keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibitions of apoptosis and mitosis regulation1. Survivin is one of the most uniformly up-regulated genes in tumor tissues compared with healthy tissues2. High survivin expression in the primary tumor is almost invariably associated with poor patient prognosis in many cancer types.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 483 | 待询 | ||
5 mg | ¥ 1,383 | 待询 | ||
10 mg | ¥ 2,283 | 待询 | ||
25 mg | ¥ 3,183 | 待询 |
产品描述 | Survivin (baculoviral inhibitor of apoptosis IAP repeat-containing protein-5) is a member of the IAP gene family, which has been implicated in both inhibitions of apoptosis and mitosis regulation1. Survivin is one of the most uniformly up-regulated genes in tumor tissues compared with healthy tissues2. High survivin expression in the primary tumor is almost invariably associated with poor patient prognosis in many cancer types. |
体外活性 | Survivin relates to poor disease outcome in a variety of tumors, i.e., neuroblastoma3, colorectal cancer4, non-small-cell lung cancers5, B-cell lymphoma6, T-cell leukemia7, hepatocellular carcinoma, esophageal carcinoma, rectal cancer, glioma, bladder cancer, soft tissue sarcoma, and astrocytic tumors. Survivin mRNA, as measured by quantitative RT-PCR in the primary tumor, has strong and independent prognostic value in human breast cancer. Survivin mRNA concentrations in the tumor can be used to classify breast cancer patients into different risk groups. 8 Cells that are unresponsive to apoptotic triggers will also be more resistant to cytotoxic treatments, as are cells that overexpress survivin9. |
分子量 | 1052.22 |
分子式 | C54H73N11O11 |
CAS No. | TP2292 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: ≥105.2mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
survivin (baculoviral IAP repeat-containing protein 5) (21-28) TP2292 Others survivin (baculoviral IAP repeat containing protein 5) (21 28) survivin (baculoviral IAP repeatcontaining protein 5) (2128) Inhibitor inhibitor inhibit