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26

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2083	PI-3065 PI3065	DNA-PK; PI3K; mTOR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PI-3065 是一种有效的PI3K p110δ抑制剂(IC50=5 nM;Ki=1.5 nM)。它对 p110α，p110β，p110γ 的作用较弱，IC50分别为 910，600，>10000 nM。
T60390	PI-55 6-(2-hydroxy-3-methylbenzylamino)purine	Others	Others
	PI-55 (6-(2-hydroxy-3-methylbenzylamino)purine) is a cytokinin receptor inhibitor that exhibits structural similarity to 6-benzylaminopurine (BAP). It competitively inhibits BAP binding on the specific Arabidopsis receptors CRE1/AHK4 and AHK3. Furthermore, PI-55 effectively suppresses cytokinins-induced haustorium formation and enhances parasite aggressiveness [1].
T6143	PI-103 PI103,PI 103	Apoptosis; DNA-PK; PI3K; mTOR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PI-103 是一种 PI3K 和 mTOR 抑制剂，抑制 p110α、p110β、p110δ、p110γ、mTORC1和 mTORC2，IC50分别为 8 nM、88 nM、48 nM、150 nM、20 nM 和 83 nM。它可诱导自噬，还抑制 DNA-PK，IC50为 2 nM。
T5831	Selective PI3Kδ Inhibitor 1	PI3K	PI3K/Akt/mTOR signaling
	Selective PI3Kδ Inhibitor 1 是一种 PI3Kδ 抑制剂 (IC50 = 0.9 nM)。
T12469	PI4KIIIbeta-IN-9	PI3K; PI4K	PI3K/Akt/mTOR signaling
	PI4KIIIbeta-IN-9 是一种 PI4KIIIβ抑制剂，其 IC50=7 nM。它也抑制 PI3Kδ (IC50:125 nM) 和 PI3Kγ (IC50:1046 nM)。
T12459	PI3K/mTOR Inhibitor-2	PI3K; mTOR	PI3K/Akt/mTOR signaling
	PI3K/mTOR Inhibitor-2 是一种有效的 PI3K 和 mTOR 泛抑制剂，对 PI3Kα、PI3Kβ、PI3Kδ、PI3Kγ 和 mTOR 的 IC50 分别为 3.4、34、16,1 和 4.7 nM。 PI3K/mTOR Inhibitor-2 具有抗肿瘤活性。
T12467	PI4KIII beta inhibitor 3	PI3K	PI3K/Akt/mTOR signaling
	PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).
T1826	PI3K-IN-1 Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409	DNA-PK; PI3K	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PI3K-IN-1 (Voxtalisib Analogue) 是 PI3K 抑制剂，PI3K-IN-1(25 μM) 能够阻断 PI3K/Akt 信号通路。
T36315	NVS-PI3-4 NVS-PI3-4
	NVS-PI3-4 is a highly selective inhibitor of the enzyme PI3Kγ. It is specifically designed for use in scientific investigations related to allergies, inflammatory conditions, and cancerous diseases[1][2].
T35525	PI3-Kinase α Inhibitor 2 PI3-Kinase α Inhibitor 2
	Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. PI3Kα inhibitor 2 is a selective inhibitor of PI3Kα with IC50 values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It...
T35526	PI3-Kinase α Inhibitor 2 (hydrochloride) PI3-Kinase α Inhibitor 2 (hydrochloride)
	PI3-Kinase α Inhibitor 2 (hydrochloride) 是一种 PI3-Kinase α 抑制剂。
T23259	(RS)-3-Hydroxyphenylglycine	GluR	Neuroscience
	(RS)-3-Hydroxyphenylglycine 是一种 PI 连接的代谢型谷氨酸受体激动剂。
T25399	ETP-45658 ETP45658,ETP 45658	DNA-PK; PI3K; mTOR	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	ETP-45658 (ETP45658) 是一种PI3K 抑制剂，抑制PI3Kα、PI3Kδ、PI3Kβ和PI3Kγ的IC50值分别为 22.0、39.8、129.0 和 717.3 nM。它可研究癌症，还抑制DNA-PK 和mTOR，IC50分别为70.6 和 152 nM。
T1949	CZC24832	PI3K	PI3K/Akt/mTOR signaling
	CZC24832 是一种PI3Kγ选择性抑制剂，其 IC50=27 nM，Kdapp=19 nM。
T16528	PI-828 LY 294002, 4gamma-NH2	Casein Kinase; PI3K	Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	PI-828 是磷脂酰肌醇3-激酶(PI3K)抑制剂，广泛用于研究 PI3K 的生理功能，也可促进干细胞向中胚层分化。
T24873	TGX-115 TGX 115	PI3K	PI3K/Akt/mTOR signaling
