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Cat. No.	Product Name	Target	Signaling Pathways
T2649	Menin-MLL inhibitor MI-2 Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	Menin-MLL inhibitor MI-2 (MI2) 抑制Menin-MLL 相互作用，IC50为 446±28 nM。
T9399	Menin-MLL inhibitor 20	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	Menin-MLL inhibitor 20 是一种不可逆的menin-MLL 相互作用抑制剂，具有抗肿瘤活性。
T2643	MI-3 Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	MI-3 (Menin-MLL Inhibitor)是一种有高亲和力的 menin-MLL 抑制剂，IC50值为 648 nM，Kd 值为 201 nM。
T69629	M‑89 MLL inhibitor
	M‑89 is a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein−Protein Interaction (Kd = 1.4 nM; IC50 = 25nM). M-89 binds to menin with a Kd value of 1.4 nM and effectively engages cellular menin protein at low nanomolar concentrations. M-89 inhibits cell growth in the MV4;11 and MOLM-13 leukemia cell lines carrying MLL fusion with IC50 values of 25 and 55 nM, respectively, and demonstrates >100-fold selectivity over the HL-60 leukemia cell line lacking MLL fusion.
T12002	Menin-MLL inhibitor 4	Others	Others
	Menin-MLL inhibitor 4 has antitumor activity.Menin-MLL inhibitor 4 is an inhibitor of Menin- MLL (mixed-lineage leukemia protein) interaction .
T78151	Bleximenib oxalate Menin-MLL inhibitor 24 oxalate	Epigenetic Reader Domain	Chromatin/Epigenetic
	Bleximenib (Menin-MLL inhibitor 24) oxalate 是一种用于癌症研究的menin-mixed-lineage leukemia 1（menin-MLL）抑制剂。
T3082	SGC0946	Histone Methyltransferase	Chromatin/Epigenetic
	SGC0946是一种组蛋白甲基转移酶DOT1L 高选择性抑制剂，IC50值为0.3nM，可选择性地杀死混合谱系白血病细胞。
T72360	Menin-MLL inhibitor 26
	Menin-MLL inhibitor 26 是一种 Menin-MLL 抑制剂。Menin-MLL inhibitor 26 也是一个活性参照物。 Menin-MLL inhibitor 26 可以抑制细胞生长。Menin-MLL inhibitor 26 可用于白血病的研究。
T79117	Menin-MLL inhibitor 27	Epigenetic Reader Domain	Chromatin/Epigenetic
	Menin-MLL inhibitor 27 是一种化合物，它能有效抑制Menin-MLL之间的相互作用，对于研究癌症具有潜在价值，尤其是在急性骨髓性白血病方面。
T79737	Menin-MLL inhibitor 29	Epigenetic Reader Domain	Chromatin/Epigenetic
	Menin-MLL inhibitor 29（Compound C1）是一种选择性Menin-MLLPPI抑制剂。该化合物与Menin紧密结合，具有138 nM的KD值，并以46 nM的IC50值明显抑制Menin与MBM1（Menin结合motif 1）的相互作用。在体外条件下，Menin-MLL inhibitor 29对HepG2和Hep3B肝癌细胞系表现出抑制增殖的作用（IC50s分别为0.31 μM和0.71 μM），也能有效抑制肿瘤生长。
T72135	(1s,4s)-Menin-MLL inhibitor-23
	(1s,4s)-Menin-MLL inhibitor-23 是Menin-MLL inhibitor-23 的对应异构体。Menin-MLL inhibitor-23 (Example 99A) 是一种menin-MLL 相互作用抑制剂。
T13336	VTP50469	Apoptosis; Epigenetic Reader Domain; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	VTP50469 是一种高选择性和口服活性的Menin-MLL 相互作用抑制剂，具有有效的抗白血病活性，Ki 为 104 pM。
T8838	CCI-007	Apoptosis; Histone Methyltransferase	Apoptosis; Chromatin/Epigenetic
	CCI 007 是一种具有细胞毒性的选择性白血病抑制剂，在MLL 重排的敏感系婴幼儿白血病细胞中，IC50为2.5-6.2 μM。
T12943	SNDX-5613	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	SNDX-5613 是一种 Menin-MLL 特异性抑制剂，Ki 为 0.149 nM，IC50 为 10 在 20 nM 之间，可用于 MLL 基因重排的急性白血病研究。
T6916	OICR-9429 OICR 9429	Histone Methyltransferase; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	OICR-9429 是一个新颖的相互作用的小分子Wdr5-MLL 拮抗剂，IC50是 5 uM，在体外抑制急性髓性白血病细胞。
T28036	MI-2-2 MI22,MI 2 2	Histone Methyltransferase	Chromatin/Epigenetic
