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Search Results for " tubulin inhibitor 1 "

105

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T13227	Tubulin inhibitor 1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase.
T13224	Tubulin inhibitor 6 iHAP1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂，抑制微管蛋白聚合，IC50为 0.87 μM。它抑制多种癌细胞系，抑制 K562 细胞生长，IC50为 840 nM。
T1992	Mertansine DM1,Maytansinoid DM1	Microtubule Associated	Cytoskeletal Signaling
	Mertansine (DM1) 是一种微管蛋白抑制剂，也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上，形成抗体偶联药物。
T4029	BTB-1 BTB 1,NSC156750	Microtubule Associated	Cytoskeletal Signaling
	BTB-1 (NSC156750) 是一种新型的有丝分裂运动蛋白 Kif18A 的小分子抑制剂，IC50值为1.69 μM。
T13996	1-Naphthohydroxamic acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	1-Naphthohydroxamic acid 是一种选择性 HDAC8抑制剂，IC50为 14 μM。它对 HDAC8的选择性高于 I 类 HDAC1 和 II 类 HDAC6，IC50大于100 μM，可诱导微管蛋白乙酰化。
T22661	CHM-1	Apoptosis; Others; Microtubule Associated	Apoptosis; Cytoskeletal Signaling; Others
	CHM-1 是细胞凋亡的诱导剂，通过激活 Cdc2 激酶活性在人肝细胞癌中显示出有效的抗肿瘤能力。 CHM-1 在体外和体内抑制微管蛋白聚合。
T9831	MKC-1 Ro-31-7453	Apoptosis; Akt; Microtubule Associated; mTOR	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	MKC-1 (Ro-31-7453) 是一种口服生物可利用的小分子双吲哚基马来酰亚胺细胞周期抑制剂，具有潜在的抗肿瘤活性。
T21408	DM1-SMe DM1-SSMe	Microtubule Associated	Cytoskeletal Signaling
	DM1-SMe (DM1-SSMe) 是美登木素微管的有效抑制剂。 DM1-SMe 的效力是母体药物美登素的 3 至 10 倍，在一组人类肿瘤细胞系中，DM1-SMe 的 IC50 为 0.003 至 0.01 nM。
T6864	Ixabepilone BMS 247550,Ixempra,Azaepothilone B,伊沙匹隆,BMS 247550-1	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Ixabepilone (Azaepothilone B) 是一种可口服的微管抑制剂，能够与微管蛋白结合，促进微管蛋白的聚合和微管的稳定，使细胞停滞在 G2-M 期，诱导细胞凋亡。
T11917	Lys-SMCC-DM1 Lys-Nε-MCC-DM1	Microtubule Associated	Cytoskeletal Signaling
	DM1 是一种微管蛋白抑制剂。 Lys-SMCC-DM1 (Lys-Nε-MCC-DM1) 是 DM1 的活性代谢物。
T15576	Indibulin 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301,D 24851	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Indibulin (D 24851) 是一种口服有效的微管蛋白合成抑制剂，具有抗有丝分裂和抗肿瘤活性，且神经毒性小。它降低了肌间神经张力，产生异常的纺锤体，激活有丝分裂检查点蛋白 Mad2 和 BubR1，并诱导有丝分裂停滞和细胞凋亡。
T77728	Tubulin polymerization-IN-55	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂，具有潜在的抗血管生成和抗肿瘤活性，对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。
T18867	Val-Cit-PAB-MMAE
	Val-Cit-PAB-MMAE 是 ADC 的药物-接头偶联物。它包含 ADC 接头（肽 Val-Cit-PAB）和有效的微管蛋白抑制剂 MMAE。
