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Search Results for " glycoprotein b "

12

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22800	Glycoprotein B (485-492)	Others	Others
	Glycoprotein B is a peptide with the sequence H2N-Ser-Ser-Ile-Glu-Phe-Ala-Arg-Leu-OH, MW= 922.04. glycoprotein B is a viral glycoprotein that is involved in the viral cell entry of Herpes simplex virus. The herpesvirus glycoprotein B is the most highly c
T7657	MOG (35-55) mouse, rat 髓鞘少突胶质细胞糖蛋白,MOG (35-55)	Others	Others
	Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) 是中枢神经鞘的一个次要成分。它能诱导强效的 T 细胞和 B 细胞反应，同时是高度脑源性的。它能够引发复发缓解性神经系统疾病，伴有广泛的斑块样脱髓鞘。
T6075	Epothilone B 帕妥匹隆,Patupilone,EPO 906	Apoptosis; Microtubule Associated; Antibiotic; Antifungal	Apoptosis; Cytoskeletal Signaling; Microbiology/Virology
	Epothilone B (EPO 906) 是微管稳定剂，Ki 为0.71 μM。它与αβ-微管蛋白异二聚体亚基结合，使αβ-微管蛋白解离减少。
TP1534	HSV-gB2 (498-505) HSV-gB2 498-505
	This is the immunodominant epitope gB-8p from herpes simplex virus (HSV) glycoprotein B (gB), amino acids 498 to 505.
T74492	CD22 ligand-1
	CD22ligand-1 (compound 12) 是一种有效的选择性CD22配体，对 hCD22 和 MAG 的KD 值分别为 0.335、30.7 µM。CD22ligand-1 具有研究 B 细胞相关疾病的潜力。
T36942	SSAA09E1 SSAA09E1
	SSAA09E1 is an inhibitor of severe acute respiratory syndrome coronavirus (SARS-CoV) viral entry.1It reduces infection of HEK293T cells transiently transfected with angiotensin-converting enzyme 2 (ACE2) by an HIV-based virus system pseudotyped with SARS-CoV surface glycoprotein (EC50= 6.7 μM). SSAA09E1 also inhibits the proteolytic activity of cathepsin L (IC50= 5.33 μM) but not cathepsin B when used at a concentration of 20 μM. 1.()
T77010	Fiztasovimab
	Fiztasovimab (NPC-21; EV2038) 是一种全人 IgG1λ 单克隆抗体，具有抗人巨细胞病毒 (hCMV) 活性。Fiztasovimab 通过结合 hCMV 包膜上糖蛋白 B 的抗原结构域 1 发挥中和活性。Fiztasovimab 还抑制 hCMV 的细胞间传播。
T77906	Briobacept BR 3FC
	Briobacept (BR 3FC)为专门针对BLyS(BAFF)的单克隆抗体，具有诱导B细胞凋亡(apoptosis)的能力。该化合物是一种重组糖蛋白，由两个BLyS受体(BR3)以及人类IgG1 Fc结构域构成。Briobacept主要用于类风湿关节炎(RA)的研究领域。
T68860	Iso-Fludelone
	Iso-Fludelone is the third-generation epothilone B analogue with potential anti-mitotic and antineoplastic activites. Iso-fludelone binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to other generations of epothilones, iso-fludelone exhibits increased stability, water solubility, potency, duration of action, tumor penetration as we...
T80919	Tumour-associated MUC1 epitope
	Tumour-associated MUC1 epitope是一种具有标志性的生物活性肽。作为高度糖基化的I型跨膜糖蛋白MUC1的一部分，该肽通过特定的胞外结构域展现，该结构域包含20个氨基酸组成的可变数量串联重复序列(VNTR)。在多种人类腺癌及血液恶性肿瘤（如多发性骨髓瘤和B细胞淋巴瘤）中细胞表面表达过量，因此，MUC1是许多免疫治疗策略的关键靶点。
T81772	MOG (92–106), mouse, rat
	MOG (92–106), mouse, rat 是一种来自小鼠/大鼠髓磷脂少突胶质细胞糖蛋白的生物活性肽，包含氨基酸片段92至106。在MOG (92–106) 诱导的实验性自身免疫性脑脊髓炎模型中，小鼠会对次级髓磷脂抗原呈现出广泛的B细胞反应性，尽管T细胞反应较弱。该肽段在SJL小鼠、DA大鼠以及恒河猴中均可诱导严重的脑炎。
T83910	S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
	S1PL-IN-31是一种鞘氨醇-1-磷酸(S1P)裂解酶的抑制剂(IC50 = 210 nM)，同时也是Smoothened(Smo)受体的对抗剂(IC50 = 440 nM)。在体内，S1PL-IN-31 (每天2 mg/kg)能够防止实验性自身免疫性脑炎(EAE)模型大鼠中，由髓鞘少突胶质细胞糖蛋白(MOG)肽段MOG29-152诱发的颈部及胸部淋巴细胞渗透和神经肌肉虚弱。该化合物降低了大鼠的淋巴细胞总数及CD4+ T细胞、CD8+ T细胞和B细胞的水平。S1PL-IN-31 (每天3及10 mg/kg剂量)在雄性和雌性大鼠心脏和淋巴结中增加了S1P水平，并且在雌性大鼠中降低了心率。

