92
3
12
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T72224 | NK1 receptor antagonist 2 | ||
NK1receptor antagonist 2 是一种 NK1受体拮抗剂。NK1receptor antagonist 2 可用于耳鸣和听力损失的研究。 | |||
T12233 |
NK-1 Antagonist 1
Rolapitant intermediate |
Others | Others |
NK-1 Antagonist 1 is a NK-1 receptor antagonist. | |||
T78268 |
Anti-Mouse NK1.1 Antibody (PK136)
|
||
Anti-Mouse NK1.1 Antibody (PK136) 是鼠源靶向 NK1.1的IgG2a类抗体,可消除外周血、脾脏和肺组织中的NK1.1和NK1.1NKT细胞,抑制 NK1.1 信号传导,可用于研究心肺衰竭。 | |||
T60733 | MNK1/2-IN-5 | ||
MNK1/2-IN-5 是 MNK1/2的有效的选择性抑制剂。 | |||
T73295 |
WNK1-IN-1
|
||
WNK1-IN-1 是 WNK1的选择性抑制剂,IC50值为 1.6 μM。WNK1-IN-1 抑制 OSR1 磷酸化,IC50值为 4.3 μM。WNK1-IN-1 可用于血压调节和癌症的研究。 | |||
T62686 | MNK1/2-IN-6 | ||
MNK1/2-IN-6 是一种有效的、选择性的 MNK1 (IC50: 2.3 nM)、MNK2 (IC50: 3.4 nM) 抑制剂。MNK1/2-IN-6 能够以浓度依赖性方式诱导细胞凋亡。 | |||
T13306L |
Vapreotide acetate
RC-160 acetate,醋酸伐普肽,BMY-41606 acetate |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Vapreotide acetate (BMY-41606 acetate) 是神经激肽-1 (NK1) 受体拮抗剂,IC50值为 330 nM。 | |||
T13329L |
Vofopitant dihydrochloride
GR 205171A,Vofopitant 2HCl |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Vofopitant dihydrochloride (GR 205171A) 是一种可口服且具有选择性的速激肽 NK1 受体拮抗剂,对 [3H]SP 与 NK1 结合有抑制作用, pKi 值分别为 9.5 和 10.6。Vofopitant dihydrochloride 是治疗病理性呕吐的潜在化合物。 | |||
T13329 |
Vofopitant
GR 205171 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Vofopitant (GR 205171) 是一种有效的 NK1 receptor 拮抗剂,具有抗焦虑和止吐活性,可用于研究创伤后应激障碍(PTSD)。 | |||
T6905 |
Netupitant
Ro 67-31898/000,奈妥吡坦,CID 6451149 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Netupitant (CID 6451149) 是一种高效选择性、可口服的神经激肽 1 受体 (NK1) 拮抗剂,具有止吐作用,在 CHO 细胞中对 hNK1的 Ki 值为 0.95 nM。 | |||
T3716 |
Rolapitant
罗拉吡坦,SCH619734,罗拉匹坦 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂,Ki 值为0.66 nM。 | |||
TP1899L1 |
Hemokinin 1 (human) acetate(491851-53-7 free base)
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Hemokinin 1 (human) acetate(491851-53-7 free base) 是一种内源性 P 物质同系物,是速激肽 NK1 受体的选择性激动剂(NK1、NK3 和 NK2 受体的 IC50 值分别为 1.8、370 和 480 nM)。在体外对 B 细胞具有增殖和抗凋亡作用,在体内具有抗高血压作用。 | |||
T19518L |
Physalaemin acetate
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Physalaemin acetate 是一种非哺乳动物速激肽,在选择性结合神经激肽 1 (NK1) 受体时具有高亲和力。 | |||
TP1772L |
Hemokinin 1 (mouse) acetate(208041-90-1 free base)
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Hemokinin 1 (mouse) acetate(208041-90-1 free base) 是一种选择性兴奋剂 1 受体激动剂,对人 NK1 受体的 Ki 值为 0.175 nM,对人 NK2 受体的 Ki 值为 560 nM。 | |||
T20413L |
Spantide acetate
Spantide acetate(91224-37-2 Free base) |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Spantide acetate 是 NK1 受体的特异性拮抗剂,对 NK1 和 NK2 的 Kis 分别为 230 nM 和 8150 nM。 | |||
TP2227L |
C14TKL-1 acetate
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
C14TKL-1 acetate 是一种 NK1 受体激动剂。 | |||
T7828 |
[Sar9,Met(O2)11]-Substance P
Bhsar-sp,NA,精氨酰-脯氨酰-赖氨酰-脯氨酰-谷氨酰-谷氨酰-苯丙氨酰-苯丙氨酰-SAR-亮氨酸-蛋氨酸[O2]-胺 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
[Sar9,Met(O2)11]-Substance P (NA) 是选择性速激肽NK1受体激动剂。 | |||
T68068 |
Ezlopitant
