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Search Results for " anti-hbv "

32

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4328	OSS_128167 SIRT6-IN-1	HBV; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	OSS_128167 (SIRT6-IN-1) 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂，对 SIRT6，SIRT1 和 SIRT2 的 IC50分别为 89 μM，1578 μM 和 751 μM。它具有抗 HBV、抗癌、抗炎和抗病毒活性，可抑制 HBV 的转录和复制。
T6439	Cetylpyridinium Chloride 西吡氯铵,Cetamium,Pristacin,Hexadecylpyridinium Chloride	Others; HBV; Antibacterial	Microbiology/Virology; Others
	Cetylpyridinium Chloride (Hexadecylpyridinium Chloride) 是阳离子季铵，是一种广谱抗菌剂。它有效抑制 HBV 衣壳装配，IC50为 2.5 μM。它被用于杀虫剂和各种漱口水以及其他个人护理产品中。
T11669	IR415	HBV	Microbiology/Virology
	IR415 选择性地与 HBx 相互作用 (Kd=2 nM) 并阻断 HBV 介导的 RNAi 抑制，逆转 HBx 蛋白对 Dicer 核糖核酸内切酶活性的抑制作用。IR415 具有抗 HBV 的活性。
T11550	Helioxanthin derivative 5-4-2 Helioxanthin 5-4-2	HBV	Microbiology/Virology
	Helioxanthin derivative 5-4-2 （Helioxanthin 5-4-2）是螺旋黄质的类似物，在体外显示出抗 HBV 活性，可用于研究HBV。
T16366	NVR 3-778	HBV	Microbiology/Virology
	NVR 3-778 是一种 SBA 类的口服有效HBV CAM 衣壳组装调制剂，具有抗 HBV 活性。
T8471	Vonafexor EYP001,PLX007,pxl007	FXR; HBV	Metabolism; Microbiology/Virology
	Vonafexor (EYP001) 是一种法尼醇 X 受体激动剂，具有抗 HBV 作用。
T4121	Bicyclol SY801,双环醇	HBV; Autophagy	Autophagy; Microbiology/Virology
	Bicyclol (SY801) 是一种抗肝炎 HBV 和 HCV 药物。
T76937	Burfiralimab hzVSF-v13	HBV	Microbiology/Virology
	Burfiralimab (hzVSF-v13) 是一种针对波形蛋白的单克隆免疫球蛋白（IgG4），具有抗HBV作用，可用于研究类风湿关节炎。
T67797	DDG-39 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine	Antiviral; HBV; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	DDG-39 (1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine)具有抗病毒活性，在细胞培养中具有有效的选择性抗 HIV-1 和HBV 活性。平均抗病毒 IC50为0.61μM。
T39043	Tenofovir amibufenamide HS-10234	HBV	Microbiology/Virology
	Tenofovir amibufenamide (HS-10234) (HS-10234) 是一种 Tenofovir 前药，是一种具有口服活性的抗病毒化合物。Tenofovir amibufenamide 对乙型肝炎病毒 (HBV)具有抑制作用，可用于慢性乙型肝炎 (CHB) 研究。
T26771	Bentysrepinine Y 101,Y101,Y-101
	Bentysrepinine, a novel anti-HBV agent, inhibits DNA-HBV and cccDNA activities for the treatment of hepatitis B virus (HBV)-infected hepatitis.
T39744	Firzacorvir
	Firzacorvir is a cyclic sulfamide compound that acts as an HBV core protein modulator and exhibits potent anti-HBV activity, with an EC50 value of < 1 μΜ.
T61115	HBV-IN-25
	HBV-IN-25 is a novel chemical compound that acts as a potent HBV cccDNA reducer when administered orally. It exhibits significant anti-HBeAg potency and anti-HBV activity, with IC50 values of 0.58 μM and 1.15 μM, respectively. Moreover, HBV-IN-25 demonstrates favorable aqueous solubility (LYSA＞452 μg/mL) and no cellular toxicity, making it a promising candidate for further investigation and development [1].
T72796	Junceellolide C
