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Cat. No. | Product Name | Target | Signaling Pathways |
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TP2453 |
Conotoxin GII
alpha-Conotoxin G II |
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Conotoxin GII is a highly toxic peptide. | |||
TP2158L1 |
TRV-120027 acetate (1234510-46-3 free base)
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RAAS; Arrestin | Endocrinology/Hormones; GPCR/G Protein |
TRV-120027 acetate (1234510-46-3 free base) 是 1 型血管紧张素 II 受体(AT1 受体)的 β-arrestin-1 偏向激动剂,可与 ß-arrestins 结合,同时阻断 G 蛋白信号传导。 | |||
TP1787L |
PKG Substrate acetate(81187-14-6 free base)
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PKA | Tyrosine Kinase/Adaptors |
PKG Substrate acetate(81187-14-6 free base) 是 cGMP 依赖性蛋白激酶 (PKG) 的选择性底物。PKG Substrate 是蛋白激酶 G (PKG) 的选择性底物,PKG Iα (Km = 59 µM) 优于 PKG II (Km = 305)微米)。 | |||
TP2158 |
TRV-120027 TFA
TRV-120027 TFA (1234510-46-3 free base) |
RAAS; Arrestin | Endocrinology/Hormones; GPCR/G Protein |
TRV-120027 TFA 是一种血管紧张素 II 介导的血管收缩抑制剂,可增加心肌细胞的收缩力。它是一种偏向 β-arrestin-1 的 AT1R 激动剂,可与 ß-arrestins 结合,同时阻断 G 蛋白信号传导。 它通过阳离子通道亚家族 C3 (TRPC3) 偶联诱导急性儿茶酚胺分泌,并促进在质膜上形成由 AT1R-β-arrestin-1-TRPC3-PLCγ 组成的大分子复合物。 | |||
T7656 |
Apelin-13
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Apelin-13 是存在于中枢和外周神经系统由13个氨基酸组成的多肽序列,是 G 蛋白偶联受体angiotensin II protein J (APJ) 的内源性配体,对 APJ 的 EC50 值为 0.37 nM。Apelin-13 具有扩张血管和降压活性,可用于研究 2 型糖尿病综合征。 | |||
T36968 |
ARN-21934
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Topoisomerase | DNA Damage/DNA Repair |
ARN-21934 是高选择性的人拓扑异构酶 II α 抑制剂,具有血脑屏障通透性。依托泊苷抑制 DNA 松弛的IC50为120 μM,ARN-21934 抑制 DNA 松弛的IC50为 2 μM。ARN-21934具有良好的体内药代动力学特性。 | |||
T81789 |
Miromavimab
M777-16-3 |
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Miromavimab (M777-16-3)为针对狂犬病毒ERAGP外域表位G-II的单克隆抗体(mAb)。 | |||
T63304 |
Topoisomerase II inhibitor 9
|
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Topoisomerase II inhibitor 9 是 Topo II 抑制剂 (IC50: 0.97 μM),也是 DNA 嵌入剂 (IC50: 43.51 μM),能够在 G2/M 期阻滞 Hep G‐2 细胞周期,诱导细胞凋亡 (apoptosis)。 | |||
T76196 |
TRV055 hydrochloride
|
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TRV055 hydrochloride,G 蛋白-偏向激动剂,作为AT1R的Gq-偏向配体,有效激发细胞内Gq介导信号传导。 | |||
T75962 |
Urotensin II, mouse acetate
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Urotensin II, mouse acetate,是孤儿G蛋白偶联受体(GPR14或SENR)的一种内源性配体,具有显著的血管收缩活性并在中枢神经系统中发挥重要功能。 | |||
T75961 |
Urotensin II, mouse TFA
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Urotensin II, mouse TFA 为孤儿G蛋白偶联受体GPR14或SENR的内源性配体,具有强效血管收缩作用,并在中枢神经系统中发挥重要角色。 | |||
TP1787 |
PKG Substrate
|
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PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with a strong preference for PKG Iα (Km = 59 µM) over PKG II (Km = 305 µM). | |||
T35459 |
Glycyl H-1152 hydrochloride
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Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits bett... | |||
T26868 |
BMS-986118
BMS 986118 |
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BMS-986118 is a full agonist of GPR40, is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial a | |||
T68207 |
Elsamitrucin
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Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). | |||
T37665 |
Endosulfan I
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Endosulfan I is an organochlorine insecticide and a stereoisomer of endosulfan II . It is active against a variety of insects, including bollworms (LD50 = 0.63 mg/g). Endosulfan I binds to GABA receptors in rat brain membranes with an IC50 value of 30 nM and is toxic to rats (LD50 = 18 mg/kg). | |||
T64266 | KR-39038 | ||
KR-39038 是一种口服具有活力的 GRK5 (G 蛋白偶联受体激酶 5) 抑制剂 (IC50: 0.02 μM)。KR-39038 能够抑制新生儿心肌细胞的 HDAC5 通路,明显抑制血管紧张素 II 诱导的细胞肥大,具有显著的抗心肌肥厚和改善心功能作用。KR-39038 能够用于进行心力衰竭的研究。 | |||
T74142 |
Angiotensin II human TFA
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Angiotensin II human (Angiotensin II) TFA 作为肾素/血管紧张素系统中关键的生物活性肽,扮演着血管收缩剂的角色并在调节人体血压中发挥中心作用。其主要通过与 G 蛋白偶联受体 (GPCRs)、血管紧张素 II 1型受体 (AT1R) 和血管紧张素 II 2型受体 (AT2R) 的相互作用来介导效应,包括刺激交感神经系统、增加醛固酮的生物合成和肾脏功能。此外,Angiotensin II human TFA 促进血管平滑肌细胞的生长和 I 型及 III 型胶原在成纤维细胞中的合成,导致血管壁与心肌增厚及纤维化,并诱导细胞凋亡。还通过LOX-1依赖的氧化还原敏感路径诱导内皮细胞中的毛细血管形成。 | |||
T36729 |
