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34

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0488	Finasteride 非那雄胺,MK-906	Reductase	Endocrinology/Hormones; Metabolism
	Finasteride (MK-906) 是 5α-还原酶的竞争性抑制剂，对 II 型 5α-还原酶的IC50为 4.2 nM，对 II 型 5α-还原酶的亲和力是 I 型酶的 100 倍。它可用于研究前列腺增生和雄激素性脱发。
T0197	Terazosin hydrochloride 盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Terazosin hydrochloride (Hytrin) 是一种竞争性和口服活性的 α1-肾上腺素受体拮抗剂，是一种喹唑啉衍生物。它通过舒张血管和打开膀胱来起作用。它可用于良性前列腺增生和高血压的研究。
T1504	Silodosin 西洛多辛,KAD 3213,KMD 3213	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Silodosin (KAD 3213) 是有选择性的、强效的、口服活性的 α1A-adrenergic receptor 阻滞剂，是一种有效且耐受性良好的试剂，可用于研究 LUTS/BPH。它对 α1A-AR 表现出高度的亲和力，是 α1B-AR 和 α1D-AR 亲和力的 162 和 50 倍。
T6461	Dapoxetine hydrochloride LY-210448,LY-210448 hydrochloride,Dapoxetine HCl,盐酸达泊西汀,Priligy	5-HT Receptor; Serotonin Transporter	GPCR/G Protein; Neuroscience
	Dapoxetine hydrochloride (LY-210448 hydrochloride) 是一种具有口服活性的、选择性的血清素再摄取 (serotonin reuptake) 抑制剂 (SSRI)，可用于研究早泄 (PE) 。
T6701	Terazosin hydrochloride dihydrate Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate,盐酸特拉唑嗪(二水合物)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Terazosin hydrochloride dihydrate (Heitrin dihydrate) 是一种竞争性和口服活性的 α1-肾上腺素受体(α1-adrenoceptor) 拮抗剂，是一种喹唑啉衍生物，通过舒张血管和打开膀胱的方式起作用。它可用于研究良性前列腺增生 (BPH) 和高血压。
T0039	Dapoxetine 达波西汀,Dapoxetina,Dapoxetinum	Others; 5-HT Receptor	GPCR/G Protein; Neuroscience; Others
	Dapoxetine (Dapoxetina) 是一种选择性5-羟色胺再摄取抑制剂，用于治疗早泄。
T13703	Gestonorone Capronate	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Gestonorone Capronate 是一种孕激素，在良性前列腺肥大和子宫内膜癌领域有研究价值。
T14843	Bifluranol BX341	Androgen Receptor	Endocrinology/Hormones
	Bifluranol (BX341) 具有抗雄激素活性，在体内实验中显示出显著的抗前列腺活性，可用于治疗良性前列腺增生（BPH）。
T22316	Doxazosin UK 33274,多沙唑嗪	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Doxazosin (UK 33274) 是选择性的拮抗突触后的α1肾上腺素受体。
T27798	Lapisteride CS891B,CS-891,CS-891B,CS891	Others	Others
	Lapisteride (CS-891) 一种类固醇5α-还原酶抑制剂，可用于治疗良性前列腺增生(BPH)和雄激素性脱发，可有效预防或治疗AGA 。
T28922	Taprizosin Taprizosin Mesylate,UK-338003,UK-338,003,UK338003,UK 338003	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Taprizosin（UK-338003）是一种具有选择性和口服活性的 α1-肾上腺素受体 (α1-adrenoceptor) 拮抗剂，可用于舒张血管，用于治疗良性前列腺增生症。
