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34

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36420	IM-156 acetate HL271 acetate
	IM-156 acetate 是一种 NADH 脱氢酶（IC50=2.2μM）和 AMP-激活蛋白激酶α（AMPKα）的激活剂，是一种可口服且具有生物利用的线粒体氧化磷酸化（OxPhos）抑制剂。IM-156 acetate 可增加 AMPKα活性，抑制氯己酮诱导的大鼠腹膜纤维化，抑制肿瘤生长。
T73486	RIG012	Others	Others
	RIG012 是一种有效的 RIG-I 抑制剂，用 NADH 偶联 ATPase 测得 IC50 值为 0.71 μM。RIG012 对 IFN-β 和 ISG hRsad2 表达有抑制作用。
T7575L1	[Sar1, Ile8]-Angiotensin II acetate	RAAS	Endocrinology/Hormones
	[Sar1, Ile8]-Angiotensin II acetate 可激活 NADPH 和 NADH 氧化酶，并刺激血管平滑肌细胞中超氧阴离子的形成。 [Sar1, Ile8]-Angiotensin II acetate 对血管平滑肌有多种作用，包括正常动脉的收缩和培养细胞或病变血管的肥大或增生。
T20067	WST-1 WST 1
	WST-1 是一种具有细胞毒性的水溶性四唑盐，诱导细胞内线粒体脱氢酶进行 NADH 依赖性酶解反应，释放出水溶性甲基苯产物。WST-1 可通过检测吸收值来检测细胞增殖和细胞活性，可用于WST-1平板测定法测定超氧化物歧化酶活性。
T60774	NITD-916 NITD916,NITD 916	Antibiotic	Microbiology/Virology
	NITD-916 是一种具有口服活性和高度亲脂性的分枝杆菌烯酰还原酶 InhA 抑制剂，IC50 为 570 nM。NITD-916是一种有有效的 4-羟基-2-吡啶酮衍生物，与 InhA 和 NADH 形成三元复合物，阻止进入脂肪酰基底物结合袋。NITD-916 具有抗结核活性。
T22223	3PO	Glucokinase; Autophagy	Autophagy; Metabolism
	3PO 是一种 PFKFB3 的小分子抑制剂，IC50值为22.9 μM。它抑制几种人类恶性造血和腺癌细胞系的增殖，IC50在1.4到24 μM 之间。它抑制葡萄糖摄取，并降低 Fru-2,6-BP、乳酸、ATP、NAD+ 和 NADH 的细胞内浓度。
T9558	KL-11743	transporter	Metabolism
	KL-11743 是葡萄糖竞争性 I 类葡萄糖转运蛋白抑制剂，口服有活性，能够抑制GLUT1 (IC50:115 nM) 、GLUT2 (IC50:137 nM) 、GLUT3 (IC50:90 nM) 及GLUT4 (IC50:68 nM) 。它能够特异性阻断葡萄糖代谢，也可与电子传递抑制剂协同作用诱导细胞死亡。
T16342	KL1333 NQO1 activator 1	NADPH; Mitochondrial Metabolism	Metabolism
	KL1333 (NQO1 activator 1) 是口服NAD+调节剂，与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。
T70935	Phenoxan
	Phenoxan is isolated from Polyangium; inhibits electron transport at NADH-ubiquinone oxidoreductase.
T36875	Sartorypyrone D
	Sartorypyrone D is a fungal metabolite that has been found inN. fischeri.1It inhibits NADH fumarate reductase (NFRD; IC50= 1.7 μM inA. suummitochondria) and NADH oxidase (IC50= 3 μM in bovine heart mitochondria). Sartorypyrone is active against the Gram-positive bacteriaB. subtilis,K. rhizophila, andM. smegmatisin disc assays. 1.Kaifuchi, S., Mori, M., Nonaka, K., et al.Sartorypyrone D: A new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897J. Antibiot. (Tokyo)68(6)403-4...
T71866	Cochlioquinone B
	Cochlioquinone B is a phytotoxin that inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from heart mitochondria.
T75289	NAD sodium
	NAD sodium（β-Nicotinamide Adenine Dinucleotide sodium）为NAD的同类物，能在有机底物氧化反应中被还原为β-烟酰胺腺嘌呤二核苷酸（NADH）。此外，NAD sodium转化成的NADH能传递至线粒体内，间接促进ATP的生成。
T76207	Glucose dehydrogenase (GDH)
	Glucose dehydrogenase (GDH)是一种氧化还原酶，催化β-D-葡萄糖氧化成β-D-葡糖酸-1,5-内酯，同时将辅助因子NADP+还原至NADPH，或以较小程度还原NAD+至NADH。此酶能接收NAD+和NADP+作为辅助因子，适用于NADH与NADPH的再生。
T61035	CBR-3465
