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21

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5315	TCA1 TCA-1,TCA 1	Antibacterial; Antibiotic	Microbiology/Virology
	TCA1 (TCA 1) 是一种小分子，具有抗耐药性和持续性结核病的活性。
T0653	Tris(2-chloroethyl) phosphate Disflamoll TCA,Fyrol CEF,磷酸三氯乙酯,Celluflex	Others	Others
	Tris(2-chloroethyl) phosphate (Fyrol CEF) 用作阻燃剂。
T23426	TC-A 2317 hydrochloride	Others; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Others
	TC-A 2317 hydrochloride 是 Aurora 激酶 A 的抑制剂，Ki 为 1.2 nM，而 Aurora 激酶 B 的 Ki 为 101 nM。 TC-A 2317 hydrochloride 显示出抗肿瘤活性。
T38437	NMTCA N-Nitroso-2-methylthiazolidine4-carboxylicacid,NMTPRO,N-nitrosomethylthioproline
	NMTCA (NMTPRO) is a sulfur-containing N-nitrosamino acid utilized as an endogenous nitrosation indicator in gas chromatography-thermal energy analysis.
T12232	Nitroxazepine CIBA 2330Go	Serotonin Transporter	Neuroscience
	Nitroxazepine (CIBA 2330Go) 是三环抗抑郁化合物，是一种 5-羟色胺去甲肾上腺素再摄取抑制剂，可用于抗抑郁的研究。
T21013	Clomipramine Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明	5-HT Receptor	GPCR/G Protein; Neuroscience
	Clomipramine (Clomicalm) 是一种三环类抗抑郁药，能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ，可用于研究强迫症 (OCD) 及抑郁症。
T0991	Desipramine hydrochloride NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Desipramine hydrochloride (Norimipramine) 是一种二苯并氮杂类衍生物三环类抗抑郁药，可作为选择性去甲肾上腺素再摄取抑制剂。它还显示出较弱的 5-羟色胺再摄取抑制、α1 阻断、抗组胺和抗胆碱能作用。
T0943	Carbamazepine 卡马西平,NSC 169864	Mitophagy; Sodium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel
	Carbamazepine (NSC-169864) 是与三环抗抑郁药化学相关的三环化合物，具有抗惊厥和镇痛特性。它通过减少多突触反应和阻断强直后增强发挥其抗惊厥活性。它通常用于治疗与三叉神经痛相关的疼痛。
T15132L	Dimetacrine tartrate Linostil,Istonil,Istonyl,Miroistonil,MO 709
	Dimetacrine tartrate is a tricyclic antidepressant (TCA) used for the therapy of depression in Europe and formerly in Japan.
T69579	Dothiepin HCl
	Dothiepin HCl is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.
T22240	Amitriptyline	Sigma receptor; 5-HT Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Amitriptyline 是一种具有镇痛特性的三环类抗抑郁药 (TCA)。它广泛用于治疗抑郁症和神经性疼痛。
T71773	Levomepromazine Maleate
	Levomepromazine Maleate is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.
T31824	Fluoroglutamine (2S,4R) FDG
	Fluoroglutamine (2S,4R) is a Glutamine analog, not metabolized in the TCA cycle, but it can be incorporated into proteins and peptides. Fluoroglutamine (2S,4R) can be used as assess transporter (ASCT2) activity or protein synthesis rate.
T61376	Opipramol
	Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA) that primarily acts as a sigma (σ) receptor agonist, exhibiting potent interaction with sigma recognition sites (K i value of 50 nM). It can be employed in the research of generalized anxiety disorder (GAD) [1] [2].
T73805	Acetyl coenzyme A
	Acetyl-coenzyme A (Acetyl-CoA) 是一种具有膜非渗透性的中枢代谢中间体，参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A 通过向目标氨基酸残基提供乙酰基团，来完成蛋白质的翻译后乙酰化反应，从而调节各种细胞机制。Acetyl Coenzyme A 也是脂质合成的关键前体。
T73796	Acetyl coenzyme A lithium
	Acetyl-coenzyme A (Acetyl-CoA) lithium 是一种膜非渗透性的中枢代谢中间体，参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A lithium 通过向目标氨基酸残基提供乙酰基团，来完成蛋白质的翻译后乙酰化反应，从而调节各种细胞机制。Acetyl Coenzyme A lithium 也是脂质合成的关键前体。
T61741	Azaphen dihydrochloride monohydrate
	Pipofezine(Azafen，Azaphen)是5-羟色胺重吸收抑制剂。
T76124	Acyl coenzyme A synthetase
	Acyl coenzyme A synthetase (ACS)，一种生化研究中常用的酶，主要通过两步硫酯化反应激活脂肪酸与辅酶A结合，形成酰基辅酶A。该过程为脂质代谢中的多种合成与分解代谢途径，以及参与TCA循环中的有氧呼吸提供了关键中间物。
T77253	β-Nicotinamide adenine dinucleotide reduced dipotassium
	β-Nicotinamide adenine dinucleotide reduced dipotassium 作为一种口服有效的还原型辅酶，在ADP-核糖基转移酶反应中担任ADP-核糖单元的供体及环状ADP-核糖的前体。该化合物在细胞能量代谢，包含糖酵解、β-氧化及三羧酸(TCA)循环中，发挥重要的再生电子供体角色。
T75430	Succinic acid tromethamine
	Succinic acid tromethamine 是一种口服活性抗焦虑剂，有效地参与三羧酸循环作为中间产物。它也广泛用作食品、化学和制药行业中多种重要工业化学品的前体。
T36401	DCVC
	DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue p...