	TGX-115是一种细胞渗透性和有效的PI 3-K 异构体p110β/p110δ抑制剂(对p110β IC50值为 0.13 μM, 对p110δ值为0.63 μM），是一种调节血小板粘附过程的酶，可抑制磷酸肌苷（PI）3-激酶，可用来治疗冠状动脉闭塞、中风、急性冠状动脉综合征、急性心肌梗塞、血管再狭窄、动脉硬化和不稳定心绞痛等心血管疾病。
T27858	LTURM-36 LTURM 36,LTURM36
	LTURM-36 is a novel inhibitor of PI 3-kinase delta.
T68443	PI-540
	PI-540 is a potent and selective inhibitor of class 1A phosphatidylinositide 3-kinases (PI3K).
T70887	GSK-1059615 sodium salt hydrate
	GSK-1059615 sodium salt hydrate is a potent inhibitor of PI 3-kinase α (PI3Kα).
T6143L	PI-103 Hydrochloride
	PI-103 Hydrochloride 是一种有效的PI3K 和mTOR 双重抑制剂，抑制p110α，p110β，p110δ，p110γ，mTORC1和mTORC2，IC50分别为 8 nM，88 nM，48 nM，150 nM，20 nM 和 83 nM。PI-103 Hydrochloride 也可抑制DNA-PK，IC50为 2 nM。PI-103 Hydrochloride 诱导细胞自噬 (autophagy)。
T36938	PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt) PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3)-P1 (1,2-dioctanoyl) is a synthetic analog of natural PtdIns featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and DAG stereochemistry as the natural compound. PtdIns-(3)-P1 can be phosphorylated to di- (PtdIns-P2; PIP2) and triphosphates (Ptd...
T71287	CDKI-83
	CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be devel...
T36806	TPC2-A1-P TPC2-A1-P
	TPC2-A1-P is a powerful and membrane permeable agonist of two pore channel 2 (TPC2) with an EC50 of 10.5 μM. TPC2-A1-P plays its role by mimicking the physiological actions of PI(3,5)P2. TPC2-A1-P also shows higher potency to induce Na2+ mobilisation from TPC2 than TPC-A1-N . TPC2-A1-P can be used to probe different functions of TPC2 channels in intact cells[1][2][3]. Two-pore channels (TPC1-3) are ancient members of the voltage-gated ion channel superfamily. TPCs are expressed throughout the en...
T70962	MHY219
	MHY219 is a novel HDAC inhibitor. MHY219 induces apoptosis via up-regulation of androgen receptor expression in human prostate cancer cells. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC50, 0.36 μM) when compared with LNCaP (IC50, 0.97 μM) and PC3 cells (IC50, 5.12 μM). MHY219 showed a potent inhibition of total HDAC activity when compared with SAHA. MHY219 increased histone H3 hyperacetylation and reduced the expression of class I HDACs (1, 2 and 3) in prostate cancer cells. M...
T37120	1,2,3-Triundecanoyl Glycerol
	1,2,3-Triundecanoyl glycerol is a triacylglycerol that contains undecanoic acid at thesn-1,sn-2, andsn-3 positions. Dietary administration of a 7:3 (w/w) mixture of 1,2,3-triundecanoyl glycerol and corn oil prevents fasting-induced decreases in plasma glucose, alanine, and insulin levels, as well as the ratio of insulin to glucagon, in rats compared with dietary administration of corn oil alone.1 1.Pi-Sunyer, F.X., Conway, J.M., Lavau, M., et al.Glucagon, insulin, and gluconeogenesis in fasted o...
T36805	TPC2-A1-N TPC2-A1-N
	TPC2-A1-N is a novel, lipophilic, membrane permeable isoform-selective small molecule agonist of two-pore channel 2 (TPC2). TPC2-A1-N plays its role by mimicking the physiological actions of NAADP and PI(3,5)P2 through independent binding sites. TPC2-A1-N has inverse effects on key lysosomal activities and increases the pH in the lysosomal lumen in a TPC2-dependent manner[1].

