氨酸 3-单加氧酶抑制剂，因此会抑制儿茶酚胺的合成。
T22368	Metyrosine 甲酪氨酸,α-Methyltyrosine	COX	Immunology/Inflammation; Neuroscience
	Metyrosine (α-Methyltyrosine) 是一种选择性酪氨酸羟化酶抑制剂，可显著抑制高 COX-2 活性和有效控制血压，具有抗炎和抗溃疡作用。
T2568L	Felypressin acetate 2-(L-Phenylalanine)-8-L-lysinevasopressin,醋酸苯赖加压素,PLV2. H-Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond),PLV 2,PLV-2	Vasopressin Receptor	GPCR/G Protein
	Felypressin acetate (PLV-2) 是加压素 1 的激动剂，作用于所有精氨酸加压素受体 1AS。 Felypressin acetate 可用于牙科手术。
T2568	Felypressin Octapressin,Felypressin Acetate,PLV-2,H-[Cys-Phe-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2,苯赖加压素	Vasopressin Receptor	GPCR/G Protein
	Felypressin (Octapressin) 是一种加压素 1 激动剂，也是血管收缩剂，可用于牙科手术中。
T26363L	Napitane A75200,A-75200,A 75200,ABT 200	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	napitane（A 75200）是一种新型儿茶酚胺摄取抑制剂，对α-肾上腺素能受体具有抑制作用且具有潜在的抗抑郁活性，可用于研究抑郁症。
T19345	GP2-114	Others	Others
	GP2-114 是一种儿茶酚胺运动模拟剂，可用于研究冠状动脉疾病（CAD）。
TP2058L	Catestatin acetate Catestatin acetate(142211-96-9 free base)	Endogenous Metabolite; AChR	Metabolism; Neuroscience
	Catestatin acetate 是 nAChR 的非竞争性拮抗剂，可抑制儿茶酚胺的释放。 Catestatin acetate 调节心脏功能和血压。
T6464	Detomidine hydrochloride 盐酸地托咪定,MPV-253 AII,Domosedan,Detomidine HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Detomidine hydrochloride (MPV-253 AII) 是咪唑衍生物，是有效的 α2-肾上腺素能 (α2-adrenergic) 激动剂，可用于促进安定、缓解疼痛的研究。
TP1618L	PACAP-38 (31-38), human, mouse, rat acetate PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base)	PACAP	GPCR/G Protein
	PACAP-38 (31-38), human, mouse, rat acetate 是 PAC1 受体的激活剂。PACAP-38 (31-38), human, mouse, rat acetate 对交感神经元 NPY 和儿茶酚胺的产生具有强效、有效和持续的刺激作用，可用于神经营养和神经保护研究。
T37424	CAY10781 CAY10781	Others	Others
	CAY10781 是一种神经纤毛蛋白-1 (NRP-1) 和 VEGF-A.1 之间蛋白质-蛋白质相互作用的抑制剂。当使用浓度为 12.5 μM 时，它可抑制 43% 的相互作用。当以相同浓度使用时，CAY10781 还抑制 VEGF-A 诱导的儿茶酚胺 A 分化 (CAD) 细胞中 VEGFR2 的磷酸化。
TP2158	TRV-120027 TFA TRV-120027 TFA (1234510-46-3 free base)	RAAS; Arrestin	Endocrinology/Hormones; GPCR/G Protein
	TRV-120027 TFA 是一种血管紧张素 II 介导的血管收缩抑制剂，可增加心肌细胞的收缩力。它是一种偏向 β-arrestin-1 的 AT1R 激动剂，可与 ß-arrestins 结合，同时阻断 G 蛋白信号传导。它通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌，并促进在质膜上形成由 AT1R-β-arrestin-1-TRPC3-PLCγ 组成的大分子复合物。
T30630	Butopamine
	Butopamine differs from dobutamine in location of only one hydroxyl group, but is no longer a catecholamine.
T30119	Arbutamine hydrochloride
	Arbutamine hydrochloride is a catecholamine which acts as a cardiac stimulant.
T38610	Pirepemat IRL752
	Pirepemat (IRL752) is a cortical-preferring catecholamine agent that enhances cognition. It is utilized in the investigation of Parkinson's disease.
T26419	A 53693 A-53693,A53693
	A 53693 is a rigid catecholamine and a selective adrenergic agonist. A 53693 has affinity to certain alpha receptor subtypes in rat alpha-2 receptors.
TP1619	PACAP-38 (16-38), human, mouse, rat
	PACAP-38 (16-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production.
T31570	DPBX-L-Dopa DPBX L-Dopa
	DPBX-L-Dopa is a boron-containing dopa-derivative, acting as a bladder relaxant through non-catecholamine receptors.
TP1618	PACAP-38 (31-38), human, mouse, rat
	PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production.
T24659	Prenylamine lactate Agozol,Angormin
	Prenylamine lactate is a drug formerly used in the treatment of angina pectoris. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity.
T80503	Proadrenomedullin (N-20) (bovine, porcine) ProADM N20(bovine, porcine),PAMP-20(bovine, porcine)
