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Search Results for " guanidine "

32

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T50058	1-(cyclohexylmethyl)guanidine hydroiodide	Others	Others
	1-(cyclohexylmethyl)guanidine hydroiodide 是一种胍衍生物，已被用作合成多种化合物的试剂，包括肽、拟肽和其他生物活性分子，也被用作合成其他催化剂，如酰胺、酯和醚。
T50030	1-(2,4-difluorophenyl)guanidine hydrochloride	Others	Others
	1-(2,4-difluorophenyl)guanidine hydrochloride 是一种化合物，是电压门控钠通道Nav1.7的强效选择性抑制剂，Nav1.7是疼痛信号传输的关键参与者，因此它能够减少疼痛信号的传递，从而产生镇痛作用。
T50092	1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride 1-(7-carbamimidamidoheptyl)guanidine dihydrochloride	Others	Others
	1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride 是糖原合成酶激酶-3（GSK-3）的有效性和选择性小分子抑制剂，用于干细胞分化、肿瘤和神经退行性疾病的研究。
T50091	1,1'-(Octane-1,8-diyl)diguanidine dihydrochloride 1-(8-carbamimidamidooctyl)guanidine dihydrochloride	Others	Others
	1,1'-(Octane-1,8-diyl)diguanidine dihydrochloride 是一种合成的阿片肽，来源于天然阿片肽脑啡肽。它是μ-阿片受体（MOR）的高效激动剂，Ki 为0.14 nM，是一种有效的MOR 激动剂。
T66809	Guanidine thiocyanate
	Guanidine thiocyanate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66809，CAS号为 593-84-0。
T24833	ZINC69391 ZINC-69391,ZINC 69391,N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine,CysHHC10 acetate(1408311-03-4 free base)	Apoptosis; Rho	Apoptosis; Cell Cycle/Checkpoint
	ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) 是 Rac1 的选择性抑制剂，具有抗增殖和抗转移作用。 ZINC69391 干扰 Rac1 与 Dock180 的相互作用，降低 Rac1-GTP 水平并诱导细胞凋亡。
T32017	m-Heptamethyleniminomethylbenzylguanidine sulfate Guanidine, (3-(hexahydro-1(2H)-azocinylmethyl)benzyl)-, sulfate
	Guanidine, (3-(hexahydro-1(2H)-azocinylmethyl)benzyl)-, sulfate is a bioactive chemical.
TNU1455	N,N’-bis-Cbz-N’’-(2-hydroxyethyl)-guanidine
	Fine Chemicals
T50109	Guanethidine
	Guanethidine 于1959年合成，被认为可以通过干扰神经节后交感神经纤维中的化学递质物质的代谢来降低血压。
T21703	4-Chlorophenylguanidine hydrochloride	Others	Others
	4-Chlorophenylguanidine hydrochloride 是一种有效的尿激酶选择性抑制剂。
T20253	N,N'-Diphenylguanidine NSC 3272,NSC3272,NSC-3272,二苯胍	Others	Others
	N,N'-Diphenylguanidine (NSC-3272) 是一种生化剂。
T0510	Sulfaguanidine Sulfaguine,Guanicil,磺胺脒	Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Sulfaguanidine (Guanicil) 是一种具有口服活性的磺胺类抗菌剂和抗生素。它可用于肠道感染，例如细菌性痢疾的研究。
T0358	Aminoguanidine hydrochloride Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐）,氨基胍盐酸盐,Guanyl hydrazine,Pimagedine	NOS; NO Synthase	Immunology/Inflammation
	Aminoguanidine hydrochloride (Hydrazinecarboximidamide) 是二胺氧化酶抑制剂，也是一氧化氮合酶抑制剂，可用于糖尿病肾病的研究。
T5969	Ditolylguanidine DTG,二邻甲苯胍,Di-o-tolylguanidine,1,3-Di-o-tolylguanidine	Sigma receptor	GPCR/G Protein
	Ditolylguanidine (Di-o-tolylguanidine) 是σ1/σ2 受体的激动剂。
T60530	Mercaptoethylguanidine (MEG) (dihydrobromide)
	Mercaptoethylguanidine (MEG) dihydrobromide 是选择性的诱导型一氧化氮合酶抑制剂和过氧亚硝酸盐清除剂，在炎症性肠病研究中具有潜力。
T20246	1,2,3-Triphenylguanidine NSC4051,NSC-4051,NSC 4051
	1,2,3-Triphenylguanidine is an agent of biochemical.
T67064	1,1-Dimethylguanidine Sulfate(2:1)
	1,1-Dimethylguanidine Sulfate(2:1) 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67064，CAS号为 598-65-2。
T78229	Aminoguanidine hemisulfate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Aminoguanidine hemisulfate 作为NOS及ROS的抑制剂，能够在体外有效清除ANE诱导的ROS生成，因此它被广泛应用于癌症研究领域。
T67763	PK095	ATPase	Membrane transporter/Ion channel
	PK095是一个基于胍的F1F0-ATPase 抑制剂家族。
T12478L	Pinacidil 吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134	Potassium Channel	Membrane transporter/Ion channel
	Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化，显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。
T4206	E6446	TLR	Immunology/Inflammation
	E6446 抑制 Toll 样受体 (TLR)7 和 9 信号传导。 E6446 在多种人和小鼠细胞类型中起作用，并在体外抑制 DNA-TLR9 相互作用。当给予小鼠时，该化合物抑制对刺激 TLR9 的含有胞苷-磷酸-胍 (CpG) 的 DNA 的挑战剂量的反应。
T62396	KB-5492 free base
	KB-5492 free base 是一种有效的和选择性的sigma 受体抑制剂，抑制 [3H]1,3-di(2-tolyl)guanidine (DTG) 与sigma 受体结合，IC50值为 3.15 μM。KB-5492 free base 是一种抗溃疡剂。
T9462	2-Amino-6-cyclopropylamino-9H-purine	Others	Others
	2-Amino-6-cyclopropylamino-9H-purine 是阿巴卡韦(abacavir) 的关键中间体，以氰基乙酸乙酯为原料，经亚硝化、盐酸胍在 EtONa 存在下环合、还原得到2,4,5-三氨基-6-羟基嘧啶
T111959	IFB-088 acetate
	IFB-088 acetate 是一种苄基胍衍生物，可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症，如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。
T1320	Disopyramide Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平	Potassium Channel; Sodium Channel; AChR	Membrane transporter/Ion channel; Neuroscience
	Disopyramide (Triombrin) 是用于研究房性和室性心律失常的 IA 类抗心律失常试剂。它阻断心肌快速内向钠电流，延长心肌动作电位持续时间。它抑制 HERG 编码的钾通道。它也表现出复杂的蛋白质结合，并具有强大的负性肌力作用。
T23662	Aganodine Aganodin
	Aganodine is a guanidine that activates presynaptic imidazoline receptors. Aganodine inhibits the presynaptic release of norepinephrine through its agonism at imidazoline receptors.
T20697	Robenidine Chimcoccide,Khimcoccid
	Robenidine, an anticoccidial guanidine, is used as an additive in rabbit fodder.
T33610	NC-174 CPDpmGA,CP Dpm GA,CP-Dpm-GA,CP-DpmGA,CPDpm-GA
	NC-174 is a trisubstituted guanidine high potency synthetic sweetener.
T37100	1,5,7-Triazabicyclo[4.4.0]dec-5-ene
	1,5,7-Triazabicyclo[4.4.0]dec-5-ene is a bicyclic guanidine base that can be used as a catalyst for a variety of base-mediated organic transformations, including Michael additions, Wittig reactions, Henry reactions, and transesterification reactions.
T68714	Iobenguane I 131
	Iobenguane I 131 is a guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
T25739	Linogliride McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida
	Linogliride 是一种基于胍的胰岛素分泌抑制剂，也是 pirogliride 的结构类似物，具有降血糖活性。它可以阻断胰腺β细胞膜上对 ATP 敏感的钾通道，从而刺激胰岛素分泌并改善葡萄糖耐受性。
T25739L	Linogliride fumarate McN 3935,McN-3935,McN3935
	Linogliride fumarate 是Linogliride 的富马酸盐。Linogliride 是一种基于胍的胰岛素分泌抑制剂，也是pirogliride 的结构类似物，具有降血糖活性。它可以阻断胰腺β细胞膜上对ATP 敏感的钾通道，从而刺激胰岛素分泌并改善葡萄糖耐受性。