	CBR-3465 是结核分枝杆菌 (Mtb) II 型 NADH 脱氢酶的有效抑制剂。CBR-3465 抑制结核分枝杆菌的 MIC 值为 0.16 μM。
T68317	VJ115
	VJ115 is a novel chemical entity that inhibits the enzyme ENOX1, a NADH oxidase. Genetic and small molecule inhibition of ENOX1 inhibits endothelial cell tubule formation and tumor-mediated neo-angiogenesis. Inhibition of ENOX1 radiosensitizes tumor vasculature, a consequence of enhanced apoptosis. VJ115 inhibition of ENOX1 can impact expression of proteins involved in cytoskeletal reorganization and support a hypothesis in which ENOX1 activity links elevated cellular NADH concentrations with cy...
T78360	Glyceraldehyde phosphate dehydrogenase GAPDH,G3PDH,GADPH
	Glyceraldehyde phosphate dehydrogenase是一种酶，既是抗胸腺细胞剂也是抗凋亡剂的靶点，它负责催化过羟基自由基对还原型烟酰胺腺嘌呤二核苷酸（NADH）的链氧化反应。
T79252	Apoptosis inducer 13	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Apoptosisinducer 13（Compound Ru4）能够诱导癌细胞进入凋亡并抑制其迁移与侵袭。该化合物能促进NADH向NAD+的转化，同时提升细胞内ROS的水平。
T76206	beta-Galactose dehydrogenase
	beta-Galactose dehydrogenase 能够将半乳糖转化为半乳糖酸内酯，并同时将 NAD 还原为具有荧光性的 NADH，适用于半乳糖的定量测定。
T61192	CBR-6672
	CBR-6672, a type II NADH dehydrogenase inhibitor, demonstrates potent antimycobacterial activity against mycobacterium tuberculosis (Mtb) with a minimum inhibitory concentration (MIC) of 0.14 μM [1].
T76116	L-Lactate dehydrogenase
	L-Lactate dehydrogenase (L-乳酸脱氢酶) 是一种氧化还原酶。L-Lactate dehydrogenase 在体内催化 NADH 将丙酮酸还原为 L-乳酸。
T27568	IACS-010759 hydrochloride IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759
	IACS-010759 is a potent inhibitor of complex I of OXPHOS with orally bioavailable. IACS-10759 effectively inhibits ATP production and oxygen consumption in isolated mitochondria, and inhibits the conversion of NADH to NAD+ in immunoprecipitated complex I
T20016	Diuron HW 920,Dirurol,Karmex,Lucenit,Marmer,Seduron
	Diuron is a Phenylurea herbicide that inhibits photosynthesis by preventing the formation of ATP and NADH. Diuron (25 nM/ml) decreases total respiration in roots of wheat by 50% and ground respiration by 100%. Diuron (2,500 ppm, dietary) increases the inc
T73478	ME-143 NV-143
	ME-143为第二代特异性NADH氧化酶抑制剂，针对结直肠癌细胞中WNT/β-catenin通路展现抑制作用。该化合物在体外及体内显示出广泛的抗癌活性。
T73032	MtInhA-IN-1
	MtInhA-IN-1是一种口服活性的选择性结核分枝杆菌NADH依赖性烯酰基载体蛋白还原酶(MtInhA)抑制剂，IC50值为0.23 μM。对结核分枝杆菌H37Rv菌株，其MIC为0.4 μM。
T37502	sn-Glycerol 3-phosphate lithium
	sn-Glycerol 3-phosphate lithium is synthesized via the cytosolic glycerol 3-phosphate dehydrogenase pathway. This process involves the conversion of dihydroxyacetone phosphate to sn-Glycerol 3-phosphate using NADH, which is generated during glycolysis.
T83800	6-Biotin-17-NAD+ sodium 6-Biotin-17-Nicotinamide adenine dinucleotide,β-Nicotinamide-N6-(2-(6-(6-[biotinyl]aminohexanoyl)aminohexanoyl)aminoethyl)adenine dinucleotide
