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Search Results for " survivin "

27

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2292	survivin (baculoviral IAP repeat-containing protein 5) (21-28)	Others	Others
	Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibitions of apoptosis and mitosis regulation1. Survivin is one of the most uniformly up-regulated genes
T8469	LQZ-7I	Survivin	Apoptosis
	LQZ-7I 能口服有效地抑制异种移植肿瘤生长并诱导肿瘤中生存素的损失。它是一种靶向生存素的抑制剂，抑制生存素二聚化。
T11383	GDP366	Survivin	Apoptosis
	GDP366 有效且特异性地抑制 survivin 和 Op18 的表达。 GDP366 增加染色体不稳定性，并通过抑制端粒酶活性诱导细胞衰老。
T2111	Sepantronium bromide YM155	Survivin; Autophagy	Apoptosis; Autophagy
	Sepantronium bromide (YM155) 是一种小分子促凋亡剂，具有潜在抗肿瘤活性。它是一种生存素抑制剂，IC50为 0.54 nM。
T83774	Shepherdin TFA Lys-His-Ser-Ser-Gly-Cys-Ala-Phe-Leu-OH,Survivin (79-87)
	Shepherdin是人体survivin的79-87氨基酸对应的合成肽，也是survivin与heat shock protein 90 (Hsp90)之间蛋白质-蛋白质相互作用的抑制剂。它以浓度依赖的方式与Hsp90的N末端结构域结合，并在150 µM的浓度下抑制了在分离的人源网状红细胞提取物中重组人survivin与Hsp90之间的相互作用。结合了穿膜肽penetratin或HIV Tat序列的Shepherdin肽结合物，体内外具有抗癌活性。
T13410	ZLDI-8	Apoptosis; Phosphatase; Gamma-secretase; Immunology/Inflammation related	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome; Stem Cells
	ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂，可抑制 Notch 蛋白裂解，并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂，以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。
T22424	1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	SC-1 是一种 Sorafenib 的衍生物，可抑制 STAT3磷酸化，通过依赖 SHP-1 的 STAT3失活诱导细胞凋亡，具有抗癌作用。
T9945	MNK8 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione	STAT	JAK/STAT signaling; Stem Cells
	MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) 是一种有效的STAT3抑制剂，降低STAT3与DNA 结合的能力，对肝癌细胞也有良好的生长抑制作用。
T61184	LQZ-7F	Apoptosis; Survivin	Apoptosis
	LQZ-7F 是一种小分子生存素二聚化抑制剂，具有抗癌活性。LQZ-7F 诱导蛋白酶体依赖性存活素降解、有丝分裂停滞和细胞凋亡，并在小鼠异种移植试验中阻断人类肿瘤的生长。
T12896L	Shepherdin 79-87 acetate Shepherdin 79-87 acetate (861224-28-4 free base)	HSP; Survivin	Apoptosis; Cytoskeletal Signaling; Metabolism
	Shepherdin 79-87 acetate 是 Hsp90 和 survivin 之间复合物的拟肽拮抗剂，survivin 是肿瘤细胞活力的另一个关键调节剂。
T3708	BP-1-102	STAT	JAK/STAT signaling; Stem Cells
	BP-1-102 是可口服的转录因子Stat3小分子抑制剂，IC50值为 6.8 μM。
T77701	FL118 FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin	Survivin	Apoptosis
	FL118是一种新型存活素抑制剂，可抑制癌症干细胞样特性。FL118 是一种新型喜树碱类似物，具有抗癌活性，通过 Wnt/β-catenin 信号通路抑制上皮-间充质转化，从而抑制人乳腺癌细胞的迁移和侵袭。
T15137	DK419	Wnt/beta-catenin; AMPK	Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells
	DK419 是一种具有口服活性的 Wnt/β-catenin 信号通路抑制剂，IC50 为 0.19 μM。 DK419 降低 Axin2、β-catenin、c-Myc、Cyclin D1 和 Survivin 的蛋白质水平。它还诱导 pAMPK 的产生。
T61030	STAT3-IN-11	Apoptosis; STAT	Apoptosis; JAK/STAT signaling; Stem Cells
	STAT3-IN-11 是一种选择性 STAT3 抑制剂，对 STAT3pTyr705位点的磷酸化和Survivin 的磷酸化有抑制作用。STAT3-IN-11 促使癌细胞凋亡，是治疗癌症的候选化合物。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T25746	LLP6 LLP 6,LLP-6
	LLP6 is used as a survivin modulator.
T70733	APX2009
	APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell proliferation and induces cell cycle arrest.
T26832	BKM1740 BKM-1740,BKM 1740
	BKM1740 induced apoptosis in prostate cancer (PCa) cells by repressing survivin at both the mRNA and protein levels in vitro.
T69845	MX107
	MX107 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.
T69840	MX106
	MX106 is a survivin inhibitor which induces degradation of XIAP and/or cIAP1, and suppresses genotoxic NF-kappaB activation.
T21834	YM-155 hydrochloride
	Sepantronium hydrochloride (YM-155 hydrochloride) 是一种新型survivin 抑制剂，抑制survivin 启动子的IC50为 0.54 nM。
T12896	Shepherdin (79-87) Shepherdin 79-87	Others	Others
	Shepherdin 79-87, comprising amino acids 79 to 87 of Shepherdin, acts as a peptidomimetic antagonist targeting the Hsp90-Survivin complex, exhibiting anticancer properties.
T38414	NSC 80467
	NSC 80467, a selective DNA damaging agent, functions by inhibiting survivin. Specifically, it preferentially targets DNA synthesis, leading to the induction of two distinct markers of DNA damage, namely γH2AX and pKAP1.
T35542	LLP-3
	Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 μM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.
T71925	Isonanangenine B
	Isonanangenine B is a drimane sesquiterpene lactone that has been found in Aspergillus. It decreases survivin mRNA expression in a reporter assay when used at concentrations of 13.6, 18.42, and 26.31 µM. Isonanagenine B (18.42 µM) inhibits STAT3 and NF-κB binding to the survivin promoter in chromatin immunoprecipitation (ChIP) assays. It also induces apoptosis in COLO 320DM cells.
T70988	Ibulocydine
	Ibulocydine is a potent CDK inhibitor. Ibulocydine has high activity against Cdk7/cyclin H/Mat1 and Cdk9/cyclin T. Ibulocydine inhibited the growth of HCC cells more effectively than other Cdk inhibitors, including olomoucine and roscovitine, whereas ibulocydine as well as the other Cdk inhibitors and BMK-Y101 minimally influenced the growth of normal hepatocyte cells. Ibulocydine induced apoptosis in HCC cells, most likely by inhibiting Cdk7 and Cdk9. In vitro treatment of HCC cells with ibuloc...
T35729	Nemadipine-A
	Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It ...

