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Search Results for " antipruritic "

22

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11723L	JNJ-39758979	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	JNJ-39758979是一种选择性的、高亲和力的、可口服的组胺 H4 受体拮抗剂，具有抗炎和止痒作用，对人、小鼠和猴子的组胺 H4 受体的 Ki 值分别为 12.5、5.3 和 25 nM。它对组胺诱导的 cAMP 抑制作用具有拮抗作用，pA2 为 7.9。
T1278	Astemizole Laridal,Histaminos,Paralergin,阿司咪唑	Potassium Channel; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Astemizole (Laridal) 是一种长效、非镇静抗组胺药，用于治疗季节性过敏性鼻炎、哮喘、过敏性结膜炎和慢性特发性荨麻疹。它是组胺 H1 受体的拮抗剂，IC50值为 4 nM，还阻断 hERG K+通道，IC50值为 0.9 nM，具有抗胆碱能和止痒作用。
T0370	Pheniramine maleate Daneral,Inhiston,Trimetose,马来酸非尼拉敏	5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pheniramine maleate (Trimetose) 是一种具有抗组胺和血管扩张特性的烷基胺衍生物，可与组胺 H1 受体结合，从而抑制磷脂酶 A2 和内皮源性松弛因子一氧化氮的产生。
T7564	Chlorphenoxamine Contristamine,氯苯沙明	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Chlorphenoxamine (Contristamine) 是一种抗组胺药和抗胆碱能药，用作止痒药和抗帕金森病药。
T0276	Hydrocortisone Valerate Westcort,氢化可的松戊酸酯	Glucocorticoid Receptor	Endocrinology/Hormones
	Hydrocortisone Valerate (Westcort) 具有抗炎、止痒和血管收缩的特性。
T21014	Thonzylamine hydrochloride Resistab,Thonzylamine HCl,Novohetramin,Neohetramine hydrochloride,Anahist	AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Thonzylamine hydrochloride (Resistab) 是一种抗胆碱能和抗组胺药，用作止痒药。
T0270	Hydrocortisone 17-butyrate 丁酸氢化可的松,Cortisol 17-butyrate,Hydrocortisone butyrate	Glucocorticoid Receptor; Annexin A; Adrenergic Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Hydrocortisone 17-butyrate (Cortisol 17-butyrate) 是一种肾上腺皮质激素类药物。
T0460	Pramocaine hydrochloride Pramoxine hydrochloride,盐酸普莫卡因,Pramoxine HCl	Sodium Channel	Membrane transporter/Ion channel
	Pramocaine hydrochloride (Pramoxine HCl) 可以降低神经细胞膜对钠离子的通透性，阻断神经冲动的产生和传导。
T3282	Alimemazine hemitartrate Alimemazine Tartrate,Methylpromazine Tartrate,酒石酸异丁嗪,Trimeprazine tartrate,Trimeprazine hemitartrate	Others	Others
	Alimemazine hemitartrate (Trimeprazine hemitartrate) 是血凝素 (HA)-受体的拮抗剂，也是一种吩噻嗪衍生物，常用作止痒剂。
T20802	Flumethasone pivalate Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten	Others	Others
	Flumethasone pivalate (Locorten) 具有止痒、抗炎和血管收缩的特性，可用于肾上腺皮质抑制、皮肤萎缩、血浆转皮质素结合和毛细血管扩张的研究。
T21361	Alclometasone dipropionate Vaderm,Sch 22219,Aclovate,Delonal	Others	Others
	Alclometasone dipropionate （Sch 22219）是一种人工合成的糖皮质激素，属于类固醇化合物，具有抗增生、抗炎、抗过敏、止痒和收缩血管的作用，可用于研究皮肤炎症。
T1124	Flumethasone 氟米松,Flumetasone,RS-2177,NSC-54702	Glucocorticoid Receptor	Endocrinology/Hormones
	Flumethasone (RS-2177) 是皮质类固醇，可局部用药。它可与 Clioquinol 联合使用，研究外耳炎和耳真菌病。它作用于动物模型时，抗炎活性比 Cortisone 高 420 倍。
T0376	Crotamiton Eurax,Crotamitone,克罗米通,Veteusan	Parasite	Microbiology/Virology
	Crotamiton (Eurax) 既是杀疥螨剂，可研究疥疮，也是止痒剂, 可除去疥疮寄生虫。
T21443	Prednicarbate Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D	Others	Others
	Prednicarbate (Hoe 777) 是一种外用皮质类固醇。Prednicarbate 可用于炎症性皮肤病的研究，如特应性皮炎。
T1198	Tetracaine hydrochloride 盐酸丁卡因,Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Tetracaine hydrochloride (Amethocalne HCl) 是一种钙通道蛋白抑制剂，可阻断肌浆网中 Ca2+的电压敏感释放。它主要用作眼科的止痒剂和局部用药，可用于表面和脊髓麻醉。
T1561	Clobetasol propionate Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725	Glucocorticoid Receptor; P450	Endocrinology/Hormones; Metabolism
	Clobetasol propionate (CGP9555) 是CYP3A5的选择性抑制剂(IC50:0.206 μM)，而对 CYP3A4 或其他主要 CYP 无抑制作用。它是皮质类固醇，对于牛皮癣和其他皮肤病具有潜在的研究价值。
T6529	Halobetasol propionate 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458	Phospholipase	Metabolism
	Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。
T69516	Thenalidine tartrate
	Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets due to a risk of neutropenia. Thenalidine is an antagonist of the H1-receptor.
T23944	DA 5018 DA-5018,DA5018
	DA 5018 is a capsaicin derivative and is also a new non-narcotic analgesic. It has an antipruritic effect.
T10281	Alimemazine Trimeprazine	Others	Others
	Alimemazine (Trimeprazine) is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist. Alimemazine also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs.
T62460	INCB38579
	INCB38579 是一种选择性的、口服具有活力的、能够透过血脑屏障的组胺 H4受体 (HH4R) 拮抗剂，能够作用于 hH4R (IC50: 4.8 nM)、mH4R (IC50: 42 nM)、rH4R (IC50: 32 nM)。INCB38579 具有抗炎和抗瘙痒作用。
T38323	A-943931 (hydrochloride hydrate)
	A-943931 is a histamine H4receptor antagonist (Ki= 3.8 nM).1In vivo, A-943931 inhibits scratching induced by clobenpropit in mice (ED50= 26 μmoles/kg, i.p.). 1.Milicic, I., Witte, D.G., Miller, T.L., et al.Identification of two potent and selective histamine H4 receptor antagonists with antipruritic activityFASEB J.23(S1)760.768-760.768(2009)

