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Search Results for " amyloid precursor protein "

41

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1655	β-Amyloid Protein Precursor 770 (135-155) β-Amyloid Protein Precursor 770 135-155
	Beta-Amyloid Protein Precursor 770 (135-155)Aβ Protein Precursor 770 (135-155)
T6483	EHT 1864 EHT 1864 2HCl	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	EHT 1864 是 Rac 家族 GTPase 抑制剂，对 Rac1、Rac1b、Rac2 和 Rac3的Kd 为 40、50、60 和 250 nM。
T9713	δ-secretase inhibitor 11	Beta Amyloid; Caspase	Apoptosis; Neuroscience; Proteases/Proteasome
	δ-secretase inhibitor 11是一种分泌酶抑制剂，可用作阿尔茨海默病（AD）治疗转化开发的先导化合物。
T80695	β-Amyloid precursor protein (96-110), cyclized (human)
	β-Amyloid precursor protein (96-110), cyclized (human) 为一种淀粉样前体蛋白衍生物，特别适用于阿尔茨海默病相关研究。
T7490	ARN2966	Beta Amyloid	Neuroscience
	ARN2966 是高效的，针对 APP 表达的转录后调节剂，能够抑制 APP 的表达从而使 Aβ的量降低。
T14673	BMS 299897	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	BMS 299897 是一种磺胺类 γ 分泌酶抑制剂。它在稳定过表达淀粉样前体蛋白（APP）的 HEK293 细胞中抑制 Aβ 生成的 IC50 值为 7 nM。
T11178L	ELN318463 racemate ELN318463 (racemate),ELN 318463 racemate	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	ELN318463 racemate (ELN 318463 racemate) 是 ELN318463 的外消旋体，ELN318463 是一种淀粉样前体蛋白 (APP) 选择性 γ-分泌酶抑制剂。
T14338	Atabecestat JNJ-54861911	BACE	Neuroscience
	Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust and high CSF Aβ reduction and it is tolerated and displays a sustained pharmacokinetic (PK) and
T61439	DSS30	Beta Amyloid; BACE; CDK	Cell Cycle/Checkpoint; Neuroscience
	DSS30 是一种 P25/CDK5抑制剂。DSS30通过抑制淀粉样前体蛋白裂解酶1 (BACEl) 磷酸化，减少 β-淀粉样蛋白 (Aβ) 的分泌发挥作用。DSS30 可用于预防和治疗阿尔茨海默病等神经退行性疾病。
T3161L	BACE-IN-1 acetate BACE-IN-1 acetate (350228-37-4，Free base)	BACE	Neuroscience
	BACE-IN-1 acetate (BACE-IN-1 acetate (350228-37-4，Free base)) 已被用作 BACE1 抑制剂测定中的 β 位淀粉样前体蛋白 (APP) 裂解酶-1 (BACE1) 抑制剂。 β-位点淀粉样前体蛋白 (APP) 切割酶-1 (BACE1)是一种天冬氨酸蛋白酶，属于蛋白酶家族，由六个腔内半胱氨酸残基组成。这些残基有助于形成三个分子间二硫键和 N-连接的糖基化位点。
T4364	Aftin-4 Aftin 4,Aftin4	Beta Amyloid; Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Aftin-4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
T80622	Trontinemab
	Trontinemab为一种双特异性人源IgG1-κ抗体，靶向Aβ前体蛋白(APP)与转铁蛋白受体p90, CD71 (TFRC)。该抗体主要应用于阿兹海默症研究。
T13253	Umibecestat CNP520	BACE	Neuroscience
	Umibecestat 是一种β-位点淀粉样前体蛋白裂解酶-1 (BACE-1) 抑制剂，对人 BACE-1 和小鼠 BACE-1 的 IC50 分别为 11 nM 和 10 nM，可用于阿尔茨海默病的研究。
T27944	LY3202626 LY 3202626,LY-3202626
	LY3202626, an amyloid precursor protein secretase (BACE protein) inhibitor, is used for the treatment of Alzheimer's disease.
T3161	β-Secretase inhibitor-STA	Beta-Secretase	Neuroscience
	BACE-IN-1 是淀粉样前体蛋白 β-分泌酶抑制剂。
T14525	Begacestat GSI-953	Beta Amyloid	Neuroscience
	Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's disease.
T12429	PF-06751979	BACE	Neuroscience
	PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
T80563	Sabirnetug
	Sabirnetug为人源化IgG2κ型抗体，专一性靶向Amyloid-β A4前体蛋白。
