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抑制剂 & 化合物

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天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2280	Endoxifen (Z-isomer) Z-因多昔芬,Endoxifen Z-isomer,4-[(1E)-1-{4-[2-(甲基氨基)乙氧基]苯基}-2-苯基-1-丁烯-1-基]苯酚	Estrogen Receptor/ERR; EGFR; Potassium Channel; Estrogen/progestogen Receptor; HER	Angiogenesis; Endocrinology/Hormones; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Endoxifen Z-isomer (EDX)是 Tamoxifen 重要的代谢产物,在表达 ERα的乳腺癌细胞中发挥抗雌激素作用。它以浓度依赖的方式抑制 hERG, IC50值为1.6μM。
T11766	Eltanexor Z-isomer KPT-8602 (Z-isomer)	Others	Others
	Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.
T6827	Endoxifen Z-isomer hydrochloride Endoxifen HCl,Z-因多昔芬盐酸盐	Estrogen Receptor/ERR; Potassium Channel; Estrogen/progestogen Receptor; HER	Angiogenesis; Endocrinology/Hormones; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	Endoxifen Z-isomer hydrochloride (Endoxifen HCl) 是Tamoxifen 最重要的代谢产物, 在表达ERα的乳腺癌细胞中发挥抗雌激素作用, Endoxifen HCl 以浓度依赖的方式抑制hERG, IC50值为1.6μM。
T1816	(Z)-JIB-04 NSC 693627,Z-JIB-04	Others	Others
	(Z)-JIB-04 (NSC 693627) 是 JIB-04 的 Z 型异构体。其中 JIB-04 有 E 型和 Z 型异构体两种形式。而(Z)-JIB-04 (NSC 693627) 在表观遗传分析中无活性。
T0835	Tamoxifen Citrate Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate,枸橼酸他莫昔芬,他莫昔芬柠檬酸盐	Apoptosis; Estrogen Receptor/ERR; HSP; Estrogen/progestogen Receptor; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; Endocrinology/Hormones; Metabolism
	Tamoxifen Citrate 是一种口服有效的，选择性雌激素受体调节剂，可阻断乳腺细胞中的雌激素作用，并可激活如骨骼、肝脏和子宫细胞中的雌激素活性。它是 Hsp90激活剂，可增强 Hsp90 分子伴侣 ATPase 的活性，可激活自噬和诱导凋亡。
T11200	Endoxifen (E-isomer) N-去甲-4-羟基-三苯氧胺,E-Endoxifen,Endoxifen E-isomer	Estrogen Receptor/ERR	Endocrinology/Hormones
	Endoxifen E-isomer (E-Endoxifen) 是一种 Endoxifen 的 E-异构体，是 Endoxifen Z-isomer 原料中主要的杂质。Endoxifen E-isomer 具有抗雌激素活性。
T16032L	(Z)-MDL 105519	Others	Others
	(Z)-MDL 105519是 MDL105519 无活性的异构体。
T1109	(Z)-Capsaicin Zucapsaicin,Civamide,cis-Capsaicin,珠卡赛辛,(Z)-辣椒素	TRP/TRPV Channel; HSV	Membrane transporter/Ion channel; Microbiology/Virology
	(Z)-Capsaicin (Zucapsaicin) 是天然辣椒素的合成顺式异构体，用于治疗膝骨关节炎。它是一种可口服的 TRPV1激动剂，可研究神经性疼痛。
T13380	(Z)-Pitavastatin calcium	Others	Others
	(Z)-Pitavastatin calcium is the Z-Isomer of Pitavastatin hemicacium. Pitavastatin calcium is a potent of hydroxymethylglutaryl-CoA (HMG-CoA) reductase.
T15186	(E)-4-Hydroxytamoxifen	Others	Others
	(E)-4-Hydroxytamoxifen is a less active isomer of (Z)-4-hydroxytamoxifen and also is an estrogen receptor modulator.
T12611	R 80123	Others	Others
	R 80123 is a highly selective inhibitor of phosphodiesterase,is the Z-isomer of R 79595
T74028	(Z)-2-Octenoic acid
	Z-2-Octenoic acid为2-Octenoic acid的Z-异构体，同时，trans-2-Octenoic acid为Mucor species的代谢产物。
T35291	Z-1,2-Dimethoxy-4-(3-fluoro-2-propenyl)benzene
	Z-1,2-Dimethoxy-4-(3-fluoro-2-propenyl)benzene 是 Methyl eugenol (ME) 的氟类似物，是东方果蝇 B. dorsalis 的引诱剂。E 型异构体的活性是Z型异构体 Z-1,2-Dimethoxy-4-(3-fluoro-2-propenyl)benzene 的两倍。
T37099	(Z)-4EGI-1
	(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2]. [1]. Khuloud Takrouri, et al. Structure-activity Relationship Study of 4EGI-1, Small Molecule eIF4E/eIF4G Protein-Protein Interaction Inhibitors. Eur J Med Chem. 2014 Apr 22;77:361-77. [2]. Poornachandran Mahalingam, et al. Synthesis of Rigidified eIF4E/...
T3645	Endoxifen E-isomer hydrochloride E-Endoxifen hydrochloride	Estrogen Receptor/ERR; Estrogen/progestogen Receptor	Endocrinology/Hormones
	Endoxifen E-isomer hydrochloride (E-Endoxifen hydrochloride) 是 Endoxifen 的 E-异构体，是 Endoxifen Z-isomer 原料中主要的杂质，具有抗雌激素作用。
T83878	Z-CITCO
	Z-CITCO是构成型雄甾烷受体（CAR；在报告基因测定中，对人类受体的EC50 = 3.9 µM）的激动剂，同时也是CAR激动剂CITCO的顺式异构体。
T35854	9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
	9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-co...
T37213	5-trans Latanoprost
	Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an impurity of between 2-5% in most commercial preparations of the bulk drug product. The present compound was prepared primarily as an analytical standard for detection and quantitation of this impurity. Fr...
T37214	5-trans Latanoprost (free acid)
	Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug. Latanoprost is an isopropyl ester, a prodrug form which is converted to latanoprost (free acid) by endogenous esterase enzymes. The free acid form is 200 times more potent than latanoprost as a ligand for the human recombinant FP receptor. 5-trans Latanoprost (free acid) is an isomer of latanoprost (free acid) wherein the double bond between carbons 5 and 6 has been changed from ci...
T36608	(±)8-HEPE
	(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 8(S)-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.[1][2] Reference：[1]. Shing, T.K.M., Gibson, K.H., Wiley, J.R., et al. First total synthesis of a barnacle hatching factor 8(R)-hydroxy-eicosa-5(Z),9(E),11(Z)-pentaenoic acid. Tetrahedron Letters 35, 1067-1070 (1994).[2]. Hill, E...
T36887	8(E),10(E),12(Z)-Octadecatrienoic Acid
	8(E),10(E),12(Z)-Octadecatrienoic acid is a conjugated polyunsaturated fatty acid (PUFA) that has been found inC. officinalisseed oil and has anticancer activity.1,2,3It inhibits the growth of Caco-2 cells when used at concentrations ranging from 10 to 50 μM.28(E),10(E),12(Z)-Octadecatrienoic acid (10 μM) induces formation of thiobarbituric acid reactive substances (TBARS) and apoptosis in DLD-1 colorectal adenocarcinoma cells.3It also inhibits prostaglandin biosynthesis in sheep vesicular gland...

