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Search Results for " antispasmodic "

38

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1460	Dicyclomine hydrochloride	AChR	Neuroscience
	Dicyclomine hydrochloride 是口服活性毒蕈碱胆碱能受体拮抗剂。它是一种抗痉挛试剂，在体内可缓解胃肠道平滑肌痉挛。它对 M1 受体亚型和 M2 受体亚型，Ki 分别为5.1和54.6nM，在刷状缘膜和基底质膜中均表现出较高的亲和力。
T3034	Eprazinone dihydrochloride Resplen,Mucitux,Eftapan,NSC 317935,盐酸依普拉酮,依普拉酮二盐酸,Eprazinone 2HCl	Others; Neurokinin receptor	GPCR/G Protein; Neuroscience; Others
	Eprazinone dihydrochloride (NSC 317935) 是一种具有镇咳和粘液溶解作用的粘液溶解剂。它是神经激肽 1 受体的配体，可改善肺功能和动脉血氧分压，可用于慢性支气管炎的研究。
T0703	Flavoxate hydrochloride Flavoxate HCl,盐酸黄酮哌酯,NSC-114649,DW61,Rec-7-0040	AChR	Neuroscience
	Flavoxate hydrochloride (DW61) 是一种毒蕈碱受体 AChR 拮抗剂， IC50为 12.2 μM。
T6375	Alibendol cebera,EB 1856,阿利苯多	Others	Others
	Alibendol (cebera) 具有促胆汁分泌及抗痉挛的作用。
T3272	Metamizole magnesium Metamizolemagnesiumsalt,安乃近镁	Antibiotic	Microbiology/Virology
	Metamizole magnesium (Metamizolemagnesiumsalt) 是一种止痛药，可以解痉。
T0023	Valethamate bromide Ediposin,Epidozin,戊沙溴铵,Epidosin,Resitan	Others	Others
	Valethamate bromide (Resitan) 是快速作用的抗胆碱能解痉和肌萎缩剂，是一种酯，能够改善宫颈扩张加速分娩。
T0072	Adiphenine hydrochloride Adiphenine HCl,盐酸阿地芬宁,Spasnil,Patrovina,Sentiv	AChR	Neuroscience
	Adiphenine hydrochloride (Patrovina) 是一种烟碱样受体抑制剂，可用作解痉药，对α1、α3β4、α4β2和α4β4的IC50值分别为 1.9、1.8、3.7 和 6.3 µM。
T68853	Diproteverine HCl	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Diproteverine HCl 是具有抗心绞痛特性的新型钙拮抗剂,具有解痉活性和血管活性。
T2138	Oxyphencyclimine Hydrochloride 盐酸奥克西利平,Spazamin,Daricon,Ulcociclinina	AChR	Neuroscience
	Oxyphencyclimine Hydrochloride (Ulcociclinina) 是一种合成的叔胺和抗毒蕈碱剂，具有抗痉挛和抗分泌活性。
T2387	Glycopyrrolate Gastrodyn,Glycopyrronium bromide,Robinul,Glycopyrrolate bromide,格隆溴铵	AChR	Neuroscience
	Glycopyrrolate (Glycopyrrolate bromide) 是一种毒蕈碱拮抗剂，在某些胃肠道疾病中用作解痉剂，并与某些麻醉剂一起减少唾液分泌。
T7603	Pinaverium bromide	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Pinaverium bromide 是一种具有解痉作用的钙通道阻滞剂，可有效缓解疼痛、腹泻和肠道不适。
T1472	Trospium chloride Spasmex,Sanctura,曲司氯铵,曲司氯胺	AChR	Neuroscience
	Trospium chloride (Spasmex) 是一种可口服的特异竞争性毒蕈碱胆碱能受体拮抗剂，可与毒蕈碱受体 M1、M2 和 M3 高亲和力结合，具有抗毒蕈碱活性。
T1475	Fesoterodine fumarate Toviaz,SPM 907,富马酸非索罗定	AChR	Neuroscience
	Fesoterodine fumarate (Toviaz) 是可口服的，非亚型选择性的竞争性毒蕈碱受体拮抗剂，用于膀胱过度活动症，对 M1、M2、M3、M4 和 M5 受体的pKi 值分别为 8.0、7.7、7.4、7.3 和 7.5。
T0786	Clidinium bromide 克利溴铵,Ro 2-3773	AChR	Neuroscience
	Clidinium bromide (Ro 2-3773) 是季胺抗毒蕈碱剂，可通过减少胃酸和减慢肠道速度，缓解痉挛和腹部疼痛的症状。
T68599	Orphenadrine Orphenadrine (free base)	Sodium Channel; NMDAR; AChR	Membrane transporter/Ion channel; Neuroscience
	Orphenadrine 是一种非竞争性的 N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，以浓度依赖性方式抑制克隆的 HERG 通道，在 HEK 细胞中产生0.85μM 的 IC。Orphenadrine 是中枢和外周毒蕈碱受体的拮抗剂，通过孔残基 Y652或 F656突变阻断衰减。 Orphenadrine 具有抗痉挛、镇痛和抗胆碱能活性，对在体外和体内对谷氨酸神经毒性具有保护作用。Orphenadrine 对钠离子通道具有抑制作用，可用来治疗帕金森。
T26614	Ambucetamide Bersen,Meritin,Dibutamid
	Ambucetamide is an antispasmodic, it may inhibit or diminish the spontaneous rhythmical activity of the human myometrium.
T69234	Piperilate HCl
	Piperilate HCl is an antispasmodic, antimuscarinic agent. It is a muscarinic cholinergic receptor antagonist.
T0346L	Camylofin Hydrochloride Camylofin HCl,Acamylophenine hydrochloride,Acamylophenine HCl,Belosin,Avocan
	Camylofin HCl is an antispasmodic used in labor treatment and is also used to deliver drug therapy for ulcerative colinitis.
T25189	Butopiprine Butopiprinum
	Butopiprine 是一种镇咳药，具有解痉、局部麻醉和镇咳活性。
T23829	Btm 1042 Btm1042,Btm-1042
	Btm 1042 is an antispasmodic drug. It has been found to depress twitch responses in the ileum of guinea pigs.
T24517	Nafiverine UNII-WLT400RC9Q,Nafiverina,Nafiverinum,EINECS 225-766-5
	Nafiverine is a new antispasmodic. The effectiveness of an intramuscular administration of nafiverine was comparable to that of an intravenous administration.
T24887	Tiropramide CR-605
	Tiropramide is an antispasmodic drug. It also useful to inhibit the contractile response of the urinary bladder and in managing abdominal pain in IBS.
