Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NVR 3-778 是一种 SBA 类的口服有效HBV CAM 衣壳组装调制剂,具有抗 HBV 活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 527 | 现货 | ||
5 mg | ¥ 1,230 | 现货 | ||
10 mg | ¥ 1,890 | 现货 | ||
25 mg | ¥ 3,730 | 现货 | ||
50 mg | ¥ 5,450 | 现货 | ||
100 mg | ¥ 7,650 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,360 | 现货 |
产品描述 | NVR 3-778 is a first-in-Class and oral bioavailable HBV CAM belonging to the SBA class It has anti-HBV activity. |
体外活性 | NVR 3-778 inhibits the generation of infectious HBV DNA-containing virus particles with a mean antiviral (EC50: 0.40?μM in HepG2.2.15 cells). NVR 3-778 inhibits pregenomic RNA encapsidation, viral replication, and the production of HBV DNA- and HBV RNA-containing particles. NVR 3-778 also inhibits de novo infection and viral replication in primary human hepatocytes with EC50s of 0.81?μM against HBV DNA and between 3.7μM and 4.8?μM against the production of HBV antigens and intracellular HBV RNA. NVR 3-778 targets HBV core protein and inhibits viral replication. NVR 3-778 has pan-genotypic antiviral activity and a lack of cross-resistance with nucleos(t)ide inhibitors of HBV replication. The EC50 values of NVR 3-778 are increased by 4.5-, 9.3-, and 15.8-fold in the presence of 10%, 20%, and 40% human serum, respectively. |
体内活性 | In dogs following oral administration, NVR 3-778 (1.5?mg/kg; i.g.) shows the mean Cmax and AUC0–inf values of 0.56?μg/ml and 3.50?μg·h/ml, respectively. And the mean oral bioavailability is determined to be 84.6%. |
分子量 | 432.39 |
分子式 | C18H16F4N2O4S |
CAS No. | 1445790-55-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (138.76 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3127 mL | 11.5636 mL | 23.1273 mL | 57.8182 mL |
5 mM | 0.4625 mL | 2.3127 mL | 4.6255 mL | 11.5636 mL | |
10 mM | 0.2313 mL | 1.1564 mL | 2.3127 mL | 5.7818 mL | |
20 mM | 0.1156 mL | 0.5782 mL | 1.1564 mL | 2.8909 mL | |
50 mM | 0.0463 mL | 0.2313 mL | 0.4625 mL | 1.1564 mL | |
100 mM | 0.0231 mL | 0.1156 mL | 0.2313 mL | 0.5782 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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