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33

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T62978	HIV-IN-3
	HIV-IN-3 (Compound 22a) 是一种 HIV 的有效抑制剂 (IC50: 1.5 μM)。HIV-IN-3 具有潜力进行 HIV 相关疾病的研究。
FL0097	beta-L-D4A 2'3'-didehydro-2'3'-dideoxyadenosine
	beta-L-D4A 是一种核苷类型的HIV-1逆转录酶抑制剂。
T0682	Lamivudine GR109714X,BCH-189,拉米夫定	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Lamivudine (BCH-189) 是一种核苷逆转录酶抑制剂，可抑制HIV 逆转录酶1和2 以及乙型肝炎病毒的逆转录酶。
T0028	Gamibetal 3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Gamibetal (4-Amino-3-hydroxybutyric Acid) 是 γ-氨基-β-羟基丁酸，对癫痫具有潜在的研究价值。
T14313	Apricitabine AVX754,SPD754	HIV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Apricitabine (SPD754) 是一种具有高选择性和口服活性的HIV-1逆转录酶抑制剂(Ki=0.08μM)，是2′-脱氧-3′-氧-4′-硫代胞苷(dOTC)的(-)对映体。 Apricitabine 对DNA 聚合酶α、β和γ具有抑制作用，Ki 值分别为300μM、12μM 和112.25μM。Apricitabine 在抗逆转录病毒HIV 感染者中显示出良好的抗逆转录病毒治疗效果，具有良好的耐受性和较低的选择性抗性。
TQ0174	Mavorixafor AMD-070	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Mavorixafor (AMD-070) 是一种有效的特异性 CXCR4 拮抗剂，对 CXCR4 125I-SDF 结合的 IC50 值为 13 nM。 Mavorixafor 在 MT-4 细胞 (IC50 = 1 nM) 和 PBMC (IC50 = 9 nM) 中抑制 T-tropic HIV-1 (NL4.3 株) 的复制。
T29393	3'-Deoxy-4-thiothymidine Thymidine, 3'-deoxy-4-thio-,Ddthds
	3'-Deoxy-4-thiothymidine can moderately active in protecting HIV-induced cytopathogenicity of MT-2 and CEM cells.
T78551	Glycolithocholic acid 3-sulfate disodium Glycolithocholate sulfate disodium,SLCG disodium,Sulfolithocholylglycine disodium
	Glycolithocholic acid 3-sulfate (disodium) 是抑制HIV-1复制的化合物，同时它也被用于HIV感染和胆囊疾病的研究。
T10986	DDX3-IN-1	Others	Others
	DDX3-IN-1 is a DEAD-box polypeptide 3 (DDX3) inhibitor with CC50 of 50 and 36 μM for HIV and HCV, respectively. Antiviral activity.
T72162	HIV-1 integrase inhibitor 10
	HIV-1integrase inhibitor 10 是一种 HIV-1变构整合酶抑制剂 (ALLINI)，具有口服活性。HIV-1integrase inhibitor 10 可抑制 NLRepRluc 病毒在 MT-2 细胞中的生长，其 EC50值为 3-5 nM。HIV-1integrase inhibitor 10 可用于人类免疫缺陷病毒-1 (HIV-1) 的研究。
T72203	Reverse transcriptase-IN-3
	Reverse transcriptase-IN-3, 作为一种嘧啶-5-羧酰胺衍生物，主要用于抑制HIV-1。它对HIV-1野生型及其突变型病毒株均展示出高效的抑制活性。
T78950	HIV-1 protease-IN-8	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1protease-IN-8（compound 34b）是一款高效的HIV-1蛋白酶抑制剂，其IC50为0.32 nM。该化合物对野生型HIV-1（HIV-1NL4-3）及耐药变体（HIV-1MDR）的IC50分别为0.29 μM与1.90 μM，表明其对这两种型别均展现出显著的抗病毒效果。
T80621	Semzuvolimab UB421
	Semzuvolimab是靶向T细胞表面抗原T4/Leu-3，即p55 (CD4)的鼠IgG1κ类抗体。该CD4抗体具备中和HIV感染的能力，潜在用于抑制HAART稳定型HIV感染。
T78737	NNRTIs-IN-3	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	NNRTIs-IN-3（化合物8）作为一种HIV-1非核苷逆转录酶抑制剂，表现出较高的效力（EC50=0.01 µM）。
T60342	HIV-1 inhibitor-47
	HIV-1 inhibitor-47 is a compound that effectively inhibits HIV-1 by preventing the vif-dependent degradation of human APOBEC3G. It has a notable inhibition effect, with an IC50 value of 14.33 μM. Additionally, HIV-1 inhibitor-47 is involved in the synthesis of derivatives of 1-(2-pyrimidinyl)piperazine, which have the potential to exhibit antianxiety, antidepressant, and antipsychotic effects [1] [2] [3].
T83707	F9170 TFA
	F9170是一种抗病毒肽，对应HIV-1包膜糖蛋白的789-803氨基酸。它与HIV-1包膜蛋白胞浆尾部的LLP1域结合，并抑制HIV-1 IIIB对MT-2细胞的感染(EC50 = 0.19 µM)。在恒河猴模型的类人猿免疫缺陷病毒(SHIV)感染中，F9170 (3 mg/kg)能降低血浆病毒负荷。
T77141	Pegaldesleukin
	Pegaldesleukin 是一种聚乙二醇与白细胞介素-2 的偶联物 (PEG-IL2)。Pegaldesleukin 具有抗病毒活性，在 HIV 中有潜在应用，可能通过保留免疫组库来延缓 HIV 感染的进展。
T61679	Abacavir monosulfate
	Abacavir monosulfate is an orally active, competitive nucleoside reverse transcriptase inhibitor that effectively inhibits HIV replication. Additionally, it exhibits anticancer properties in prostate cancer cell lines, and has the ability to penetrate the blood-brain-barrier and suppress telomerase activity [1] [2] [3].
T75330	Lysozyme chloride
	Lysozyme chloride 是一种杀菌酶，它能裂解革兰氏阳性细菌 (bacteria)。Lysozyme chloride 还可用于HIV 感染和肺气肿的研究。
T73904	Ditiocarb
	Ditiocarb (Diethyldithiocarbamic acid) 是一种铜试剂，与 Cu2+溶液反应，生成络合物，提高了铜置换沉淀速率。Sodium diethyldithiocarbamate 可降低HIV 感染，并应用于高危乳腺癌的辅助免疫研究。
T61193	DDX3-IN-2