	MI-2-2 是一种抑制 menin 和 MLL 之间二价蛋白质-蛋白质相互作用的抑制剂，IC50 为 46 nM。 MI-2-2 与 menin 结合，Kd 为 22 nM。
T69628	Iptacopan hydrochloride hydrate
	Iptacopan hydrochloride hydrate is a highly potent and highly selective factor B inhibitor.
T12886	SGC-iMLLT	Histone Methyltransferase	Chromatin/Epigenetic
	SGC-iMLLT 是一种选择性的MLLT1/3-组蛋白相互作用抑制剂，IC50值为 0.26 μM，也是化学探针。它对 MLLT1 YEATS 域 (YD) 和 MLLT3 YD (AF9/YEATS3) 具有高结合力，Kd 值分别为 0.129 和 0.077 μM。
T69581	NVS MLLT-1
	NVS-MLLT-1 is a selective inhibitor of YEATS domain of MLLT1 and MLLT3.
TQ0069	MI-503	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-503 是一种高效且可口服的 menin-mLL 相互作用抑制剂。
T16072	MI-538	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-538是一种menin 和MLL 融合蛋白相互作用的抑制剂，IC50值为 21 nM。
T11925	M‑89	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	M-89 可抑制 Menin-MLL 蛋白之间的相互作用，有研究混合谱系白血病的潜力。它是一种强特异性 menin 抑制剂，结合到 menin 的Kd 值为 1.4 nM。
TQ0058	MI-463	Epigenetic Reader Domain; Histone Methyltransferase	Chromatin/Epigenetic
	MI-463 是一种有口服活性的menin-mLL 相互作用的高效小分子抑制剂，IC50为15.3 nM。
T10706	CCI-006	Mitochondrial Metabolism	Metabolism
	CCI-006 是一种 MLL 重排白血病细胞的选择性抑制剂和化学增敏剂。它能够抑制线粒体呼吸，造成 MLL-r 白血病细胞亚群中无法克服的线粒体去极化和促凋亡未折叠蛋白反应。
T77339	BRD4-IN-4	Epigenetic Reader Domain	Chromatin/Epigenetic
	BRD4-IN-4 是一种具有选择性的 BRD4 抑制剂，对 BRD4 的IC50值为 6.83 μM。BRD4-IN-4 选择性抑制 MV4-11 细胞系增殖并将细胞阻滞在 G1 期。BRD4-IN-4可用于研究 MLL 白血病。
T8768	MM-102 TFA HMTase Inhibitor IX TFA	Histone Methyltransferase	Chromatin/Epigenetic
	MM-102 TFA (HMTase Inhibitor IX TFA) 是一种有效的 WDR5/MLL 相互作用抑制剂，在 WDR5 结合检测中，IC50为 2.4 nM，Ki 小于 1 nM。
T4247	I-CBP112 hydrochloride	Epigenetic Reader Domain	Chromatin/Epigenetic
	I-CBP112 hydrochloride 是含溴结构域转录因子的选择性抑制剂，靶向 CBP/p300 溴结构域。在体内外，它以剂量依赖性方式显着降低 MLL-AF9(+) 急性髓细胞白血病细胞的白血病起始潜力，还增加 BET 溴结构域抑制剂 JQ1 以及阿霉素的细胞毒活性。
T6889	MI-136	Apoptosis; Epigenetic Reader Domain; Androgen Receptor	Apoptosis; Chromatin/Epigenetic; Endocrinology/Hormones
	MI136 是 menin-MLL(PPI) 蛋白互作的抑制剂，其 IC50值为31 nM，Kd 值为23.6 nM。它可抑制 DHT 诱导的雄激素受体 (AR) 靶基因的表达，有用于去势抵抗性肿瘤的潜能。
T6333	MM-102 MM102,HMTase Inhibitor IX	Histone Methyltransferase	Chromatin/Epigenetic
	MM-102 (HMTase Inhibitor IX) 是一种有效的 WDR5/MLL 相互作用抑制剂，在 WDR5 结合检测中，IC50为 2.4 nM，Ki 小于 1 nM。
T39937	M-808
	M-808 is a potent and efficacious covalent inhibitor, targeting the interaction between Menin and MLL. It demonstrates a high binding affinity with an IC50 value of 2.6 nM.
T27134	DCYM21 DC YM 21,DC-YM21,DCYM-21,DC_YM21,DC YM21
	DCYM21 is an inhibitor of menin-MLL interaction. DCYM21 demonstrates potent and selective blockage of proliferation and induces both cell cycle arrest and differentiation of leukemia cells harboring MLL translocations.
T15831	M-525	Others	Others
	M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, irreversible, and covalent menin-MLL
T69624	TC-5115
	TC-5115 is a potent inhibitor of MLL methyltransferase with IC50 value of 16 nM. TC-5115 may lead to the development of a new therapy for the treatment of human MLL leukemia. The mixed-lineage leukemia (MLL) protein, also known as MLL1, is a lysine methyltransferase specifically responsible for methylation of histone 3 lysine 4. MLL has been pursued as an attractive therapeutic target for the treatment of acute leukemia carrying the MLL fusion gene or MLL leukemia.