	Junceellolide C 是一种 cccDNA 转录抑制剂。Junceellolide C 能抑制 HepAD38 细胞中 HBVDNA 的复制，且能显著降低细胞上清液中的 HBVRNA 水平，其 EC50值分别为 5.19 和 3.52 μM。Junceellolide C 具有抗乙肝病毒活性。
T36747	HBV-IN-4
	HBV-IN-4, a derivative of phthalazinone, functions as a potent, orally active inhibitor of HBV DNA replication, exhibiting an IC50 value of 14 nM. It effectively induces the formation of genome-free capsids, demonstrating significant anti-HBV potency[1].
T73147	Neracorvir
	Neracorvir 是一种有效的抗病毒剂。Neracorvir 表现出抗 HBV 活性。
T29198	Z060228 Z 060228,Z-060228
	Z060228 is an potent anti-HBV inhibitor. The HBV DNA replication was effectively inhibited by Z060228 in the supernatants of the HepG2.2.15 cells. Z060228 exhibited effects on the self-assembly of Cp149. SEC data revealed that Z060228 altered the equilibr
T62704	HBV-IN-23
	HBV-IN-23 (Compound 5k) 是一种 HBV DNA 复制抑制剂 (IC50: 0.58 μM)。HBV-IN-23 能够抑制药物敏感和耐药株。HBV-IN-23 可以诱导 HepG2 细胞凋亡，表现出抗肝癌细胞 (HCC) 效果。
T62626	HBV-IN-12
	HBV-IN-12 是一种乙型肝炎表面抗原 (HBsAg) 的有效抑制剂，其 EC50 值大于 0.001 μM 且不大于 0.05 μM。HBV-IN-12 具有抗 HBV DNA 活性，其 EC50 值大于 0.001 μM 且不大于 0.02 μM。
T77001	Exbivirumab
	Exbivirumab 是一种抗HBV 单克隆抗体。Exbivirumab 能增强乙型肝炎免疫球蛋白 (HBIG) 的抗病毒活性。
T78783	HBV-IN-35	HBV	Microbiology/Virology
	HBV-IN-35（Compound 88）是具有对小鼠和人肝细胞中HBV抗病毒活性的抑制剂，其EC50值分别为100 nM和400 nM。
T73282	HBV-IN-31
	HBV-IN-31 是一种有效的共价闭合环状 DNA (cccDNA) 抑制剂。HBV-IN-31 具有抗HBV 活性，对 HBsAg 的 IC50值为 0.13 µM。HBV-IN-31 抑制细胞生长。
T11549	Helioxanthin 8-1 Helioxanthin analogue 8-1	Others	Others
	Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM.
T73283	HBV-IN-32
	HBV-IN-31 是一种有效的共价闭合环状 DNA (cccDNA) 抑制剂。HBV-IN-31 具有抗HBV 活性，对 HBsAg 的 IC50值为 0.14 µM。HBV-IN-31 抑制细胞生长。
T72324	Lagociclovir valactate
	Lagociclovir valactate 是 Lagociclovir 的前药。Lagociclovir valactate 是一种具有口服活性的抗HBV 试剂。
T60285	L-2'-Fd4C
	L-2'-Fd4C 是一种L-核苷类似物，具有抗人类免疫缺陷病毒 (HIV) 和抗乙型肝炎病毒 (HBV) 活性。
T78756	Yhhu6669	HBV	Microbiology/Virology
	Yhhu6669为抗HBV药物，能够抑制HBVDNA。该化合物通过诱导无DNA衣壳的形成，从而抑制HBV复制，且能有效降低AAV/HBV感染小鼠中的HBVDNA及HBcAg水平，展现出优良的药代动力学特性。
T79469	HBV-IN-34	HBV	Microbiology/Virology
	HBV-IN-34（化合物17i）是一款抗HBV药物，可以有效抑制HBsAg的生成。在体外实验中，HBV-IN-34对HBVDNA和HBsAg的EC50值分别为0.018 μM和0.044 μM，显示出卓越的抗病毒活性。
T78812	HBV-IN-36	HBV	Microbiology/Virology
	HBV-IN-36（compound 42）是一种抗乙型肝炎病毒（HBV）活性显著的化合物，其抑制剂效力（IC50=2 μM）以及EC50值为0.85 μM，表明其作为HBV抑制剂具有潜在的临床应用价值。
T76321	Brain Derived Basic Fibroblast Growth Factor (1-24)
	Brain Derived BasicFibroblast Growth Factor(1-24) (FGF basic 1-24) 是一种合成肽，表现出抗细菌和抗HBV 的活性。Brain Derived BasicFibroblast Growth Factor(1-24) 可用于感染性疾病和免疫性疾病的研究。
T60374	L-Fd4A
	L-Fd4A (compound 36) 是腺嘌呤衍生物，具有抗人类免疫缺陷病毒 (HIV) (EC50=1.5 μM) 和抗乙型肝炎病毒 (HBV) (EC50=1.7 μM) 活性。L-Fd4A 具有低细胞毒性。
T37065	6-Chloro-2-fluoropurine
	6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV)in vitro.2 1.Wilson, S.C., Atrash, B., Barlow, C., et al.Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitorsBioorg. Med. Chem.19(22)6949-6965(2011) 2....