化合物

Glycoprotein B (485-492)

Cat.No: T22800

Target: Others

MOG (35-55) mouse, rat

Cat.No: T7657

Synonym: 髓鞘少突胶质细胞糖蛋白,MOG (35-55)

Target: Others

Cat.No: T6075

Synonym: 帕妥匹隆,Patupilone,EPO 906

Target: Apoptosis, Microtubule Associated, Antibiotic, Antifungal

HSV-gB2 (498-505)

Cat.No: TP1534

Synonym: HSV-gB2 498-505

Cat.No: T74492

Cat.No: T36942

Synonym: SSAA09E1

Cat.No: T77010

Cat.No: T77906

Synonym: BR 3FC

Cat.No: T68860

Tumour-associated MUC1 epitope

Cat.No: T80919

MOG (92–106), mouse, rat

Cat.No: T81772

Cat.No: T83910

Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31

Cat. No.	Product Name	Target	Signaling Pathways
T12540	Pristinamycin IA Mikamycin IA,普利霉素IA,Mikamycin B	Others; Antibiotic; P-gp	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Pristinamycin IA (Mikamycin B) 是 P-糖蛋白的底物，也是一种环肽类大环内酯抗生素。
TJS1159	Chrysosplenetin 猫眼草黄素,Chrysosptertin B	P450; Ferroptosis; P-gp	Apoptosis; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Chrysosplenetin 是青蒿和其他几种中草药中的一种多甲氧基化黄酮类天然产物，抑制 P-gp 活性并逆转由青蒿素诱导的上调的 P-gp 和 MDR1 水平。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T4085	Paris saponin VII 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII	Apoptosis; BCL; Others; PARP; p38 MAPK; Akt; Caspase; P-gp; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Membrane transporter/Ion channel; Neuroscience; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Paris saponin VII (Dioscini) 是从延龄草的根和根茎中分离的一种甾体皂苷。它减弱线粒体膜电位，增加凋亡相关蛋白的表达，并降低Bcl-2、caspase-9、caspase-3、PARP-1和p-Akt 的蛋白表达水平。它在 K562/ADR 细胞中诱导强烈的自噬，可研究白血病。
TN2256	Taccalonolide B 根薯酮内酯B,根薯酮内酯 B	Microtubule Associated	Cytoskeletal Signaling
	Taccalonolide B 是从广西裂果薯中分离得到的一种微管稳定剂，具有抗肿瘤活性。它抑制 SK-OV-3 细胞的生长，IC50 为 208 nM，在体外对过表达 P-糖蛋白 (Pgp) 和多药耐药蛋白 (MRP7) 的细胞系有效。
TN5114	Taxinine	P-gp	Membrane transporter/Ion channel; Neuroscience
	Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
TN5113	Taxinine B	Others	Others
	Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).
TN1099	Dihydroevocarpine	MAO; P-gp; Antifection	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A.

天然产物

Pristinamycin IA

Cat.No: T12540

Synonym: Mikamycin IA,普利霉素IA,Mikamycin B

Target: Others, Antibiotic, P-gp

Chrysosplenetin

Cat.No: TJS1159

Synonym: 猫眼草黄素,Chrysosptertin B

Target: P450, Ferroptosis, P-gp

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Paris saponin VII

Cat.No: T4085

Synonym: 重楼皂苷 VII,Chonglou Saponin VII,Polyphyllin-VII,Dioscinin,Paris saponin-VII

Target: Apoptosis, BCL, Others, PARP, p38 MAPK, Akt, Caspase, P-gp, Autophagy

Taccalonolide B

Cat.No: TN2256

Synonym: 根薯酮内酯B,根薯酮内酯 B

Target: Microtubule Associated

Cat.No: TN5114

Target: P-gp

Cat.No: TN5113

Target: Others

Dihydroevocarpine

Cat.No: TN1099

Target: MAO, P-gp, Antifection

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