T25339	Dipiproverine
	Dipiproverine 是α-氨基酸酯类化合物，是一种解痉化合物。它被用作抗胆碱能药物。
T21050	Pridinol
	Pridinol is an antispasmodic and muscle relaxant.
T24443	Medazomide Medazomidum,L 1777,L1777,L-1777
	Medazomide is a antispasmodic drug.
T62889	Fenoverine
	Fenoverine 是一种抗痉挛药物，对钙通道电流表现出抑制作用，可以引发横纹肌溶解。
T71236	Oxybutynin R-isomer HCl
	Oxybutynin R-isomer , also known as Aroxybutynin, is a muscarinic receptor antagonist. Aroxybutynin is the optically avtice inhibitor of proliferation and supresses gene expression in bladder smooth muscle cells. Oxybutynin exerts direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. It exhibits one-fifth of the anticholinergic activity of atropine on the rabbit detrusor muscle, but four to ten times the antispasmodic activity. No blo...
T25325	Dicyclonon LAB 145-138H,BAS 145-138
	Dicyclonon is a muscarinic antagonist utilized as an antispasmodic and in urinary incontinence. It has little effect on glandular secretion or the cardiovascular system. It has some local anesthetic properties and is utilized in biliary, gastrointestinal,
T28883	Sultroponium A118,A-118,A 118
	Sultroponium may be used as an anticholinergic agent or antispasmodic.
T61309	(R)-Oxybutynin
	(R)-Oxybutynin (Aroxybutynin) is an orally active muscarinic receptor antagonist, which exhibits antimuscarinic, antispasmodic, and anticholinergic activity. This compound, being the (R)-isomer of Oxybutynin, competitively antagonizes Carbachol-induced contractions. It is particularly useful in researching neurogenic bladder dysfunction-related incontinence [1] [2] [3].
T23918	Cularine
	Cularine is an isoquinoline alkaloid from the Fumariaceae family. It displays non-specific antispasmodic activity on guinea-pig and human airways.
T69150	Anisodine
	Anisodine, also known as Daturamine, is an antispasmodic and anticholinergic drug used in the treatment of acute circulatory shock. Anisodine acts as a muscarinic acetylcholine receptor antagonist and α1-adrenergic receptor agonist.
T25339L	Dipiproverine hydrochloride L.D. 935,LD 935
	Dipiproverine 是 Dipiproverine 的盐酸盐形式。Dipiproverine 是α-氨基酸酯类化合物，一种解痉化合物，它被用作抗胆碱能药物。
T60577	Cycrimine
	Cycrimine 是毒蕈碱胆碱能受体(mAChR)M1的口服活性拮抗剂，可降低帕金森模型中乙酰胆碱的水平。Cycrimine 具有解痉活性，可用于研究行为和精神障碍。
T70153	Pipoxolan hydrochloride
	Pipoxolan (HCl) is an antispasmodic drug. In vivo, the drug inhibited the contractions of intestines caused by neostigmine, barium chloride or injection of acetylcholine. The drug possesses ganglioplegic action and inhibited the decrease in blood pressure caused by stimulation of the vagus nerve. The drug is marketed under tradename Rowapraxin worldwide for the treatment of spasms and colics in the gastrointestinal tract, gallbladder and urogenital area, bronchial spasms, spastic menstrual cramp...
T69363	Emepronium bromide
	Emepronium bromide is an anticholinergic drug used in urology as an antispasmodic. It can cause ulceration of esophagus, so it should be taken in orthostatic position with sufficient amounts of liquids. It is a muscarinic antagonist used mainly in the treatment of urinary syndromes. It is incompletely absorbed from the gastrointestinal tract and does not cross the blood-brain barrier.
T69661	Pipoxolan (free base)
	Pipoxolan (free base) is an antispasmodic drug. In vivo, the drug inhibited the contractions of intestines caused by neostigmine, barium chloride or injection of acetylcholine. The drug possesses ganglioplegic action and inhibited the decrease in blood pressure caused by stimulation of the vagus nerve. The drug is marketed under tradename Rowapraxin worldwide for the treatment of spasms and colics in the gastrointestinal tract, gallbladder and urogenital area, bronchial spasms, spastic menstrual...
T60751	Dicyclomine
	Dicyclomine (Dicycloverine) 是口服有效的毒蕈碱胆碱能受体拮抗剂，它是一种解痉剂，可缓解体内胃肠道平滑肌痉挛。Dicyclomine 对 M1 受体亚型和 M2 受体亚型具有高亲和力，在刷状缘膜和基底质膜中的Ki 值分别为5.1 nM 和54.6 nM 。