化合物

Cat.No: T4328

Synonym: SIRT6-IN-1

Target: HBV, Sirtuin

Cetylpyridinium Chloride

Cat.No: T6439

Synonym: 西吡氯铵,Cetamium,Pristacin,Hexadecylpyridinium Chloride

Target: Others, HBV, Antibacterial

Cat.No: T11669

Target: HBV

Helioxanthin derivative 5-4-2

Cat.No: T11550

Synonym: Helioxanthin 5-4-2

Target: HBV

Cat.No: T16366

Target: HBV

Cat.No: T8471

Synonym: EYP001,PLX007,pxl007

Target: FXR, HBV

Cat.No: T4121

Synonym: SY801,双环醇

Target: HBV, Autophagy

Cat.No: T76937

Synonym: hzVSF-v13

Target: HBV

Cat.No: T67797

Synonym: 1-(2,3-dideoxy-2-fluoropentofuranosyl)cytosine

Target: Antiviral, HBV, HIV Protease

Tenofovir amibufenamide

Cat.No: T39043

Synonym: HS-10234

Target: HBV

Cat.No: T26771

Synonym: Y 101,Y101,Y-101

Cat.No: T39744

Cat.No: T61115

Junceellolide C

Cat.No: T72796

Cat.No: T36747

Cat.No: T73147

Cat.No: T29198

Synonym: Z 060228,Z-060228

Cat.No: T62704

Cat.No: T62626

Cat.No: T77001

Cat.No: T78783

Target: HBV

Cat.No: T73282

Helioxanthin 8-1

Cat.No: T11549

Synonym: Helioxanthin analogue 8-1

Target: Others

Cat.No: T73283

Lagociclovir valactate

Cat.No: T72324

Cat.No: T60285

Cat.No: T78756

Target: HBV

Cat.No: T79469

Target: HBV

Cat.No: T78812

Target: HBV

Brain Derived Basic Fibroblast Growth Factor (1-24)

