Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of the amyloid precursor protein.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 1,990 | 待询 | ||
10 mg | ¥ 2,910 | 待询 | ||
50 mg | ¥ 5,410 | 待询 | ||
100 mg | ¥ 8,740 | 待询 | ||
200 mg | 待询 | 待询 | ||
500 mg | 待询 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,480 | 待询 |
Anatabine dicitrate 的其他形式现货产品:
产品描述 | Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. It is a potent α4β2 nAChR agonist and inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of the amyloid precursor protein. |
体外活性 | Anatabine (600 μg/mL; 24 hours; SHSY-5Y cells) treatment shows inhibition of p65 NF-κB phosphorylation. Anatabine (500-1000μg/mL; 30 minutes; SHSY-5Y cells) treatment fully prevents the increase in BACE-1 mRNA levels induced by TNF-α. After 24 hours, Anatabine treatment shows dose-dependent inhibition of BACE-1 protein levels.Anatabine dose-dependently inhibits Aβ1-40 and Aβ1-42 (IC50: 640 μg/mL for both Aβ1-40 and Aβ1-42 in 7W CHO cells). Anatabine inhibits sAPPβ secretion without impacting sAPPα [1]. |
体内活性 | Anatabine (0.5-2 mg/kg; i.p; daily; for 4 days; transgenic mouse) treatment significantly lowers brain soluble Aβ1-40 and Aβ1-42 levels in a transgenic mouse model of Alzheimer's disease [1]. |
分子量 | 544.46 |
分子式 | C22H28N2O14 |
CAS No. | T10318 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (55.10 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.8367 mL | 9.1834 mL | 18.3668 mL | 45.9171 mL |
5 mM | 0.3673 mL | 1.8367 mL | 3.6734 mL | 9.1834 mL | |
10 mM | 0.1837 mL | 0.9183 mL | 1.8367 mL | 4.5917 mL | |
20 mM | 0.0918 mL | 0.4592 mL | 0.9183 mL | 2.2959 mL | |
50 mM | 0.0367 mL | 0.1837 mL | 0.3673 mL | 0.9183 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Anatabine dicitrate T10318 NF-Κb NF-κB Anatabine Dicitrate Anatabine Inhibitor inhibitor inhibit