	DDX3-IN-2, a potent inhibitor of DEADbox polypeptide 3 (DDX3), demonstrates remarkable activity against the target with an IC50 value of 0.3 μM. Notably, this compound exhibits a wide range of antiviral effects, showcasing its efficacy against various viral strains. Importantly, DDX3-IN-2 exhibits the potential to overcome resistance observed in the context of HIV [1].
T75783	Apelin-36(human) TFA
	Apelin-36(human) TFA 是一种内源性孤儿 G 蛋白偶联受体 APJ 激动剂，EC50为 20 nM。Apelin-36(human) TFA 对 HEK 293 细胞表达的人 APJ 受体有很高的亲和力 (pIC50=8.61)。Apelin-36(human) TFA 与两种主要的生物活性有关：心血管和代谢。Apelin-36(human) TFA 抑制 HIV-1和 HIV-2进入表达 APJ 的 NP2/CD4细胞。
T36490	AZT triphosphate TEA
	AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in ...
T37344	5,6-dimethyl-2-Thiouracil
	5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones.1 It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma.2 \|1. Navrotskii, M.B. Synthesis and anti-HIV-1 activity of new 2-[(2-phthalimidoethyl)thio]-4(3H)-pyrimidinone derivatives. Pharm. Chem. J. 39(9), 466-467 (2005).\|2. Schmidt, K.S. In-house validation and factorial effect analysis of a liquid chroma...
T37347	6'-Sialyllactose Sodium Salt 6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose
	6'-Sialyllactose consists of the monosaccharide N-acetylneuraminic acid linked to the galactosyl subunit of lactose at the 6 position. This connection is at the 3 position in the related compound, 3’-sialyllactose. Both are major milk oligosaccharides that avidly bind several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus.[1],[2],[3],[4],[5],[6] These compounds can be used to differentiate and characterize the binding domains of viruses that recognize N-acetylne...
T70856	3-Oxobetulin Acetate
	3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblasto...
T38103	Defensin HNP-3 (human) (trifluoroacetate salt)
	Defensin HNP-3 is a peptide secreted by human polymorphonuclear leukocytes (PMNs) that has antimicrobial properties. It induces lysis of mammalian cells when used at a concentration of 25 μg/mL. It also inhibits growth of E. faecalis (ED50 = 100 nM) and clinical isolates of P. aeruginosa (MIC90 = 4 μM). HNP-3 binds to recombinant HIV-1 envelope glycoprotein (gp120) and human CD4 (Kds = 52.8 and 34.9 nM, respectively). It also binds to recombinant, immobilized human surfactant protein D (SP-D; Kd...
T37065	6-Chloro-2-fluoropurine
	6-Chloro-2-fluoropurine is a heterocyclic building block.1,2It has been used in the synthesis of purine nucleosides that inhibit cyclin-dependent kinases (CDKs)in vitro.16-Chloro-2-fluoropurine has also been used in the synthesis of purine nucleosides that are active against HIV-1 and hepatitis B virus (HBV)in vitro.2 1.Wilson, S.C., Atrash, B., Barlow, C., et al.Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitorsBioorg. Med. Chem.19(22)6949-6965(2011) 2....
T35762	MC1742
	MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin...
T35904	O-11
	O-11 is an analog of the fully saturated, 14-carbon fatty acid myristic acid, in which the methylene group at position 11 is replaced with oxygen. It is highly effective and selective at killingTrypanosoma brucei, the protozoan parasite responsible for African sleeping sickness, exhibiting an LD50of less than 1 μM in a cell culture assay.1,2The toxic effects of O-11 appear to be caused by its ability to inhibit the incorporation of a single myristate into the GPI anchor of the variant surface gl...
T10296	Mavorixafor trihydrochloride AMD-070 trihydrochloride	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Mavorixafor trihydrochloride is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs (IC50s: 1 and 9 nM).
T35406	α-MSH TFA
	α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo...
T35428	β-Rubromycin
	β-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and <0.1 μM, respectively. β-rubromycin inhibits HIV-1 reverse transcriptase activity by 39.7% when used at a concentration of 10 μM. It also has antibacterial activity against Gram-positive bacteria. The structure of β-rubromycin was originally described as containing an ortho-quinone group,...