CJ 11974,CJ-11974,CJ11974 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Ezlopitant (CJ-11974) 是一种基于喹啉的原型 NK1受体拮抗剂 CP-96345的衍生物。 | |||
TP1572 |
GR-73632
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
GR-73632 强效和选择性速激肽 NK1 受体激动剂,可通过传递瘙痒信号的 NK1 受体直接作用于初级感觉神经元的外周末端。 | |||
T7209 |
Maropitant
马罗匹坦,马罗皮坦 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Maropitant 是一种可口服的选择性神经激肽受体拮抗剂,通过阻止催吐中心与化学感受器触发区中 P 物质的结合而起作用,有预防呕吐作用。 | |||
TP1369L |
[Sar9,Met(O2)11]-Substance P acetate
[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base) 是一种速激肽 NK1 受体选择性激动剂。它是一种选择性速激肽 NK1 受体激动剂。它和 septide(每只大鼠 10-100 pmol,i.c.v.)在增加平均动脉血压 (MAP) 和心率 (HR),但它们的时间进程不同。两种激动剂都以剂量依赖性方式增加洗脸和吸鼻,而它是一种产生美容效果的化合物。 | |||
T68068L |
(R)-CJ 11974
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
T3724 |
Rolapitant hydrochloride
Rolapitant HCl,罗拉匹坦盐酸盐 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Rolapitant (SCH619734) hydrochloride 是一种高效选择性和具有口服活性的神经激肽 1 (NK1) 受体拮抗剂,Ki 值为 0.66 nM。Rolapitant hydrochloride (Rolapitant HCl) 不与 CYP3A4 产生互作。Rolapitant hydrochloride 在雪貂呕吐模型中显示出强效的中枢介导的止吐活性。 | |||
T1790 |
Fosaprepitant dimeglumine
福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂,可用于预防化疗引起的恶心呕吐。 | |||
T8235 |
L-732138
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
L-732138 是选择性有效和竞争性神经激肽-1受体拮抗剂,IC50为 2.3 nM,可减轻痛觉过敏并具有抗肿瘤作用。它在克隆的人 NK-1受体中的效力比在克隆大鼠 NK-1受体中高 200 倍,比人类 NK-2 和 NK-3 受体高 1000 倍以上。 | |||
T1743 |
Aprepitant
MK-869,MK-0869,阿瑞匹坦,L-754030,Aprepitant` |
HIV Protease; Antibacterial; Antibiotic; Neurokinin receptor | GPCR/G Protein; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Aprepitant (Aprepitant`) 是选择性和高亲和力的神经激肽1受体拮抗剂,Kd 值为86 pM。 | |||
T22690 |
CP 96345
|
Others | Others |
CP 96345 is a NK1 receptor antagonist. | |||
T78104 |
Fosnetupitant chloride monohydrochloride
Pronetupitant chloride monohydrochloride |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Fosnetupitant chloride monohydrochloride(Pronetupitant chloride monohydrochloride)为NK1受体拮抗剂,对人NK1受体和NK3受体的pKi分别为9.5和6.1。它是奈妥匹坦的亚甲基磷酸酯前体。 | |||
T68519 |
Maropitant citrate anhydrous
|
||
Maropitant citrate anhydrous is a neurokinin (NK1) receptor antagonist. | |||
T68769 |
HSP-117 free base
|
||
HSP-117 free base is a novel tachykinin NK1-receptor antagonist. | |||
T35344 |
Maropitant citrate
|
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Maropitant citrate 是一种新型神经激肽 1 型 (neurokinin type-1, NK1) 受体拮抗剂,具有抗炎和镇痛特性。 | |||
T68623 |
RO4583298
|
||
RO4583298 is a highly potent dual NK1/NK3 receptor antagonist with in vivo activity. | |||
T15341 |
Fosnetupitant
Pronetupitant |
Others | Others |
Fosnetupitant is a methylene phosphate prodrug of Netupitant. It has a pKi of 9.5 for the human NK1 receptor. | |||
T22691 |
CP 99994 dihydrochloride
|
Others | Others |
High affinity NK1 antagonist | |||
T22902 |
L-733060 hydrochloride
L-733,060 hydrochloride |
Others | Others |
Potent NK1 antagonist | |||
T22906 |
L 760735
|
Others | Others |
L 760735 is a NK1 receptor antagonist. | |||
T23251 |
RP 67580
|
Others | Others |