化合物

Cat.No: T2083

Synonym: PI3065

Target: DNA-PK, PI3K, mTOR

Cat.No: T60390

Synonym: 6-(2-hydroxy-3-methylbenzylamino)purine

Target: Others

Cat.No: T6143

Synonym: PI103,PI 103

Target: Apoptosis, DNA-PK, PI3K, mTOR, Autophagy

Selective PI3Kδ Inhibitor 1

Cat.No: T5831

Target: PI3K

PI4KIIIbeta-IN-9

Cat.No: T12469

Target: PI3K, PI4K

PI3K/mTOR Inhibitor-2

Cat.No: T12459

Target: PI3K, mTOR

PI4KIII beta inhibitor 3

Cat.No: T12467

Target: PI3K

Cat.No: T1826

Synonym: Voxtalisib Analogue,Voxtalisib (SAR245409, XL765) Analogue,XL765,SAR245409

Target: DNA-PK, PI3K

Cat.No: T36315

Synonym: NVS-PI3-4

PI3-Kinase α Inhibitor 2

Cat.No: T35525

Synonym: PI3-Kinase α Inhibitor 2

PI3-Kinase α Inhibitor 2 (hydrochloride)

Cat.No: T35526

Synonym: PI3-Kinase α Inhibitor 2 (hydrochloride)

(RS)-3-Hydroxyphenylglycine

Cat.No: T23259

Target: GluR

Cat.No: T25399

Synonym: ETP45658,ETP 45658

Target: DNA-PK, PI3K, mTOR

Cat.No: T1949

Target: PI3K

Cat.No: T16528

Synonym: LY 294002, 4gamma-NH2

Target: Casein Kinase, PI3K

Cat.No: T24873

Synonym: TGX 115

Target: PI3K

Cat.No: T27858

Synonym: LTURM 36,LTURM36

Cat.No: T68443

GSK-1059615 sodium salt hydrate

Cat.No: T70887

PI-103 Hydrochloride

Cat.No: T6143L

PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)

Cat.No: T36938

Synonym: PtdIns-(3)-P1 (1,2-dioctanoyl) (sodium salt)

Cat.No: T71287

Cat.No: T36806

Synonym: TPC2-A1-P

Cat.No: T70962

1,2,3-Triundecanoyl Glycerol

Cat.No: T37120

Cat.No: T36805

Synonym: TPC2-A1-N

Cat. No.	Product Name	Target	Signaling Pathways
T8187	Tetrahydroepiberberine	Others; Influenza Virus; Antifungal	Microbiology/Virology; Others
	Tetrahydroepiberberine 是从Corydalis impatiens(Pall) 中分离得到的一种异喹啉生物碱，具有抗真菌和选择性抑制 PI-3 病毒活性的作用。
T81952	Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo-
	Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo- 是一种从土津皮 (山楝的根皮) 提取的羊毛甾烷型化合物。

天然产物

Tetrahydroepiberberine

Cat.No: T8187

Target: Others, Influenza Virus, Antifungal

Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo-

Cat.No: T81952

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