Urotensin II (goby) (trifluoroacetate salt)
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Urotensin II is a peptide vasoconstrictor and agonist of the urotensin (UT) receptor (Ki= 2.06 nM for the human recombinant receptor expressed in HEK293 cells).1It stimulates intracellular calcium mobilization in HEK293 cells expressing human and rat UT (EC50s = 0.47 and 0.78 nM, respectively) but decreases intracellular calcium concentration in goby (G. mirabilis) enterocytes when used at a concentration of 500 nM.2Urotensin II (20 mU/ml) stimulates active sodium and chloride absorption across ... | |||
T36722 |
Deltorphin II (trifluoroacetate salt)
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Deltorphin II is a peptide agonist of δ2-opioid receptors.1,2It is selective for δ-opioid receptors over μ- and κ-opioid receptors in radioligand bindings assays (Kis = 0.0033, >1, and >1 μM, respectively) and induces [35S]GTPγS binding in mouse brain membrane preparations (EC50= 0.034 μM). Deltorphin II (0.12 mg/kg) decreases the infarction zone:risk zone ratio in a rat model of myocardial ischemia-reperfusion injury induced by coronary occlusion, an effect that can be reversed by the δ2-opioid... | |||
TP1816 |
Urotensin II, mouse
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Jump to search UTS2 Identifiers Aliases UTS2, PRO1068, U-II, UCN2, UII, urotensin 2 External IDs OMIM: 604097 MGI: 1346329 HomoloGene: 4939 GeneCards: UTS2 hide Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.23 Start 7,843,083 bp[1] En | |||
T70222 | Ethonafide | ||
Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerat... | |||
T35814 |
Urocortin III (human) (trifluoroacetate salt)
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Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin II , frog sauvagine, and piscine urotensin I.1 Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III , mouse urocortin II , human urocortin , and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (Kis = 21.7, 13.5, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively).... | |||
T35855 |
AAA
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AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-induced phosphorylation of EGFR, NF-κB, and Akt in, and cell migration of, PC3 cells.In vivo, AAA (10 mg/kg per day) reduces systolic blood pressure, albuminuria, renal angiotensin II levels, and cardiac hypertrophy in a Cyp1a1-Ren-2 transgenic rat model of malignant hypertension... | |||
T37847 |
Zonisamide-13C2,15N
Zonisamide-13C2,15N |
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Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium... | |||
T37794 |
Rec 15/2615 (hydrochloride)
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Rec 15/2615 is an antagonist of α1B-adrenergic receptors (α1B-ARs; Ki = 0.45 nM for the recombinant human receptor).1 It selectively inhibits α1B-ARs over α1A-, α1D-, and α1L-ARs (Kis = 7.59, 10.23, and 49 nM, respectively). Rec 15/2615 inhibits norepinephrine-induced contractions of isolated rabbit prostate and urethral strips (Kis = 100 and 316.2 nM, respectively), as well as reduces norepinephrine-induced contractions of chloroethylclonidine-precontracted isolated rabbit aortic rings (Ki = 50... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T31993 |
Grayanotoxin II
G-II,Deacetylanhydroandromedotoxin,delta(sup 10 (18))-Andromedenol |
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Grayanotoxins are a group of closely related neurotoxins named after Leucothoe grayana. Extract from leaves of Ericaceae. | |||
TN7109 |
Prosaikogenin G
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RAAS | Endocrinology/Hormones |
Prosaikogenin G 是一种从柴胡的根中分离出的化合物,是 Saikosaponin d 在胃肠道中的衍生物。Prosaikogenin G 对 Angiotensin II 诱导的大鼠系膜细胞增殖具有明显的抑制作用,同时对肾脏有保护作用。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
TN3557 |
Cabraleadiol
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ATPase; Antifection | Membrane transporter/Ion channel; Microbiology/Virology |
Cabraleadiol displays antimycobacterial activity against Mycobacterium tuberculosis, it also is weakly cytotoxic to a breast cancer (BC) cell line. Cabraleadiol inhibits photosystem II (PS II) and induces the appearance of small G band which is related wi |