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Search Results for " mek2 "

Targets Recommended: MEK

19

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T6636	Refametinib BAY 86-97661,瑞法替尼//瑞美替尼,BAY 869766,RDEA119	MEK	MAPK
	Refametinib (RDEA119) 是可口服的、非 ATP 竞争和选择性的 MEK1/MEK2变构抑制剂，IC50分别为 19 和 47 nM。
T5412	RO4987655 CH4987655,RG7167	MEK	MAPK
	RO4987655 (RG7167) 是一种具有口服活性和高选择性的 MEK 抑制剂，抑制MEK1/MEK2，IC50为 5.2 nM。
T2125	Trametinib GSK1120212,曲美替尼,JTP-74057	Apoptosis; MEK; Autophagy	Apoptosis; Autophagy; MAPK
	Trametinib (GSK1120212) 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=0.7/0.9 nM)，具有 ATP 非竞争性和口服活性。Trametinib 可以激活自噬，诱导凋亡。
T2623	PD98059 PD 98059	ERK; Aryl Hydrocarbon Receptor; MEK; Autophagy	Autophagy; Immunology/Inflammation; MAPK
	PD98059 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=2/50 μM)，具有非 ATP 竞争性。PD98059 也是一种 AHR 的配体而起拮抗作用。PD98059 可以抑制细胞自噬。
T2253	TCS PIM-1 1 3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮,SC 204330	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	TCS PIM-1 1 (SC 204330) 是一种特异性有效的 ATP 竞争性 Pim-1 激酶抑制剂，IC50为 50 nM，对 MEK1/MEK2 和 Pim-2 表现出良好的特异性，IC50值大于 20000 nM。
T6131	Pimasertib AS703026,MSC1936369B,N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺,SAR 245509	MEK	MAPK
	Pimasertib (AS703026) 是一种高效选择性和ATP 非竞争性的MEK1/2抑制剂，可用于癌症研究。
T6785	BI-847325	Apoptosis; MEK; Aurora Kinase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK
	BI847325是MEK 和极光激酶 (AK)的一种选择性双重抑制剂，对人类MEK2和AK-C 的IC50值分别为4和15 nM。
T6692	TAK-733 TAK733,TAK 733	MEK	MAPK
	TAK-733 是选择性 MEK 抑制剂，IC50为 3.2 nM。
T6223	U0126-EtOH U0126 Ethanol,U0126	Mitophagy; Influenza Virus; MEK; Autophagy	Autophagy; MAPK; Microbiology/Virology
	U0126-EtOH (U0126 Ethanol) 是一种非 ATP 竞争性的选择性MEK1和MEK2抑制剂，IC50分别为 72 nM 和 58 nM。U0126-EtOH 可抑制自噬和线粒体自噬。
T6083	AZD8330 ARRY-424704,ARRY-704	ERK; MEK	MAPK
	AZD8330 (ARRY-704) 是非竞争性的 MEK1/MEK2抑制剂，IC50为 7 nM。
T5857	Trametinib (DMSO solvate) Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)	Apoptosis; MEK	Apoptosis; MAPK
	Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) 是一种口服有效的 MEK 抑制剂，抑制 MEK1 和 MEK2 的 IC50分别为 2 nM。它还能激活自噬，诱导凋亡。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T13782	MS432	MEK	MAPK
	MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
T2708	SL327 SL 327,SL-327	MEK; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK
	SL327 是能通过血脑屏障运输的选择性 MEK1/2 抑制剂，IC50 分别为 0.18 和 0.22 μM。
T69826	U-0126
	U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. It was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 72 nM for MEK1 and 58 nM for MEK2. U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase and mammalian target of rapamycin pathways.
T2443	CI-1040 PD 184352	Apoptosis; MEK	Apoptosis; MAPK
	CI-1040 (PD 184352) 是一种有口服活性的高度特异性MEK 小分子抑制剂，对 MEK1 的IC50值为 17 nM 。
T71163	Pimasertib HCl
	Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activati...
T21332	U0126 U 0126,U-0126	Mitophagy; MEK; Autophagy	Autophagy; MAPK
	U0126 是一种有效的特异性非竞争性 MAP 激酶抑制剂，抑制 MEK-1 和 MEK-2，IC50 值分别为 0.07 和 0.06 μM。 U0126 抑制自噬和线粒体自噬。
T14928	Agerafenib hydrochloride RXDX-105 hydrochloride,CEP-32496 (hydrochloride)	c-RET; c-Kit	Apoptosis; Tyrosine Kinase/Adaptors
	Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).

化合物

Cat.No: T6636

Synonym: BAY 86-97661,瑞法替尼//瑞美替尼,BAY 869766,RDEA119

Target: MEK

Cat.No: T5412

Synonym: CH4987655,RG7167

Target: MEK

Cat.No: T2125

Synonym: GSK1120212,曲美替尼,JTP-74057

Target: Apoptosis, MEK, Autophagy

Cat.No: T2623

Synonym: PD 98059

Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy

Cat.No: T2253

Synonym: 3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮,SC 204330

Target: Pim

Cat.No: T6131

Synonym: AS703026,MSC1936369B,N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺,SAR 245509

Target: MEK

Cat.No: T6785

Target: Apoptosis, MEK, Aurora Kinase

Cat.No: T6692

Synonym: TAK733,TAK 733

Target: MEK

Cat.No: T6223

Synonym: U0126 Ethanol,U0126

Target: Mitophagy, Influenza Virus, MEK, Autophagy

Cat.No: T6083

Synonym: ARRY-424704,ARRY-704

Target: ERK, MEK

Trametinib (DMSO solvate)

Cat.No: T5857

Synonym: Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)

Target: Apoptosis, MEK

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cat.No: T13782

Target: MEK

Cat.No: T2708

Synonym: SL 327,SL-327

Target: MEK, DNA/RNA Synthesis

Cat.No: T69826

Cat.No: T2443

Synonym: PD 184352

Target: Apoptosis, MEK

Cat.No: T71163

Cat.No: T21332

Synonym: U 0126,U-0126

Target: Mitophagy, MEK, Autophagy

Agerafenib hydrochloride

Cat.No: T14928

Synonym: RXDX-105 hydrochloride,CEP-32496 (hydrochloride)

Target: c-RET, c-Kit

Cat. No.	Product Name	Target	Signaling Pathways
T15542	Hypothemycin	Others	Others
	Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively).

天然产物

Cat.No: T15542

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04544	MEK2 Protein, Human, Recombinant (GST) mitogen-activated protein kinase kinase 2,FLJ2<...	Human	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ...
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST) Raf-1 proto-oncogene, serine/threonine kinase,CRAF,NS5,CMD1N...	Human	Baculovirus Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell p...

重组蛋白

MEK2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04544

Species: Human

Expression System: Baculovirus Insect Cells

RAF1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-05095

Species: Human

Expression System: Baculovirus Insect Cells

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