TP1303	β-Amyloid (1-40) β-Amyloid 1-40
	Amyloid β1-40 is one of the fragments generated after cleavage of the amyloid peptide precursor protein by β and γ secretases.
T70366	PF-06663195
	PF-06663195 is a potent inhibitor of β-site amyloid precursor protein (APP) Cleaving Enzyme 1 (BACE1, β-Secretase 1).
TP1099	M-2420 Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl
	M-2420 is a fluorogenic substrate designed specifically for the β-secretase site found in the Swedish mutation of the amyloid precursor protein (APP).
T25685	Leucyl-phenylalanine amide Leu-phe-NH2
	Leucyl-phenylalanine amide is an intermediate in the synthesis of γ-Secretase Inhibitor, the enzyme complex that catalyzes the cleavage of the amyloid precursor protein (APP) to produce amyloid β-peptide (Aβ) which is the major causative agent in Alzheime
T10318	Anatabine dicitrate	NF-κB	NF-κB
	Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of the amyloid precursor protein.
T11178	ELN318463 ELN 318463	Others	Others
	ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.
T76087	Biotin-β-Amyloid (17-40)
	Biotin-β-Amyloid (17-40) 是 N 端标记的生物素化的β-Amyloid (17-40) 肽段。该化合物为 Aβ 蛋白中的 24 个氨基酸残基构成的片段，源自于淀粉样前体蛋白(APP)的翻译及加工过程。
T37148	TML-6
	TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, and enhancement of the anti-oxidative Nrf2 gene activity. Considering its diverse pharmacological profile, TML-6 holds promise as a valuable research tool for investigating Alzheimer's disease (AD)[1].
T38116	Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2
	Fmoc-Ala-Glu-Asn-Lys-NH2 is a peptide inhibitor that selectively targets asparagine endopeptidase (AEP) and inhibits the cleavage of amyloid precursor protein (APP). AEP, a pH-controlled cysteine proteinase, plays a crucial role in the proteolytic processing of APP, and its activity is enhanced during the aging process [1].
T81299	Remternetug LY3372993
	Remternetug为一种人源化IgG1-kappa型单克隆抗体，针对APP (Aβ42 N3pGlu)的特定焦谷氨酸形式。该抗体能够特异性识别并结合形成淀粉样斑块的Aβ聚集体。
T71855	Z640
	Z640 an aPKC agonist. Z640 was further confirmed as a non‑selective aPKC agonist that can activate the kinase activity of both PKCι and PKCζ. In the cell‑based assay, Z640 was found to protect neuronal cell lines from amyloid‑β (Aβ) oligomer‑induced cell death by reducing reactive oxygen species production and restore mitochondrial function. In addition, Z640 could reduce Aβ40 generation in a dose‑dependent manner and shift amyloid precursor protein processing towards the non‑amyloid pathway
T76393	Amyloid 17-42
	Amyloid 17-42 (Aβ(17-42))，作为阿尔茨海默病中弥漫性斑块与唐氏综合症小脑前区的主要淀粉样蛋白成分，源于淀粉样蛋白前体蛋白(APP)经α与γ分泌酶的裂解作用。此外，Amyloid 17-42能通过Fas样/caspase-8途径促使神经细胞发生凋亡。
T35498	β-Amyloid (1-14),mouse,rat