T15688	L-771688 SNAP 6383	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L-771688（SNAP 6383）是一种新型有效和选择性的 α1A-肾上腺素受体拮抗剂， Ki 值为 0.43±0.02 nM。L-771688 KE 用于治疗良性前列腺增生。
T1499	Dutasteride GG 745,Avodart,度他雄胺,GI 198745	Apoptosis; Reductase	Apoptosis; Endocrinology/Hormones; Metabolism
	Dutasteride (GI 198745) 是一种 5α 还原酶同工酶抑制剂，还可能因其结构域 DHT 相似对雄激素受体产生脱靶效应。
T83965	Tamsolusin Hydrochloride YM 12617,LY-253352	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tamsolusin Hydrochloride (YM 12617) 是一种高选择性α-1A肾上腺素受体拮抗剂，可用于治疗良性前列腺肥大。
T0091	Alfuzosin hydrochloride SL 77499-10,Alfuzosin HCl,盐酸阿夫唑嗪	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Alfuzosin hydrochloride (Alfuzosin HCl) 是一种 α1 肾上腺素受体拮抗剂，可用于良性前列腺增生(BPH)的研究。
T35182	Xinidamine BRN 0891979,Xinidaminum,Xinidamino
	Xinidamine (BRN 0891979) 具有抗肿瘤活性，可用于研究良性前列腺增生、黄斑变性和前列腺上皮内瘤。Xinidamine 对PWR-1E 细胞的增殖具有抑制作用，IC50为4μM。
T11286	Fiduxosin A 185980.1,ABT 980	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Fiduxosin 是一种具有选择性和有效性的 α1-adrenoceptor 拮抗剂，对 α1a-adrenoceptor，α1b-adrenoceptor 和 α1d-adrenoceptor 有抑制作用，Ki 值分别为 0.160 nM，24.9 nM 和 0.920 nM。Fiduxosin 可用于治疗良性前列腺增生。
T0210L	Tamsulosin LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tamsulosin ((R)-(-)-YM12617 free base) 是一种肾上腺素能受体α 1A 拮抗剂，用于良性前列腺增生(BPH)的治疗。Tansulosin 用于治疗排尿困难，这是前列腺肥大的一种常见症状。Tansulosin 和其他被称为α受体阻滞剂的药物通过放松膀胱颈部肌肉和前列腺本身的肌肉纤维来发挥作用，使其更容易排尿。
T22232	Alfuzosin
	Alfuzosin 是选择性和竞争性的α1肾上腺素受体拮抗剂，可用于良性前列腺增生（BPH）的研究。
T28956	TF-505 FR-146687,FK-687,TF 505,FK687
	TF-505, a steroid 5α-reductase inhibitor, is used potentially for the treatment of benign prostatic hyperplasia.
T33069	Lysinenorleucine Lys-nle
	Lysinenorleucine s a Lysine and hydroxylysine derivatives that can be used for the treatment of malignant and benign tumors.
T70396	Fexapotide triflutate
	Fexapotide triflutate is a caspase and TNF signaling pathway activator used to treat benign prostatic hyperplasia (BPH).
T20024	Tadalafil, (6R ,12aS)- Tadalafil (6R ,12aS)- Lilly,Tadalafil specified impurity A,(-)-Tadalafil (6R ,12aS) diastereomer
	Tadalafil is a carboline derivative and Phosphodiesterase 5 Inhibitor. It is used primarily to treat Erectile dysfunction, Benign Prostatic Hyperplasia, and Primary Pulmonary Hypertension.