	6-Biotin-17-NAD+ 是信号分子及酶辅因子NAD+的生物素化衍生物，已应用于高通量筛选(HTS)中，用于测定线粒体复合物I（又称NADH脱氢酶）的活性。
T38230	Iromycin A
	Iromycin A is a bacterial pyridone metabolite that inhibits nitric oxide synthase (NOS) activity, with selectivity for NOS III (endothelial NOS) over NOS I (neuronal NOS). Iromycin metabolites and derivatives block NADH oxidation in beef heart submitochondrial particles (IC50 = 0.461 μM for iromycin A).
T37583	XTT (sodium salt hydrate)
	XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis.3 1.Berridge, M.V., Tan, A.S., and Herst, P.M.Tetrazolium dyes as tools in cell biology: New insights into their cellular reductionBiotechnol. Ann. Rev.11127-152(2005) 2.Berridge, M.V., and Tan, A.S.Trans-plas...
T37070	Pyridomycin
	Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg/ml).
T83866	LCC-12 formate
	LCC-12是一种铜(II)螯合剂，为二甲双胍的衍生物。作为单体，它能结合铜(II)并在20 µM的浓度下减少氢过氧化物依赖的NADH向NAD+的氧化。在10 µM的浓度下，LCC-12降低一次性人类细胞因子激活的单核衍生的巨噬细胞(MDMs)中IL-1β、IL-2、IL-6、IL-8和TNF-α的细胞因子水平，以及JAK2、STAT2和IL-1受体相关激酶4(IRAK4)的水平。此外，同样浓度的LCC-12减少了细胞因子激活的MDMs中CD80+和CD86+的数量。每日0.3 mg/kg的剂量可提高LPS或盲肠结扎穿孔模型小鼠的存活率。
T83865	HP661
	HP661是一种针对线粒体复合物I（也称为NADH脱氢酶）的抑制剂，对复合物I具有选择性，以1 µM的浓度抑制其77.6%，而对复合物III抑制率为28.1%，对复合物II和IV则无抑制作用。HP661特异性降低具有高水平氧化磷酸化作用的人类肺癌细胞H460、NCI H441及对trametinib耐药的A549细胞的生存能力（IC50分别为10.6、29.7和15.1 nM），相较于氧化磷酸化水平低的NCI H358人类肺癌细胞（IC50 >10,000 nM）以及非癌性人类胰腺正常上皮细胞（HPNE）和MRC-5人类胎肺成纤维细胞（两者的IC50均>10,000 nM）。当以每天两次，每次30 mg/kg的剂量给药时，HP661在H460小鼠异种移植模型中减少肿瘤体积，并对trametinib引导的肿瘤生长减少产生加成效应。
T37692	Piericidin B
	Piericidin B is a bacterial metabolite that has been found inS. mobaraensisand has insecticidal and antimicrobial activities.1,2,3It inhibits NADH oxidase activity in isolated bovine heart mitochondria and inhibits respiration in isolated rat liver mitochondria and isolated cockroach (P. americana) muscle mitochondria.2,3Topical application of piericidin B (4 μg/insect) induces mortality in 87.5% of houseflies (M. domestica).1It induces 93.3, 100, and 100% mortality in rice stem borer (C. simple...
T35712	Debutyldronedarone hydrochloride SR35021 hydrochloride
	N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...
T35520	Aflatoxin G1-13C17 Aflatoxin G1-13C17
	Aflatoxin G1-13C17is intended for use as an internal standard for the quantification of aflatoxin G1by GC- or LC-MS. Aflatoxin G1is a mycotoxin that has been found inA. terricola.1In vivo, aflatoxin G1is lethal to ducklings (LD50= 1.18 mg/kg).2It induces hepatocellular carcinoma tumor formation and lethality in rats when administered at doses of 1.4 and 3 mg/animal, respectively. Aflatoxin G1also inhibits liver and kidney succinate dehydrogenase and fumarase, as well as kidney cytochrome oxidase...

