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Search Results for " gm-csf "

Targets Recommended: IL Receptor Interleukin

21

抑制剂 & 化合物

22

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T3133	YM-90709 YM90709,YM 90709	IL Receptor; Interleukin	Immunology/Inflammation
	YM-90709是新型的能够抑制IL-5与IL-5受体结合的拮抗剂, 。
T3185	R112 (E)-Elafibranor	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	R112 ((E)-Elafibranor) 是ATP 竞争性的 Syk 激酶抑制剂，它能够抑制Syk 激酶活性，Ki=6 nM，IC50=226 nM。
T0089	Cetirizine dihydrochloride 盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cetirizine dihydrochloride (UCB P071) 是羟嗪的羧化代谢物，是特异性口服有效的 H1 受体长效拮抗剂。它标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化，可有效治疗过敏性鼻炎、确诊荨麻疹和花粉诱发的哮喘。
T80585	Anti-Mouse GM-CSF Antibody (MP1-22E9)	c-Fms	Tyrosine Kinase/Adaptors
	Anti-MouseGM-CSFAntibody 为特异性针对小鼠GM-CSF的IgG2a类免疫球蛋白抗体，由大鼠血清中提取。
T9840	Ataquimas	Immunology/Inflammation related	Immunology/Inflammation
	Ataquimas 抑制来自人类细胞的 IL-5 以及 TNF-a、IL-4 和 GM-CSF 的分泌。
T77125	Otilimab GSK 3196165,MOR103	CSF-1R	Tyrosine Kinase/Adaptors
	Otilimab (GSK 3196165) 是一种人源化抗粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 单克隆抗体。Otilimab 具有抗炎活性，通过阻断 GM-CSF 与其细胞表面受体的相互作用来调节 GM-CSF 的生物学功能，可用于研究治疗重症 COVID-19 肺炎。
T76690	Mavrilimumab CAM 3001	Virus Protease; CSF-1R	Microbiology/Virology; Tyrosine Kinase/Adaptors
	Mavrilimumab (CAM 3001) 是一种单克隆抗体，具有抗病毒活性，对粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 受体的 α 亚基有亲和力，并阻止 GM-CSF 下游细胞内信号传导。GM-CSF 可能与呼吸衰竭和死亡相关的过度活跃炎症反应有关，可用于研究类风湿性关节炎。
T29797	AKB-6899 AKB6899	VEGFR; HIF/HIF Prolyl-Hydroxylase; HIF	Angiogenesis; Chromatin/Epigenetic; Metabolism; Tyrosine Kinase/Adaptors
	AKB-6899 是脯氨酰羟化酶结构域 3 (PHD3) 的抑制剂，可增加 GM-CSF 处理的巨噬细胞产生的 VEGF 受体的可溶形式 (sVEGFR-1)。 AKB-6899 能稳定 HIF-2α，从而诱导肿瘤相关巨噬细胞产生 sVEGFR-1 并减少肿瘤生长。
TP2008L	Lyn peptide inhibitor acetate Lyn peptide inhibitor acetate(222018-18-0 free base)	IL Receptor	Immunology/Inflammation
	Lyn peptide inhibitor acetate(222018-18-0 free base) 是一种有效的细胞渗透性 Lyn 偶联 IL-5 受体信号通路抑制剂，同时保持其他信号完整。它阻断 Lyn 活化并抑制 Lyn 酪氨酸激酶与 IL-3/GM-CSF/IL-5 受体的 βc 亚基的结合。它可用于哮喘、过敏和其他嗜酸性粒细胞疾病的研究。
T76820	Namilumab
	Namilumab (AMG203) 是一种人的IgG4单克隆抗体，与GM-CSF 配体高亲和力结合，有效地中和GM-CSF。Namilumab 可用于类风湿关节炎的研究。
T79149	Magmas-IN-1	Others	Others
	Magmas-IN-1（compound 9）为针对Magmas的小分子抑制剂（SMMI），后者是线粒体相关粒细胞-巨噬细胞集落刺激因子（GM-CSF）的信号分子，并参与骨髓细胞的GM-CSF诱导基因表达。Magmas-IN-1作用于Magmas，进而调控线粒体功能，并在4 μM浓度下可显著抑制酵母细胞的增殖。
T77116	Plonmarlimab
	Plonmarlimab (TJ003234) 是一种抗GM-CSF 单克隆抗体。Plonmarlimab 可用于类风湿性关节炎和 COVID-19 的研究。
T77025	Gimsilumab
	Gimsilumab 是一种人源化的抗 GM-CSF 单克隆抗体。Gimsilumab 具有研究 COVID-19 和类风湿性关节炎的潜力。
T76751	Lenzilumab
	Lenzilumab (KB 003) 是一种靶向CSF2/GM-CSF 的人源化单克隆抗体，可用于 COVID-19、慢性粒单核细胞白血病 (CMML) 和幼年粒单核细胞白血病 (JMML) 研究。
T74971	Diamino lipid DAL4
	Diamino lipid DAL4 是一种新型脂质纳米颗粒 (LNPs)，可包裹编码 IL-12、IL-27 和 GM-CSF 等细胞因子的 mRNA。Diamino lipid DAL4 能够传递细胞因子 mRNA 给肿瘤细胞，发挥抗肿瘤效力。
T80959	Trabikibart CSL311
	Trabikibart（CSL311）为βc特异性的全人源单克隆抗体，专一性结合人βc受体的细胞因子结合位点表位，并展现高皮摩尔级别的结合亲和力。此抗体能有效抑制IL-3、GM-CSF和IL-5在嗜酸性粒细胞存活中的协同作用，显示出治疗慢性炎症性疾病的应用潜力。
T73659	HLF1-11
	HLF1-11，一种人乳铁蛋白衍生肽，是一种广谱抗菌剂。HLF1-11 抑制MPO(human) 的活性。HLF1-11 还使GM-CSF 驱动的单核细胞向巨噬细胞分化，并增强其免疫反应。
T82938	ATUX-1215
	ATUX-1215是一种蛋白磷酸酶 2A (PP2A)的激活剂，能够在BLM治疗的动物模型中降低ERK、p38、JNK和Akt的磷酸化及IL-12p70、GM-CSF与IL1α的分泌，从而有助于减缓肺纤维化的发展。
T75806	Lyn peptide inhibitor TFA
	Lyn peptide inhibitor TFA 是一种有效的，可以细胞渗透的抑制剂，抑制Lyn 偶联的IL-5受体相关信号通路，同时保持其他信号的完整。Lyn peptide inhibitor TFA 可以阻断 Lyn 的激活，抑制 Lyn 酪氨酸激酶与 IL-3/GM-CSF/IL-5 受体的 βc 亚基结合。Lyn peptide inhibitor TFA 可用于哮喘、过敏等嗜酸性疾病的研究。
TP2008	Lyn peptide inhibitor
	Cell-permeable inhibitor of Lyn-dependent effects of the IL-5 receptor. Blocks binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors, blocking Lyn activation. Inhibits IL-5 receptor-mediated eosinophil differentiation and survival in
T38384	Nexinhib20
	Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 μM).[1] It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 μM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflamma...