	β-Amyloid (1-14),mouse,rat is a 1 to 14 fragment of Amyloid-β peptide. β-Amyloid (1-14),mouse,rat is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by β- and γ-secretases. β-Amyloid (1-14),mouse,rat accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer’s disease, which is the most common form of dementia associated with plaques and tangles in the brain[1]. [1]. Chen GF, et al. Amyloid beta: stru...
T83123	Amyloid β-Protein (3-42)
	Amyloid β-Protein (3-42) 为Pyr肽前体, 其焦谷氨酸修饰的形式 Aβ (pEAβ) (3-42) 构成阿尔茨海默病淀粉样斑块的关键。pEAβ (3-42) 能促进 Aβ(1-42) 聚集，并且 Aβ(1-42) 显著延缓pEAβ(3-42) 的初级及次级成核过程。
T10453	BACE1-IN-5	Beta Amyloid; BACE	Neuroscience
	BACE1-IN-5 (Compound 15) 是一种 BACE1抑制剂，IC50为 9.1 nM。BACE1-IN-5还可抑制细胞 Aβ，IC50为 0.82 nM。并且，BACE1-IN-5 具有改善 hERG 抑制和 P-gp 外排的药物化学作用。
T62181	BACE-IN-1
	BACE-IN-1 是一种咪唑[1,2-a ]吡啶衍的生物，对 β 位点淀粉样蛋白前体蛋白切割酶 (BACE) 句有抑制作用。BACE-IN-1 具有研究涉及 BACE 疾病（如阿尔茨海默氏病）的潜力。
T61206	AChE/BChE/BACE-1-IN-1
	AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor that targets acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1). It displays IC50 values of 0.058 μM, 0.082 μM, and 0.115 μM against hAChE, hBChE, and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 exhibits significant binding affinity with PAS-AChE, excellent ability to cross the blood-brain barrier, potential disassembly of amyloid-beta (Aβ) aggregates, and ne...
T83506	[Asn23]-beta-Amyloid (1-42), iowa mutation
	[Asn23]-beta-Amyloid (1-42), iowa mutation 是具有生物活性的肽，与阿尔茨海默病中的一种严重神经病理状况——大脑淀粉样蛋白血管病 (CAA) 密切相关。这种变异是由于在 APP 694 位点发生了错义突变，其中 Asp 23 被 Asn 取代，导致的。该变异形式的β-淀粉样肽倾向于更快聚集，形成具有毒性的原纤维。
T37369	Amyloid-β (1-8, A2V) Peptide Amyloid-β (1-8, A2V) Peptide
	Amyloid-β (1-8, A2V) is a truncated form of amyloid-β (Aβ) that contains a valine to alanine substitution at position 2 of the Aβ numbering convention (Aβ A2V), which corresponds to position 673 of the amyloid precursor protein (APP) numbering convention (APP A673V). An Aβ (1-40) (Aβ40) A2V peptide increases the production of Aβ and the rate and amount of amyloid fibril formation in vitro, effects that can be reduced by coincubation with wild-type Aβ40. Aβ40 and Aβ42 levels are increased in CHO ...
T35608	16F16
	16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal ...
T36639	Donecopride (fumarate hydrate)
	Donecopride is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT4E(Ki= 8.5 nM) and an inhibitor of acetylcholinesterase (AChE; IC50= 16 nM).1It is selective for AChE over butyrylcholinesterase (BChE; IC50= 3,530 nM) but does bind to 5-HT2Band sigma-2 (σ2) receptors (Ki= 1.6 nM for both) in a panel of 42 neurotransmitter receptors and transporters. Donecopride induces release of soluble amyloid precursor protein-α (sAPP-α) in COS-7 cells transiently expressing 5-HT4with an EC50value...
T78739	PD07
	PD07是一种口服AChE抑制剂，对hAChE的IC50为0.29 μM。体外实验表明PD07也能抑制ChE、BACE1（IC50：13.42 μM）和Aβ1-42的聚集。作为抗氧化剂，PD07显示出DPPH抑制活性（IC50：26.46 μM），能改善因Scopolamine诱导而失忆的大鼠的记忆和认知功能。该化合物适用于阿尔茨海默病的研究。
T36903	Rasagiline-13C3 (mesylate) Rasagiline-13C3 (mesylate)
	Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral ede...