tachykinin NK1 receptor antagonist | |||
T23345 |
SDZ NKT 343
|
Others | Others |
human tachykinin NK1 receptor antagonist | |||
T29184 |
YM44778
YM-44778,YM 44778 |
||
YM44778 is a NK1-receptor antagonist for treating restless legs syndrome. | |||
T12212 |
Netupitant metabolite N-desmethyl Netupitant
N-desmethyl Netupitant |
Others | Others |
N-desmethyl Netupitant is a highly selective antagonist of NK1 receptor, and is Netupitant metabolite. | |||
T22811L |
GR 94800 acetate
GR 94800 acetate (141636-65-9 free base) |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
GR 94800 acetate 是一种有效的选择性神经激肽 2(NK-2) 拮抗剂。 | |||
T34799 |
Telmapitant
|
||
Telmapitant is an antagonist of the neurokinin NK1 receptor. | |||
T28917 |
TAK-637
TAK 637 |
||
TAK-637 is a tachykinin 1 (NK1) receptor antagonist. | |||
T70136 |
CAM 4750
|
||
CAM 4750 is a nonpeptide tachykinin NK1 receptor antagonist. | |||
T27771 |
L-703606 Oxalate
L 703606,L703,606,L-703,606,L703606,L 703,606,L-703606 |
||
L-703,606 is a potent, selective human NK1 receptor antagonist. | |||
T70132 |
HSP-117 dihydrochloride
|
||
HSP-117 dihydrochloride is a novel tachykinin NK1-receptor antagonist. | |||
T23385 |
SR 140333
|
Others | Others |
SR 140333 is a NK1 receptor antagonist. | |||
T22786 |
FK 888
|
Others | Others |
FK 888 is a selective, high-affinity tachykinin NK1 receptor antagonist. | |||
T27360 |
FR 113680
FR113680,FR-113680 |
||
FR 113680 is a tripeptide substance P antagonist with NK1 receptor selectivity. | |||
T9471 |
Imnopitant
|
||
Imnopitant 是 NK1 受体的拮抗剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8789 |
N-Acetyl-L-tryptophan
N-acetyltryptophan,N-乙酰-L-色氨酸 |
Endogenous Metabolite; Neurokinin receptor | GPCR/G Protein; Metabolism; Neuroscience |
N-Acetyl-L-tryptophan (N-acetyltryptophan) 是内源性代谢产物的一种。 | |||
T71833 |
Acetylaszonalenin
|
||
Acetylaszonalenin is a fungal metabolite that has been found in A. flavipes.1 It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P with a Ki value of 170 μM. | |||
T38033 |
Benzomalvin B
|
||
Benzomalvin B is a fungal metabolite originally isolated from Penicillium. It acts as an antagonist of neurokinin-1 (NK1) receptors, inhibiting binding of substance P by 24% in vitro when used at a concentration of 100 μg/ml. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03290 |
HGF Protein, Mouse, Recombinant
hepatocyte growth factor (hepapoietin A,NK1 |
Mouse | HEK293 Cells |
HGF Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 79.3 kDa and the accession number is Q08048-1. | |||
TMPY-01905 |
CD160 Protein, Human, Recombinant (His)
BY55,NK1,NK28,CD160 mole... |
Human | HEK293 Cells |
CD160 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.4 kDa and the accession number is O95971-1. | |||
TMPK-00062 |
CD160 Protein, Human, Recombinant (His & Avi)
BY55FLJ46513,NK28,NK1, B... |
Human | HEK293 Cells |
CD160 (also Natural killer cell receptor BY55) is a 27 ‑ 30 kDa member of the Ig superfamily. In human, it is expressed principally on nonmyeloid hematopoietic cells. CD160 antigenis a receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta... | |||