化合物

1-(cyclohexylmethyl)guanidine hydroiodide

Cat.No: T50058

Target: Others

1-(2,4-difluorophenyl)guanidine hydrochloride

Cat.No: T50030

Target: Others

1,1'-(Heptane-1,7-diyl)diguanidine dihydrochloride

Cat.No: T50092

Synonym: 1-(7-carbamimidamidoheptyl)guanidine dihydrochloride

Target: Others

1,1'-(Octane-1,8-diyl)diguanidine dihydrochloride

Cat.No: T50091

Synonym: 1-(8-carbamimidamidooctyl)guanidine dihydrochloride

Target: Others

Guanidine thiocyanate

Cat.No: T66809

Cat.No: T24833

Synonym: ZINC-69391,ZINC 69391,N'-(4,6-dimethylpyrimidin-2-yl)-N-[2-(trifluoromethyl)phenyl]guanidine,CysHHC10 acetate(1408311-03-4 free base)

Target: Apoptosis, Rho

m-Heptamethyleniminomethylbenzylguanidine sulfate

Cat.No: T32017

Synonym: Guanidine, (3-(hexahydro-1(2H)-azocinylmethyl)benzyl)-, sulfate

N,N’-bis-Cbz-N’’-(2-hydroxyethyl)-guanidine

Cat.No: TNU1455

Cat.No: T50109

4-Chlorophenylguanidine hydrochloride

Cat.No: T21703

Target: Others

N,N'-Diphenylguanidine

Cat.No: T20253

Synonym: NSC 3272,NSC3272,NSC-3272,二苯胍

Target: Others

Cat.No: T0510

Synonym: Sulfaguine,Guanicil,磺胺脒

Target: Antibacterial, Antibiotic, Autophagy

Aminoguanidine hydrochloride

Cat.No: T0358

Synonym: Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐）,氨基胍盐酸盐,Guanyl hydrazine,Pimagedine