化合物

Cat.No: T3133

Synonym: YM90709,YM 90709

Target: IL Receptor, Interleukin

Cat.No: T3185

Synonym: (E)-Elafibranor

Target: Syk

Cetirizine dihydrochloride

Cat.No: T0089

Synonym: 盐酸西替利嗪,P071,UCB P071,Cetirizine DiHCl

Target: Histamine Receptor

Anti-Mouse GM-CSF Antibody (MP1-22E9)

Cat.No: T80585

Target: c-Fms

Cat.No: T9840

Target: Immunology/Inflammation related

Cat.No: T77125

Synonym: GSK 3196165,MOR103

Target: CSF-1R

Cat.No: T76690

Synonym: CAM 3001

Target: Virus Protease, CSF-1R

Cat.No: T29797

Synonym: AKB6899

Target: VEGFR, HIF/HIF Prolyl-Hydroxylase, HIF

Lyn peptide inhibitor acetate

Cat.No: TP2008L

Synonym: Lyn peptide inhibitor acetate(222018-18-0 free base)

Target: IL Receptor

Cat.No: T76820

Cat.No: T79149

Target: Others

Cat.No: T77116

Cat.No: T77025

Cat.No: T76751

Diamino lipid DAL4

Cat.No: T74971

Cat.No: T80959

Synonym: CSL311

Cat.No: T73659

Cat.No: T82938

Lyn peptide inhibitor TFA

Cat.No: T75806

Lyn peptide inhibitor

Cat.No: TP2008

Cat.No: T38384

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03858	GM-CSF/CSF2 Protein, Human, Recombinant CSF2,colony stimulating factor 2 (granulocyte-macro...	Human	HEK293 Cells
	GM-CSF/CSF2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is P04141.
TMPY-00750	GM-CSF/CSF2 Protein, Human, Recombinant (hFc) 集落刺激因子,CSF2,GM-CSF,colony stimula...	Human	HEK293 Cells
	GM-CSF/CSF2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 41 kDa and the accession number is P04141.
TMPJ-01465	GM-CSF/CSF2 Protein, Human, Recombinant (E. coli) Colony-Stimulating Factor,CSF2,CSF,Sargram...	Human	E. coli
	Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryo...
TMPY-03662	GM-CSF/CSF2 Protein, Mouse, Recombinant (His) GMCSF,MGI-IGM,colony stimulating ...	Mouse	HEK293 Cells
	GM-CSF/CSF2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.10 kDa and the accession number is P01587.
TMPY-04114	GM-CSF/CSF2 Protein, Mouse, Recombinant MGI-IGM,colony stimulating factor 2 (granulocyte-ma...	Mouse	HEK293 Cells
	GM-CSF/CSF2 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.1 kDa and the accession number is P01587.
TMPY-05236	GM-CSF/CSF2 Protein, Human, Recombinant, Biotinylated CSF2,GMCSF,GM-CSF	Human	HEK293 Cells
	GM-CSF/CSF2 Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 14.5 kDa and the accession number is P04141.
TMPY-02466	GM-CSF/CSF2 Protein, Human, Recombinant (His) colony stimulating factor 2 (granulocyte-macrophage),GM<...	Human	HEK293 Cells
	GM-CSF/CSF2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.9 kDa and the accession number is P04141.
TMPY-01065	GM-CSFR alpha Protein, Human, Recombinant (His) GM-CSF-R-α,colony stimulating factor 2 rec...	Human	HEK293 Cells
	GM-CSFR alpha Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36 kDa and the accession number is P15509-1.
TMPY-03631	GM-CSF/CSF2 Protein, Mouse, Recombinant (hFc) GMCSF,Csfgm,集落刺激因子,colon...	Mouse	HEK293 Cells
	GM-CSF/CSF2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.5 kDa and the accession number is P01587.
TMPY-03713	GM-CSF/CSF2 Protein, Rat, Recombinant (His) colony stimulating factor 2 (granulocyte-macrophage),集落刺激因子	Rat	HEK293 Cells
	GM-CSF/CSF2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.9 kDa and the accession number is P48750.
TMPK-00930	GM-CSFR alpha Protein, Mouse, Recombinant (His) CSF2RAX,CSF2RX,CD116,CSF2RAY,...	Mouse	HEK293 Cells
	In the first trimester, the GM-CSF-R was found to be present on villous cytotrophoblast and all populations of extravillous trophoblast. Expression by villous syncytiotrophoblast was weak or absent, but this increased markedly by term. GM-CSF-R were also expressed by fetal Hofbauer cells within the mesenchyme of the chorionic villi and by uterine glandular epithelium and decidual macrophages within maternal decidua. GM-CSFR alpha Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian...