化合物

survivin (baculoviral IAP repeat-containing protein 5) (21-28)

Cat.No: TP2292

Target: Others

Cat.No: T8469

Target: Survivin

Cat.No: T11383

Target: Survivin

Sepantronium bromide

Cat.No: T2111

Synonym: YM155

Target: Survivin, Autophagy

Cat.No: T83774

Synonym: Lys-His-Ser-Ser-Gly-Cys-Ala-Phe-Leu-OH,Survivin (79-87)

Cat.No: T13410

Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

Cat.No: T22424

Target: Apoptosis, STAT

Cat.No: T9945

Synonym: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione

Target: STAT

Cat.No: T61184

Target: Apoptosis, Survivin

Shepherdin 79-87 acetate

Cat.No: T12896L

Synonym: Shepherdin 79-87 acetate (861224-28-4 free base)

Target: HSP, Survivin

Cat.No: T3708

Target: STAT

Cat.No: T77701

Synonym: FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin

Target: Survivin

Cat.No: T15137

Target: Wnt/beta-catenin, AMPK

Cat.No: T61030

Target: Apoptosis, STAT

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cat.No: T25746

Synonym: LLP 6,LLP-6

Cat.No: T70733

Cat.No: T26832

Synonym: BKM-1740,BKM 1740

Cat.No: T69845

Cat.No: T69840

YM-155 hydrochloride

Cat.No: T21834

Shepherdin (79-87)

Cat.No: T12896

Synonym: Shepherdin 79-87

Target: Others

Cat.No: T38414

Cat.No: T35542

Isonanangenine B

Cat.No: T71925

Cat.No: T70988

Cat.No: T35729

Cat. No.	Product Name	Target	Signaling Pathways
T8213	Isolinderalactone	NOS; STAT	Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Isolinderalactone 具有抗炎和抗癌能力，具有中等的 iNOS 抑制活性，IC50 值为 0.30 uM。
T3S1471	Cucurbitacin IIA 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis; Survivin	Apoptosis
	Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯，可诱导细胞凋亡和增强自噬，有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达，降低磷酸化组蛋白 H3 的水平，增加裂解的 PARP 的水平。

天然产物

Isolinderalactone

Cat.No: T8213

Target: NOS, STAT

Cucurbitacin IIA

Cat.No: T3S1471

Synonym: 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

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