T8820	BML-284 hydrochloride BML-284 HCL,Wnt agonist 1 HCL	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	BML-284 hydrochloride (Wnt agonist 1 HCL) 是细胞通透性 Wnt 信号激活剂。它能够诱导 TCF 依赖的转录活性(EC50>700 nM)。
T60757	SB-216	Microtubule Associated	Cytoskeletal Signaling
	SB-216 可用于研究癌症，是微管蛋白聚合的有效抑制剂。SB-216 在一组人类癌细胞系中表现出强大的抗增殖能力，包括黑色素瘤、乳腺癌和肺癌。
T61472	Tubulin inhibitor 18
	Tubulin inhibitor 18 (compound 5j) is a highly potent chalcone compound that effectively inhibits tubulin. Its unique molecular structure renders Tubulin inhibitor 18 as a promising candidate for cancer research [1].
T61069	Tubulin polymerization-IN-15
	Tubulin polymerization-IN-15 (compound 4) is a highly effective inhibitor of tubulin polymerization, with significant potential in cancer research [1].
T61084	Tubulin polymerization-IN-37
	Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in cancer research, notably for lymphomas [1].
T61545	Tubulin inhibitor 28
	Tubulin inhibitor 28 (compound 2g) 是一种有效的微管抑制剂，IC50值为 1.2 μM。Tubulin inhibitor 28 对 MCF-7 细胞具有抗增殖活性。
T61129	Tubulin polymerization-IN-27
	Tubulin polymerization-IN-27 (compound 5j) is an inhibitor of tubulin polymerization. It has the ability to halt the cell cycle specifically at the G2/M phase and also induce apoptosis [1].
T60459	Tubulin inhibitor 15
	Tubulin inhibitor 15 是有效的微管蛋白抑制剂，具有抗增殖活性。Tubulin inhibitor 15 在 HepG2 细胞中表现出细胞毒性。
T60460	Tubulin inhibitor 16
	Tubulin inhibitor 16 是有效的微管蛋白抑制剂，具有抗增殖活性。Tubulin inhibitor 16 在 HepG2 细胞中表现出细胞毒性。
T60755	Tubulin inhibitor 20
	Tubulin inhibitor 20 (compound 1) 作为tubulin 的有效抑制剂，显示出癌症研究的潜力。
T61524	Tubulin/HDAC-IN-1
	Tubulin/HDAC-IN-1 is a compound that functions as a dual inhibitor for tubulin and HDAC-IN-1. It achieves this by interacting with tubulin through CH/π interaction and with HDAC8 through hydrogen bond interaction. This compound effectively inhibits tubulin polymerization and selectively targets HDAC8 with an IC50 of 150 nM. Additionally, Tubulin/HDAC-IN-1 demonstrates cytotoxicity against various human cancer cells, induces cell cycle arrest in the G2/M phase, and triggers cell apoptosis. This c...
T61242	Tubulin inhibitor 12
	Tubulin inhibitor 12 (Hit 9) is a recently developed compound with potent inhibitory effects on tubulin (IC50 = 25.3 μM). This compound exhibits noteworthy anti-tumor and anti-proliferative activities, making it a promising candidate for the treatment of cancer [1].