	Proadrenomedullin (N-20) (bovine, porcine) 是一种来源于嗜铬细胞的、具有降压及抑制 catecholamine release 的非竞争性肽类。该化合物能显著抑制 PC12 嗜铬细胞瘤细胞的 catecholamine 分泌，显示出 350 nM 的 IC50 值。此外，Proadrenomedullin (N-20) (bovine, porcine) 作为 EC50 约为 270 nM 的阻断剂，能够有效抵抗烟碱能激动剂引起的 catecholamine release 脱敏现象和烟碱相关的信号通道 (22Na+摄取)。
TP1490	Proadrenomedullin (1-20), human
	Endogenous peptide agonist of Mas related GPR X2 (MRGPRX2, EC50 = 251 nM). Also a noncompetitive nicotinic cholinergic antagonist. Inhibits nicotine-stimulated catecholamine secretion from PC12 cells in vitro, and from sympathetic nerve endings and adrena
TP2058	Catestatin
	Non-competitive nicotinic cholinergic antagonist; selectively inhibits nicotinic-stimulated catecholamine secretion from chromaffin cells and noradrenergic neurons (IC50 ~ 200 nM). Blocks nicotinic-induced cationic signaling (IC50 ~ 200 - 250 nM) and inhi
T10200	9-Hydroxyellipticine hydrochloride	Others	Others
	9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. It exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride inihibits Hela S-3 and 293T cells (IC50s: 1.6 μM and 1.2μM).
T20396	Levadopa Related Compound A 6-Hydroxydopa, L-,L-Hydroxydopa
	Levadopa Related Compound A is the 6-hydroxy derivative of the amino acid L-DOPA with neurotoxic properties. Exogenously administered 6-Hydroxy-L-DOPA is biotransformed by an amino acid decarboxylase to the highly potent and catecholamine-selective neurot
T60950	Pirepemat fumarate
	Pirepemat (IRL752) fumarate 可用于研究帕金森病。Pireemat fumarate 是一种偏向皮质的儿茶酚胺传递剂和认知促进剂。
T80080	PAMP-12 (unmodified) (TFA)
	PAMP-12 (unmodified) TFA 作为MRGPRX2 (MrgX2)激动剂，展现出高效性（EC50=20-50 nM）。该化合物为内源性肽，能够通过抑制交感神经末梢及肾上腺嗜铬细胞中的儿茶酚胺释放来诱发低血压。
T60677	Dobutamine
	Dobutamine 是合成儿茶酚胺，可增加心排血量，矫正低灌注。Dobutamine 作用于α1-AR,β1-AR 和β2-AR（α-1、β-1和β-2肾上腺素能受体），是 β1-AR 受体的选择性激动剂，对 α1-AR 和 β2-AR 活性相对较弱。
T78027	PAMP-12 (unmodified)
	PAMP-12 (unmodified)为有效的MRGPRX2 (MrgX2)激动剂，其EC50值为20-50 nM。作为内源性肽，它能够通过抑制交感神经末梢和肾上腺嗜铬细胞的儿茶酚胺分泌来引发低血压。
T60344	L-Cytidine
	L-Cytidine 是Cytidine 的 L-构型形式。L-Cytidine 是一种嘧啶核苷，是RNA 的组成部分。Cytidine 可控制神经胶质谷氨酸循环，影响脑磷脂代谢，儿茶酚胺的合成和线粒体功能。
T75878	Catestatin TFA
	Catestatin TFA，一个含有21个氨基酸残基、阳离子性疏水性肽，作为内源性肽，调节心脏功能及血压。它通过烟碱型乙酰胆碱受体(nAChRs)以非竞争性方式抑制儿茶酚胺释放，功能为烟碱类拮抗剂。
T80069	PACAP (6-27) (human, ovine, rat) Pituitary adenylate cyclase-activating peptide (6-27)
	PACAP (6-27) (human, ovine, rat) 是一种对PACAP受体具有拮抗作用的化合物，可以抑制犬肾上腺对外源性VIP的反应。此化合物在心血管疾病和神经系统疾病研究中展现出应用潜力。
T36384	DL-Tyrosine-13C9,15N L-Tyrosine-13C9,15N
	L-Tyrosine-13C9,15N is intended for use as an internal standard for the quantification of L-tyrosine by GC- or LC-MS. L-Tyrosine is a non-essential amino acid.1It is produced by hydroxylation of phenylalanine by phenylalanine hydroxylase but can also be obtained from dietary sources or degradation of endogenous proteins, resulting in L-tyrosine release.1,2L-Tyrosine is a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones.3Plasma, skeletal muscle, and...
T83697	PAMP-12 (human, mouse, rat, porcine, bovine) TFA Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)
	Proadrenomedullin N-terminal 12 peptide (PAMP-12) 是一种内源性肽段，源自人体肾上腺髓质，对应人类PAMP-20的9-20氨基酸，涉及降低血压。它是MAS相关G蛋白偶联受体家族成员X2 (MRGPRX2) 的激动剂。在表达人MRGPRX2的CHO细胞中，PAMP-12抑制forskolin诱导的cAMP积累（EC50 = 57.2 nM），特异性诱导表达MRGPRX2的CHO细胞的钙离子动员（EC50 = 41 nM），而在表达MRGPRX1、MRGPRX3或MRGPRX4的细胞中则无此效应（在1 µM浓度下）。PAMP-12还能作为烟碱型乙酰胆碱受体（nAChRs）的拮抗剂，抑制carbachol诱导的儿茶酚胺释放（IC50 = 1.3 µM）及钙和钠的流入（IC50分别为0.39 µM和0.87 µM），但不抑制组胺诱导的儿茶酚胺释放或钙和钠的流入（IC50 >1 µM），在初级牛肾上腺嗜铬细胞中有此表现。当以10至50 nmol/kg剂量给予正常血压大鼠时，PAMP-12能降低平均动脉血压。