T61735	MI-1
	MI-1 抑制 Menin-MLL 相互作用，IC50为 1.9 μM。
T24472	MIV-6R MIV6R,VU05163101,VU0516310-1,VU0516310 1,MIV 6R
	MIV-6R is an inhibitor of the menin- MLL interaction that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanisms of action.
T12091L	MM-589 TFA	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	MM-589 TFA is a potent WD repeat domain 5 (WDR5)inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.
T22978	MI-2 (hydrochloride)	Others	Others
	MI-2 (Menin-MLL Inhibitor) is an effective menin-MLL interaction inhibitor (IC50: 446 ± 28 nM).
T12290	OICR-0547	Others	Others
	OICR-0547 is a closely related derivative of OICR-9429. OICR-9429 is a novel small-molecule Wdr5-MLL interaction antagonist.
T24484	ML399 VU-0516340,VU 0516340,ML-399,VU0516340,ML 399
	ML399 is the menin-- MLL interaction inhibitor that acts by demonstrating strong and selective effects in MLL leukemia cells and validating specific mechanism of action.
T39585	Ziftomenib KO-539	Histone Methyltransferase	Chromatin/Epigenetic
	Ziftomenib (KO-539) 是一种具有抗肿瘤活性的 menin-MLL 相互作用抑制剂，可以用于研究白血病。
T39938	M-1211
	M 1121 is a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.
T24463	MI-1481 MI 1481
	MI-1481 is an effective MML1 inhibitor (IC50: 3.6 nM). MI-1481 showed very potent inhibition of the menin-MLL1 interaction (IC50: 3.6 nM). MI-1481 also demonstrates pronounced activity in MLL leukemia cells and in vivo in MLL leukemia models.
T82598	DDO-2213
	DDO-2213是一口服有效的WDR5-MLL1抑制剂，具有29 nM的IC50和72.9 nM的Kd值针对WDR5蛋白。该化合物对MLL组蛋白甲基转移酶活性及MLL易位细胞增殖具有选择性抑制作用，可用于研究MLL融合型白血病。
TP2115	SAH-EZH2
	EZH2/EPP interaction inhibitor (Kd = 320 nM). Suppresses EZH2 expression and H3K27 trimethylation by PCR2 complex. Arrests proliferation and induces monocyte to macrophage differentiation of MLL-AF9 leukemia cell line.
T12091	MM-589	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	MM-589 is a potent WD repeat domain 5 (WDR5) inhibitor and mixed lineage leukemia (MLL) protein-protein interaction.
T13336L	VTP50469 fumarate	Others	Others
	VTP50469 fumarate is a highly selective and orally active inhibitor of Menin-MLL interaction (Ki: 104 pM), and has potently anti-leukemia activity.
T28269	ORY-1001 free base RG 6016,ORY-1001,ORY 1001,ORY1001,RG-6016,RG6016
	ORY-1001 is a KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/dose dependent me2H3K4 accumulation a
T72239	DDO-2093 dihydrochloride
	DDO-2093 dihydrochloride 是一种有效的MLL1和WDR5蛋白-蛋白相互作用抑制剂 (IC50=8.6 nM ; Kd=11.6 nM)，具有抗肿瘤活性。DDO-2093 dihydrochloride 选择性抑制 MLL 复合物的催化活性。
T62915	Dot1L-IN-7
	Dot1L-IN-7 (compound 25) 是一种选择性的、有效的端粒沉默 1 样蛋白 (DOT1L) 抑制剂 (IC50: 1.0 μM)。Dot1L-IN-7 能够选择性地杀死 MLL-AF9，且不影响 E2A-HLF 细胞的生长。
T69846	VTP50469 mesylate
	VTP-50469 is a novel, potent, selective, orally-available MeninMLL1 inhibitor, being effectively against MLL-rearranged and NPM1c+ leukemia, selectively killing cell lines with MLLrearrangements and NPM1c+ mutations.

