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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8773 |
MID-1
|
Others; IGF-1R | Others; Tyrosine Kinase/Adaptors |
MID-1 是 MG53-IRS-1 相互作用的抑制剂,能够破坏 MG53 与 IRS-1 的分子缔合,并消除 MG53 诱导的 IRS-1 泛素化和骨骼肌降解,升高 IRS-1 表达水平,增加胰岛素信号传导和葡萄糖摄取。 | |||
T75151 | Aganirsen | ||
Aganirsen 是一种反义寡核苷酸(25个核苷酸),抑制胰岛素受体底物1 (IRS-1)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0760 |
Cholesterol
Cholesterin,Cholesteryl alcohol,胆固醇 |
Estrogen Receptor/ERR; MRP; Endogenous Metabolite; ROR | Endocrinology/Hormones; Immunology/Inflammation; Metabolism |
Cholesterol (Cholesteryl alcohol) 属于天然产物,是哺乳动物中的主要固醇,是一种雌激素相关受体 α (ERRα) 的激动剂。Cholesterol 广泛存在于动物的细胞膜,也是合成几种重要荷尔蒙及胆酸的材料。 | |||
T4S1545 |
Licarin B
(-)-Licarin B,Licarine B,(-)-利卡灵B |
transporter; Antibacterial; PPAR | DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Licarin B (Licarine B) 是来源于肉豆蔻种子的一种天然产物,是 NO 生成抑制剂,可通过激活 IRS-1/PI3K/AKT 通路中的PPARγ和GLUT4 改善胰岛素敏感性。 | |||
TL0014 | Pinusolide | ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK | Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes. |