化合物

Cat.No: T20700

Target: Others

Cat.No: T22368

Synonym: 甲酪氨酸,α-Methyltyrosine

Target: COX

Felypressin acetate

Cat.No: T2568L

Synonym: 2-(L-Phenylalanine)-8-L-lysinevasopressin,醋酸苯赖加压素,PLV2. H-Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond),PLV 2,PLV-2

Target: Vasopressin Receptor

Cat.No: T2568

Synonym: Octapressin,Felypressin Acetate,PLV-2,H-[Cys-Phe-Phe-Gln-Asn-Cys]-Pro-Lys-Gly-NH2,苯赖加压素

Target: Vasopressin Receptor

Cat.No: T26363L

Synonym: A75200,A-75200,A 75200,ABT 200

Target: Adrenergic Receptor

Cat.No: T19345

Target: Others

Catestatin acetate

Cat.No: TP2058L

Synonym: Catestatin acetate(142211-96-9 free base)

Target: Endogenous Metabolite, AChR

Detomidine hydrochloride

Cat.No: T6464

Synonym: 盐酸地托咪定,MPV-253 AII,Domosedan,Detomidine HCl

Target: Adrenergic Receptor

PACAP-38 (31-38), human, mouse, rat acetate

Cat.No: TP1618L

Synonym: PACAP-38 (31-38), human, mouse, rat acetate(138764-85-9 Free base)

Target: PACAP

Cat.No: T37424

Synonym: CAY10781

Target: Others

Cat.No: TP2158

Synonym: TRV-120027 TFA (1234510-46-3 free base)

Target: RAAS, Arrestin

Cat.No: T30630

Arbutamine hydrochloride

Cat.No: T30119

Cat.No: T38610

Synonym: IRL752

Cat.No: T26419

Synonym: A-53693,A53693

PACAP-38 (16-38), human, mouse, rat

Cat.No: TP1619

Cat.No: T31570

Synonym: DPBX L-Dopa

PACAP-38 (31-38), human, mouse, rat

Cat.No: TP1618

Prenylamine lactate

Cat.No: T24659

Synonym: Agozol,Angormin

Proadrenomedullin (N-20) (bovine, porcine)