化合物

Cat.No: T36420

Synonym: HL271 acetate

Cat.No: T73486

Target: Others

[Sar1, Ile8]-Angiotensin II acetate

Cat.No: T7575L1

Target: RAAS

Cat.No: T20067

Synonym: WST 1

Cat.No: T60774

Synonym: NITD916,NITD 916

Target: Antibiotic

Cat.No: T22223

Target: Glucokinase, Autophagy

Cat.No: T9558

Target: transporter

Cat.No: T16342

Synonym: NQO1 activator 1

Target: NADPH, Mitochondrial Metabolism

Cat.No: T70935

Sartorypyrone D

Cat.No: T36875

Cochlioquinone B

Cat.No: T71866

Cat.No: T75289

Glucose dehydrogenase (GDH)

Cat.No: T76207

Cat.No: T61035

Cat.No: T68317

Glyceraldehyde phosphate dehydrogenase

Cat.No: T78360

Synonym: GAPDH,G3PDH,GADPH

Apoptosis inducer 13

Cat.No: T79252

Target: Reactive Oxygen Species

beta-Galactose dehydrogenase

Cat.No: T76206

Cat.No: T61192

L-Lactate dehydrogenase

Cat.No: T76116

IACS-010759 hydrochloride

Cat.No: T27568

Synonym: IACS-010759 HCl,IACS-010759,IACS10759,IACS-10759,IACS 10759

Cat.No: T20016

Synonym: HW 920,Dirurol,Karmex,Lucenit,Marmer,Seduron

Cat.No: T73478

Synonym: NV-143

Cat.No: T73032

sn-Glycerol 3-phosphate lithium

Cat.No: T37502

6-Biotin-17-NAD+ sodium

Cat.No: T83800

Synonym: 6-Biotin-17-Nicotinamide adenine dinucleotide,β-Nicotinamide-N6-(2-(6-(6-[biotinyl]aminohexanoyl)aminohexanoyl)aminoethyl)adenine dinucleotide

Cat.No: T38230

XTT (sodium salt hydrate)