化合物

Cat.No: T62978

Cat.No: FL0097

Synonym: 2'3'-didehydro-2'3'-dideoxyadenosine

Cat.No: T0682

Synonym: GR109714X,BCH-189,拉米夫定

Target: HIV Protease, Reverse Transcriptase

Cat.No: T0028

Synonym: 3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid

Target: HIV Protease

Cat.No: T14313

Synonym: AVX754,SPD754

Target: HIV Protease, DNA/RNA Synthesis

Cat.No: TQ0174

Synonym: AMD-070

Target: CXCR

3'-Deoxy-4-thiothymidine

Cat.No: T29393

Synonym: Thymidine, 3'-deoxy-4-thio-,Ddthds

Glycolithocholic acid 3-sulfate disodium

Cat.No: T78551

Synonym: Glycolithocholate sulfate disodium,SLCG disodium,Sulfolithocholylglycine disodium

Cat.No: T10986

Target: Others

HIV-1 integrase inhibitor 10

Cat.No: T72162

Reverse transcriptase-IN-3

Cat.No: T72203

HIV-1 protease-IN-8

Cat.No: T78950

Target: HIV Protease

Cat.No: T80621

Synonym: UB421

Cat.No: T78737

Target: HIV Protease

HIV-1 inhibitor-47

Cat.No: T60342

Cat.No: T83707

Cat.No: T77141

Abacavir monosulfate

Cat.No: T61679

Lysozyme chloride

Cat.No: T75330

Cat.No: T73904

Cat.No: T61193

Apelin-36(human) TFA

Cat.No: T75783

AZT triphosphate TEA

Cat.No: T36490

5,6-dimethyl-2-Thiouracil

Cat.No: T37344

6'-Sialyllactose Sodium Salt

Cat.No: T37347

Synonym: 6'-Sialyllactose Sodium Salt,6'-N-Acetylneuraminyl-D-lactose

3-Oxobetulin Acetate

Cat.No: T70856

Defensin HNP-3 (human) (trifluoroacetate salt)