化合物

Cat.No: T11723L

Target: Histamine Receptor

Cat.No: T1278

Synonym: Laridal,Histaminos,Paralergin,阿司咪唑

Target: Potassium Channel, Histamine Receptor

Pheniramine maleate

Cat.No: T0370

Synonym: Daneral,Inhiston,Trimetose,马来酸非尼拉敏

Target: 5-HT Receptor, Histamine Receptor

Chlorphenoxamine

Cat.No: T7564

Synonym: Contristamine,氯苯沙明

Target: Histamine Receptor

Hydrocortisone Valerate

Cat.No: T0276

Synonym: Westcort,氢化可的松戊酸酯

Target: Glucocorticoid Receptor

Thonzylamine hydrochloride

Cat.No: T21014

Synonym: Resistab,Thonzylamine HCl,Novohetramin,Neohetramine hydrochloride,Anahist

Target: AChR, Histamine Receptor

Hydrocortisone 17-butyrate

Cat.No: T0270

Synonym: 丁酸氢化可的松,Cortisol 17-butyrate,Hydrocortisone butyrate

Target: Glucocorticoid Receptor, Annexin A, Adrenergic Receptor

Pramocaine hydrochloride

Cat.No: T0460

Synonym: Pramoxine hydrochloride,盐酸普莫卡因,Pramoxine HCl

Target: Sodium Channel

Alimemazine hemitartrate

Cat.No: T3282

Synonym: Alimemazine Tartrate,Methylpromazine Tartrate,酒石酸异丁嗪,Trimeprazine tartrate,Trimeprazine hemitartrate

Target: Others

Flumethasone pivalate

Cat.No: T20802

Synonym: Locacorten,NSC-107680,特戊酸氟米松,Lorinden,NSC 107680,NSC107680,Locorten

Target: Others

Alclometasone dipropionate

Cat.No: T21361

Synonym: Vaderm,Sch 22219,Aclovate,Delonal

Target: Others

Cat.No: T1124

Synonym: 氟米松,Flumetasone,RS-2177,NSC-54702

Target: Glucocorticoid Receptor

Cat.No: T0376

Synonym: Eurax,Crotamitone,克罗米通,Veteusan

Target: Parasite

Cat.No: T21443

Synonym: Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D

Target: Others

Tetracaine hydrochloride

Cat.No: T1198

Synonym: 盐酸丁卡因,Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl

Target: Calcium Channel, Sodium Channel

Clobetasol propionate

Cat.No: T1561

Synonym: Dermovate,Clobetasol 17-propionate,CGP9555,Temovate,丙酸氯倍他索,CCl 4725

Target: Glucocorticoid Receptor, P450

Halobetasol propionate

Cat.No: T6529

Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Target: Phospholipase

Thenalidine tartrate

Cat.No: T69516

Cat.No: T23944

Synonym: DA-5018,DA5018

Cat.No: T10281

Synonym: Trimeprazine

Target: Others

Cat.No: T62460

A-943931 (hydrochloride hydrate)

Cat.No: T38323

Cat. No.	Product Name	Target	Signaling Pathways
T2952	Camphor 樟脑,(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa	Influenza Virus; TRP/TRPV Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Camphor (2-Camphanone) 是一种双环单萜酮，广泛存在于植物中，尤其是樟脑。它是一种激动剂，局部用作皮肤止痒剂和抗感染剂，具有抗病毒，镇咳和抗癌活性。

天然产物

Cat.No: T2952

Synonym: 樟脑,(±)-Camphor,Bornan-2-one,2-Camphanone,2-Bornanone,Formosa

Target: Influenza Virus, TRP/TRPV Channel

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