Cat.No: T37583

Cat.No: T37070

Cat.No: T83866

Cat.No: T83865

Cat.No: T37692

Debutyldronedarone hydrochloride

Cat.No: T35712

Synonym: SR35021 hydrochloride

Aflatoxin G1-13C17

Cat.No: T35520

Synonym: Aflatoxin G1-13C17

Cat. No.	Product Name	Target	Signaling Pathways
T5283	NADH disodium salt Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠	Others; Endogenous Metabolite	Metabolism; Others
	NADH disodium salt (Disodium NADH) hydrate 是氧化还原酶的辅酶。NADH disodium salt hydrate 在分解代谢过程中起到再生电子供体的作用，包括糖酵解，柠檬酸循环和β-氧化。
T8347	Rifamycin S	Reactive Oxygen Species; ROS; Antibacterial; Antibiotic	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Rifamycin S 是一种 DNA 依赖性 RNA 聚合酶抑制剂，是一种醌和一种针对革兰氏阳性细菌的抗生素试剂。它是涉及两个电子的可逆氧化还原系统的氧化形式。它能产生活性氧并抑制微粒体脂质过氧化，可研究肺结核和麻风病。
TN1774	Isobavachromene	Others; Antibacterial	Microbiology/Virology; Others
	Isobavachromene 是一种抗菌剂。
T1609	NAD+ 烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD	NADPH; Endogenous Metabolite	Metabolism
	NAD+ (β-Nicotinamide Adenine Dinucleotide) 即烟酰胺腺嘌呤二核苷酸，是转递氢离子的辅酶。
T19343L	Glycerol 3-phosphate biscyclohexylammonium salt	Endogenous Metabolite	Metabolism
	Glycerol 3-phosphate biscyclohexylammonium salt 是胞质甘油 3-磷酸脱氢酶途径中产生的，即利用 NADH 还原二羟丙酮磷酸的过程。
T81570	Paecilaminol FKI-0550
	Paecilaminol (FKI-0550) 为一种高效的 NADH 富马酸还原酶 (NADH-fumarate reductase) 抑制剂，其对蛔虫 (Ascaris suum) NADH 富马酸还原酶展现了 5.1 μM 的 IC50 值。
T74201	3′-Hydroxy-4′-O-methylglabridin
	3′-Hydroxy-4′-O-methylglabridin 是一种抗氧化剂，可有效防止 NADH 依赖的过氧化。
T19343	sn-Glycerol 3-phosphate Glycerol 3-phosphate,SN-甘油3-磷酸锂盐,sn-Glycerol 3-phosphate lithium salt	Endogenous Metabolite	Metabolism
	sn-Glycerol 3-phosphate 是一种人内源性化合物，由NADH 还原磷酸二羟基丙酮而产生。
T40529	(R)-(-)-1,2-Propanediol
	(R)-(-)-1,2-Propanediol is the (R)-enantiomer of 1,2-Propanediol, which is derived from glucose through the expression of NADH-linked glycerol dehydrogenase genes in Escherichia coli.
T80016	Aurachin D	Antibiotic	Microbiology/Virology
	Aurachin D为一种具备抑菌活性的抗生素，对革兰氏阳性细菌及部分真菌种类显示出抑制效果，能够阻断牛心脏亚线粒体颗粒中的NADH氧化过程。
TN3069	4beta-Carboxy-19-nortotarol	NADPH-oxidase	Immunology/Inflammation
	4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not generation of superoxide anion.
T37714	Fuscin
	Fuscin is a quinonoid fungal metabolite originally isolated from O. fuscum that has diverse biological activities. It inhibits binding of the ADP/ATP translocase inhibitor atractyloside to rat liver mitochondria in an ADP-dependent manner when used at a concentration of 50 μM in a radioligand binding assay. Fuscin (20 μM) reduces the glutathione content of rat liver mitochondria to 28% of controls and inhibits NADH oxidation in sonicated pigeon heart mitochondria preparations in a concentration-...

天然产物

NADH disodium salt

Cat.No: T5283

Synonym: Disodium NADH,NADH, disodium salt hydrate,beta-烟酰胺腺嘌呤二核苷二钠

Target: Others, Endogenous Metabolite

Cat.No: T8347

Target: Reactive Oxygen Species, ROS, Antibacterial, Antibiotic

Isobavachromene

Cat.No: TN1774

Target: Others, Antibacterial

Cat.No: T1609

Synonym: 烟酰胺腺嘌呤二核苷酸,Cozymase,煙酸胺,β-DPN,DPN,β-Nicotinamide Adenine Dinucleotide,β-NAD

Target: NADPH, Endogenous Metabolite

Glycerol 3-phosphate biscyclohexylammonium salt

Cat.No: T19343L

Target: Endogenous Metabolite

Cat.No: T81570

Synonym: FKI-0550

3′-Hydroxy-4′-O-methylglabridin

Cat.No: T74201

sn-Glycerol 3-phosphate

Cat.No: T19343

Synonym: Glycerol 3-phosphate,SN-甘油3-磷酸锂盐,sn-Glycerol 3-phosphate lithium salt

Target: Endogenous Metabolite

(R)-(-)-1,2-Propanediol

Cat.No: T40529

Cat.No: T80016

Target: Antibiotic

4beta-Carboxy-19-nortotarol

Cat.No: TN3069

Target: NADPH-oxidase

Cat.No: T37714

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