T32029	GYKI-16084 GYKI 16084
	GYKI-16084 is a postsynaptic alpha2 receptor blocker with potential efficacy in the treatment of benign prostatic hyperplasia.
T24378	L-771688 dihydrochloride L 771688 dihydrochloride
	L-771688 is an α1A-adrenoceptor antagonist potentially for the treatment of benign prostatic hyperplasia.
T3290L	Pikamilone Sodium GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na
	Pikamilone Sodium is a prodrug of GABA used for therapy of neurogenic bladder in spinal and benign prostatic hyperplasia.
T69927	Fiduxosin hydrochloride
	Fiduxosin hydrochloride is an alpha 1a-adrenoceptor antagonist that may be useful in the treatment of Benign Prostatic Hyperplasia.
T61729	Terazosin
	Terazosin, a quinazoline derivative, is an orally active and competitive antagonist of α1-adrenoceptors. Its mechanism of action involves relaxing blood vessels and promoting bladder opening. Terazosin exhibits therapeutic potential for treating benign prostatic hyperplasia (BPH) and high blood pressure [1][2][3].
T28245	ONO-0300302 ONO 0300302
	ONO-0300302 is a slow tight binding LPA1 antagonist (IC50: 0.16 nM) used to treat Benign Prostatic Hyperplasia. ONO-0300302 inhibits significantly an LPA-induced increase of intraurethral pressure (IUP) in rat (3 mg/kg, p.o.) and dog (1 mg/kg, p.o.) over
T36859	C16 Globotriaosylceramide (d18:1/16:0) C16 Globotriaosylceramide (d18:1/16:0)
	C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien...
T76275	Fexapotide
	Fexapotide (NX-1207 free acid) 在细胞水平上通过选择性诱导细胞凋亡，降低前列腺体积。它主要用于研究下尿路症状(LUTS)与良性前列腺增生(BPH)。
T62841	Tinlorafenib
	Tinlorafenib (PF-07284890) (compound 10) 是一种口服具有活力的、具有中枢神经系统 (CNS) 渗透性的 BRAF kinase 抑制剂，能够作用于 BRAFV600E (IC50: 4.25 nM) 和 V600K (IC50: 2.7 nM)。Tinlorafenib 能够用于 BRAF 相关的中枢神经系统恶性和良性肿瘤以及颅外恶性肿瘤的研究。
T21668	Finasteride acetate
	Finasteride (MK-906) acetate 是一种高效的5α-还原酶 (5α-reductase) 竞争性抑制剂，其对 II 型 5α-还原酶的IC50值仅为 4.2 nM，其对该型酶的亲和力是对 I 型酶亲和力的约100倍。因此，Finasteride acetate 主要在良性前列腺增生症 (BPH) 和雄激素性脱发研究领域中应用。
T60935	H-Tyr-Phe-OH
	H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) 可用作区分良性甲状腺结节和甲状腺癌的生物标志物。H-Tyr-Phe-OH 是一种口服活性的血管紧张素转换酶抑制剂，在50 μM 时抑制率为 48%。H-Tyr-Phe-OH 具有黄嘌呤氧化酶抑制活性 (降低尿酸) ，可调节中性粒细胞样细胞中 IL-8 的产生。