化合物

Cat.No: T5315

Synonym: TCA-1,TCA 1

Target: Antibacterial, Antibiotic

Tris(2-chloroethyl) phosphate

Cat.No: T0653

Synonym: Disflamoll TCA,Fyrol CEF,磷酸三氯乙酯,Celluflex

Target: Others

TC-A 2317 hydrochloride

Cat.No: T23426

Target: Others, Aurora Kinase

Cat.No: T38437

Synonym: N-Nitroso-2-methylthiazolidine4-carboxylicacid,NMTPRO,N-nitrosomethylthioproline

Cat.No: T12232

Synonym: CIBA 2330Go

Target: Serotonin Transporter

Cat.No: T21013

Synonym: Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明

Target: 5-HT Receptor

Desipramine hydrochloride

Cat.No: T0991

Synonym: NSC-114901,Desmethylimipramine,盐酸去甲咪嗪,JB-8181,EX-4355,Norimipramine,G-35020

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor

Cat.No: T0943

Synonym: 卡马西平,NSC 169864

Target: Mitophagy, Sodium Channel, Autophagy

Dimetacrine tartrate

Cat.No: T15132L

Synonym: Linostil,Istonil,Istonyl,Miroistonil,MO 709

Cat.No: T69579

Cat.No: T22240

Target: Sigma receptor, 5-HT Receptor, Norepinephrine, Histamine Receptor

Levomepromazine Maleate

Cat.No: T71773

Fluoroglutamine (2S,4R)

