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Cat. No. | Product Name | Target | Signaling Pathways |
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T21806 |
HNHA
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HNHA 是组蛋白去乙酰化酶抑制剂。它通过 p21诱导将细胞周期阻滞在 G1/S 期,抑制肿瘤生长及肿瘤新生血管形成。HNHA 可能是一种有效的抗乳腺癌药物。 | |||
T30549 |
BMY-21502
Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168 |
Antioxidant | oxidation-reduction |
BMY-21502 是一种潜在认知增强剂,在KCN-缺氧模型中显示出抗缺氧作用,可在体外延缓海马突触增强的衰变,可用于研究阿尔茨海默症。 | |||
T61635 |
hCAI/II-IN-4
|
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hCAI/II-IN-4 (compound 6d) is a powerful inhibitor of both hCA I and hCA II enzymes, with Ki values of 16.95 nM and 15.22 nM, respectively. It demonstrates inhibitory activity against hCA IX with a Ki value of 27.04 nM. Additionally, hCAI/II-IN-4 exhibits anti-hypoxia properties while maintaining low toxicity. This compound is suitable for investigating acute mountain sickness (AMS) in research studies [1]. | |||
T68324 |
KCN1
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KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF reporter gene activity in several glioma cell lines at the nanomolar level. KCN1 also downregulated transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE)-dependent manner. KCN1 potently inhibited the grow... | |||
T75074 | 6-Methoxypurine-9-β-D-5’(R)-C-methylriboside | ||
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside 是一种嘌呤碱基,属于次黄嘌呤似物,主要在肌肉组织中发现。作为黄嘌呤在嘌呤氧化酶作用下的代谢产物,次黄嘌呤具备显著的抗炎性质,并可作为内源性 poly(ADP-ribose) polymerase (PARP) 的抑制剂。其通过抑制 PARP 活性,防止过氧亚硝酸盐引起的线粒体去极化及次级超氧化物的产生,展现出细胞保护作用。同时,次黄嘌呤也被用作缺氧的生物标志物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5773 |
Moslosooflavone
5-羟基-7,8-二甲氧基黄酮,5-hydroxy-7,8-dimethoxyflavone |
NF-κB; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) 是一种从雪莲中分离出来的类黄酮,具有抗缺氧和抗炎作用。 | |||
T2763 |
Panaxadiol
人参二醇,20(R)-Panaxadiol |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Panaxadiol (20(R)-Panaxadiol) 是从人参根中获得,具有神经保护和抗肿瘤作用,能够抑制程序性细胞死亡配体-1(PD-L1)的表达和肿瘤增殖。 | |||
T11589 |
Hydroxycitric acid tripotassium hydrate
柠檬酸钾一水合物,三水合钾柠檬酸,Potassium citrate monohydrate |
ATP Citrate Lyase; HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) 是一种藤黄果的主要活性成分,也是一种柠檬酸的衍生物。它可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ,并具有减肥作用。它有效抑制结石形成,并抑制HIF,具有抗氧化,抗炎和抗肿瘤活性。 | |||
T0256 |
Citric acid trilithium salt tetrahydrate
Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate |
Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。 | |||
TN1916 |
Matairesinol
罗汉松树脂酚 |
ATPase; p38 MAPK; ROS | Immunology/Inflammation; MAPK; Membrane transporter/Ion channel |
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells. | |||
TWS1977 |
Kamebakaurin
尾叶香茶菜丙素,Kamebakaurine |
NF-κB | NF-κB |
Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物,是一种NF-κB 的抑制剂,能够抑制 p50 的 DNA 结合活性。 | |||
T3822 |
Bellidifolin
Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮 |
Others; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Bellidifolin (Bellidifoline) 是从獐牙菜的茎中提取的一种呫吨酮,它能作为病毒蛋白 R 的抑制剂,具有保肝、降血糖、抗炎、抗氧化、抗肿瘤作用。 | |||
T2S0843 |
Negletein
黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether |
IL Receptor; TNF; NOS; Interleukin | Apoptosis; Immunology/Inflammation |
Negletein (7-O-Methylbaicalein) 一种神经保护剂,可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性,其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。 | |||
TN6417 |
N-Methylcorydalmine
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N-Methylcorydalmine may exhibit significant anti-hypoxia activity. |