化合物

Dicyclomine hydrochloride

Cat.No: T1460

Target: AChR

Eprazinone dihydrochloride

Cat.No: T3034

Synonym: Resplen,Mucitux,Eftapan,NSC 317935,盐酸依普拉酮,依普拉酮二盐酸,Eprazinone 2HCl

Target: Others, Neurokinin receptor

Flavoxate hydrochloride

Cat.No: T0703

Synonym: Flavoxate HCl,盐酸黄酮哌酯,NSC-114649,DW61,Rec-7-0040

Target: AChR

Cat.No: T6375

Synonym: cebera,EB 1856,阿利苯多

Target: Others

Metamizole magnesium

Cat.No: T3272

Synonym: Metamizolemagnesiumsalt,安乃近镁

Target: Antibiotic

Valethamate bromide

Cat.No: T0023

Synonym: Ediposin,Epidozin,戊沙溴铵,Epidosin,Resitan

Target: Others

Adiphenine hydrochloride

Cat.No: T0072

Synonym: Adiphenine HCl,盐酸阿地芬宁,Spasnil,Patrovina,Sentiv

Target: AChR

Diproteverine HCl

Cat.No: T68853

Target: Calcium Channel

Oxyphencyclimine Hydrochloride

Cat.No: T2138

Synonym: 盐酸奥克西利平,Spazamin,Daricon,Ulcociclinina

Target: AChR

Cat.No: T2387

Synonym: Gastrodyn,Glycopyrronium bromide,Robinul,Glycopyrrolate bromide,格隆溴铵

Target: AChR

Pinaverium bromide

Cat.No: T7603

Target: Calcium Channel

Trospium chloride

Cat.No: T1472

Synonym: Spasmex,Sanctura,曲司氯铵,曲司氯胺

Target: AChR

Fesoterodine fumarate

Cat.No: T1475

Synonym: Toviaz,SPM 907,富马酸非索罗定

Target: AChR

Clidinium bromide

Cat.No: T0786

Synonym: 克利溴铵,Ro 2-3773

Target: AChR

Cat.No: T68599

Synonym: Orphenadrine (free base)