化合物

Cat.No: T0488

Synonym: 非那雄胺,MK-906

Target: Reductase

Terazosin hydrochloride

Cat.No: T0197

Synonym: 盐酸特拉唑嗪,Terazosin HCl,Terazosine,Blavin,Hytrin,Zayasel,Fosfomic

Target: Adrenergic Receptor

Cat.No: T1504

Synonym: 西洛多辛,KAD 3213,KMD 3213

Target: Adrenergic Receptor

Dapoxetine hydrochloride

Cat.No: T6461

Synonym: LY-210448,LY-210448 hydrochloride,Dapoxetine HCl,盐酸达泊西汀,Priligy

Target: 5-HT Receptor, Serotonin Transporter

Terazosin hydrochloride dihydrate

Cat.No: T6701

Synonym: Flotrin dihydrate,Terazosin HCl Dihydrate,Dysalfa dihydrate,Heitrin dihydrate,盐酸特拉唑嗪(二水合物)

Target: Adrenergic Receptor

Cat.No: T0039

Synonym: 达波西汀,Dapoxetina,Dapoxetinum

Target: Others, 5-HT Receptor

Gestonorone Capronate

Cat.No: T13703

Target: Prostaglandin Receptor

Cat.No: T14843

Synonym: BX341

Target: Androgen Receptor

Cat.No: T22316

Synonym: UK 33274,多沙唑嗪

Target: Adrenergic Receptor

Cat.No: T27798

Synonym: CS891B,CS-891,CS-891B,CS891

Target: Others

Cat.No: T28922

Synonym: Taprizosin Mesylate,UK-338003,UK-338,003,UK338003,UK 338003

Target: Adrenergic Receptor

Cat.No: T15688

Synonym: SNAP 6383

Target: Adrenergic Receptor

Cat.No: T1499

Synonym: GG 745,Avodart,度他雄胺,GI 198745

Target: Apoptosis, Reductase

Tamsolusin Hydrochloride

Cat.No: T83965

Synonym: YM 12617,LY-253352

Target: Adrenergic Receptor

Alfuzosin hydrochloride

Cat.No: T0091

Synonym: SL 77499-10,Alfuzosin HCl,盐酸阿夫唑嗪

Target: Adrenergic Receptor

Cat.No: T35182

Synonym: BRN 0891979,Xinidaminum,Xinidamino

Cat.No: T11286

Synonym: A 185980.1,ABT 980

Target: Adrenergic Receptor

Cat.No: T0210L

Synonym: LY253351 free base,HSDB7744,(R)-(-)-YM12617 free base,Harnal-D,Flowmax,HSDB 7744,HSDB-7744

Target: Adrenergic Receptor

Cat.No: T22232

Cat.No: T28956

Synonym: FR-146687,FK-687,TF 505,FK687

Lysinenorleucine

Cat.No: T33069

Synonym: Lys-nle

Fexapotide triflutate

Cat.No: T70396

Tadalafil, (6R ,12aS)-

Cat.No: T20024

Synonym: Tadalafil (6R ,12aS)- Lilly,Tadalafil specified impurity A,(-)-Tadalafil (6R ,12aS) diastereomer

Cat.No: T32029

Synonym: GYKI 16084

L-771688 dihydrochloride

Cat.No: T24378

Synonym: L 771688 dihydrochloride

Pikamilone Sodium

Cat.No: T3290L

Synonym: GABA-NG,Nicotinoyl-GABA sodium salt,GABA NG,GABANG,Pikamilone Na

Fiduxosin hydrochloride

Cat.No: T69927

Cat.No: T61729

Cat.No: T28245

Synonym: ONO 0300302

C16 Globotriaosylceramide (d18:1/16:0)

Cat.No: T36859

Synonym: C16 Globotriaosylceramide (d18:1/16:0)

Cat.No: T76275

Cat.No: T62841

Finasteride acetate

Cat.No: T21668

Cat.No: T60935

Cat. No.	Product Name	Target	Signaling Pathways
TN3651	Cichoriin	Others	Others
	Cichoriin 对SARS-CoV-2有明显活性，是治疗重症COVID-19的潜在候选物质。
T19687	Phenylethyl isothiocyanate JC 5411,2-苯基乙基异硫代氰酸酯,JC5411,JC-5411	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Phenylethyl isothiocyanate (JC5411) 是一种 HDAC 抑制剂。它有可能用于治疗良性前列腺肥大。
TN5031	Sitostenone 豆甾-4-烯-3-酮	Others	Others
	Sitostenone 具有抗氧化活性。 Stigmasta-4-en-3-one(Sitostenone)可用于治疗雄激素依赖性疾病，尤其是治疗良性前列腺增生。
T39836	Monoethyl phthalate
	Monoethyl phthalate is a metabolite of diethyl phthalate, serving as a urinary biomarker for phthalate exposure, and indicating potential risks of thyroid cancer and benign nodules.
TN1061	Ganoderol B	Androgen Receptor	Endocrinology/Hormones
	Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of andr
TN4164	Grandifloroside	TNF	Apoptosis
	Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, suggests that it might be developed as a source of potent anti-oxidative and anti-inflammatory ag

天然产物

Cat.No: TN3651

Target: Others

Phenylethyl isothiocyanate

Cat.No: T19687

Synonym: JC 5411,2-苯基乙基异硫代氰酸酯,JC5411,JC-5411

Target: HDAC

Cat.No: TN5031

Synonym: 豆甾-4-烯-3-酮

Target: Others

Monoethyl phthalate

Cat.No: T39836

Cat.No: TN1061

Target: Androgen Receptor

Grandifloroside

Cat.No: TN4164

Target: TNF

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