Cat.No: T38103

6-Chloro-2-fluoropurine

Cat.No: T37065

Cat.No: T35762

Cat.No: T35904

Mavorixafor trihydrochloride

Cat.No: T10296

Synonym: AMD-070 trihydrochloride

Target: HIV Protease

Cat.No: T35406

Cat.No: T35428

Cat. No.	Product Name	Target	Signaling Pathways
T6S2391	L-Chicoric Acid (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	L-Chicoric Acid (trans-Caffeoyltartaric acid) 是一种二咖啡酰酒石酸，是一种选择性可逆的 HIV-1 整合酶抑制剂，IC50约为 100 nM。它还可抑制 HIV-1 复制。
T5429	Theaflavin 3,3'-digallate 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG	Virus Protease; Antioxidant; HIV Protease; HSV	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂，IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制，可抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚，有抗肿瘤作用。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 属于生物碱类天然产物，可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。
TN2951	3-(hydroxymethyl)cyclopentanone	CCR	Immunology/Inflammation; Microbiology/Virology
	3-Hydroxymethylcyclopentanone is a precursor to synthesize methyl epijasmonate. 3-Hydroxymethylcyclopentanone compounds, which are useful as intermediates in the preparation of HIV chemokine CCR-5 receptor antagonists.
T73758	Glycolithocholic acid 3-sulfate
	Glycolithocholic acid 3-sulfate (SLCG) 为一种胆汁酸衍生物及甘胆酸的代谢产物，具有抑制HIV-1复制的作用。该化合物在HIV感染和胆囊疾病的研究中有潜在应用价值。
T36438	Sporogen-AO 1
	Sporogen-AO 1 is a fungal metabolite originally isolated fromA. oryzaethat has diverse biological activities.1,2,3,4,5It inhibits HIV-1 Tat transactivation in a cell-based assay with an IC50value of 15.8 μM.4Sporogen-AO 1 is cytotoxic to HeLa, KB, and NCI H187 cancer cells (IC50s = 8.3, 9, and 5.1 μM, respectively).2,5It is active againstC. albicans(MIC = 4 mM).3 1.Tanaka, S., Wada, K., Marumo, S., et al.Structure of sporogen-ao 1, a sporogenic substance of Aspergillus oryzaeTetrahedron Lett.25(...
T36000	3-Hydroxyterphenyllin
	3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi...
T72429	α-Lipoic Acid sodium Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium
	α-Lipoic Acid (Thioctic acid) sodium 是一种抗氧化剂，是线粒体酶复合物的重要辅助因子。α-Lipoic Acid sodium 可抑制NF-κB 依赖性的HIV-1LTR 活化。α-Lipoic Acid sodium 诱导内质网应激 (ERS) 介导的肝癌细胞凋亡 (apoptosis)。α-Lipoic Acid sodium 可与CPUL1 合成自组装的纳米聚合体 CPUL1-LA NA，其抗肿瘤效果优于 CPUL1。
T37451	Stachybotrysin B
	Stachybotrysin B is a fungal metabolite originally isolated from S. chartarum and has antiviral and anticancer activities.1,2 It has antiviral activity against HIV in SupT1 cells (IC50 = 19.2 μM).1 Stachybotrysin B is cytotoxic to K562, HeLa, and HL-60 cells (IC50s = 21.72, 39.63, and 18.5 μM, respectively).2 \|1. Zhao, J., Feng, J., Tan, Z., et al. Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J. Nat. Prod. 80(6), 1819-1826 (2017).\|2. Ma, X.-h., Zhen...

天然产物

L-Chicoric Acid

Cat.No: T6S2391

Synonym: (-)-Chicoric acid,trans-Caffeoyltartaric acid,Chicoric acid,L-菊苣酸,dicaffeoyltartaric acid,菊苣酸

Target: Others, HIV Protease

Theaflavin 3,3'-digallate

Cat.No: T5429

Synonym: 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

3-(hydroxymethyl)cyclopentanone

Cat.No: TN2951

Target: CCR

Glycolithocholic acid 3-sulfate

Cat.No: T73758

Cat.No: T36438

3-Hydroxyterphenyllin

Cat.No: T36000

α-Lipoic Acid sodium

Cat.No: T72429

Synonym: Thioctic acid sodium,DL-α-Lipoic acid sodium,Thioctic acid sodium ; (±)-α-Lipoic acid sodium ; DL-α-Lipoic acid sodium,(±)-α-Lipoic acid sodium

Stachybotrysin B

Cat.No: T37451

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