TMPK-00490	GM-CSFR alpha Protein, Cynomolgus, Recombinant (His) CSF2RY,SMDP4,GMCSFR-α,GM...	Cynomolgus	HEK293 Cells
	In the first trimester, the GM-CSF-R was found to be present on villous cytotrophoblast and all populations of extravillous trophoblast. Expression by villous syncytiotrophoblast was weak or absent, but this increased markedly by term. GM-CSF-R were also expressed by fetal Hofbauer cells within the mesenchyme of the chorionic villi and by uterine glandular epithelium and decidual macrophages within maternal decidua. GM-CSFR alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mamm...
TMPY-00816	GM-CSFR alpha Protein, Human, Recombinant (hFc) CSF2RAX,CSF2R,CD116,CSF2RY,GM...	Human	HEK293 Cells
	GM-CSFR alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.2 kDa and the accession number is P15509-1.
TMPK-00254	GM-CSFR alpha Protein, Human, Recombinant (His & Avi), Biotinylated GM-CSF-R-α,GMR-α,GMR-alp...	Human	HEK293 Cells
	In the first trimester, the GM-CSF-R was found to be present on villous cytotrophoblast and all populations of extravillous trophoblast. Expression by villous syncytiotrophoblast was weak or absent, but this increased markedly by term. GM-CSF-R were also expressed by fetal Hofbauer cells within the mesenchyme of the chorionic villi and by uterine glandular epithelium and decidual macrophages within maternal decidua. GM-CSFR alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed...
TMPY-04036	GM-CSF/CSF2 Protein, Rat, Recombinant (hFc) 集落刺激因子,colony stimulating factor 2 (granulocyte-macrophage)	Rat	HEK293 Cells
	GM-CSF/CSF2 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43 kDa and the accession number is P48750.
TMPJ-01467	Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His) Oncostatin-M,OSM	Human	E. coli
	Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological ac...
TMPY-01280	FOLR2 Protein, Human, Recombinant (His) FBP,β-HFR,FR-P3,BETA-HFR,folate receptor 2 (fetal),FR-BETA,F...	Human	HEK293 Cells
	Folate receptor beta, also known as Folate receptor 2, FBP, and FOLR2, is a member of the folate receptor family. FOLR2 is expressed in placenta and hematopoietic cells. The expression of FOLR2 is increased in malignant tissues. Members of the Folate receptor family members (FOLRs) have a high affinity for folic acid and for several reduced folic acid derivatives. They mediate the delivery of 5-methyltetrahydrofolate to the interior of, out of within, or between cells in a process known as potoc...
TMPH-03345	Oncostatin M/OSM Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. Oncostatin M/OSM Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 24.2 kDa and ...
TMPY-04421	FES Protein, Human, Recombinant (His & GST) FPS,FES proto-oncogene, tyrosine kinase	Human	Baculovirus Insect Cells
	Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and oneSH2 domain. FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. FES is observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-6. T...
TMPJ-01237	IL-17D Protein, Human, Recombinant IL17D,Interleukin-17D,IL-17D	Human	E. coli
	The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence ho...
TMPJ-01361	Siglec-8 Protein, Human, Recombinant (mFc) CD329 antigen,Siglec-8,SAF2SAF-2,CDw329,Siglec8,SAF-2,SAF2	Human	HEK293 Cells
	Siglec-8 is also known as SIGLEC8, SAF2, SIGLEC-8, SIGLEC8L and sialic acid binding Ig like lectin 8, is an approximately 75 kDa transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Siglec-8 is expressed on eosinophils, basophils, and mast cells, and it shows a binding preference for the carbohydrate 6-O sulfated sLex. At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Mature human Siglec-8 c...
TMPY-03504	CBFB Protein, Human, Recombinant (His) core-binding factor, β subunit,core-binding factor, beta sub...	Human	E. coli
	CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). CBFB is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enh...