Target: Sodium Channel, NMDAR, AChR

Cat.No: T26614

Synonym: Bersen,Meritin,Dibutamid

Cat.No: T69234

Camylofin Hydrochloride

Cat.No: T0346L

Synonym: Camylofin HCl,Acamylophenine hydrochloride,Acamylophenine HCl,Belosin,Avocan

Cat.No: T25189

Synonym: Butopiprinum

Cat.No: T23829

Synonym: Btm1042,Btm-1042

Cat.No: T24517

Synonym: UNII-WLT400RC9Q,Nafiverina,Nafiverinum,EINECS 225-766-5

Cat.No: T24887

Synonym: CR-605

Cat.No: T25339

Cat.No: T21050

Cat.No: T24443

Synonym: Medazomidum,L 1777,L1777,L-1777

Cat.No: T62889

Oxybutynin R-isomer HCl

Cat.No: T71236

Cat.No: T25325

Synonym: LAB 145-138H,BAS 145-138

Cat.No: T28883

Synonym: A118,A-118,A 118

Cat.No: T61309

Cat.No: T23918

Cat.No: T69150

Dipiproverine hydrochloride

Cat.No: T25339L

Synonym: L.D. 935,LD 935

Cat.No: T60577

Pipoxolan hydrochloride

Cat.No: T70153

Emepronium bromide

Cat.No: T69363

Pipoxolan (free base)

Cat.No: T69661

Cat.No: T60751

Cat. No.	Product Name	Target	Signaling Pathways
TQ0275	LysoPC(14:0/0:0)	Others; Endogenous Metabolite	Metabolism; Others
	LysoPC(14:0/0:0) 是一种溶血磷脂，它是单甘油磷脂，其中甘油取代位点被磷酸胆碱占据。LysoPC(14:0/0:0) 有抗痉挛作用。
T2981	Xanthoxylin Brevifolin,Xanthoxyline,花椒素,2'-Hydroxy-4',6'-dimethoxyacetophenone	Others; Antifungal	Microbiology/Virology; Others
	Xanthoxylin (Brevifolin)e 是从Zanthoxylum simulans 中分离出来的是一种冰片和樟脑味化合物，有抗真菌和抗癫痫作用。
TN1084	1,3,5,8-Tetrahydroxyxanthone Desmethylbellidifolin,去甲基雏叶龙胆酮	Anti-infection	Microbiology/Virology
	1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) 是一种天然黄酮，从 Gentianella acuta 中提取得到。它具有镇痉作用和抗炎作用。
TN1264	3'-O-Methylbatatasin III	Antifungal	Microbiology/Virology
	3'-O-Methylbatatasin III 是一种来自兰科植物白芨的天然化合物，具有抗生素活性和解痉活性。3'-O-Methylbatatasin III 具有抗真菌活性。
T5581	6-(γ,γ-Dimethylallylamino)purine N6-(2-lsopentenyl)adenine,三刺皂荚碱,Triacanthine	Others	Others
	6-(γ,γ-Dimethylallylamino)purine (Triacanthine) 是植物生长调节剂。
T0525	Flopropione 夫洛丙酮,Phloropropiophenone	5-HT Receptor; Transferase	GPCR/G Protein; Metabolism; Neuroscience
	Flopropione (Phloropropiophenone) 是一种解痉剂，用作 5-HT1A 受体拮抗剂，也是儿茶酚-O-甲基转移酶抑制剂。
T8178	Acetagastrodin 乙酰天麻素,Acegastrodine	Others	Others
	Acetagastrodin (Acegastrodine) 是一种抗氧化剂，也是合成 DBPG 的中间体。
T8787	Drotaverine hydrochloride	PDE	Metabolism
	Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂，也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果，但无抗胆碱能的效果。
TN1528	Cotoin	AChE	Neuroscience
	Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。Cotoin 具有解痉活性，可降低孤立的兔肠的音调和收缩。它部分抑制乙酰胆碱、毛果芸香碱和 BaCl 对分离肠的影响。
T6S1369	Vitexin 牡荆素,Apigenin-8-C-glucoside	Antioxidant	oxidation-reduction
	Vitexin 是一种存在于多种药用植物（如榕树、螺旋藻）中的 c-糖基化的黄酮。它具有广泛的药理作用，包括抗氧化，抗癌，抗炎，抗痛觉过敏和神经保护作用。
T6718	Zingerone Gingerone,Vanillylacetone,姜酮,NSC 15335	NF-κB	NF-κB
	Zingerone (Vanillylacetone) 是一种从生姜中得到的无毒的甲氧基苯酚，具有抗炎、抗糖尿病、抗脂质过敏、抗腹泻、抗痉挛和抗肿瘤等活性。它作为抗有丝分裂剂，能够抑制神经母细胞瘤的生长。它能够缓解氧化应激和炎症，下调 NF-κB 介导的信号通路。
T6S1684	8-Gingerol	Antioxidant; Antibacterial; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology; oxidation-reduction
	8-Gingerol 分离自姜的根状茎，是口服有效的 TRPV1激活剂，EC50值为5.0 µM。8-Gingerol 抑制 COX-2，还能抑制体外 H. pylori 的生长。
T3S2259	Methyl eugenol 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Methyl eugenol (4-allylveratrole) 是一种苯丙类化合物，存在于植物叶子、果实、根茎中，当植物相应的部位因食草动物进食而受损时，就会释放。它可用于消灭雄性东方果蝇。
T10195	7-O-Geranylscopoletin 7-Geranyloxy-6-methoxycoumarin	Others	Others
	7-O-Geranylscopoletin is a natural coumarin from the root of Atalantia monophylla. Various parts of this plant have been used for folk medicine for several purposes such as the treatment of chronic rheumatism, antispasmodic, paralysis, hemiplegia, and sti
T14192	α-Amyrin acetate Α-香树精乙酯,α-Amyrin acetate	Others	Others
	α-Amyrin acetate 是一种具有抗炎活性、抗痉挛特性和松弛作用的三萜类化合物。