化合物

β-Amyloid Protein Precursor 770 (135-155)

Cat.No: TP1655

Synonym: β-Amyloid Protein Precursor 770 135-155

Cat.No: T6483

Synonym: EHT 1864 2HCl

Target: Rho, Ras

δ-secretase inhibitor 11

Cat.No: T9713

Target: Beta Amyloid, Caspase

β-Amyloid precursor protein (96-110), cyclized (human)

Cat.No: T80695

Cat.No: T7490

Target: Beta Amyloid

Cat.No: T14673

Target: Beta Amyloid, Gamma-secretase

ELN318463 racemate

Cat.No: T11178L

Synonym: ELN318463 (racemate),ELN 318463 racemate

Target: Gamma-secretase

Cat.No: T14338

Synonym: JNJ-54861911

Target: BACE

Cat.No: T61439

Target: Beta Amyloid, BACE, CDK

BACE-IN-1 acetate

Cat.No: T3161L

Synonym: BACE-IN-1 acetate (350228-37-4，Free base)

Target: BACE

Cat.No: T4364

Synonym: Aftin 4,Aftin4

Target: Beta Amyloid, Gamma-secretase

Cat.No: T80622

Cat.No: T13253

Synonym: CNP520

Target: BACE

Cat.No: T27944

Synonym: LY 3202626,LY-3202626

β-Secretase inhibitor-STA

Cat.No: T3161

Target: Beta-Secretase

Cat.No: T14525

Synonym: GSI-953

Target: Beta Amyloid

Cat.No: T12429

Target: BACE

Cat.No: T80563

β-Amyloid (1-40)

Cat.No: TP1303

Synonym: β-Amyloid 1-40

Cat.No: T70366

Cat.No: TP1099

Synonym: Methoxycoumarin-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys-dinitrophenyl

Leucyl-phenylalanine amide

Cat.No: T25685

Synonym: Leu-phe-NH2

Anatabine dicitrate

Cat.No: T10318

Target: NF-κB

Cat.No: T11178

Synonym: ELN 318463

Target: Others

Biotin-β-Amyloid (17-40)

Cat.No: T76087

Cat.No: T37148

Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T38116

Synonym: Fmoc-Ala-Glu-Asn-Lys-NH2

Cat.No: T81299

Synonym: LY3372993

Cat.No: T71855

Amyloid 17-42

Cat.No: T76393

β-Amyloid (1-14),mouse,rat

Cat.No: T35498

Amyloid β-Protein (3-42)

Cat.No: T83123

Cat.No: T10453

Target: Beta Amyloid, BACE

Cat.No: T62181

AChE/BChE/BACE-1-IN-1

Cat.No: T61206

[Asn23]-beta-Amyloid (1-42), iowa mutation

Cat.No: T83506

Amyloid-β (1-8, A2V) Peptide

Cat.No: T37369

Synonym: Amyloid-β (1-8, A2V) Peptide

Cat.No: T35608

Donecopride (fumarate hydrate)

Cat.No: T36639

Cat.No: T78739

Rasagiline-13C3 (mesylate)

Cat.No: T36903

Synonym: Rasagiline-13C3 (mesylate)

Cat. No.	Product Name	Target	Signaling Pathways
TN2190	Scoulerine	Apoptosis; Beta-Secretase; BACE; Parasite	Apoptosis; Microbiology/Virology; Neuroscience
	Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖，阻止细胞周期，并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。

天然产物

Cat.No: TN2190

Target: Apoptosis, Beta-Secretase, BACE, Parasite

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