Target: NOS, NO Synthase

Ditolylguanidine

Cat.No: T5969

Synonym: DTG,二邻甲苯胍,Di-o-tolylguanidine,1,3-Di-o-tolylguanidine

Target: Sigma receptor

Mercaptoethylguanidine (MEG) (dihydrobromide)

Cat.No: T60530

1,2,3-Triphenylguanidine

Cat.No: T20246

Synonym: NSC4051,NSC-4051,NSC 4051

1,1-Dimethylguanidine Sulfate(2:1)

Cat.No: T67064

Aminoguanidine hemisulfate

Cat.No: T78229

Target: Reactive Oxygen Species

Cat.No: T67763

Target: ATPase

Cat.No: T12478L

Synonym: 吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134

Target: Potassium Channel

Cat.No: T4206

Target: TLR

KB-5492 free base

Cat.No: T62396

2-Amino-6-cyclopropylamino-9H-purine

Cat.No: T9462

Target: Others

IFB-088 acetate

Cat.No: T111959

Cat.No: T1320

Synonym: Triombrin,Hypaque sodium,amidotrizoate sodium,达舒平

Target: Potassium Channel, Sodium Channel, AChR

Cat.No: T23662

Synonym: Aganodin

Cat.No: T20697

Synonym: Chimcoccide,Khimcoccid

Cat.No: T33610

Synonym: CPDpmGA,CP Dpm GA,CP-Dpm-GA,CP-DpmGA,CPDpm-GA

1,5,7-Triazabicyclo[4.4.0]dec-5-ene

Cat.No: T37100

Iobenguane I 131

Cat.No: T68714

Cat.No: T25739

Synonym: McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida

Linogliride fumarate

Cat.No: T25739L

Synonym: McN 3935,McN-3935,McN3935

Cat. No.	Product Name	Target	Signaling Pathways
T0415	Guanidine hydrochloride Guanidine HCl,Aminoformamidine HCl,盐酸胍,Aminoformamidine Hydrochloride,Guanidinium chloride	Others; Arginase; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Others
	Guanidine hydrochloride (Aminoformamidine Hydrochloride) 是一种强离液剂和一种蛋白质的强变性剂。
T4904	1-Methylguanidine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	1-Methylguanidine hydrochloride 是内源性代谢产物的一种。
T20390	Cyanoguanidine NSC2031,Dicyandiamide,NSC 2031,NSC-2031
	Cyanoguanidine is an agent of antimicrobial.
T4238	Glycocyamine 乙酸胍,2-Guanidinoacetic acid,Guanidoacetic acid	Others; Endogenous Metabolite	Metabolism; Others
	Glycocyamine (2-Guanidinoacetic acid) 是一种肌酸的前体，能够为鸟类的体内平衡提供能量，也能够成为食用精氨酸的替代物。
T4753	Imidazoleacetic acid hydrochloride I4AA,(4-Imidazolyl)acetic acid hydrochloride,4-咪唑乙酸盐酸盐,4-Imidazoleacetic acid hydrochloride	Endogenous Metabolite; Antibiotic	Metabolism; Microbiology/Virology
	Imidazoleacetic acid hydrochloride (I4AA) 是咪唑衍生物，具有潜在的抗结核性能。它还用于制备β-分泌酶的酰基胍抑制剂。
T35532	Galegine hydrochloride
	Galegine hydrochloride, a guanidine derivative derived from G. officinalis, plays a role in inducing weight loss in mice and has contributed to the development of biguanides, including metformin and phenformin. This compound stimulates AMPK activation in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma, and HEK293 human kidney cell lines. Additionally, galegine hydrochloride exhibits antibacterial properties, particularly demonstrating a minimum inhibitory concentration of 4 mg/L against Staph...

天然产物

Guanidine hydrochloride

Cat.No: T0415

Synonym: Guanidine HCl,Aminoformamidine HCl,盐酸胍,Aminoformamidine Hydrochloride,Guanidinium chloride

Target: Others, Arginase, DNA/RNA Synthesis, Endogenous Metabolite, Autophagy

1-Methylguanidine hydrochloride

Cat.No: T4904

Target: Others, Endogenous Metabolite

Cat.No: T20390

Synonym: NSC2031,Dicyandiamide,NSC 2031,NSC-2031

Cat.No: T4238

Synonym: 乙酸胍,2-Guanidinoacetic acid,Guanidoacetic acid

Target: Others, Endogenous Metabolite

Imidazoleacetic acid hydrochloride

Cat.No: T4753

Synonym: I4AA,(4-Imidazolyl)acetic acid hydrochloride,4-咪唑乙酸盐酸盐,4-Imidazoleacetic acid hydrochloride

Target: Endogenous Metabolite, Antibiotic

Galegine hydrochloride

Cat.No: T35532

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