Cat.No: T76321

Cat.No: T60374

6-Chloro-2-fluoropurine

Cat.No: T37065

Cat. No.	Product Name	Target	Signaling Pathways
TN1482	Chamaechromone	P450; HBV	Metabolism; Microbiology/Virology
	Chamaechromone 是从 Stellera chamaejasme L. 的根中分离出来的天然产物。 Chamaechromone 具有抗 HBV 和杀虫活性。
T4S1718	Punicalin	HBV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的，一种可水解的单宁，具有抗炎活性。它是一种抗乙型肝炎病毒药物。
T2780	Catalpol 梓醇,Catalpinoside,Digitalis purpurea L	Others; HBV	Microbiology/Virology; Others
	Catalpol (Catalpinoside) 是一种在Rehmannia glutinosa 中发现的鸢尾花苷，具有神经保护、降血糖、抗癌、抗痉挛、抗氧化、抗HBV 和抗肝炎病毒作用。
T3921	Punicalagin 安石榴甙,安石榴苷	SARS-CoV; HBV	Microbiology/Virology
	Punicalagin 是一种在石榴中发现的主要鞣花单宁，是可逆且非竞争性的3CLpro 抑制剂，有抗氧化、抗炎和抗癌作用。它有潜力研究 COVID-19 。
T2S1158	4,5-Dicaffeoylquinic acid 3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C	Others; HBV; Endogenous Metabolite	Metabolism; Microbiology/Virology; Others
	4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物，有抗病毒、抗肝毒性活性。
TN5845	Neochlorogenic acid methyl ester 5-O-Caffeoylquinic acid methyl ester,Methyl 3-caffeoylquinate,GIP (1-39) acetate(725474-97-5 Free base),Methyl neochlorogenate,新绿原酸甲酯	Antioxidant; HBV	Microbiology/Virology; oxidation-reduction
	Neochlorogenic acid methyl ester (5-O-Caffeoylquinic acid methyl ester) 来源于毛蒿和黑色苦莓(Aronia melanocarpa)果实。Neochlorogenic acid methyl ester 显示出抗 HBV 活性、抗氧化活性和醌还原酶活性，CD 为 6.7 μM。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T5S2254	Swertianolin Bellidifolin-8-O-Glucoside,当药醇苷	Others; HBV; Antibacterial; AChE	Microbiology/Virology; Neuroscience; Others
	Swertianolin (Bellidifolin-8-O-Glucoside) 是从Gentianella Acuta 分离得到的一种黄酮，具有抗 HBV 和抗菌活性，可抑制乙酰胆碱酯酶。
TN2188	Schisanwilsonin B Schisanwilsonin I,鹤庆五味子素 B	Others	Others
	Schisanwilsonin D, and schisantherin C show anti-HBV activity.
TN1732	Herpetone	HBV	Microbiology/Virology
	Herpetone exhibits protective effects on CCl(4)-induced hepatocyte injury, it shows anti-hepatitis B virus (HBV) activity.
T79975	Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside	HBV	Microbiology/Virology
	Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside（化合物1）是一种具有抗HBV活性的木脂素类化合物。该化合物对HBV表面抗原（HBsAg）的IC50为0.58 mM，而对HBV e抗原（HBeAg）的IC50 > 2.4 mM。其可从八角茴香中提取分离。
T79976	Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside	HBV	Microbiology/Virology
	Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside 作为一种抗HBV剂，在Hep G2.2.15细胞系上能够抑制HBsAg和HBeAg的分泌，其IC50值分别约为1.67 mM和>2.15 mM。
TN3687	Coclauril	HBV	Microbiology/Virology
	Coclauril shows anti-Hepatitis B virus (HBV) activities, with EC50 values of 7.6 ± 0.5 ug/mL.
TN2220	Sophoranol 槐醇,(+)-Sophoranol	HBV	Microbiology/Virology
	(+)-Sophoranol exhibits antiviral activity against the Coxsackie virus B3. It also shows potent anti-HBV activity with an inhibitory potency against HBsAg secretion and against HBeAg secretion.
T81531	Pedunculosumoside F
	Pedunculosumoside F，一种从Ophioglossum pedunculosum分离得到的同型黄酮苷，对HepG2 2.2.15细胞表现出细胞毒性，其CC50值为56.7 μM，但缺乏抗HBV活性。然而，其类似物能够抑制HBV感染的HepG2 2.2.15细胞中HBsAg的分泌。

天然产物

Cat.No: TN1482

Target: P450, HBV

Cat.No: T4S1718

Target: HBV, HIV Protease

Cat.No: T2780

Synonym: 梓醇,Catalpinoside,Digitalis purpurea L

Target: Others, HBV

Cat.No: T3921

Synonym: 安石榴甙,安石榴苷

Target: SARS-CoV, HBV

4,5-Dicaffeoylquinic acid

Cat.No: T2S1158

Synonym: 3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C

Target: Others, HBV, Endogenous Metabolite

Neochlorogenic acid methyl ester

Cat.No: TN5845

Synonym: 5-O-Caffeoylquinic acid methyl ester,Methyl 3-caffeoylquinate,GIP (1-39) acetate(725474-97-5 Free base),Methyl neochlorogenate,新绿原酸甲酯

Target: Antioxidant, HBV

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Cat.No: T5S2254

Synonym: Bellidifolin-8-O-Glucoside,当药醇苷

Target: Others, HBV, Antibacterial, AChE

Schisanwilsonin B

Cat.No: TN2188

Synonym: Schisanwilsonin I,鹤庆五味子素 B

Target: Others

Cat.No: TN1732

Target: HBV

Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside

Cat.No: T79975

Target: HBV

Dihydrodehydrodiconiferyl alcohol 9-O-β-D-xylopyranoside

Cat.No: T79976

Target: HBV

Cat.No: TN3687

Target: HBV

Cat.No: TN2220

Synonym: 槐醇,(+)-Sophoranol

Target: HBV

Pedunculosumoside F

Cat.No: T81531

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