化合物

Endoxifen (Z-isomer)

Cat.No: T2280

Synonym: Z-因多昔芬,Endoxifen Z-isomer,4-[(1E)-1-{4-[2-(甲基氨基)乙氧基]苯基}-2-苯基-1-丁烯-1-基]苯酚

Target: Estrogen Receptor/ERR, EGFR, Potassium Channel, Estrogen/progestogen Receptor, HER

Eltanexor Z-isomer

Cat.No: T11766

Synonym: KPT-8602 (Z-isomer)

Target: Others

Endoxifen Z-isomer hydrochloride

Cat.No: T6827

Synonym: Endoxifen HCl,Z-因多昔芬盐酸盐

Target: Estrogen Receptor/ERR, Potassium Channel, Estrogen/progestogen Receptor, HER

Cat.No: T1816

Synonym: NSC 693627,Z-JIB-04

Target: Others

Tamoxifen Citrate

Cat.No: T0835

Synonym: Tamoxifen Z-isomer citrate,ICI 46474,ICI 46474 Citrate,枸橼酸他莫昔芬,他莫昔芬柠檬酸盐

Target: Apoptosis, Estrogen Receptor/ERR, HSP, Estrogen/progestogen Receptor, Autophagy

Endoxifen (E-isomer)

Cat.No: T11200

Synonym: N-去甲-4-羟基-三苯氧胺,E-Endoxifen,Endoxifen E-isomer

Target: Estrogen Receptor/ERR

Cat.No: T16032L

Target: Others

Cat.No: T1109

Synonym: Zucapsaicin,Civamide,cis-Capsaicin,珠卡赛辛,(Z)-辣椒素

Target: TRP/TRPV Channel, HSV

(Z)-Pitavastatin calcium

Cat.No: T13380

Target: Others

(E)-4-Hydroxytamoxifen

Cat.No: T15186

Target: Others

Cat.No: T12611

Target: Others

(Z)-2-Octenoic acid

Cat.No: T74028

Z-1,2-Dimethoxy-4-(3-fluoro-2-propenyl)benzene

Cat.No: T35291

Cat.No: T37099

Endoxifen E-isomer hydrochloride

Cat.No: T3645

Synonym: E-Endoxifen hydrochloride

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat.No: T83878

9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)

Cat.No: T35854

5-trans Latanoprost

Cat.No: T37213

5-trans Latanoprost (free acid)

Cat.No: T37214

Cat.No: T36608

8(E),10(E),12(Z)-Octadecatrienoic Acid

Cat.No: T36887

Cat. No.	Product Name	Target	Signaling Pathways
T8137	(Z)-Aconitic acid 顺乌头酸,顺式乌头酸,Cls-Aconitic acid	Others; Endogenous Metabolite	Metabolism; Others
	(Z)-Aconitic acid 是 Aconitic acid 的顺式异构体。它是三羧酸循环中柠檬酸盐异构化为异柠檬酸盐的中间产物。

天然产物

(Z)-Aconitic acid

Cat.No: T8137

Synonym: 顺乌头酸,顺式乌头酸,Cls-Aconitic acid

Target: Others, Endogenous Metabolite

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