Cat.No: T31824

Synonym: FDG

Cat.No: T61376

Acetyl coenzyme A

Cat.No: T73805

Acetyl coenzyme A lithium

Cat.No: T73796

Azaphen dihydrochloride monohydrate

Cat.No: T61741

Acyl coenzyme A synthetase

Cat.No: T76124

β-Nicotinamide adenine dinucleotide reduced dipotassium

Cat.No: T77253

Succinic acid tromethamine

Cat.No: T75430

Cat.No: T36401

Cat. No.	Product Name	Target	Signaling Pathways
T4862	Oxaloacetic acid	Endogenous Metabolite	Metabolism
	Oxaloacetic acid 是一种代谢中间体，涉及多种途径，如葡萄糖异生、柠檬酸循环、乙醛酸循环、尿素循环、氨基酸合成和脂肪酸合成。
T8073	Disodium succinate 丁二酸二钠,Sodium succinate	Others	Others
	Disodium succinate (Sodium succinate) 是 Succinic acid 的盐形式。Succinic acid 是无氧代谢的发酵产物，也是三羧酸循环的中间产物。
T5980	2-Ketoglutaric acid α-酮戊二酸,alpha-酮戊二酸	Tyrosinase; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	2-Ketoglutaric acid 是 Krebs 循环的中间体，可以产生 ATP 或 GTP 。2-Ketoglutaric acid 还充当氮同化反应的主要碳骨架。2-Ketoglutaric acid 是酪氨酸酶(tyrosinase)的可逆抑制剂 (IC50=15 mM)。
T5283	NADH disodium salt Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠	Others; Endogenous Metabolite	Metabolism; Others
	NADH disodium salt (Disodium NADH) hydrate 是氧化还原酶的辅酶。NADH disodium salt hydrate 在分解代谢过程中起到再生电子供体的作用，包括糖酵解，柠檬酸循环和β-氧化。
T4920	2-Ketoglutaric acid Sodium Oxoglutaric acid,AKG,2-oxoglutarate monobasic,LPHA-酮戊二酸钠,α-Ketoglutaric acid sodium salt	Tyrosinase; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	2-Ketoglutaric acid Sodium (AKG) 是一种三羧酸循环的中间产物，它可以由谷氨酸通过谷氨酸脱氢酶氧化脱氨产生，也可以作为磷酸吡哆醛依赖的转氨化反应的产物(由支链氨基酸转氨酶介导)，其中谷氨酸是常见的氨基供体。
T68351	Homodestcardin
	Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells.
T19121	3-Hydroxyvaleric acid	Others	Others
	3-Hydroxyvaleric acid is anaplerotic, meaning it can refill the pool of TCA cycle intermediates.
T4921	Oxoadipic acid 2-氧代己二酸,2-Oxoadipic acid	Endogenous Metabolite	Metabolism
	Oxoadipic acid (2-Oxoadipic acid) 是必需氨基酸色氨酸和赖氨酸的一种代谢物。
T8096	Diethyl succinate	Others	Others
	Diethyl succinate 能够在生理 pH 下使用并穿过生物膜，掺入组织培养物中的细胞中，通过 TCA 循环进行代谢。它不具有毒性，可用于香料和调味剂中。
T4838	(S)-Malic acid L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸	Others; Endogenous Metabolite	Metabolism; Others
	(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸，是水果酸甜味的来源，常用作食品添加剂。

天然产物

Oxaloacetic acid

Cat.No: T4862

Target: Endogenous Metabolite

Disodium succinate

Cat.No: T8073

Synonym: 丁二酸二钠,Sodium succinate

Target: Others

2-Ketoglutaric acid

Cat.No: T5980

Synonym: α-酮戊二酸,alpha-酮戊二酸

Target: Tyrosinase, Endogenous Metabolite

NADH disodium salt

Cat.No: T5283

Synonym: Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠

Target: Others, Endogenous Metabolite

2-Ketoglutaric acid Sodium

Cat.No: T4920

Synonym: Oxoglutaric acid,AKG,2-oxoglutarate monobasic,LPHA-酮戊二酸钠,α-Ketoglutaric acid sodium salt

Target: Tyrosinase, Endogenous Metabolite

Cat.No: T68351

3-Hydroxyvaleric acid

Cat.No: T19121

Target: Others

Cat.No: T4921

Synonym: 2-氧代己二酸,2-Oxoadipic acid

Target: Endogenous Metabolite

Diethyl succinate

Cat.No: T8096

Target: Others

Cat.No: T4838

Synonym: L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸

Target: Others, Endogenous Metabolite

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