化合物

Menin-MLL inhibitor MI-2

Cat.No: T2649

Synonym: Menin-MLL Inhibitor,MI2,MI-2,Menin-MLL inhibitor 2,MI 2

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Menin-MLL inhibitor 20

Cat.No: T9399

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T2643

Synonym: Menin-MLL Inhibitor,Menin-MLL inhibitor 3,MI 3

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

M‑89 MLL inhibitor

Cat.No: T69629

Menin-MLL inhibitor 4

Cat.No: T12002

Target: Others

Bleximenib oxalate

Cat.No: T78151

Synonym: Menin-MLL inhibitor 24 oxalate

Target: Epigenetic Reader Domain

Cat.No: T3082

Target: Histone Methyltransferase

Menin-MLL inhibitor 26

Cat.No: T72360

Menin-MLL inhibitor 27

Cat.No: T79117

Target: Epigenetic Reader Domain

Menin-MLL inhibitor 29

Cat.No: T79737

Target: Epigenetic Reader Domain

(1s,4s)-Menin-MLL inhibitor-23

Cat.No: T72135

Cat.No: T13336

Target: Apoptosis, Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T8838

Target: Apoptosis, Histone Methyltransferase

Cat.No: T12943

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T6916

Synonym: OICR 9429

Target: Histone Methyltransferase, JAK

Cat.No: T28036

Synonym: MI22,MI 2 2

Target: Histone Methyltransferase

Iptacopan hydrochloride hydrate

Cat.No: T69628

Cat.No: T12886

Target: Histone Methyltransferase

Cat.No: T69581

Cat.No: TQ0069

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T16072

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T11925

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: TQ0058

Target: Epigenetic Reader Domain, Histone Methyltransferase

Cat.No: T10706

Target: Mitochondrial Metabolism

Cat.No: T77339

Target: Epigenetic Reader Domain

Cat.No: T8768

Synonym: HMTase Inhibitor IX TFA

Target: Histone Methyltransferase

I-CBP112 hydrochloride

Cat.No: T4247

Target: Epigenetic Reader Domain

Cat.No: T6889

Target: Apoptosis, Epigenetic Reader Domain, Androgen Receptor

Cat.No: T6333

Synonym: MM102,HMTase Inhibitor IX

Target: Histone Methyltransferase

Cat.No: T39937

Cat.No: T27134

Synonym: DC YM 21,DC-YM21,DCYM-21,DC_YM21,DC YM21

Cat.No: T15831

Target: Others

Cat.No: T69624

Cat.No: T61735

Cat.No: T24472

Synonym: MIV6R,VU05163101,VU0516310-1,VU0516310 1,MIV 6R

Cat.No: T12091L

Target: JAK

MI-2 (hydrochloride)

Cat.No: T22978

Target: Others

Cat.No: T12290

Target: Others

Cat.No: T24484

Synonym: VU-0516340,VU 0516340,ML-399,VU0516340,ML 399

Cat.No: T39585

Synonym: KO-539

Target: Histone Methyltransferase

Cat.No: T39938

Cat.No: T24463

Synonym: MI 1481

Cat.No: T82598

Cat.No: TP2115

Cat.No: T12091

Target: JAK

VTP50469 fumarate

Cat.No: T13336L

Target: Others

ORY-1001 free base

Cat.No: T28269

Synonym: RG 6016,ORY-1001,ORY 1001,ORY1001,RG-6016,RG6016

DDO-2093 dihydrochloride

Cat.No: T72239

Cat.No: T62915

VTP50469 mesylate

Cat.No: T69846

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