Cat.No: T80503

Synonym: ProADM N20(bovine, porcine),PAMP-20(bovine, porcine)

Proadrenomedullin (1-20), human

Cat.No: TP1490

Cat.No: TP2058

9-Hydroxyellipticine hydrochloride

Cat.No: T10200

Target: Others

Levadopa Related Compound A

Cat.No: T20396

Synonym: 6-Hydroxydopa, L-,L-Hydroxydopa

Pirepemat fumarate

Cat.No: T60950

PAMP-12 (unmodified) (TFA)

Cat.No: T80080

Cat.No: T60677

PAMP-12 (unmodified)

Cat.No: T78027

Cat.No: T60344

Cat.No: T75878

PACAP (6-27) (human, ovine, rat)

Cat.No: T80069

Synonym: Pituitary adenylate cyclase-activating peptide (6-27)

DL-Tyrosine-13C9,15N

Cat.No: T36384

Synonym: L-Tyrosine-13C9,15N

PAMP-12 (human, mouse, rat, porcine, bovine) TFA

Cat.No: T83697

Synonym: Proadrenomedullin N-terminal 12 Peptide,PAMP (9-20)

Cat. No.	Product Name	Target	Signaling Pathways
T1644	Dopamine hydrochloride 盐酸多巴胺,Dopamine HCl,ASL279	Ferroptosis; Dopamine Receptor; 5-HT Receptor; Endogenous Metabolite	Apoptosis; GPCR/G Protein; Metabolism; Neuroscience
	Dopamine hydrochloride (ASL279) 是在脑黑质、脑腹侧被盖区和下丘脑中产生的一种天然儿茶酚胺，由二羟基苯丙氨酸脱羧形成，是去甲肾上腺素和肾上腺素的前体。它通过 D2 多巴胺受体来诱导 VEGFR2 的内吞作用，有促进血管生成活性。
T8149	Dobutamine hydrochloride 盐酸多巴酚丁胺,Dobutamine (hydrochloride)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Dobutamine hydrochloride (Dobutamine(hydrochloride)) 是一种合成的儿茶酚胺，可作用于肾上腺素能受体α1-AR、β1-AR 和β2-AR，是一种选择性的 β1-AR 受体激动剂，对 α1-AR 和 β2-AR 作用相对较弱。它能够增加心输出量，矫正低灌注。
T0611	Vanillylmandelic acid 4-Hydroxy-3-methoxymandelic acid,3-甲氧基-4-羟基扁桃酸	Others	Others
	Vanillylmandelic acid (4-Hydroxy-3-methoxymandelic acid) 是儿茶酚胺、肾上腺素和去甲肾上腺素代谢的最终产物，常用于帮助诊断嗜铬细胞瘤，以及其升高与抑郁症状有关。
T40158	N-acetyldopamine NADA,N-乙酰多巴胺
	N-acetyldopamine (NADA) is a catecholamine utilized by insects as a precursor for sclerotization, a process that strengthens their cuticle.
T19600	Vanilpyruvic acid Vanylpyruvic acid	Others	Others
	Vanilpyruvic acid is a metabolite of catecholamine and precursor of vanillactic acid.
TN4882	Quinine HCl 奎宁树	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Quinine HCl produces alpha-adrenergic blockade. Quinine modifies catecholamine- and calcium-induced myocardial contractile force responses.

天然产物

Dopamine hydrochloride

Cat.No: T1644

Synonym: 盐酸多巴胺,Dopamine HCl,ASL279

Target: Ferroptosis, Dopamine Receptor, 5-HT Receptor, Endogenous Metabolite

Dobutamine hydrochloride

Cat.No: T8149

Synonym: 盐酸多巴酚丁胺,Dobutamine (hydrochloride)

Target: Adrenergic Receptor

Vanillylmandelic acid

Cat.No: T0611

Synonym: 4-Hydroxy-3-methoxymandelic acid,3-甲氧基-4-羟基扁桃酸

Target: Others

N-acetyldopamine

Cat.No: T40158

Synonym: NADA,N-乙酰多巴胺

Vanilpyruvic acid

Cat.No: T19600

Synonym: Vanylpyruvic acid

Target: Others

Cat.No: TN4882

Synonym: 奎宁树

Target: Adrenergic Receptor

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