天然产物

LysoPC(14:0/0:0)

Cat.No: TQ0275

Target: Others, Endogenous Metabolite

Cat.No: T2981

Synonym: Brevifolin,Xanthoxyline,花椒素,2'-Hydroxy-4',6'-dimethoxyacetophenone

Target: Others, Antifungal

1,3,5,8-Tetrahydroxyxanthone

Cat.No: TN1084

Synonym: Desmethylbellidifolin,去甲基雏叶龙胆酮

Target: Anti-infection

3'-O-Methylbatatasin III

Cat.No: TN1264

Target: Antifungal

6-(γ,γ-Dimethylallylamino)purine

Cat.No: T5581

Synonym: N6-(2-lsopentenyl)adenine,三刺皂荚碱,Triacanthine

Target: Others

Cat.No: T0525

Synonym: 夫洛丙酮,Phloropropiophenone

Target: 5-HT Receptor, Transferase

Cat.No: T8178

Synonym: 乙酰天麻素,Acegastrodine

Target: Others

Drotaverine hydrochloride

Cat.No: T8787

Target: PDE

Cat.No: TN1528

Target: AChE

Cat.No: T6S1369

Synonym: 牡荆素,Apigenin-8-C-glucoside

Target: Antioxidant

Cat.No: T6718

Synonym: Gingerone,Vanillylacetone,姜酮,NSC 15335

Target: NF-κB

Cat.No: T6S1684

Target: Antioxidant, Antibacterial, TRP/TRPV Channel

Cat.No: T3S2259

Synonym: 4-allylveratrole,eugenyl methyl ether,O-methyleugenol,Eugenol Methyl ether,丁香酚甲醚,丁子香酚甲醚

Target: GABA Receptor

7-O-Geranylscopoletin

Cat.No: T10195

Synonym: 7-Geranyloxy-6-methoxycoumarin

Target: Others

α-Amyrin acetate

Cat.No: T14192

Synonym: Α-香树精乙酯,α-Amyrin acetate

Target: Others

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