TMPY-05291 |
CD57/B3gat1 Protein, Human, Recombinant (mFc)
LEU7,NK1,beta-1,3-glucuronyltrans... |
Human | HEK293 Cells |
B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. Saturating concentrations of rVAR2 inhibited downstream integrin signaling, which was mimicked by knockdown of the core chondroitin sulfate synthesis enzymes β-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1). | |||
TMPJ-00220 |
B3GAT1 Protein, Human, Recombinant (His)
beta-1,3-glucuronyltransferase 1 (glucuron... |
Human | HEK293 Cells |
B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. It adds a glucuronic residue to the terminal lactosamine residue (Gal beta 14GlcNAc) of a glycoprotein or glycolipid, which can be further sulfated to become the HNK1 epitope, a unique trisaccharide structure, HSO3-3GlcA beta 1-3Gal beta 1-4GlcNAc. The enzyme activity was found to be enhanced in the presence of sphingomyelin an... | |||
TMPY-03237 |
HGF Protein, Mouse, Recombinant (His)
SF/HGF,hepatocyte growth factor (hepapoietin A,肝细胞生长因子,N... |
Mouse | HEK293 Cells |
HGF Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 80.8 kDa and the accession number is Q08048-1. | |||
TMPY-04402 |
CSNK1G1 Protein, Human, Recombinant (His & GST)
CK1γ1,casein kinase 1, gamma ... |
Human | Baculovirus Insect Cells |
Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are serine / threonine-selective enzymes that function as regulators ofsignal transductionpathways in most eukaryotic cell types. Casein has been used as a substrate since the earliest days of research on protein phosphorylation. Casein kinase activity associated with the endopla... | |||
TMPH-02897 |
SPINK1 Protein, Mouse, Recombinant (His)
|
Mouse | P. pastoris (Yeast) |
Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens.; In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production. SPINK1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 8.1 kDa and the accession number is P09036. | |||
TMPH-01054 |
CSNK1E Protein, Human, Recombinant (His)
Casein kinase I isoform epsilon,CKI-epsilon,CSNK |
Human | E. coli |
CSNK1E Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 51.3 kDa and the accession number is P49674. | |||
TMPY-04554 |
JNK1 Protein, Human, Recombinant (GST)
PRKM8,JNK,JNK-46,JNK21B<... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in ... | |||
TMPJ-00733 |
SPINK1 Protein, Human, Recombinant (His)
PSTI,Pancreatic Secretory Trypsin Inhibitor,TATI,Serine Prot... |
Human | HEK293 Cells |
Serine Protease Inhibitor Kazal-Type 1 (SPINK1) is a trypsin inhibitor that prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). Recombinant SPINK1 protein (rSPINK1) stimulated cell proliferation in benign RWPE ... | |||
TMPY-02381 |
NK1.1/KLRB1F Protein, Mouse, Recombinant (hFc)
Nkrp1f,MGC130066,MGC1300... |
Mouse | HEK293 Cells |
NK1.1/KLRB1F Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46 kDa and the accession number is Q8VD98. |