T39139	PARP1-IN-6 PARP1-IN-6
	PARP1-IN-6 is a dual tubulin/PARP-1 inhibitor with IC 50 values of 0.94 and 0.48 μM, respectively.
T62058	αβ-Tubulin-IN-1
	αβ-Tubulin-IN-1 是有效且具有口服活性的αβ-Tubulin 抑制剂。αβ-Tubulin-IN-1 将细胞周期阻滞在 G2/M 期并诱导细胞凋亡 (apoptosis)。αβ-Tubulin-IN-1 抑制肿瘤细胞迁移和转移。αβ-Tubulin-IN-1 具有显著的抗肿瘤功效。
T60793	Tubulin inhibitor 26
	Tubulin inhibitor 26 (compound 3c) 是一种吲唑衍生物，是微管蛋白抑制剂，对 HepG2、HCT116、SW620、HT29 和 A549 癌细胞系具有显著的低纳摩尔效力。Tubulin inhibitor 26 抑制G2/M 期肿瘤细胞，并且诱导细胞凋亡。Tubulin inhibitor 26 在体内抑制肿瘤生长，并且不影响小鼠体重。
T61401	3-(3-Phenoxybenzyl)amino-β-carboline
	3-(3-Phenoxybenzyl)amino-β-carboline is a highly effective tubulin inhibitor, selectively degrading αβ-tubulin heterodimers. It induces cell cycle arrest and apoptosis in the G2/M phase. Additionally, 3-(3-Phenoxybenzyl)amino-β-carboline displays notable anticancer activity [1].
T18702	DBA-DM4	Others	Others
	DBA-DM4 is a drug-linker conjugate for antibody-drug conjugate (ADC) synthesis, combining the tubulin inhibitor DM1 with the SPDP linker[1].
T61190	Tubulin inhibitor 27
	Tubulin inhibitor 27 (DYT-1) 是一种微管蛋白聚集 (tubulin polymerisation) 抑制剂，IC50为 25.6 μM。Tubulin inhibitor 27 具有抗血管生成活性和抗肿瘤活性。
T78772	Tubulin inhibitor 37
	Tubulin inhibitor 37（化合物 12）作为Tubulin抑制剂，对Tubulin聚合表现出显著的抑制作用（IC50=1.3 µM）。此外，该化合物在人肿瘤细胞系上展现抗增殖潜力，因此对癌症研究颇具价值。
T60402	Tubulin inhibitor 14
	Tubulin inhibitor 14 是一种有效的 NQO2（醌氧化还原酶 2）抑制剂，IC50 为 1.0 μM，也抑制微管蛋白聚合和内皮细胞毛细管样管的形成。Tubulin inhibitor 14 是一种微管去稳定剂，具有潜在的肿瘤选择性以及抗血管生成和血管破坏的功能[1]。
T60436	Tubulin inhibitor 17
	Tubulin inhibitor 17 (Compound 3b) 是微管蛋白聚合抑制剂（IC50 = 12.38 μM）。Tubulin inhibitor 17 显示出抗癌活性并且诱导细胞凋亡。
T60758	Tubulin polymerization-IN-36
	Tubulin polymerization-IN-36 可用于癌症研究，例如淋巴癌。Tubulin polymerization-IN-36 结合微管蛋白的秋水仙碱位点并且抑制秋水碱结合，是一种微管蛋白聚合的抑制剂，IC50值为 2.8 μM。
T79429	Tubulin polymerization-IN-50
	Tubulin polymerization-IN-50（compound 7n）是一种Tubulin polymerization抑制剂，其在SK-Mel-28细胞中的IC50值为5.05 μM，能够诱导(cell cycle)阻滞在G2/M期。
T79341	Tubulin polymerization-IN-45
	Tubulin polymerization-IN-45 是针对微管蛋白的靶向抑制剂，通过与微管蛋白秋水仙碱结合位点相结合，能够诱导肝细胞癌细胞 (HCC) 发生细胞凋亡 (apoptosis)。
T61600	Tubulin polymerization-IN-10