重组蛋白

GM-CSF/CSF2 Protein, Human, Recombinant

Cat.No: TMPY-03858

Species: Human

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00750

Species: Human

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)

Cat.No: TMPJ-01465

Species: Human

Expression System: E. coli

GM-CSF/CSF2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03662

Species: Mouse

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Mouse, Recombinant

Cat.No: TMPY-04114

Species: Mouse

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Human, Recombinant, Biotinylated

Cat.No: TMPY-05236

Species: Human

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02466

Species: Human

Expression System: HEK293 Cells

GM-CSFR alpha Protein, Human, Recombinant (His)

Cat.No: TMPY-01065

Species: Human

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03631

Species: Mouse

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03713

Species: Rat

Expression System: HEK293 Cells

GM-CSFR alpha Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00930

Species: Mouse

Expression System: HEK293 Cells

GM-CSFR alpha Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00490

Species: Cynomolgus

Expression System: HEK293 Cells

GM-CSFR alpha Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00816

Species: Human

Expression System: HEK293 Cells

GM-CSFR alpha Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00254

Species: Human

Expression System: HEK293 Cells

GM-CSF/CSF2 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-04036

Species: Rat

Expression System: HEK293 Cells

Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPJ-01467

Species: Human

Expression System: E. coli

FOLR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01280

Species: Human

Expression System: HEK293 Cells

Oncostatin M/OSM Protein, Rat, Recombinant (His)

Cat.No: TMPH-03345

Species: Rat

Expression System: HEK293 Cells

FES Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04421

Species: Human

Expression System: Baculovirus Insect Cells

IL-17D Protein, Human, Recombinant

Cat.No: TMPJ-01237

Species: Human

Expression System: E. coli

Siglec-8 Protein, Human, Recombinant (mFc)

Cat.No: TMPJ-01361

Species: Human

Expression System: HEK293 Cells

CBFB Protein, Human, Recombinant (His)

Cat.No: TMPY-03504

Species: Human

Expression System: E. coli

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