	Tubulin polymerization-IN-10 is a highly potent inhibitor of tubulin polymerization, exhibiting an IC50 value of 4.25±0.75 μM. It possesses significant anti-tumor properties [1].
T80924	Tubulin polymerization-IN-51
	Tubulin polymerization-IN-51（compound 7u）是抑制SK-Mel-28细胞微管蛋白聚合的化合物，IC50介于2.55至17.89μM。该化合物适用于癌症研究。
T60600	Tubulin polymerization-IN-14
	Tubulin polymerization-IN-14 (Compound 20a) 是一种微管蛋白聚合抑制剂(IC 50 = 3.15 μM) ，具有强大的抗血管和抗癌活性，包括诱导癌细胞凋亡。
T73832	Tubulin inhibitor 21
	Tubulin inhibitor 21 (compound 6f) 为基于查尔酮与褪黑激素混合的有效tubulin抑制剂。该化合物对SW480细胞展现显著的细胞毒性活性（IC50=0.26 μM），对非恶性细胞的毒性较低。
T18306	MC-Alkyl-Hydrazine Modified MMAF	Others	Others
	MC-Alkyl-Hydrazine Modified MMAF is a potent antitumor drug-linker conjugate for ADC, incorporating Modified MMAF, a tubulin inhibitor, through a noncleavable MC-Alkyl-Hydrazine linkage[1].
T61482	Tubulin polymerization-IN-13
	Tubulin polymerization-IN-13 (Compound 4f) is a potent inhibitor of tubulin polymerization, with an IC50 value of 0.37 μM. It displays significant anti-proliferative effects against cancer cells, inducing apoptosis and exhibiting potential antivascular activity [1].
T78917	Tubulin inhibitor 33
	Tubulin inhibitor 33为一种抗微管蛋白聚合化合物，其抑制作用表现为剂量依赖性，具有9.05 μM的IC50。该化合物不仅具备抗肿瘤活性，还能诱导细胞凋亡(apoptosis)，在抗肿瘤研究领域有应用潜力。
T60735	Tubulin polymerization-IN-22
	Tubulin aggregation-IN-22 抑制细胞周期在 G2/M 期，并且诱导细胞凋亡。Tubulin aggregation-IN-22 是一种微管蛋白聚合抑制剂 (IC50 = 8.1 μM)。
T18310	AZ1508 MC-Lys-MMETA	Others	Others
	AZ1508, a tubulin inhibitor[1], serves as a drug-linker conjugate for antibody-drug conjugates (ADC) targeting breast and stomach cancer treatment.
T60568	Tubulin inhibitor 29
	Tubulin inhibitor 29 (compound 3c) 是一种有效的微管抑制剂，可抑制微管聚合并与秋水仙碱位点结合 (IC 50 = 1.2 μM)。Tubulin inhibitor 29 具有抗增殖作用，对人乳腺癌细胞 MCF-7 细胞的 IC50值为 7.5 μM。
T61459	Tubulin inhibitor 19
	Tubulin inhibitor 19 (compound 9b) is a potent indole chalcone compound that exhibits strong inhibitory activity against tubulin. Its potential in cancer research makes it valuable for studying cancer diseases [1].
T62332	Tubulin inhibitor 13
	Tubulin inhibitor 13 (E27) 是一种有效的tubulin抑制剂，其对tubulin聚合的抑制IC50值为16.1 μM。该化合物不仅可以抑制癌细胞迁移和侵袭，还能诱导apoptosis，显示出抗癌活性。
T72676	Tubulin/MMP-IN-1
	Tubulin/MMP-IN-1 是一种有效的tubulin 和MMP 抑制剂。Tubulin/MMP-IN-1具有研究癌症疾病的潜力。Tubulin/MMP-IN-1 抑制微管蛋白聚合，诱导细胞周期停滞在 G2/M 期，导致 HepG2 细胞产生反应性氧化应激 (ROS)，并通过线粒体依赖性凋亡途径导致细胞凋亡[ 1]。

化合物

Tubulin inhibitor 1

Cat.No: T13227

Target: Microtubule Associated

Tubulin inhibitor 6

Cat.No: T13224

Synonym: iHAP1

Target: Microtubule Associated

Cat.No: T1992

Synonym: DM1,Maytansinoid DM1

Target: Microtubule Associated

Cat.No: T4029

Synonym: BTB 1,NSC156750

Target: Microtubule Associated

1-Naphthohydroxamic acid

Cat.No: T13996

Target: HDAC

Cat.No: T22661

Target: Apoptosis, Others, Microtubule Associated

Cat.No: T9831

Synonym: Ro-31-7453

Target: Apoptosis, Akt, Microtubule Associated, mTOR

Cat.No: T21408

Synonym: DM1-SSMe

Target: Microtubule Associated

Cat.No: T6864

Synonym: BMS 247550,Ixempra,Azaepothilone B,伊沙匹隆,BMS 247550-1

Target: Apoptosis, Microtubule Associated

Cat.No: T11917

Synonym: Lys-Nε-MCC-DM1

Target: Microtubule Associated

Cat.No: T15576

Synonym: 2-(1-(4-氯苄基)-1H-吲哚-3-基)-2-氧代-N-(吡啶-4-基)乙酰胺,ZIO 301,D 24851

Target: Apoptosis, Microtubule Associated

Tubulin polymerization-IN-55

Cat.No: T77728

Target: Microtubule Associated

Val-Cit-PAB-MMAE

Cat.No: T18867

BML-284 hydrochloride

Cat.No: T8820

Synonym: BML-284 HCL,Wnt agonist 1 HCL

Target: Wnt/beta-catenin

Cat.No: T60757

Target: Microtubule Associated

Tubulin inhibitor 18

Cat.No: T61472

Tubulin polymerization-IN-15

Cat.No: T61069

Tubulin polymerization-IN-37

Cat.No: T61084

Tubulin inhibitor 28

Cat.No: T61545

Tubulin polymerization-IN-27

Cat.No: T61129

Tubulin inhibitor 15

Cat.No: T60459

Tubulin inhibitor 16

Cat.No: T60460

Tubulin inhibitor 20

Cat.No: T60755

Tubulin/HDAC-IN-1

Cat.No: T61524

Tubulin inhibitor 12

Cat.No: T61242

Cat.No: T39139

Synonym: PARP1-IN-6

αβ-Tubulin-IN-1

Cat.No: T62058

Tubulin inhibitor 26

Cat.No: T60793

3-(3-Phenoxybenzyl)amino-β-carboline

Cat.No: T61401

Cat.No: T18702

Target: Others

Tubulin inhibitor 27

Cat.No: T61190

Tubulin inhibitor 37

Cat.No: T78772

Tubulin inhibitor 14

Cat.No: T60402

Tubulin inhibitor 17

Cat.No: T60436

Tubulin polymerization-IN-36

Cat.No: T60758

Tubulin polymerization-IN-50

Cat.No: T79429

Tubulin polymerization-IN-45

Cat.No: T79341

Tubulin polymerization-IN-10

Cat.No: T61600

Tubulin polymerization-IN-51

Cat.No: T80924

Tubulin polymerization-IN-14

Cat.No: T60600

Tubulin inhibitor 21

Cat.No: T73832

MC-Alkyl-Hydrazine Modified MMAF

Cat.No: T18306

Target: Others

Tubulin polymerization-IN-13

Cat.No: T61482

Tubulin inhibitor 33

Cat.No: T78917

Tubulin polymerization-IN-22

Cat.No: T60735

Cat.No: T18310

Synonym: MC-Lys-MMETA

Target: Others

Tubulin inhibitor 29

Cat.No: T60568

Tubulin inhibitor 19

Cat.No: T61459

Tubulin inhibitor 13

Cat.No: T62332

Tubulin/MMP-IN-1

Cat.No: T72676

Cat. No.	Product Name	Target	Signaling Pathways
T82241	Halichondrin B
	Halichondrin B，源自海绵 Halichondria okadai，为非竞争性Vinca-alkaloid 微管蛋白结合抑制剂，微管蛋白聚合 IC50 值为1.2-1.4 μM，表现出抗肿瘤活性。
T75521	PM050489
	PM050489 是一种有效的聚酮类微管/微管蛋白 (Microtubule/Tubulin) 抑制剂，可从马达加斯加海绵Lithoplocamia lithistoides 中分离。PM050489 抑制有丝分裂，IC50值为 26.4 nM。PM050489 具有抗肿瘤活性，能用于癌症研究。
T75646	Moroidin
	Moroidin是一种双环八肽，隶属于荨麻疹科环肽科，有效抑制纯化的微管蛋白聚合，表现为微管蛋白聚合抑制剂。此外，Moroidin对包括A549人肺癌细胞在内的多种癌细胞显示出细胞毒性作用，能诱导细胞凋亡。

天然产物

Cat.No: T82241

Cat.No: T75521

Cat.No: T75646

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